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Carcinogenic and anticarcinogenic factors in food : symposium
| Carcinogenic and anticarcinogenic factors in food : symposium |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2000 |
| Descrizione fisica | 1 online resource (539 pages) |
| Disciplina | 616.99/40654 |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Carcinogens - Toxicology
Food - Nutritional aspects Cancer Risk Factors Carcinogens Anticarcinogenic Agents Neoplasms Diet Food Analysis Risk Causality Noxae Protective Agents Diseases Food Technology Nutritional Physiological Phenomena Investigative Techniques Antineoplastic Agents Probability Food Industry Toxic Actions Analytical, Diagnostic and Therapeutic Techniques and Equipment Physiological Phenomena Specialty Uses of Chemicals Epidemiologic Factors Therapeutic Uses Physiological Effects of Drugs Chemical Actions and Uses Statistics as Topic Pharmacologic Actions Phenomena and Processes Quality of Health Care Industry Public Health Epidemiologic Methods Chemicals and Drugs Technology, Industry, and Agriculture Environment and Public Health Health Care Quality, Access, and Evaluation Health Care Evaluation Mechanisms Health Care Technology, Industry, Agriculture Oncology Medicine Health & Biological Sciences |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-55818-0
9786610558186 3-527-60624-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910143969803321 |
| [Place of publication not identified], : Wiley VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carcinogenic and anticarcinogenic factors in food : symposium
| Carcinogenic and anticarcinogenic factors in food : symposium |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2000 |
| Descrizione fisica | 1 online resource (539 pages) |
| Disciplina | 616.99/40654 |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Carcinogens - Toxicology
Food - Nutritional aspects Cancer Risk Factors Carcinogens Anticarcinogenic Agents Neoplasms Diet Food Analysis Risk Causality Noxae Protective Agents Diseases Food Technology Nutritional Physiological Phenomena Investigative Techniques Antineoplastic Agents Probability Food Industry Toxic Actions Analytical, Diagnostic and Therapeutic Techniques and Equipment Physiological Phenomena Specialty Uses of Chemicals Epidemiologic Factors Therapeutic Uses Physiological Effects of Drugs Chemical Actions and Uses Statistics as Topic Pharmacologic Actions Phenomena and Processes Quality of Health Care Industry Public Health Epidemiologic Methods Chemicals and Drugs Technology, Industry, and Agriculture Environment and Public Health Health Care Quality, Access, and Evaluation Health Care Evaluation Mechanisms Health Care Technology, Industry, Agriculture Oncology Medicine Health & Biological Sciences |
| ISBN |
1-280-55818-0
9786610558186 3-527-60624-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830883603321 |
| [Place of publication not identified], : Wiley VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ernh̃rungsforschung in Deutschland - Situation und Perspektiven / Nutritional Research in Germany: Standpunkte / Positions
| Ernh̃rungsforschung in Deutschland - Situation und Perspektiven / Nutritional Research in Germany: Standpunkte / Positions |
| Autore | Joost Hans-Georg |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons Incorporated, 1900 |
| ISBN | 3-527-62217-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910144382403321 |
Joost Hans-Georg
|
||
| [Place of publication not identified], : John Wiley & Sons Incorporated, 1900 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ernh̃rungsforschung in Deutschland - Situation und Perspektiven / Nutritional Research in Germany: Standpunkte / Positions
| Ernh̃rungsforschung in Deutschland - Situation und Perspektiven / Nutritional Research in Germany: Standpunkte / Positions |
| Autore | Joost Hans-Georg |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons Incorporated, 1900 |
| Descrizione fisica | 1 online resource (x, 83 pages) : illustrations |
| Disciplina | 613.2 |
| Collana | DFG-Publikationen |
| Soggetto topico |
Nutrition
Nutrition - Research |
| ISBN | 3-527-62217-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830172103321 |
|
Joost Hans-Georg
|
||
| [Place of publication not identified], : John Wiley & Sons Incorporated, 1900 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
| Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (476 p. ) : ill. (some col.) |
