Lead optimization for medicinal chemists [[electronic resource] ] : pharmacokinetic properties of functional groups and organic compounds / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2012 |
Descrizione fisica | 1 online resource (623 p.) |
Disciplina | 615.19 |
Soggetto topico |
Pharmacokinetics
Drug development |
ISBN |
3-527-64564-0
1-283-89324-X 3-527-64566-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | pt. 1. Introduction -- pt. 2. The pharmacokinetic properties of compound classes. |
Record Nr. | UNINA-9910138868603321 |
Dörwald Florencio Zaragoza | ||
Weinheim, Germany, : Wiley-VCH, 2012 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Lead optimization for medicinal chemists : pharmacokinetic properties of functional groups and organic compounds / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Edizione | [1st ed.] |
Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2012 |
Descrizione fisica | 1 online resource (623 p.) |
Disciplina | 615.19 |
Soggetto topico |
Pharmacokinetics
Drug development |
ISBN |
3-527-64564-0
1-283-89324-X 3-527-64566-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | pt. 1. Introduction -- pt. 2. The pharmacokinetic properties of compound classes. |
Record Nr. | UNINA-9910807906503321 |
Dörwald Florencio Zaragoza | ||
Weinheim, Germany, : Wiley-VCH, 2012 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Metal carbenes in organic synthesis / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 1999 |
Descrizione fisica | 1 online resource (311 p.) |
Disciplina |
547.050459
547.2 |
Soggetto topico |
Carbenes (Methylene compounds)
Organic compounds - Synthesis |
Soggetto genere / forma | Electronic books. |
ISBN |
1-281-84252-4
9786611842529 3-527-61406-0 3-527-61407-9 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Metal Carbenes in Organic Synthesis; Table of Contents; Abbreviations; Experimental Procedures; 1 The Carbon-Metal Double Bond; 1 1 Reactivity of Carbene Complexes; 1.2 Fischer-Type and Schrock-Type Carbene Complexes: Theoretical Treatment; 1.3 Olefin Metathesis and Olefin Cyclopropanation; 1.4 Characteristic NMR Data; 2 Heteroatom-Substituted Carbene Complexes; 2.1 Generation of Heteroatom-Substituted Carbene Complexes; 2.1.1 From Acyl Complexes; 2.1.1.1 From Acyl Complexes Generated from Carbonyl Complexes; 2.1.1.2 From Acyl Complexes Generated from Metallates
2.1.1.3 From Acyl Complexes Generated by Other Methods2.1.2 From Isonitrile Complexes; 2.1.3 From a-Haloiminium Salts and Metallates; 2.1.4 From Carboxamides and Metallates; 2.1.5 From Vinylidene Complexes; 2.1.5.1 From Vinylidene Complexes Generated from Alkynes; 2.1.5.2 From Vinylidene Complexes Generated from Alkynyl Complexes; 2.1.6 From Carbenes and Carbenoids; 2.1.7 From Alkyl Complexes by a-Abstraction; 2.1.8 From Carbyne Complexes; 2.1.9 Other Methods; 2.2 Synthetic Applications of Heteroatom-Substituted Carbene Complexes; 2.2.1 General Considerations 2.2.2 Demetallation and Formation of Acyclic Products2.2.3 Photochemical Transformations; 2.2.4 Cyclopropanation; 2.2.5 Thermal Benzannulations; 2.2.5.1 The Dötz Benzannulation Reaction; 2.2.5.2 Other Thermal Benzannulations; 2.2.6 Formation of Five-Membered Rings; 2.2.6.1 Cyclization of (1,3-Butadien-1-yl)carbene Complexes; 2.2.6.2 Cyclization of Functionalized Carbene Complexes; 2.2.6.3 Rearrangement of Ammonium Ylides; 2.2.6.4 Other Methods; 2.2.7 Formation of Six-Membered. Non-Aromatic Carbocycles and Six-Membered Heterocycles; 2.2.8 Formation of Seven-Membered