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Translational neuroscience [[electronic resource] ] : a guide to a successful program / / edited by Edgar Garcia-Rill
| Translational neuroscience [[electronic resource] ] : a guide to a successful program / / edited by Edgar Garcia-Rill |
| Pubbl/distr/stampa | Chichester, West Sussex, UK, : Wiley-Blackwell, c2012 |
| Descrizione fisica | 1 online resource (178 p.) |
| Disciplina | 362.196/80072 |
| Altri autori (Persone) | Garcia-RillEdgar |
| Soggetto topico |
Neurosciences - Research
Neurosciences |
| ISBN |
1-283-33303-1
9786613333032 1-118-26030-9 1-118-26047-3 1-118-26054-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Translational Neuroscience : A Guide to a Successful Program; Contents; Contributors; Preface; Acknowledgments; 1 A Brief History of Translational Neuroscience; Some recent history; Funding translational research; Lack of funding; Making NIH funding more equitable and efficient; How much funding is needed?; Medical research funding in Europe; References; 2 Mentoring in Translational Neuroscience; T1 blocks; T2 blocks; References; 3 Core Facilities for Translational Neuroscience; Designing translational neuroscience core facilities; Preattentional measure-the P50 potential
Attentional measures-psychomotor vigilanceFrontal lobe blood flow measures; References; 4 Translational Studies Using TMS; Overview; Introduction; Development of a sham stimulation technique for humans; PET-guided TMS studies of tinnitus perception; TMS investigations of decision-making in tobacco addiction; TMS investigations in rodents; Conclusion; References; 5 Translational Studies in Drug Abuse; Background and significance; Behavioral Core Facility; Voltage-sensitive dye imaging; Intravenous drug self-administration; References; 6 Electrophysiology in Translational Neuroscience In vivo and in vitro animal modelsModafinil; Patch clamp recordings; Gamma band activity; Population responses; Preconscious awareness; Magnetoencephalography, the Cadillac of human electrophysiology; References; 7 Translational Research on Spinal Cord Injury; Electrophysiological approach: H-reflex frequency-dependent depression; Biomechanical approach: windup of the stretch reflex; Interventions: passive exercise; Interventions: pharmacology (L-Dopa, Modafinil); Conclusions; References; 8 Translational Research in Neonatology; Introduction; The need for neonatal research The building blocks: basic researchPups to babies and back again: T1 Research; No problem can be solved unless it is first identified; From the bedside to the community: T2 research; The role of comparative effectiveness research; Barriers and rewards in translational research in neonatology; Opportunities for translational research in neonatology; Conclusion; References; 9 Telemedicine in Translational Neuroscience; History of telemedicine; Enabling access to care; Telemedicine Core Facility; Neonatal intensive care; Emergency departments; Conclusion; References 10 Implications for the FutureFragmented infrastructure; Incompatible databases; The benefits of translational research; The reshaping of basic science departments; References; Index; Color plates appear between pages 96 and 97. |
| Record Nr. | UNINA-9910139698603321 |
| Chichester, West Sussex, UK, : Wiley-Blackwell, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Translational neuroscience : a guide to a successful program / / edited by Edgar Garcia-Rill
| Translational neuroscience : a guide to a successful program / / edited by Edgar Garcia-Rill |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, UK, : Wiley-Blackwell, c2012 |
| Descrizione fisica | 1 online resource (178 p.) |
| Disciplina | 362.196/80072 |
| Altri autori (Persone) | Garcia-RillEdgar |
| Soggetto topico |
Neurosciences - Research
Neurosciences |
| ISBN |
9786613333032
9781283333030 1283333031 9781118260302 1118260309 9781118260470 1118260473 9781118260548 1118260546 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Translational Neuroscience : A Guide to a Successful Program; Contents; Contributors; Preface; Acknowledgments; 1 A Brief History of Translational Neuroscience; Some recent history; Funding translational research; Lack of funding; Making NIH funding more equitable and efficient; How much funding is needed?; Medical research funding in Europe; References; 2 Mentoring in Translational Neuroscience; T1 blocks; T2 blocks; References; 3 Core Facilities for Translational Neuroscience; Designing translational neuroscience core facilities; Preattentional measure-the P50 potential
