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Between Pathogenicity and Commensalism [[electronic resource] /] / edited by Ulrich Dobrindt, Jörg H. Hacker, Catharina Svanborg
| Between Pathogenicity and Commensalism [[electronic resource] /] / edited by Ulrich Dobrindt, Jörg H. Hacker, Catharina Svanborg |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (360 p.) |
| Disciplina | 616.9/041 |
| Collana | Current Topics in Microbiology and Immunology |
| Soggetto topico |
Medical microbiology
Immunology Vaccines Medical Microbiology Vaccine |
| ISBN | 3-642-36560-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Between Commensalism and Pathogenicity:Bacterial and Host Aspects -- E. coli as an all-rounder: The thin line between commensalism and pathogenicity.- What distinguishes non-pathogenic, from medium and highly pathogenic staphylococci? -- Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung.- Lactobacillus: Host-Microbe Relationships -- Bacterial Moonlighting Proteins and Bacterial Virulence.- Symbionts and pathogens - what is the difference? -- Host-microbe Interaction in the Intestinal Tract -- Ecology and physiology of the intestinal tract -- The gut microflora and its variety of roles in health and disease -- Mammalian intestinal host-microbe relationships -- Contribution of the intestinal microbiota to human health - from birth to 100 years of age.- Subject index. |
| Record Nr. | UNINA-9910437856703321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth
| Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth |
| Pubbl/distr/stampa | Washington, DC, : ASM Press, c2011 |
| Descrizione fisica | 1 online resource (404 p.) |
| Disciplina | 362.1969 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich KurthReinhard <1942-> |
| Soggetto topico |
Communicable diseases - Genetic aspects
Microbial genomes Pathogenic microorganisms - Genetics |
| ISBN |
1-68367-093-0
1-283-65649-3 1-55581-721-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Bacterial Infections; 1. Impact Of Genome Plasticity On Adaption Of; REDUCTIVE EVOLUTION OF E. COLI: ASYMPTOMATIC BACTERIURIA AS AN EXAMPLE OF BACTERIAL ADAPTATION TO PROLONGED IN VIVO GROWTH IN THE URINARY TRACT; IMPACT OF GENOMIC CHANGES ON BACTERIUM-HOST INTERACTION AND FITNESS; INTRAVESICLE GROWTH AFFECTS THE MOTILITY OF E. COLI; INTRAVESICLE GROWTH AFFECTS BACTERIAL GROWTH CHARACTERISTICS AND METABOLISM OF E. COLI; ANALYSIS OF HOST FACTORS AND THEIR IMPACT ON ADAPTATION OF E. COLI; CONCLUSIONS; ACKNOWLEDGMENTS
REFERENCES 2. Genotypic Changes In Enterohemorrhagic Escherichia coli During Human Infection; EHEC: OVERVIEW OF EPIDEMIOLOGY AND CLINICAL PATHOGENESIS; GENOMES OF EHEC; IDENTIFICATION OF GENETIC CHANGES DURING EHEC INFECTIONS; INTERSEROTYPE DIFFERENCES IN CONVERSION OF EHEC TO EHEC-LST; CONSEQUENCES OF IN VIVO GENETIC CHANGES IN EHEC; DOES stx LOSS MITIGATE CLINICAL OUTCOME?; EVOLUTIONARY ASPECTS AND ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCE; 3. Genomic Fluidity Of The Human Gastric Pathogen Helicobacter pylori; THE HELICOBACTER GENOMES GENETIC MECHANISMS UNDERLYING GENOME DIVERSITY IN