| Disciplina | 363.1922 |
| Altri autori (Persone) |
EisenbrandGerhard
GuthSabine HabermeyerMichael Kochte-ClemensBarbara |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Phytochemicals
Food - Safety measures |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786613302489
1-283-30248-9 3-527-63471-1 3-527-63470-3 3-527-63483-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction. 3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion. Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?. 3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References. 4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines. |
| Record Nr. | UNINA-9910265225503321 |
| Weinheim [Germany], : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
| Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (476 p. ) : ill. (some col.) |
| Disciplina | 363.1922 |
| Altri autori (Persone) |
EisenbrandGerhard
GuthSabine HabermeyerMichael Kochte-ClemensBarbara |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Phytochemicals
Food - Safety measures |
| ISBN |
9786613302489
1-283-30248-9 3-527-63471-1 3-527-63470-3 3-527-63483-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction. 3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion. Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?. 3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References. 4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines. |
| Record Nr. | UNINA-9910830691103321 |
| Weinheim [Germany], : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thermal processing of food [[electronic resource] ] : potential health benefits and risks : symposium / / editors Gerhard Eisenbrand ... [et al.] ; scientific secretariat Sabine Guth ... [et al.] ; Senate Commission on Food Safety (SKLM)
| Thermal processing of food [[electronic resource] ] : potential health benefits and risks : symposium / / editors Gerhard Eisenbrand ... [et al.] ; scientific secretariat Sabine Guth ... [et al.] ; Senate Commission on Food Safety (SKLM) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (297 p.) |
| Disciplina |
664
664.028 |
| Altri autori (Persone) | EisenbrandGerhard |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Processed foods
Food - Thermal properties Food - Preservation |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-08800-5
1-282-11842-0 9786612118425 9786611088002 3-527-61149-5 3-527-61150-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Thermal Processing of Food: Potential Health Benefits and Risks; Inhalt/Contents; Vorwort; Preface; I Bericht und Schlussfolgerungen; 1 Einleitung; 2 Allgemeine und lebensmitteltechnologische Aspekte; 3 Gesundheitliche Aspekte thermischer Behandlung von Lebensmitteln; 4 Fazit; 5 Forschungsbedarf; II Report and Conclusions; 1 Foreword; 2 General and Food Technological Aspects; 3 Health Aspects of Thermal Food Processing; 4 Conclusions; 5 Research Needs; III Contributions; 1 Thermal Processing of Foods: Technological Aspects; 2 Thermal Processing: More than Extending the Shelf Life of Foods
3 Nutritional Aspects4 Biological Activities of Maillard Reaction Products; 5 Risk Assessment of Acrylamide; 6 An Ex-vivo Approach to Assess Low Dose Effects of Acrylamide; 7 Risk Assessment of Furan; 8 Heterocyclic Aromatic Amines: Potent Genotoxicants Formed in Cooked Meats; 9 Molecular Epidemiology of Food Pyrolysis Products in Relation to Colon, Breast, and Prostate Cancer; 10 The Formation of 3-Monochloropropane-1,2-diol (3-MCPD) in Food and Potential Measures of Control; 11 Minimization Strategies: Acrylamide 12 Deep-fat Frying as Food Heating Process: Product Quality, Safety and Process Control13 Thermal Processing of Food: Allergenicity; 14 The Acrylamide Minimisation Concept - A Risk Management Tool; 15 The Consequences of Cooking: How the Origin of Cuisine Shaped Human Culture, Ecology, and Biology; IV Posters; 1 Formation, Structural Elucidation, Analysis and Toxicity of Thermal Degradation Products of the Fusarium Mycotoxin Nivalenol; 2 Influence of Different Heating Processes on the Formation of Nucleotides, Nucleosides and Free Bases in Vegetables 3 Determination of Free 3-Monochloropropane-1,2-Diol in Coffee and Coffee Surrogates4 Minimisation Concept - A Reaction on the Potential Health Risk of Acrylamide; 5 Isomerisation of Lycopene Due to Thermal Treatment of Carrot Homogenates: Increased Bioavailability of Total Lycopene and Generation of 5-cis-Lycopene in the Human Intestine; 6 Influence of High Hydrostatic Pressure on the