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Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan
| Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan |
| Autore | El-Kattan Ayman F. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley Blackwell, , 2017 |
| Descrizione fisica | 1 online resource (455 pages) : illustrations |
| Disciplina | 615.1/9 |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico | Dental pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-91693-X
1-118-91694-8 1-118-91692-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
| Record Nr. | UNINA-9910467485103321 |
El-Kattan Ayman F.
|
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| Hoboken, New Jersey : , : Wiley Blackwell, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan
| Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan |
| Autore | El-Kattan Ayman F. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley Blackwell, , 2017 |
| Descrizione fisica | 1 online resource (455 pages) : illustrations |
| Disciplina | 615.1/9 |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico | Dental pharmacology |
| ISBN |
1-118-91693-X
1-118-91694-8 1-118-91692-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
| Record Nr. | UNINA-9910533954403321 |
|
El-Kattan Ayman F.
|
||
| Hoboken, New Jersey : , : Wiley Blackwell, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan
| Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan |
| Autore | El-Kattan Ayman F. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley Blackwell, , 2017 |
| Descrizione fisica | 1 online resource (455 pages) : illustrations |
| Disciplina | 615.1/9 |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico | Dental pharmacology |
| ISBN |
1-118-91693-X
1-118-91694-8 1-118-91692-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
| Record Nr. | UNINA-9910809803503321 |
|
El-Kattan Ayman F.
|
||
| Hoboken, New Jersey : , : Wiley Blackwell, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||