H. PYLORIGENOMIC ISLANDS OF H. PYLORI; FUNCTIONAL RELEVANCE OF THE PLASTIC GENOMES OF H. PYLORI; GENOMIC FLUIDITY OF H. PYLORI: CLINICAL IMPLICATIONS; PERSPECTIVES; REFERENCES; 4. Genome Structure And Variability in Coagulase-Negative Staphylococci; FITNESS AND VIRULENCE-ASSOCIATED FACTORS OF CoNS; THE oriC ENVIRON OF CoNS GENOMES: A HOT SPOT FOR GENOME REARRANGEMENTS; CoNS HAVE AN UNBALANCED GENOME STRUCTURE; CoNS GENOMES AND MOBILE GENETIC ELEMENTS; EXTENSIVE HORIZONTAL GENE TRANSFER AMONG CoNS AND MECHANISMS OF ITS LIMITATION BIOFILM FORMATION ON MEDICAL DEVICES AND EVASION OF HOST DEFENSES BY CoNSPHENOTYPIC AND GENETIC INSTABILITY OF CoNS; CLINICAL IMPACT OF CoNS HETEROGENEOUS GENE EXPRESSION AND GENOME VARIABILITY; CONCLUSIONS; REFERENCES; 5. Genome Plasticity In Legionella pneumophila And Legionella longbeachae: Impact On Host Cell Exploitation; GENERAL FEATURES OF THE L. PNEUMOPHILA AND L. LONGBEACHAE GENOMES; HOST-PATHOGEN INTERACTION: SPECIFICITIES AND COMMON FEATURES OF L. PNEUMOPHILA AND L. LONGBEACHAE; EVOLUTION OF EUKARYOTIC EFFECTORS: ACQUISITION BY HORIZONTAL GENE TRANSFER; CONCLUSIONS; ACKNOWLEDGMENTS REFERENCES6. Genome Plasticity In Salmonella enterica And Its Relevance To Host-Pathogen Interactions; GENETIC MECHANISMS LEADING TO PLASTICITY AND HOST ADAPTATION IN SALMONELLA; GENOME ORGANIZATION IN SALMONELLA; SALMONELLA SEROVARS AND HOST ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7. Mechanisms Of Genome Plasticity In Neisseria meningitidis: Fighting Change With Change; GENETIC VARIABILITY AT THE POPULATION LEVEL; GENOME PLASTICITY IN THE PREGENOMIC ERA; THE SEQUENCED GENOMES OF N. MENINGITIDIS: AN OVERVIEW; GENERATION OF GENOME VARIABILITY IN N. MENINGITIDIS GENETIC BASIS OF VIRULENCE IN N. MENINGITIDIS |
| Record Nr. | UNINA-9910574099503321 |
| Washington, DC, : ASM Press, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth
| Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth |
| Pubbl/distr/stampa | Washington, DC, : ASM Press, c2011 |
| Descrizione fisica | 1 online resource (404 p.) |
| Disciplina | 362.1969 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich KurthReinhard <1942-> |
| Soggetto topico |
Communicable diseases - Genetic aspects
Microbial genomes Pathogenic microorganisms - Genetics |
| ISBN |
1-68367-093-0
1-283-65649-3 1-55581-721-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Bacterial Infections; 1. Impact Of Genome Plasticity On Adaption Of; REDUCTIVE EVOLUTION OF E. COLI: ASYMPTOMATIC BACTERIURIA AS AN EXAMPLE OF BACTERIAL ADAPTATION TO PROLONGED IN VIVO GROWTH IN THE URINARY TRACT; IMPACT OF GENOMIC CHANGES ON BACTERIUM-HOST INTERACTION AND FITNESS; INTRAVESICLE GROWTH AFFECTS THE MOTILITY OF E. COLI; INTRAVESICLE GROWTH AFFECTS BACTERIAL GROWTH CHARACTERISTICS AND METABOLISM OF E. COLI; ANALYSIS OF HOST FACTORS AND THEIR IMPACT ON ADAPTATION OF E. COLI; CONCLUSIONS; ACKNOWLEDGMENTS
