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Handbook of antimicrobial resistance / / edited by Matthias Gotte, Albert Berghuis, Greg Matlashewski, Mark Wainberg, Donald Sheppard
| Handbook of antimicrobial resistance / / edited by Matthias Gotte, Albert Berghuis, Greg Matlashewski, Mark Wainberg, Donald Sheppard |
| Pubbl/distr/stampa | New York : , : Springer New York : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (1400 pages) |
| Disciplina | 616.9041 |
| Soggetto topico |
Anti-infective agents
Drug resistance in microorganisms |
| ISBN | 1-4939-0667-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Bacteria -- Origins of antibiotic resistance (Resistome) -- Dissemination of antibiotic resistance -- Mechanisms of antibiotic resistance -- Strategies for combating antibiotic resistance -- Multiple-drug-resistant bacteria -- Resistant Tuberculosis -- MRSA -- Fungi -- Microevolution of drug resistance -- Environmental induction of azole resistance in medical molds -- Echinocandin resistance in medically relevant fungi -- Role of drug efflux in azole resistance -- Parasites -- Drug-resistant Leishmania -- Drug resistance in Helminth infections -- Drug resistance in Malaria -- Drug resistance in schistosome infections -- Drug resistance in trypanosome infections -- HIV -- Resistance to RT inhibitors -- Resistance to Integrase Inhibitors -- Resistance to Entry inhibitors -- Resistance Testing -- Virology -- Resistance to viral protease inhibitors: The substrate envelope -- Resistance to new Direct-Acting-Antivirals against HCV -- HBV Resistance -- Resistance to antiherpetic drugs -- Influenza Resistance. |
| Record Nr. | UNINA-9910349295603321 |
| New York : , : Springer New York : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success / / Stuart LeGrice, Matthias Gotte, editors
| Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success / / Stuart LeGrice, Matthias Gotte, editors |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (358 p.) |
| Disciplina | 616.979201 |
| Altri autori (Persone) |
LeGriceStuart
GotteMatthias |
| Soggetto topico |
Immunology
HIV infections - Research - Methodology |
| ISBN | 1-4614-7291-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1.7.1 Highly Active Antiretroviral Therapy (HAART)1.8 Prevention of HIV Transmission; 1.9 Conclusions; References; Part I Structure and Function of HIV RT; Chapter 2: Proviral DNA Synthesis in HIV: Background; 2.1 Introduction; 2.2 The Viral RNA Genome and DNA Provirus; 2.3 Location of the Reverse Transcription Process; 2.4 HIV-1 Reverse Transcriptase; 2.5 Selection of the tRNA Primer for HIV-1; 2.6 Placement of tRNA3Lys onto the Viral Genome; 2.7 Initiation of Reverse Transcription; 2.8 First (Minus)-Strand DNA Transfer; 2.9 Recombination Between the Two Copies of the RNA Genome
2.10 Plus-Strand DNA Synthesis2.11 tRNA Primer Removal from the (+)PBS; 2.12 Plus (Second)-Strand DNA Transfer; 2.13 Priming and Termination of DNA Synthesis Within the cPPT Region; 2.14 Completion of the Viral DNA Genome; 2.15 Integration of the HIV-1 Genome into the Host Genome; 2.16 Unintegrated Viral DNA; 2.17 Conclusion; References; Chapter 3: The RNase H Domain: Structure, Function and Mechanism; 3.1 Overview; 3.2 Structures of RNases H1; 3.3 Substrate Binding; 3.4 Catalysis; 3.5 Catalytic Mechanism of HIV-1 RNase H; 3.6 The Role of RNase H Activity in Reverse Transcription 5.2.1 Interaction Between HIV-1 RT and Nucleoside Triphosphates5.2.2 Crystallographic Structural Studies; 5.3 Mechanisms of Drug Resistance; 5.3.1 Resistance Through Increased Discrimination Against the Active Form of the Drug; 5.3.2 Resistance Through ATP-Mediated Excision of Chain-Terminating Nucleotides; 5.3.3 Mutations in RT that Antagonize the Effect of TAMs; 5.4 Structural Dissection of Drug-Resistant RT; 5.4.1 TAMs and Excision of AZTMP; 5.4.2 The K65R Mutation: Resistance to Tenofovir Disoproxil Fumarate (TDF) and Suppression of TAMs; 5.5 Uptake and Phosphorylation of NRTIs and NtRTIs 5.6 Intracellular dNTP Concentrations |
| Record Nr. | UNINA-9910739405103321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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