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High-density lipoproteins : from basic biology to clinical aspects / / edited by Christopher J. Fielding
| High-density lipoproteins : from basic biology to clinical aspects / / edited by Christopher J. Fielding |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2007 |
| Descrizione fisica | 1 online resource (555 p.) |
| Disciplina |
572.68
572/.68 |
| Soggetto topico |
Lipoproteins
High density lipoproteins |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-02162-1
9786612021626 3-527-62517-8 3-527-62518-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
High-Density Lipoproteins; Contents; Preface; List of Contributors; I HDL Structure; 1 Apolipoprotein A-I Structure; 1.1 Introduction and Perspective; 1.2 Lipid-Free ApoA-I; 1.3 The Role of Protein Structure in ApoA-I Function; 1.4 Full-Length ApoA-I X-Ray Structure; 1.5 Apolipoprotein A-I Structure - Lipid-Bound State; 1.6 Structural Studies of ApoA-I on Discoidal Nascent HDL; 1.7 Hinge Domain; 1.8 Computer Models; 1.9 Spherical HDL; 1.10 Future Directions; 1.11 Acknowledgments; 2 Apolipoprotein A-II; 2.1 Apolipoprotein A-II Structure and Plasma Level Regulation
2.1.1 Structural Organization and Transcriptional Regulation of the Gene2.1.2 ApoA-II Mutations and Polymorphisms; 2.1.3 Protein Structure, Synthesis, Secretion, and Metabolism; 2.1.4 Other Determinants of ApoA-II Levels; 2.2 Pathophysiological Role of ApoA-II; 2.2.1 On HDL Metabolism; 2.2.1.1 HDL Remodeling; 2.2.1.2 Reverse Cholesterol Transport Function; 2.2.1.3 Antioxidant and Anti-inflammatory Effects; 2.2.2 Role of ApoA-II in Triglyceride and Glucose Metabolism; 2.2.2.1 Triglyceride and Free Fatty Acid (FFA) Metabolism; 2.2.2.2 Glucose Homeostasis 2.2.2.3 Role of ApoA-II in Dyslipidemia and Type 2 Diabetes Mellitus2.2.3 ApoA-II in Atherogenesis; 2.3 Acknowledgments; 3 Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking; 3.1 Introduction; 3.2 Role of ApoE in Triglyceride-Rich Lipoprotein Metabolism; 3.2.1 ApoE and Lipoprotein Assembly and Secretion; 3.2.2 ApoE and Lipoprotein Processing and Catabolism; 3.2.3 ApoE and Lipoprotein Uptake; 3.3 Role of ApoE in HDL Metabolism; 3.3.1 HDL Formation and Maturation; 3.3.2 Cholesterol Efflux and RCT 3.3.3 Roles of apoE in RCT and HDL Metabolism3.3.4 Critical Roles for ApoE and SR-BI in RCT; 3.4 ApoE and Recycling; 3.4.1 Evidence for apoE Recycling; 3.4.2 Regulation of ApoE recycling; 3.4.3 ApoE Recycling and Cholesterol Efflux; 3.4.4 Form of Recycled ApoE; 3.4.5 ApoE Recycling: Relevance to Atherosclerosis; 3.5 Summary; 4 ApoM - A Novel Apolipoprotein with Antiatherogenic Properties; 4.1 Introduction; 4.2 Cloning and Characterization of Human ApoM; 4.3 Gene Location and Amino Acid Sequence of ApoM; 4.4 Protein Structure of ApoM; 4.5 Distribution of ApoM in Plasma Lipoproteins 4.6 Tissue Distribution and Cellular Expression of ApoM4.7 Putative Functions of ApoM; 4.8 Regulation of ApoM; 4.9 Hormonal Regulation of ApoM; 4.10 Clinical Observations; 4.11 Conclusions and Perspectives; II HDL Plasma Metabolic Factors; 5 ATP Binding Cassette Transporters; 5.1 The Family of ABC Transporters - General Features; 5.2 ABC Transporters and Lipid Transport; 5.3 The ABCA Subfamily and the Handling of Excess Lipids; 5.3.1 ABCA1; 5.3.1.1 ABCA1 Expression and its Control; 5.3.1.2 Structural Considerations 5.3.1.3 ABCA1 and Cellular Effluxes of Phospholipid and Cholesterol - Facts and Speculation |
| Record Nr. | UNINA-9910144407203321 |
| Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
High-density lipoproteins : from basic biology to clinical aspects / / edited by Christopher J. Fielding
| High-density lipoproteins : from basic biology to clinical aspects / / edited by Christopher J. Fielding |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2007 |
| Descrizione fisica | 1 online resource (555 p.) |
| Disciplina |
572.68
572/.68 |
| Soggetto topico |
Lipoproteins
High density lipoproteins |
| ISBN |
1-282-02162-1
9786612021626 3-527-62517-8 3-527-62518-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
High-Density Lipoproteins; Contents; Preface; List of Contributors; I HDL Structure; 1 Apolipoprotein A-I Structure; 1.1 Introduction and Perspective; 1.2 Lipid-Free ApoA-I; 1.3 The Role of Protein Structure in ApoA-I Function; 1.4 Full-Length ApoA-I X-Ray Structure; 1.5 Apolipoprotein A-I Structure - Lipid-Bound State; 1.6 Structural Studies of ApoA-I on Discoidal Nascent HDL; 1.7 Hinge Domain; 1.8 Computer Models; 1.9 Spherical HDL; 1.10 Future Directions; 1.11 Acknowledgments; 2 Apolipoprotein A-II; 2.1 Apolipoprotein A-II Structure and Plasma Level Regulation
2.1.1 Structural Organization and Transcriptional Regulation of the Gene2.1.2 ApoA-II Mutations and Polymorphisms; 2.1.3 Protein Structure, Synthesis, Secretion, and Metabolism; 2.1.4 Other Determinants of ApoA-II Levels; 2.2 Pathophysiological Role of ApoA-II; 2.2.1 On HDL Metabolism; 2.2.1.1 HDL Remodeling; 2.2.1.2 Reverse Cholesterol Transport Function; 2.2.1.3 Antioxidant and Anti-inflammatory Effects; 2.2.2 Role of ApoA-II in Triglyceride and Glucose Metabolism; 2.2.2.1 Triglyceride and Free Fatty Acid (FFA) Metabolism; 2.2.2.2 Glucose Homeostasis 2.2.2.3 Role of ApoA-II in Dyslipidemia and Type 2 Diabetes Mellitus2.2.3 ApoA-II in Atherogenesis; 2.3 Acknowledgments; 3 Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking; 3.1 Introduction; 3.2 Role of ApoE in Triglyceride-Rich Lipoprotein Metabolism; 3.2.1 ApoE and Lipoprotein Assembly and Secretion; 3.2.2 ApoE and Lipoprotein Processing and Catabolism; 3.2.3 ApoE and Lipoprotein Uptake; 3.3 Role of ApoE in HDL Metabolism; 3.3.1 HDL Formation and Maturation; 3.3.2 Cholesterol Efflux and RCT 3.3.3 Roles of apoE in RCT and HDL Metabolism3.3.4 Critical Roles for ApoE and SR-BI in RCT; 3.4 ApoE and Recycling; 3.4.1 Evidence for apoE Recycling; 3.4.2 Regulation of ApoE recycling; 3.4.3 ApoE Recycling and Cholesterol Efflux; 3.4.4 Form of Recycled ApoE; 3.4.5 ApoE Recycling: Relevance to Atherosclerosis; 3.5 Summary; 4 ApoM - A Novel Apolipoprotein with Antiatherogenic Properties; 4.1 Introduction; 4.2 Cloning and Characterization of Human ApoM; 4.3 Gene Location and Amino Acid Sequence of ApoM; 4.4 Protein Structure of ApoM; 4.5 Distribution of ApoM in Plasma Lipoproteins 4.6 Tissue Distribution and Cellular Expression of ApoM4.7 Putative Functions of ApoM; 4.8 Regulation of ApoM; 4.9 Hormonal Regulation of ApoM; 4.10 Clinical Observations; 4.11 Conclusions and Perspectives; II HDL Plasma Metabolic Factors; 5 ATP Binding Cassette Transporters; 5.1 The Family of ABC Transporters - General Features; 5.2 ABC Transporters and Lipid Transport; 5.3 The ABCA Subfamily and the Handling of Excess Lipids; 5.3.1 ABCA1; 5.3.1.1 ABCA1 Expression and its Control; 5.3.1.2 Structural Considerations 5.3.1.3 ABCA1 and Cellular Effluxes of Phospholipid and Cholesterol - Facts and Speculation |
| Record Nr. | UNINA-9910831198103321 |
| Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||