REFERENCES 2. Genotypic Changes In Enterohemorrhagic Escherichia coli During Human Infection; EHEC: OVERVIEW OF EPIDEMIOLOGY AND CLINICAL PATHOGENESIS; GENOMES OF EHEC; IDENTIFICATION OF GENETIC CHANGES DURING EHEC INFECTIONS; INTERSEROTYPE DIFFERENCES IN CONVERSION OF EHEC TO EHEC-LST; CONSEQUENCES OF IN VIVO GENETIC CHANGES IN EHEC; DOES stx LOSS MITIGATE CLINICAL OUTCOME?; EVOLUTIONARY ASPECTS AND ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCE; 3. Genomic Fluidity Of The Human Gastric Pathogen Helicobacter pylori; THE HELICOBACTER GENOMES GENETIC MECHANISMS UNDERLYING GENOME DIVERSITY IN H. PYLORIGENOMIC ISLANDS OF H. PYLORI; FUNCTIONAL RELEVANCE OF THE PLASTIC GENOMES OF H. PYLORI; GENOMIC FLUIDITY OF H. PYLORI: CLINICAL IMPLICATIONS; PERSPECTIVES; REFERENCES; 4. Genome Structure And Variability in Coagulase-Negative Staphylococci; FITNESS AND VIRULENCE-ASSOCIATED FACTORS OF CoNS; THE oriC ENVIRON OF CoNS GENOMES: A HOT SPOT FOR GENOME REARRANGEMENTS; CoNS HAVE AN UNBALANCED GENOME STRUCTURE; CoNS GENOMES AND MOBILE GENETIC ELEMENTS; EXTENSIVE HORIZONTAL GENE TRANSFER AMONG CoNS AND MECHANISMS OF ITS LIMITATION BIOFILM FORMATION ON MEDICAL DEVICES AND EVASION OF HOST DEFENSES BY CoNSPHENOTYPIC AND GENETIC INSTABILITY OF CoNS; CLINICAL IMPACT OF CoNS HETEROGENEOUS GENE EXPRESSION AND GENOME VARIABILITY; CONCLUSIONS; REFERENCES; 5. Genome Plasticity In Legionella pneumophila And Legionella longbeachae: Impact On Host Cell Exploitation; GENERAL FEATURES OF THE L. PNEUMOPHILA AND L. LONGBEACHAE GENOMES; HOST-PATHOGEN INTERACTION: SPECIFICITIES AND COMMON FEATURES OF L. PNEUMOPHILA AND L. LONGBEACHAE; EVOLUTION OF EUKARYOTIC EFFECTORS: ACQUISITION BY HORIZONTAL GENE TRANSFER; CONCLUSIONS; ACKNOWLEDGMENTS REFERENCES6. Genome Plasticity In Salmonella enterica And Its Relevance To Host-Pathogen Interactions; GENETIC MECHANISMS LEADING TO PLASTICITY AND HOST ADAPTATION IN SALMONELLA; GENOME ORGANIZATION IN SALMONELLA; SALMONELLA SEROVARS AND HOST ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7. Mechanisms Of Genome Plasticity In Neisseria meningitidis: Fighting Change With Change; GENETIC VARIABILITY AT THE POPULATION LEVEL; GENOME PLASTICITY IN THE PREGENOMIC ERA; THE SEQUENCED GENOMES OF N. MENINGITIDIS: AN OVERVIEW; GENERATION OF GENOME VARIABILITY IN N. MENINGITIDIS GENETIC BASIS OF VIRULENCE IN N. MENINGITIDIS |
| Record Nr. | UNINA-9910830185003321 |
| Washington, DC, : ASM Press, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth
| Genome plasticity and infectious diseases [[electronic resource] /] / edited by Jörg Hacker, Ulrich Dobrindt, Reinhard Kurth |
| Pubbl/distr/stampa | Washington, DC, : ASM Press, c2011 |
| Descrizione fisica | 1 online resource (404 p.) |
| Disciplina | 362.1969 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich KurthReinhard <1942-> |
| Soggetto topico |
Communicable diseases - Genetic aspects
Microbial genomes Pathogenic microorganisms - Genetics |
| ISBN |
1-68367-093-0
1-283-65649-3 1-55581-721-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Bacterial Infections; 1. Impact Of Genome Plasticity On Adaption Of; REDUCTIVE EVOLUTION OF E. COLI: ASYMPTOMATIC BACTERIURIA AS AN EXAMPLE OF BACTERIAL ADAPTATION TO PROLONGED IN VIVO GROWTH IN THE URINARY TRACT; IMPACT OF GENOMIC CHANGES ON BACTERIUM-HOST INTERACTION AND FITNESS; INTRAVESICLE GROWTH AFFECTS THE MOTILITY OF E. COLI; INTRAVESICLE GROWTH AFFECTS BACTERIAL GROWTH CHARACTERISTICS AND METABOLISM OF E. COLI; ANALYSIS OF HOST FACTORS AND THEIR IMPACT ON ADAPTATION OF E. COLI; CONCLUSIONS; ACKNOWLEDGMENTS