Rings 3 Non-Heteroatom-Substituted Carbene Complexes3.1 Generation of Non-Heteroatom-Substituted Carbene Complexes; 3.1.1 a-Abstraction of Electrophiles (Nucleophilic Abstraction); 3.1.2 a-Abstraction of Nucleophiles (Electrophilic Abstraction); 3.1.2.1 a-Abstraction of Hydride; 3.1.2.2 a-Abstraction of Oxygen-Bound Leaving Groups; 3.1.2.3 a-Abstraction of Thioethers; 3.1.2.4 a-Abstraction of Halides; 3.1.3 From Ylides; 3.1.3.1 From Diazoalkanes; 3.1.3.2 From Other Ylides; 3.1.4 From Carbyne Complexes; 3.1.4.1 Nucleophilic Additions to Carbyne Complexes 3.1.4.2 Electrophilic Additions to Carbyne Complexes3.1.5 From Alkynyl and Alkenyl Complexes; 3.1.6 From Alkyne and Cyclopropene Complexes; 3.1.7 By [2 + 2] Cycloreversion; 3.1.8 Other Methods; 3.2 Synthetic Applications of Non-Heteroatom-Substituted Carbene Complexes; 3.2.1 General Considerations; 3.2.2 Cyclopropanation; 3.2.2.1 Stoichiometric Cyclopropanations; 3.2.2.2 Catalytic Cyclopropanations with Diazoalkanes; 3.2.2.3 Catalytic Cyclopropanations with Other Carbene Precursors; 3.2.3 C-H Insertions; 3.2.3.1 C-H Insertions of Nucleophilic Carbene Complexes 3.2.3.2 C-H Insertions of Electrophilic Carbene Complexes |
Record Nr. | UNINA-9910144281503321 |
Dörwald Florencio Zaragoza | ||
Weinheim, [Germany] : , : Wiley-VCH, , 1999 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Metal carbenes in organic synthesis / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 1999 |
Descrizione fisica | 1 online resource (311 p.) |
Disciplina |
547.050459
547.2 |
Soggetto topico |
Carbenes (Methylene compounds)
Organic compounds - Synthesis |
ISBN |
1-281-84252-4
9786611842529 3-527-61406-0 3-527-61407-9 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Metal Carbenes in Organic Synthesis; Table of Contents; Abbreviations; Experimental Procedures; 1 The Carbon-Metal Double Bond; 1 1 Reactivity of Carbene Complexes; 1.2 Fischer-Type and Schrock-Type Carbene Complexes: Theoretical Treatment; 1.3 Olefin Metathesis and Olefin Cyclopropanation; 1.4 Characteristic NMR Data; 2 Heteroatom-Substituted Carbene Complexes; 2.1 Generation of Heteroatom-Substituted Carbene Complexes; 2.1.1 From Acyl Complexes; 2.1.1.1 From Acyl Complexes Generated from Carbonyl Complexes; 2.1.1.2 From Acyl Complexes Generated from Metallates
2.1.1.3 From Acyl Complexes Generated by Other Methods2.1.2 From Isonitrile Complexes; 2.1.3 From a-Haloiminium Salts and Metallates; 2.1.4 From Carboxamides and Metallates; 2.1.5 From Vinylidene Complexes; 2.1.5.1 From Vinylidene Complexes Generated from Alkynes; 2.1.5.2 From Vinylidene Complexes Generated from Alkynyl Complexes; 2.1.6 From Carbenes and Carbenoids; 2.1.7 From Alkyl Complexes by a-Abstraction; 2.1.8 From Carbyne Complexes; 2.1.9 Other Methods; 2.2 Synthetic Applications of Heteroatom-Substituted Carbene Complexes; 2.2.1 General Considerations 2.2.2 Demetallation and Formation of Acyclic Products2.2.3 Photochemical Transformations; 2.2.4 Cyclopropanation; 2.2.5 Thermal Benzannulations; 2.2.5.1 The Dötz Benzannulation Reaction; 2.2.5.2 Other Thermal Benzannulations; 2.2.6 Formation of Five-Membered Rings; 2.2.6.1 Cyclization of (1,3-Butadien-1-yl)carbene Complexes; 2.2.6.2 Cyclization of Functionalized Carbene Complexes; 2.2.6.3 Rearrangement of Ammonium Ylides; 2.2.6.4 Other Methods; 2.2.7 Formation of Six-Membered. Non-Aromatic Carbocycles and Six-Membered Heterocycles; 2.2.8 Formation of Seven-Membered Rings 3 Non-Heteroatom-Substituted Carbene Complexes3.1 Generation of