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Tumor Microenvironment : Study Protocols / / edited by Constantinos Koumenis, Lisa M. Coussens, Amato Giaccia, Ester Hammond
| Tumor Microenvironment : Study Protocols / / edited by Constantinos Koumenis, Lisa M. Coussens, Amato Giaccia, Ester Hammond |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (VIII, 297 p. 85 illus., 64 illus. in color.) |
| Disciplina | 616.994071 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Cancer research
Molecular biology Immunology Cancer Research Molecular Medicine |
| ISBN | 3-319-26666-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1.Staining against phospho-H2AX (γ-H2AX) as a marker for DNA damage and genomic instability in cancer tissues and cells -- 2.Measuring DNA replication rates in hypoxic conditions -- 3.Isolation of Proteins on Nascent DNA in hypoxia and reoxygenation conditions -- 4.In vivo interrogation of the hypoxic transcriptome of solid tumors: optimizing hypoxic probe labelling with Laser-Capture Microdissection for isolation of high-quality RNA for deep sequencing analysis -- 5.Gas chromatography coupled to mass spectrometry (GC-MS) to study metabolism in cultured cells -- 6.Probing Cancer Cell Metabolism using NMR Spectroscopy -- 7.Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenases Activity in Cultured Cells -- 8.Measuring Autophagy in the Context of Cancer -- 9.Methods for studying autophagy within the tumor microenvironment -- 10.Using 3 Dimensional Culture (Spheroids) as an in vitro Model of Tumour Hypoxia -- 11.Isolation of Glioma Initiating Cells for Biological Study -- 12.Isolation of mouse and human tumor associated macrophages -- 13.Mouse models of brain metastasis for unravelling tumour progression -- 14.Quantification of lung metastases from in vivo mouse models -- 15.A multimodal data analysis approach for targeted drug discovery involving topological data analysis (TDA) -- 16.Efficient protocol for the identification of hypoxic cell radiosensitisers. |
| Record Nr. | UNINA-9910253873803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Tumor Microenvironment and Cellular Stress : Signaling, Metabolism, Imaging, and Therapeutic Targets / / edited by Constantinos Koumenis, Ester Hammond, Amato Giaccia
| Tumor Microenvironment and Cellular Stress : Signaling, Metabolism, Imaging, and Therapeutic Targets / / edited by Constantinos Koumenis, Ester Hammond, Amato Giaccia |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (293 p.) |
| Disciplina | 616.994 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Cancer research
Immunology Human physiology Medical microbiology Cancer Research Human Physiology Medical Microbiology |
| ISBN | 1-4614-5915-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Hypoxia and metabolism in cancer -- Hypoxia and Regulation of Cancer Cell Stemness -- Hypoxia-mediated metastasis -- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective -- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy -- Hypoxia directed drug strategies to target the tumor microenvironment -- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications -- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic -- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer -- miR-210: Fine-Tuning the Hypoxic Response -- The role of complement in tumor growth -- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging -- Index. |
| Record Nr. | UNINA-9910298328603321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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