REFERENCES 2. Genotypic Changes In Enterohemorrhagic Escherichia coli During Human Infection; EHEC: OVERVIEW OF EPIDEMIOLOGY AND CLINICAL PATHOGENESIS; GENOMES OF EHEC; IDENTIFICATION OF GENETIC CHANGES DURING EHEC INFECTIONS; INTERSEROTYPE DIFFERENCES IN CONVERSION OF EHEC TO EHEC-LST; CONSEQUENCES OF IN VIVO GENETIC CHANGES IN EHEC; DOES stx LOSS MITIGATE CLINICAL OUTCOME?; EVOLUTIONARY ASPECTS AND ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCE; 3. Genomic Fluidity Of The Human Gastric Pathogen Helicobacter pylori; THE HELICOBACTER GENOMES GENETIC MECHANISMS UNDERLYING GENOME DIVERSITY IN H. PYLORIGENOMIC ISLANDS OF H. PYLORI; FUNCTIONAL RELEVANCE OF THE PLASTIC GENOMES OF H. PYLORI; GENOMIC FLUIDITY OF H. PYLORI: CLINICAL IMPLICATIONS; PERSPECTIVES; REFERENCES; 4. Genome Structure And Variability in Coagulase-Negative Staphylococci; FITNESS AND VIRULENCE-ASSOCIATED FACTORS OF CoNS; THE oriC ENVIRON OF CoNS GENOMES: A HOT SPOT FOR GENOME REARRANGEMENTS; CoNS HAVE AN UNBALANCED GENOME STRUCTURE; CoNS GENOMES AND MOBILE GENETIC ELEMENTS; EXTENSIVE HORIZONTAL GENE TRANSFER AMONG CoNS AND MECHANISMS OF ITS LIMITATION BIOFILM FORMATION ON MEDICAL DEVICES AND EVASION OF HOST DEFENSES BY CoNSPHENOTYPIC AND GENETIC INSTABILITY OF CoNS; CLINICAL IMPACT OF CoNS HETEROGENEOUS GENE EXPRESSION AND GENOME VARIABILITY; CONCLUSIONS; REFERENCES; 5. Genome Plasticity In Legionella pneumophila And Legionella longbeachae: Impact On Host Cell Exploitation; GENERAL FEATURES OF THE L. PNEUMOPHILA AND L. LONGBEACHAE GENOMES; HOST-PATHOGEN INTERACTION: SPECIFICITIES AND COMMON FEATURES OF L. PNEUMOPHILA AND L. LONGBEACHAE; EVOLUTION OF EUKARYOTIC EFFECTORS: ACQUISITION BY HORIZONTAL GENE TRANSFER; CONCLUSIONS; ACKNOWLEDGMENTS REFERENCES6. Genome Plasticity In Salmonella enterica And Its Relevance To Host-Pathogen Interactions; GENETIC MECHANISMS LEADING TO PLASTICITY AND HOST ADAPTATION IN SALMONELLA; GENOME ORGANIZATION IN SALMONELLA; SALMONELLA SEROVARS AND HOST ADAPTATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7. Mechanisms Of Genome Plasticity In Neisseria meningitidis: Fighting Change With Change; GENETIC VARIABILITY AT THE POPULATION LEVEL; GENOME PLASTICITY IN THE PREGENOMIC ERA; THE SEQUENCED GENOMES OF N. MENINGITIDIS: AN OVERVIEW; GENERATION OF GENOME VARIABILITY IN N. MENINGITIDIS GENETIC BASIS OF VIRULENCE IN N. MENINGITIDIS |
| Record Nr. | UNINA-9910841763303321 |
| Washington, DC, : ASM Press, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt
| Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina | 579.2 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich |
| Soggetto topico |
Pathogenic microorganisms
Microbiology |
| ISBN |
1-280-72279-7