Attentional measures-psychomotor vigilanceFrontal lobe blood flow measures; References; 4 Translational Studies Using TMS; Overview; Introduction; Development of a sham stimulation technique for humans; PET-guided TMS studies of tinnitus perception; TMS investigations of decision-making in tobacco addiction; TMS investigations in rodents; Conclusion; References; 5 Translational Studies in Drug Abuse; Background and significance; Behavioral Core Facility; Voltage-sensitive dye imaging; Intravenous drug self-administration; References; 6 Electrophysiology in Translational Neuroscience In vivo and in vitro animal modelsModafinil; Patch clamp recordings; Gamma band activity; Population responses; Preconscious awareness; Magnetoencephalography, the Cadillac of human electrophysiology; References; 7 Translational Research on Spinal Cord Injury; Electrophysiological approach: H-reflex frequency-dependent depression; Biomechanical approach: windup of the stretch reflex; Interventions: passive exercise; Interventions: pharmacology (L-Dopa, Modafinil); Conclusions; References; 8 Translational Research in Neonatology; Introduction; The need for neonatal research The building blocks: basic researchPups to babies and back again: T1 Research; No problem can be solved unless it is first identified; From the bedside to the community: T2 research; The role of comparative effectiveness research; Barriers and rewards in translational research in neonatology; Opportunities for translational research in neonatology; Conclusion; References; 9 Telemedicine in Translational Neuroscience; History of telemedicine; Enabling access to care; Telemedicine Core Facility; Neonatal intensive care; Emergency departments; Conclusion; References 10 Implications for the FutureFragmented infrastructure; Incompatible databases; The benefits of translational research; The reshaping of basic science departments; References; Index; Color plates appear between pages 96 and 97. |
| Record Nr. | UNINA-9910827948703321 |
| Chichester, West Sussex, UK, : Wiley-Blackwell, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Waking and the reticular activating system in health and disease / / edited by Carol K. Baron
| Waking and the reticular activating system in health and disease / / edited by Carol K. Baron |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (330 p.) |
| Disciplina | 591.188 |
| Soggetto topico |
Reticular formation
Wakefulness |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Waking and The Reticular Activating System in Health and Disease; Copyright; Contents; Acknowledgments; Dedication; Preface; Chapter 1: Governing Principles of Brain Activity; Why Waking?; The Gorilla in the Room; Cell Assemblies; Coherence and Frequency; Content and Context; Cortical Columns; Thalamocortical Resonance; Clinical Implications: Thalamocortical Dysrhythmia; References; Chapter 2: The EEG and the Discovery of the RAS; The EEG and the RAS; Limitations of the EEG; Early Theories of Sleep; The Pedunculopontine Nucleus; Dorsal and Ventral Cholinergic Pathways
Clinical Implications: "Sleep Problems" vs. "Waking Problems"References; Chapter 3: Other Regions Modulating Waking; A Matter of Time; The Lateral Hypothalamus and Hypocretin; The Basal Forebrain and Acetylcholine; The TMN and Histamine; Clinical Implications: Coma; References; Chapter 4: Wiring Diagram of the RAS; Wiring Diagram; Locus Coeruleus; Dorsal Raphe Nucleus; Pedunculopontine Nucleus; Intrinsic Properties of PPN Neurons; Inputs to PPN Neurons; Electrical Coupling; Cell Clusters; Clinical Implications; References; Chapter 5: Development and the RAS; Development of Wake-Sleep States Evolutionary ConsiderationsDevelopmental Decrease in REM Sleep; REM Sleep Inhibition; Changes in Intrinsic Properties; Changes in Transmitter Responses; Puberty and Wake-Sleep; Gonadal Steroids; Clinical Implications; References; Chapter 6: Ascending Projections of the RAS; The Ascending Reticular Activating System; Intralaminar Thalamus; Cortex; Clinical Implications; References; Chapter 7: Descending Projections of the RAS; Descending Targets; The Subcoeruleus Nucleus; The PPN and the MLR; Posture and Locomotion; Push-Pull on Reticulospinal Cells; The Startle Response; Spinal Cord Clinical ImplicationsReferences; Chapter 8: The 10 Hz Fulcrum; Alpha Frequency (~ 10 Hz) Activity; Alpha Rhythm; The mu Rhythm; Physiological Tremor; The 10 Hz Fulcrum; Natural Frequency; Clinical Implications; References; Chapter 9: Gamma Band Activity; What