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Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar L. Mehta, Pankaj Mathur, Naranjan S. Dhalla
| Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar L. Mehta, Pankaj Mathur, Naranjan S. Dhalla |
| Edizione | [2nd ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (IX, 548 p. 62 illus., 55 illus. in color.) |
| Disciplina | 612 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Human physiology
Cardiology Cancer research Proteins Molecular biology Stem cells Human Physiology Cancer Research Receptors Molecular Medicine Stem Cells |
| ISBN | 3-319-61115-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part1. Molecular Mechanisms in Angiogenesis -- 1.Endothelial Growth Factor Receptors in Angiogenesis -- 2.The Role of Integrins in Angiogenesis -- 3.Toll-Like Receptors in Angiogenesis -- 4.Vascular Stem Cells in Regulation of Angiogenesis -- 5.Role of Transforming Growth Factor Beta Family in Angiogenesis -- 6.Angiogenesis-based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases: From Biology to Clinical Trials -- 7.Functions of MicroRNAs in Angiogenesis -- 8.Mast Cells in Angiogenesis. The role of Angiogenic Cytokines -- Part2.Therapeutic Implications of Angiogenesis in Cancer -- 9.Therapeutic Implications of Angiogenesis in Cancer -- 10.The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior -- 11.Angiogenesis and Prostate Cancer: Friends or Foes -- Part3.Therapeutic Implications of Angiogenesis in Eye Disorders -- 12.Angiogenesis-based Therapies for Eye Diseases -- 13.Anti-Angiogenesis Therapy in Diabetic Retinopathy -- Part4.Therapeutic Implications of Angiogenesis in Cardiovascular Disorders and Peripheral Vascular Disease -- 14.Therapeutic Angiogenesis, Cell Therapy and Peripheral Vascular Disease -- 15.Cell-based Therapy in Ischemic Heart Disease -- 16.Angiogenesis and Atherosclerosis -- 17.microRNAs, Angiogenesis and Atherosclerosis -- 18.Trials of Angiogenesis Therapy in Patients with Ischemic Heart Disease -- Part5.Therapeutic Implications of Angiogenesis in Miscellaneous Disease States -- 19.Perspectives in New Advances in Retinal Neovascularization Pathogenesis and Therapeutic Approaches -- 20.Role of Estrogens and Androgens in Angiogenesis -- 21.Brain Angiogenesis after Stroke -- 22.Stimulated Microgravity and Induction of Angiogenesis; A New Perspective in Wound Healing -- 23.Role of Skeletal Muscle Angiogenesis in Peripheral Artery Disease. |
| Record Nr. | UNINA-9910253939903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar Mehta, Naranjan S. Dhalla
| Biochemical Basis and Therapeutic Implications of Angiogenesis [[electronic resource] /] / edited by Jawahar Mehta, Naranjan S. Dhalla |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (532 p.) |
| Disciplina | 612.13 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Human physiology
Cardiology Cancer research Proteins Molecular biology Stem cells Human Physiology Cancer Research Receptors Molecular Medicine Stem Cells |
| ISBN | 1-4614-5857-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part A: Molecular Mechanisms of Angiogenesis -- Endothelial Growth Factor Receptors in Angiogenesis -- Role of Transforming Growth Factor Beta in Angiogenesis -- Role of Cytokines in Angiogenesis: Turning it On and Off -- Neuropeptides in Angiogenesis -- The Role of Integrins in Angiogenesis -- Regulation of Angiogenesis by Hypoxia-inducible Factors -- Role of Mast Cells in Angiogenesis -- Vascular Stem Cells in Regulation of Angiogenesis -- Toll-like Receptor-linked Signal Transduction in Angiogenesis -- The Role of Sex Steroids in Angiogenesis -- Biochemical Mechanisms of Exercise-induced Angiogenesis -- Part B: Pathophysiological Aspects of Angiogenesis -- Angiogenesis in Atherosclerosis: An Overview -- Role of Serotonin in Angiogenesis in Diabetes -- Brain Angiogenesis after Stroke -- Angiogenesis in Myocardial Ischemia -- Adipose Tissue-derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease -- Trials