Non-Heteroatom-Substituted Carbene Complexes; 3.1.1 a-Abstraction of Electrophiles (Nucleophilic Abstraction); 3.1.2 a-Abstraction of Nucleophiles (Electrophilic Abstraction); 3.1.2.1 a-Abstraction of Hydride; 3.1.2.2 a-Abstraction of Oxygen-Bound Leaving Groups; 3.1.2.3 a-Abstraction of Thioethers; 3.1.2.4 a-Abstraction of Halides; 3.1.3 From Ylides; 3.1.3.1 From Diazoalkanes; 3.1.3.2 From Other Ylides; 3.1.4 From Carbyne Complexes; 3.1.4.1 Nucleophilic Additions to Carbyne Complexes 3.1.4.2 Electrophilic Additions to Carbyne Complexes3.1.5 From Alkynyl and Alkenyl Complexes; 3.1.6 From Alkyne and Cyclopropene Complexes; 3.1.7 By [2 + 2] Cycloreversion; 3.1.8 Other Methods; 3.2 Synthetic Applications of Non-Heteroatom-Substituted Carbene Complexes; 3.2.1 General Considerations; 3.2.2 Cyclopropanation; 3.2.2.1 Stoichiometric Cyclopropanations; 3.2.2.2 Catalytic Cyclopropanations with Diazoalkanes; 3.2.2.3 Catalytic Cyclopropanations with Other Carbene Precursors; 3.2.3 C-H Insertions; 3.2.3.1 C-H Insertions of Nucleophilic Carbene Complexes 3.2.3.2 C-H Insertions of Electrophilic Carbene Complexes |
Record Nr. | UNISA-996201940903316 |
Dörwald Florencio Zaragoza | ||
Weinheim, [Germany] : , : Wiley-VCH, , 1999 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. di Salerno | ||
|
Metal carbenes in organic synthesis / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 1999 |
Descrizione fisica | 1 online resource (311 p.) |
Disciplina |
547.050459
547.2 |
Soggetto topico |
Carbenes (Methylene compounds)
Organic compounds - Synthesis |
ISBN |
1-281-84252-4
9786611842529 3-527-61406-0 3-527-61407-9 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Metal Carbenes in Organic Synthesis; Table of Contents; Abbreviations; Experimental Procedures; 1 The Carbon-Metal Double Bond; 1 1 Reactivity of Carbene Complexes; 1.2 Fischer-Type and Schrock-Type Carbene Complexes: Theoretical Treatment; 1.3 Olefin Metathesis and Olefin Cyclopropanation; 1.4 Characteristic NMR Data; 2 Heteroatom-Substituted Carbene Complexes; 2.1 Generation of Heteroatom-Substituted Carbene Complexes; 2.1.1 From Acyl Complexes; 2.1.1.1 From Acyl Complexes Generated from Carbonyl Complexes; 2.1.1.2 From Acyl Complexes Generated from Metallates
2.1.1.3 From Acyl Complexes Generated by Other Methods2.1.2 From Isonitrile Complexes; 2.1.3 From a-Haloiminium Salts and Metallates; 2.1.4 From Carboxamides and Metallates; 2.1.5 From Vinylidene Complexes; 2.1.5.1 From Vinylidene Complexes Generated from Alkynes; 2.1.5.2 From Vinylidene Complexes Generated from Alkynyl Complexes; 2.1.6 From Carbenes and Carbenoids; 2.1.7 From Alkyl Complexes by a-Abstraction; 2.1.8 From Carbyne Complexes; 2.1.9 Other Methods; 2.2 Synthetic Applications of Heteroatom-Substituted Carbene Complexes; 2.2.1 General Considerations 2.2.2 Demetallation and Formation of Acyclic Products2.2.3 Photochemical Transformations; 2.2.4 Cyclopropanation; 2.2.5 Thermal Benzannulations; 2.2.5.1 The Dötz Benzannulation Reaction; 2.2.5.2 Other Thermal Benzannulations; 2.2.6 Formation of Five-Membered Rings; 2.2.6.1 Cyclization of (1,3-Butadien-1-yl)carbene Complexes; 2.2.6.2 Cyclization of Functionalized Carbene Complexes; 2.2.6.3 Rearrangement of Ammonium Ylides; 2.2.6.4 Other Methods; 2.2.7 Formation of Six-Membered. Non-Aromatic Carbocycles and Six-Membered Heterocycles; 2.2.8 Formation of Seven-Membered Rings 3 Non-Heteroatom-Substituted Carbene Complexes3.1 Generation of Non-Heteroatom-Substituted Carbene Complexes; 3.1.1 a-Abstraction