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The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich
| The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | London, : Imperial College Press |
| Descrizione fisica | 1 online resource (447 p.) |
| Disciplina | 571.96 |
| Altri autori (Persone) | GabrilovichDmitry I |
| Soggetto topico |
Neutrophils
Immunology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-299-46292-8
1-84816-837-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
List of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF)
1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBPα - Generation of GMP from CMP; 1.3.2.3 C/EBPε - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox 2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; References Chapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References Chapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions 4.5.5 PECAM-1 |
| Record Nr. | UNINA-9910452307003321 |
| London, : Imperial College Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich
| The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hackensack, N.J., : Imperial College Press, 2004 |
| Descrizione fisica | 1 online resource (378 p.) |
| Disciplina | 612.1/12 |
| Altri autori (Persone) | GabrilovichDmitry I |
| Soggetto topico |
Neutrophils
Physiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-86662-8
9786611866624 1-86094-605-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 The Remarkable Neutrophil! Developing a Blueprint for Integrated Cellular Signaling; 2 The Neutrophil Respiratory Burst Oxidase; 3 Novel Neutrophil Receptors and Their Signal Transduction; 4 Mechanisms of Neutrophil Migration; 5 Neutrophils and Apoptosis; 6 Regulation of Neutrophil Functions by Long Chain Fatty Acids; 7 Cytokine Production by Neutrophils; 8 Neutrophils in Viral Infections; 9 Polymorphonuclear Neutrophils and Cancer: Ambivalent Role in Host Defense Against Tumor
10 Use of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious Diseases11 Neutrophil Transfusion Therapy in the G-CSF Era; Index |
| Record Nr. | UNINA-9910449805403321 |
| Hackensack, N.J., : Imperial College Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich
| The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hackensack, N.J., : Imperial College Press, 2004 |
| Descrizione fisica | 1 online resource (378 p.) |
| Disciplina | 612.1/12 |
| Altri autori (Persone) | GabrilovichDmitry I |
| Soggetto topico |
Neutrophils
Physiology |
| ISBN |
1-281-86662-8
9786611866624 1-86094-605-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 The Remarkable Neutrophil! Developing a Blueprint for Integrated Cellular Signaling; 2 The Neutrophil Respiratory Burst Oxidase; 3 Novel Neutrophil Receptors and Their Signal Transduction; 4 Mechanisms of Neutrophil Migration; 5 Neutrophils and Apoptosis; 6 Regulation of Neutrophil Functions by Long Chain Fatty Acids; 7 Cytokine Production by Neutrophils; 8 Neutrophils in Viral Infections; 9 Polymorphonuclear Neutrophils and Cancer: Ambivalent Role in Host Defense Against Tumor
10 Use of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious Diseases11 Neutrophil Transfusion Therapy in the G-CSF Era; Index |
| Record Nr. | UNINA-9910783405903321 |
| Hackensack, N.J., : Imperial College Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich
| The neutrophils [[electronic resource] ] : new outlook for old cells / / editor, Dmitry I. Gabrilovich |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hackensack, N.J., : Imperial College Press, 2004 |
| Descrizione fisica | 1 online resource (378 p.) |
| Disciplina | 612.1/12 |
| Altri autori (Persone) | GabrilovichDmitry I |
| Soggetto topico |
Neutrophils
Physiology |
| ISBN |
1-281-86662-8
9786611866624 1-86094-605-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 The Remarkable Neutrophil! Developing a Blueprint for Integrated Cellular Signaling; 2 The Neutrophil Respiratory Burst Oxidase; 3 Novel Neutrophil Receptors and Their Signal Transduction; 4 Mechanisms of Neutrophil Migration; 5 Neutrophils and Apoptosis; 6 Regulation of Neutrophil Functions by Long Chain Fatty Acids; 7 Cytokine Production by Neutrophils; 8 Neutrophils in Viral Infections; 9 Polymorphonuclear Neutrophils and Cancer: Ambivalent Role in Host Defense Against Tumor
10 Use of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious Diseases11 Neutrophil Transfusion Therapy in the G-CSF Era; Index |
| Record Nr. | UNINA-9910819886403321 |
| Hackensack, N.J., : Imperial College Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Tumor-Induced Immune Suppression [[electronic resource] ] : Mechanisms and Therapeutic Reversal / / edited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz
| Tumor-Induced Immune Suppression [[electronic resource] ] : Mechanisms and Therapeutic Reversal / / edited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz |
| Edizione | [2nd ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (471 p.) |
| Disciplina |
571.6
571.8 599935 610 |
| Soggetto topico |
Cancer research
Immunology Medical microbiology Cell biology Human genetics Developmental biology Cancer Research Medical Microbiology Cell Biology Human Genetics Developmental Biology |
| ISBN | 1-4899-8056-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface.- Regulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index. |
| Record Nr. | UNINA-9910298349303321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||