A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery / / edited by Robert A. Goodnow, Jr. ; contributors Raksha A. Acharya [and twenty five others] |
Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
Descrizione fisica | 1 online resource (497 p.) |
Disciplina | 615.1/9 |
Soggetto topico |
Combinatorial Chemistry Techniques
DNA - chemical synthesis Drug Discovery Gene Library - Small Molecule Libraries Small Molecule Libraries - chemical synthesis |
ISBN |
1-118-83267-1
1-118-83273-6 1-118-83269-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology. |
Record Nr. | UNINA-9910139121703321 |
Hoboken, New Jersey : , : Wiley, , 2014 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery / / edited by Robert A. Goodnow, Jr. ; contributors Raksha A. Acharya [and twenty five others] |
Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
Descrizione fisica | 1 online resource (497 p.) |
Disciplina | 615.1/9 |
Soggetto topico |
Combinatorial Chemistry Techniques
DNA - chemical synthesis Drug Discovery Gene Library - Small Molecule Libraries Small Molecule Libraries - chemical synthesis |
ISBN |
1-118-83267-1
1-118-83273-6 1-118-83269-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology. |
Record Nr. | UNINA-9910806871903321 |
Hoboken, New Jersey : , : Wiley, , 2014 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|