of Electrophiles (Nucleophilic Abstraction); 3.1.2 a-Abstraction of Nucleophiles (Electrophilic Abstraction); 3.1.2.1 a-Abstraction of Hydride; 3.1.2.2 a-Abstraction of Oxygen-Bound Leaving Groups; 3.1.2.3 a-Abstraction of Thioethers; 3.1.2.4 a-Abstraction of Halides; 3.1.3 From Ylides; 3.1.3.1 From Diazoalkanes; 3.1.3.2 From Other Ylides; 3.1.4 From Carbyne Complexes; 3.1.4.1 Nucleophilic Additions to Carbyne Complexes 3.1.4.2 Electrophilic Additions to Carbyne Complexes3.1.5 From Alkynyl and Alkenyl Complexes; 3.1.6 From Alkyne and Cyclopropene Complexes; 3.1.7 By [2 + 2] Cycloreversion; 3.1.8 Other Methods; 3.2 Synthetic Applications of Non-Heteroatom-Substituted Carbene Complexes; 3.2.1 General Considerations; 3.2.2 Cyclopropanation; 3.2.2.1 Stoichiometric Cyclopropanations; 3.2.2.2 Catalytic Cyclopropanations with Diazoalkanes; 3.2.2.3 Catalytic Cyclopropanations with Other Carbene Precursors; 3.2.3 C-H Insertions; 3.2.3.1 C-H Insertions of Nucleophilic Carbene Complexes 3.2.3.2 C-H Insertions of Electrophilic Carbene Complexes |
Record Nr. | UNINA-9910831161403321 |
Dörwald Florencio Zaragoza | ||
Weinheim, [Germany] : , : Wiley-VCH, , 1999 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Side reactions in organic synthesis : a guide to successful synthesis design / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim : , : WILEY-VCH Verlag, , 2005 |
Descrizione fisica | 1 online resource (392 p.) |
Disciplina | 547.2 |
Soggetto topico | Organic compounds - Synthesis |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-52013-2
9786610520138 3-527-60426-X 3-527-60498-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Organic synthesis : general remarks. -- Stereoelectronic effects and reactivity. -- The stability of organic compounds. -- Aliphatic nucleophilic substitutions : problematic electrophiles. -- The alkylation of carbanions. -- The alkylation of heteroatoms. -- The acylation of heteroatoms. -- Palladium-catalyzed C-C bond formation. -- Cyclizations. -- Monofunctionalization of symmetric difunctional substrates. |
Record Nr. | UNINA-9910144328703321 |
Dörwald Florencio Zaragoza | ||
Weinheim : , : WILEY-VCH Verlag, , 2005 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Side reactions in organic synthesis : a guide to successful synthesis design / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Pubbl/distr/stampa | Weinheim : , : WILEY-VCH Verlag, , 2005 |
Descrizione fisica | 1 online resource (392 p.) |
Disciplina | 547.2 |
Soggetto topico | Organic compounds - Synthesis |
ISBN |
1-280-52013-2
9786610520138 3-527-60426-X 3-527-60498-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Organic synthesis : general remarks. -- Stereoelectronic effects and reactivity. -- The stability of organic compounds. -- Aliphatic nucleophilic substitutions : problematic electrophiles. -- The alkylation of carbanions. -- The alkylation of heteroatoms. -- The acylation of heteroatoms. -- Palladium-catalyzed C-C bond formation. -- Cyclizations. -- Monofunctionalization of symmetric difunctional substrates. |
Record Nr. | UNINA-9910829855803321 |
Dörwald Florencio Zaragoza | ||
Weinheim : , : WILEY-VCH Verlag, , 2005 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Side reactions in organic synthesis II : aromatic substitutions / / Florencio Zaragoza Dörwald |
Autore | Dörwald Florencio Zaragoza |
Edizione | [Second edition.] |
Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH Verlag GmbH & Co. KGaA, , [2014] |