9786610722792 3-527-60801-X 3-527-60751-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pathogenomics; Foreword; Contents; Preface; List of Contributors; Color Plates; I Methods; 1 Bioinformatics: Data Mining Among Genome Sequences; 1.1 Systematic Genome Analysis of Pathogens as a Basis for Pharmacogenomic Strategies; 1.2 Direct Sequence Annotation Tools for Functional Genomics; 1.3 Identification of Protein Function; 1.4 Obtaining Protein Information from a Domain Server; 1.5 Pathway Analysis; 1.6 Network Analysis; 1.7 Adaptation in Time and to Stimuli; 1.7.1 Experimental Design for Microarray Analysis; 1.7.2 Data Analysis; 1.8 Pathogen-Specific Challenges
1.9 Pathogen Adaptation Potential1.10 The Fight Against Resistance; 1.11 Drug Design and Antibiotics; 1.12 Annotation Platforms Suitable for Pathogenomics; 1.13 Conclusions; 2 Transcriptome Analysis: Towards a Comprehensive Understanding of Global Transcription Activity; 2.1 Introduction; 2.2 Development of Transcriptomics; 2.2.1 From Genomics to Functional Genomics; 2.2.2 From Gene to Whole Genome; 2.3 Introducing the Microarray; 2.3.1 What Is a Microarray?; 2.3.2 The Affymetrix Gene Chip; 2.3.3 The Spotted Microarray; 2.4 Microarray Methods; 2.4.1 Experimental Design 2.4.1.1 Type of Experiment2.4.1.2 Replicates; 2.4.2 RNA Extraction; 2.4.3 Labeling/Reverse Transcription; 2.4.4 Hybridization; 2.4.5 Scanning; 2.5 Data Normalization and Analysis; 2.5.1 Image Quantification; 2.5.2 Data Processing; 2.5.3 Data Analysis; 2.5.3.1 Detection of Differential Expression; 2.5.3.2 Pattern Recognition; 2.5.3.3 Graphical Representations; 2.5.6 Microarray Analysis Tools; 2.5.7 Microarray Follow-Up; 2.5.8 Data Storage and Reanalysis; 2.6 Transcriptomics: Where We Are Now and What's to Come 3 Physiological Proteomics of Bacillus subtilis and Staphylococcus aureus: Towards a Comprehensive Understanding of Cell Physiology and Pathogenicity3.1 Introduction; 3.2 Proteomics of Bacillus subtilis: The Gram-positive Model Organism; 3.2.1 The Vegetative Proteome; 3.2.2 Proteomes of Nongrowing Cells: Proteomic Signatures of Stress/Starvation Stimuli; 3.3 Physiological Proteomics of Staphylococcus aureus; 3.3.1 The Postgenome Era of S. aureus; 3.3.2 Proteomes of Growing and Nongrowing Cells; 3.3.3 Extracellular Proteins and Pathogenicity Networks 3.4 Outlook: Second Generation Proteomics and New Fields in S. aureus Physiology and Infection Biology4 Impact of Genome Sequences on Mutational Analysis of Fungal and Bacterial Pathogens; 4.1 The Long Road from Sequence to Function; 4.2 Classical Genetics Still at the Forefront in the Postgenome Era; 4.2.1 Reverse Genetics; 4.2.2 Transposon Mutagenesis; 4.3 Genome-Scale Mutational Analyses; 4.3.1 Saccharomyces cerevisiae; 4.3.2 Bacterial Workhorses: E. coli and Bacillus subtilis; 4.3.3 Bacterial Pathogens; 4.3.3.1 Mycoplasma Species; 4.3.3.2 Pseudomonas aeruginosa 4.3.3.3 Staphylococcus aureus |
| Record Nr. | UNINA-9910144558703321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt
| Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina | 579.2 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich |
| Soggetto topico |
Pathogenic microorganisms
Microbiology |
| ISBN |
1-280-72279-7
