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Autore: | Doran Robert |
Titolo: | Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones / / by Robert Doran |
Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
Edizione: | 1st ed. 2015. |
Descrizione fisica: | 1 online resource (218 p.) |
Disciplina: | 547.2 |
Soggetto topico: | Organic chemistry |
Catalysis | |
Medicinal chemistry | |
Organic Chemistry | |
Medicinal Chemistry | |
Note generali: | "Doctoral thesis accepted by the University College Dublin, Ireland." |
Nota di bibliografia: | Includes bibliographical references at the end of each chapters. |
Nota di contenuto: | Introduction to the Total Synthesis of Lactone-Containing Natural Products using ZrCl4 -- Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide -- Asymmetric Synthesis of Both Enantiomers of a d-Lactone Analogue of Muricatacin -- Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones -- A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones -- Asymmetric Synthesis of Tertiary α-Aryl Ketones by Decarboxylative Asymmetric Protonation. |
Sommario/riassunto: | This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source. |
Titolo autorizzato: | Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones |
ISBN: | 3-319-20544-7 |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910298611203321 |
Lo trovi qui: | Univ. Federico II |
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