Formation of N(ε)-Carboxymethyllysine and N(ε)-Carboxyethyllysine in Maillard-type Reactions 7 Effect of Acrylamide from a Heated Potato Product on the Acrylamide Content in Eggs, Breast Muscle Meat, Liver and Kidney of Hens8 PAH in Oil and Tocopherols - Analytical Challenges in Complying with EC Recommendations; 9 Acrylamide in Fried Potato Products - Influence of Process Conditions and Precursor Contents; 10 Thermal Stability of Zeaxanthin in Potato Homogenates; 11 Osmotic Treatment as a Pre-Step to Drying and Frying; 12 Influence of Maillard Reaction Products on the Inflammatory Cellular Response of Macrophages 13 Dosimetry of Acrylamide and Glycidamide Binding to Proteins in Human Blood |
| Record Nr. | UNINA-9910143967603321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Thermal processing of food [[electronic resource] ] : potential health benefits and risks : symposium / / editors Gerhard Eisenbrand ... [et al.] ; scientific secretariat Sabine Guth ... [et al.] ; Senate Commission on Food Safety (SKLM)
| Thermal processing of food [[electronic resource] ] : potential health benefits and risks : symposium / / editors Gerhard Eisenbrand ... [et al.] ; scientific secretariat Sabine Guth ... [et al.] ; Senate Commission on Food Safety (SKLM) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (297 p.) |
| Disciplina |
664
664.028 |
| Altri autori (Persone) | EisenbrandGerhard |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Processed foods
Food - Thermal properties Food - Preservation |
| ISBN |
1-281-08800-5
1-282-11842-0 9786612118425 9786611088002 3-527-61149-5 3-527-61150-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Thermal Processing of Food: Potential Health Benefits and Risks; Inhalt/Contents; Vorwort; Preface; I Bericht und Schlussfolgerungen; 1 Einleitung; 2 Allgemeine und lebensmitteltechnologische Aspekte; 3 Gesundheitliche Aspekte thermischer Behandlung von Lebensmitteln; 4 Fazit; 5 Forschungsbedarf; II Report and Conclusions; 1 Foreword; 2 General and Food Technological Aspects; 3 Health Aspects of Thermal Food Processing; 4 Conclusions; 5 Research Needs; III Contributions; 1 Thermal Processing of Foods: Technological Aspects; 2 Thermal Processing: More than Extending the Shelf Life of Foods
3 Nutritional Aspects4 Biological Activities of Maillard Reaction Products; 5 Risk Assessment of Acrylamide; 6 An Ex-vivo Approach to Assess Low Dose Effects of Acrylamide; 7 Risk Assessment of Furan; 8 Heterocyclic Aromatic Amines: Potent Genotoxicants Formed in Cooked Meats; 9 Molecular Epidemiology of Food Pyrolysis Products in Relation to Colon, Breast, and Prostate Cancer; 10 The Formation of 3-Monochloropropane-1,2-diol (3-MCPD) in Food and Potential Measures of Control; 11 Minimization Strategies: Acrylamide 12 Deep-fat Frying as Food Heating Process: Product Quality, Safety and Process Control13 Thermal Processing of Food: Allergenicity; 14 The Acrylamide Minimisation Concept - A Risk Management Tool; 15 The Consequences of Cooking: How the Origin of Cuisine Shaped Human Culture, Ecology, and Biology; IV Posters; 1 Formation, Structural Elucidation, Analysis and Toxicity of Thermal Degradation Products of the Fusarium Mycotoxin Nivalenol; 2 Influence of Different Heating Processes on the Formation of Nucleotides, Nucleosides and Free Bases in Vegetables 3 Determination of Free 3-Monochloropropane-1,2-Diol in Coffee and Coffee Surrogates4 Minimisation Concept - A Reaction on the Potential Health Risk of Acrylamide; 5 Isomerisation of Lycopene Due to Thermal Treatment of Carrot Homogenates: Increased Bioavailability of Total Lycopene and Generation of 5-cis-Lycopene in the Human Intestine; 6 Influence of High Hydrostatic Pressure on the Formation of N(ε)-Carboxymethyllysine and N(ε)-Carboxyethyllysine in Maillard-type Reactions 7 Effect of Acrylamide from a Heated Potato Product on the Acrylamide Content in Eggs, Breast Muscle Meat, Liver and Kidney of Hens8 PAH in Oil and Tocopherols - Analytical Challenges in Complying with EC Recommendations; 9 Acrylamide in Fried Potato Products - Influence of Process Conditions and Precursor Contents; 10 Thermal Stability of Zeaxanthin in Potato Homogenates; 11 Osmotic Treatment as a Pre-Step to Drying and Frying; 12 Influence of Maillard Reaction Products on the Inflammatory Cellular Response of Macrophages 13 Dosimetry of Acrylamide and Glycidamide Binding to Proteins in Human Blood |
| Record Nr. | UNINA-9910830769303321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||