9786610722792 3-527-60801-X 3-527-60751-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pathogenomics; Foreword; Contents; Preface; List of Contributors; Color Plates; I Methods; 1 Bioinformatics: Data Mining Among Genome Sequences; 1.1 Systematic Genome Analysis of Pathogens as a Basis for Pharmacogenomic Strategies; 1.2 Direct Sequence Annotation Tools for Functional Genomics; 1.3 Identification of Protein Function; 1.4 Obtaining Protein Information from a Domain Server; 1.5 Pathway Analysis; 1.6 Network Analysis; 1.7 Adaptation in Time and to Stimuli; 1.7.1 Experimental Design for Microarray Analysis; 1.7.2 Data Analysis; 1.8 Pathogen-Specific Challenges
1.9 Pathogen Adaptation Potential1.10 The Fight Against Resistance; 1.11 Drug Design and Antibiotics; 1.12 Annotation Platforms Suitable for Pathogenomics; 1.13 Conclusions; 2 Transcriptome Analysis: Towards a Comprehensive Understanding of Global Transcription Activity; 2.1 Introduction; 2.2 Development of Transcriptomics; 2.2.1 From Genomics to Functional Genomics; 2.2.2 From Gene to Whole Genome; 2.3 Introducing the Microarray; 2.3.1 What Is a Microarray?; 2.3.2 The Affymetrix Gene Chip; 2.3.3 The Spotted Microarray; 2.4 Microarray Methods; 2.4.1 Experimental Design 2.4.1.1 Type of Experiment2.4.1.2 Replicates; 2.4.2 RNA Extraction; 2.4.3 Labeling/Reverse Transcription; 2.4.4 Hybridization; 2.4.5 Scanning; 2.5 Data Normalization and Analysis; 2.5.1 Image Quantification; 2.5.2 Data Processing; 2.5.3 Data Analysis; 2.5.3.1 Detection of Differential Expression; 2.5.3.2 Pattern Recognition; 2.5.3.3 Graphical Representations; 2.5.6 Microarray Analysis Tools; 2.5.7 Microarray Follow-Up; 2.5.8 Data Storage and Reanalysis; 2.6 Transcriptomics: Where We Are Now and What's to Come 3 Physiological Proteomics of Bacillus subtilis and Staphylococcus aureus: Towards a Comprehensive Understanding of Cell Physiology and Pathogenicity3.1 Introduction; 3.2 Proteomics of Bacillus subtilis: The Gram-positive Model Organism; 3.2.1 The Vegetative Proteome; 3.2.2 Proteomes of Nongrowing Cells: Proteomic Signatures of Stress/Starvation Stimuli; 3.3 Physiological Proteomics of Staphylococcus aureus; 3.3.1 The Postgenome Era of S. aureus; 3.3.2 Proteomes of Growing and Nongrowing Cells; 3.3.3 Extracellular Proteins and Pathogenicity Networks 3.4 Outlook: Second Generation Proteomics and New Fields in S. aureus Physiology and Infection Biology4 Impact of Genome Sequences on Mutational Analysis of Fungal and Bacterial Pathogens; 4.1 The Long Road from Sequence to Function; 4.2 Classical Genetics Still at the Forefront in the Postgenome Era; 4.2.1 Reverse Genetics; 4.2.2 Transposon Mutagenesis; 4.3 Genome-Scale Mutational Analyses; 4.3.1 Saccharomyces cerevisiae; 4.3.2 Bacterial Workhorses: E. coli and Bacillus subtilis; 4.3.3 Bacterial Pathogens; 4.3.3.1 Mycoplasma Species; 4.3.3.2 Pseudomonas aeruginosa 4.3.3.3 Staphylococcus aureus |
| Record Nr. | UNINA-9910830272903321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt
| Pathogenomics [[electronic resource] ] : genome analysis of pathogenic microbes / / edited by Jörg Hacker and Ulrich Dobrindt |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina | 579.2 |
| Altri autori (Persone) |