Descrizione fisica | 1 online resource (311 p.) |
Disciplina | 547.6 |
Soggetto topico |
Aromatic compounds - Synthesis
Organic compounds - Synthesis Aromatic compounds |
ISBN |
3-527-68172-8
3-527-68780-7 3-527-68174-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Side Reactions in Organic Synthesis II; Contents; Preface; Glossary and Abbreviations; Journal Abbreviation List; Chapter 1 Electrophilic Alkylation of Arenes; 1.1 General Aspects; 1.1.1 Catalysis by Transition-Metal Complexes; 1.1.2 Typical Side Reactions; 1.2 Problematic Arenes; 1.2.1 Electron-Deficient Arenes; 1.2.2 Phenols; 1.2.3 Anilines; 1.2.4 Azoles; 1.3 Problematic Electrophiles; 1.3.1 Methylations; 1.3.2 Olefins; 1.3.3 Allylic Electrophiles; 1.3.4 Epoxides; 1.3.5 α-Haloketones and Related Electrophiles; 1.3.6 Nitroalkanes; 1.3.7 Ketones; 1.3.8 Alcohols; References
Chapter 2 Electrophilic Olefination of Arenes2.1 General Aspects; 2.2 Olefinations with Leaving-Group-Substituted Olefins; 2.3 Olefinations with Unsubstituted Olefins; 2.4 Olefinations with Alkynes; References; Chapter 3 Electrophilic Arylation of Arenes; 3.1 General Aspects; 3.2 Arylations with Aryl Halides; 3.2.1 Via Cationic Intermediates; 3.2.2 Via Radicals; 3.2.3 Via Transition-Metal Chelates; 3.2.4 By Transition-Metal Catalysis; 3.3 Arylations with Diazonium Salts; 3.4 Arylations with Other Functionalized Arenes; 3.5 Arylations with Unsubstituted Arenes; References Chapter 4 Electrophilic Acylation of Arenes4.1 General Aspects; 4.2 Problematic Arenes; 4.2.1 Dealkylation/Isomerization of Arenes; 4.2.2 Styrenes; 4.2.3 Anilines, Phenols, and Thiophenols; 4.2.4 Electron-Deficient Arenes; 4.2.5 Azoles; 4.3 Problematic Electrophiles; 4.3.1 Problematic Acyl Halides; 4.3.2 Carboxylic Esters and Lactones; 4.3.3 Carbonic Acid Derivatives; 4.3.4 Formic Acid Derivatives; 4.3.5 Mixed Carboxylic Anhydrides and Other Polyelectrophiles; References; Chapter 5 Electrophilic Halogenation of Arenes; 5.1 General Aspects; 5.2 Typical Side Reactions; 5.3 Regioselectivity 5.4 Catalysis5.5 Fluorinations; 5.6 Electron-Deficient Arenes; 5.6.1 Pyridines; 5.6.2 Benzoic Acid Derivatives; 5.7 Electron-Rich Arenes; 5.7.1 Phenols and Arylethers; 5.7.2 Anilines; 5.7.3 Azoles; 5.8 Sensitive Functional Groups; 5.8.1 Alkenes; 5.8.2 Amines; 5.8.3 Ethers; 5.8.4 Thiols and Thioethers; 5.8.5 Aldehydes, Ketones, and Other C-H Acidic Compounds; 5.8.6 Amides; References; Chapter 6 Electrophilic Formation of Aromatic C-N Bonds; 6.1 Nitration of Arenes; 6.1.1 Mechanisms; 6.1.2 Regioselectivity; 6.1.3 Catalysis; 6.1.4 Electron-Deficient Arenes; 6.1.5 Electron-Rich Arenes 6.1.5.1 Anilines6.1.5.2 Indoles; 6.1.5.3 Phenols; 6.2 Electrophilic Aromatic Aminations; 6.2.1 Typical Side Reactions; 6.3 Electrophilic Aromatic Amidations; 6.3.1 Typical Side Reactions; References; Chapter 7 Electrophilic Formation of Aromatic C-S Bonds; 7.1 Sulfonylation; 7.1.1 General Aspects; 7.1.2 Typical Side Reactions; 7.2 Sulfinylation; 7.2.1 General Aspects; 7.2.2 Typical Side Reactions; 7.3 Sulfenylation; 7.3.1 General Aspects; 7.3.2 Typical Side Reactions; References; Chapter 8 Aromatic Nucleophilic Substitutions; 8.1 General Aspects; 8.1.1 Mechanisms; 8.1.2 Regioselectivity 8.1.3 Acid-/Base-Catalysis |
Altri titoli varianti |
Side reactions in organic synthesis 2
Side reactions in organic synthesis two |
Record Nr. | UNINA-9910830571203321 |
Dörwald Florencio Zaragoza | ||
Weinheim, Germany : , : Wiley-VCH Verlag GmbH & Co. KGaA, , [2014] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|