does the EEG measure?; Binding and Perception; Cortical Mechanisms of Gamma Band Activity; Coordination of Gamma Band Activity; RAS Mechanisms of Gamma Band Activity; Gamma Maintenance; Gamma in Waking vs. REM Sleep; Clinical Implications; References; Chapter 10: Preconscious Awareness; The Role of Gamma Band Activity in the RAS Levels of AwarenessWaking and Preconscious Awareness; Volition and Free Will; Mechanisms for Preconscious Awareness; Everyday Preconscious Awareness; The PPN and Behavior; Clinical Implications; References; Chapter 11: Psychiatric Disorders and the RAS; Arousal, Waking, and Psychiatric Disorders; Schizophrenia; Bipolar Disorder; Major Depression; Posttraumatic Stress Disorder; Attention Deficit Hyperactivity Disorder; Autism; Clinical Implications; References; Chapter 12: Neurological Disorders and the RAS; Arousal, Waking, and Neurological Disorders; Parkinson's Disease; Alzheimer's Disease Huntington's Disease |
| Record Nr. | UNINA-9910788108803321 |
| Amsterdam, Netherlands : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Waking and the reticular activating system in health and disease / / edited by Carol K. Baron
| Waking and the reticular activating system in health and disease / / edited by Carol K. Baron |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (330 p.) |
| Disciplina | 591.188 |
| Soggetto topico |
Reticular formation
Wakefulness |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Waking and The Reticular Activating System in Health and Disease; Copyright; Contents; Acknowledgments; Dedication; Preface; Chapter 1: Governing Principles of Brain Activity; Why Waking?; The Gorilla in the Room; Cell Assemblies; Coherence and Frequency; Content and Context; Cortical Columns; Thalamocortical Resonance; Clinical Implications: Thalamocortical Dysrhythmia; References; Chapter 2: The EEG and the Discovery of the RAS; The EEG and the RAS; Limitations of the EEG; Early Theories of Sleep; The Pedunculopontine Nucleus; Dorsal and Ventral Cholinergic Pathways
Clinical Implications: "Sleep Problems" vs. "Waking Problems"References; Chapter 3: Other Regions Modulating Waking; A Matter of Time; The Lateral Hypothalamus and Hypocretin; The Basal Forebrain and Acetylcholine; The TMN and Histamine; Clinical Implications: Coma; References; Chapter 4: Wiring Diagram of the RAS; Wiring Diagram; Locus Coeruleus; Dorsal Raphe Nucleus; Pedunculopontine Nucleus; Intrinsic Properties of PPN Neurons; Inputs to PPN Neurons; Electrical Coupling; Cell Clusters; Clinical Implications; References; Chapter 5: Development and the RAS; Development of Wake-Sleep States Evolutionary ConsiderationsDevelopmental Decrease in REM Sleep; REM Sleep Inhibition; Changes in Intrinsic Properties; Changes in Transmitter Responses; Puberty and Wake-Sleep; Gonadal Steroids; Clinical Implications; References; Chapter 6: Ascending Projections of the RAS; The Ascending Reticular Activating System; Intralaminar Thalamus; Cortex; Clinical Implications; References; Chapter 7: Descending Projections of the RAS; Descending Targets; The Subcoeruleus Nucleus; The PPN and the MLR; Posture and Locomotion; Push-Pull on Reticulospinal Cells; The Startle Response; Spinal Cord Clinical ImplicationsReferences; Chapter 8: The 10 Hz Fulcrum; Alpha Frequency (~ 10 Hz) Activity; Alpha Rhythm; The mu Rhythm; Physiological Tremor; The 10 Hz Fulcrum; Natural Frequency; Clinical Implications; References; Chapter 9: Gamma Band Activity; What does the EEG measure?; Binding and Perception; Cortical Mechanisms of Gamma Band Activity; Coordination of Gamma Band Activity; RAS Mechanisms of Gamma Band Activity; Gamma Maintenance; Gamma in Waking vs. REM Sleep; Clinical Implications; References; Chapter 10: Preconscious Awareness; The Role of Gamma Band Activity in the RAS Levels of AwarenessWaking and Preconscious Awareness; Volition and Free Will; Mechanisms for Preconscious Awareness; Everyday Preconscious Awareness; The PPN and Behavior; Clinical Implications; References; Chapter 11: Psychiatric Disorders and the RAS; Arousal, Waking, and Psychiatric Disorders; Schizophrenia; Bipolar Disorder; Major Depression; Posttraumatic Stress Disorder; Attention Deficit Hyperactivity Disorder; Autism; Clinical Implications; References; Chapter 12: Neurological Disorders and the RAS; Arousal, Waking, and Neurological Disorders; Parkinson's Disease; Alzheimer's Disease Huntington's Disease |
| Record Nr. | UNINA-9910818320803321 |
| Amsterdam, Netherlands : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||