HackerJörg (Jörg Hinrich)
DobrindtUlrich |
| Soggetto topico |
Pathogenic microorganisms
Microbiology |
| ISBN |
1-280-72279-7
9786610722792 3-527-60801-X 3-527-60751-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pathogenomics; Foreword; Contents; Preface; List of Contributors; Color Plates; I Methods; 1 Bioinformatics: Data Mining Among Genome Sequences; 1.1 Systematic Genome Analysis of Pathogens as a Basis for Pharmacogenomic Strategies; 1.2 Direct Sequence Annotation Tools for Functional Genomics; 1.3 Identification of Protein Function; 1.4 Obtaining Protein Information from a Domain Server; 1.5 Pathway Analysis; 1.6 Network Analysis; 1.7 Adaptation in Time and to Stimuli; 1.7.1 Experimental Design for Microarray Analysis; 1.7.2 Data Analysis; 1.8 Pathogen-Specific Challenges
1.9 Pathogen Adaptation Potential1.10 The Fight Against Resistance; 1.11 Drug Design and Antibiotics; 1.12 Annotation Platforms Suitable for Pathogenomics; 1.13 Conclusions; 2 Transcriptome Analysis: Towards a Comprehensive Understanding of Global Transcription Activity; 2.1 Introduction; 2.2 Development of Transcriptomics; 2.2.1 From Genomics to Functional Genomics; 2.2.2 From Gene to Whole Genome; 2.3 Introducing the Microarray; 2.3.1 What Is a Microarray?; 2.3.2 The Affymetrix Gene Chip; 2.3.3 The Spotted Microarray; 2.4 Microarray Methods; 2.4.1 Experimental Design 2.4.1.1 Type of Experiment2.4.1.2 Replicates; 2.4.2 RNA Extraction; 2.4.3 Labeling/Reverse Transcription; 2.4.4 Hybridization; 2.4.5 Scanning; 2.5 Data Normalization and Analysis; 2.5.1 Image Quantification; 2.5.2 Data Processing; 2.5.3 Data Analysis; 2.5.3.1 Detection of Differential Expression; 2.5.3.2 Pattern Recognition; 2.5.3.3 Graphical Representations; 2.5.6 Microarray Analysis Tools; 2.5.7 Microarray Follow-Up; 2.5.8 Data Storage and Reanalysis; 2.6 Transcriptomics: Where We Are Now and What's to Come 3 Physiological Proteomics of Bacillus subtilis and Staphylococcus aureus: Towards a Comprehensive Understanding of Cell Physiology and Pathogenicity3.1 Introduction; 3.2 Proteomics of Bacillus subtilis: The Gram-positive Model Organism; 3.2.1 The Vegetative Proteome; 3.2.2 Proteomes of Nongrowing Cells: Proteomic Signatures of Stress/Starvation Stimuli; 3.3 Physiological Proteomics of Staphylococcus aureus; 3.3.1 The Postgenome Era of S. aureus; 3.3.2 Proteomes of Growing and Nongrowing Cells; 3.3.3 Extracellular Proteins and Pathogenicity Networks 3.4 Outlook: Second Generation Proteomics and New Fields in S. aureus Physiology and Infection Biology4 Impact of Genome Sequences on Mutational Analysis of Fungal and Bacterial Pathogens; 4.1 The Long Road from Sequence to Function; 4.2 Classical Genetics Still at the Forefront in the Postgenome Era; 4.2.1 Reverse Genetics; 4.2.2 Transposon Mutagenesis; 4.3 Genome-Scale Mutational Analyses; 4.3.1 Saccharomyces cerevisiae; 4.3.2 Bacterial Workhorses: E. coli and Bacillus subtilis; 4.3.3 Bacterial Pathogens; 4.3.3.1 Mycoplasma Species; 4.3.3.2 Pseudomonas aeruginosa 4.3.3.3 Staphylococcus aureus |
| Record Nr. | UNINA-9910841543903321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||