of Angiogenesis Therapy in Patients with ischemic Heart Disease -- Angiogenesis in Cancer -- Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer -- Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small Cell Lung Cancer Tumor Behavior -- Part C: Pharmacology and Therapy of Angiogenesis -- Angiogenesis and Arteriogenesis Factors: Their Role in the Treatment of Cancer and Arterial Regeneration -- Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis -- Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis -- Microarray and MiRs in Angiogenesis -- MicroRNA and Cardiovascular Disorders, with a Focus on Angiogenesis -- An Overview of Angiogenesis Inhibitors from Natural Sources -- Index. |
| Record Nr. | UNINA-9910437619703321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cardiac Adaptations [[electronic resource] ] : Molecular Mechanisms / / edited by Bohuslav Ostadal, Naranjan S. Dhalla
| Cardiac Adaptations [[electronic resource] ] : Molecular Mechanisms / / edited by Bohuslav Ostadal, Naranjan S. Dhalla |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina | 616.1/05 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Medical biochemistry
Molecular biology Cardiology Biochemistry Proteins Human physiology Medical Biochemistry Molecular Medicine Biochemistry, general Receptors Human Physiology |
| ISBN |
1-283-69721-1
1-4614-5203-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Comparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease. |
| Record Nr. | UNINA-9910437825903321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cardiac Energy Metabolism in Health and Disease [[electronic resource] /] / edited by Gary D. Lopaschuk, Naranjan S. Dhalla
| Cardiac Energy Metabolism in Health and Disease [[electronic resource] /] / edited by Gary D. Lopaschuk, Naranjan S. Dhalla |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (301 p.) |
| Disciplina |
612.173
616.1205 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Biochemistry
Metabolism Cardiology Biochemistry, general Metabolomics |
| ISBN | 1-4939-1227-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1. Control of Energy Metabolism -- 1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease. |
| Record Nr. | UNINA-9910298350603321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Hydrophilic Vitamins in Health and Disease
| Hydrophilic Vitamins in Health and Disease |
| Autore | Shah Anureet K |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing AG, , 2024 |
| Descrizione fisica | 1 online resource (407 pages) |
| Altri autori (Persone) |
TappiaParamjit S
DhallaNaranjan S |
| Collana | Advances in Biochemistry in Health and Disease Series |
| ISBN | 3-031-55474-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Contributors -- Part I General Aspects of Hydrophilic Vitamins -- 1 The Cardio-protective Effect of Water-Soluble Vitamins on Anticancer Drug-Induced Cardiotoxicity -- Introduction -- Chemotherapeutic Drugs Causing Cardiotoxicity -- Cardio-Protective Vitamins -- Conclusion and Discussion -- References -- 2 Water Soluble Vitamins in the Ocular and Cardiac Diseases: Application of These Vitamins as Biosensors and in Related Epigenetic Changes -- The Role of Water-Soluble Vitamins in Eye Health and Disease -- Vitamins and Biosensors -- Vitamin Detection and Measurement -- Point-of-Care Diagnostics -- Nutritional Monitoring -- Customized Nutritional Plans -- Research and Drug Development -- Feedback for Health Apps -- Vitamins and Epigenetics -- DNA Methylation -- Nutrigenomics -- Histone Modifications -- Vitamin D -- Vitamin A -- MicroRNAs -- Developmental Programming -- Disease Risk -- Nutrigenomics -- Personalized Nutrition -- Conclusions -- References -- 3 Antiatherogenic Effects of Vitamins, Mediterranean Diet and DASH Diet: An Overview for the Prevention of Cardiovascular Diseases -- Introduction -- Pathophysiology of Atherosclerosis -- Influence of Antioxidant and Anti-inflammation Diets on Atherosclerosis -- Vitamin C or Ascorbic Acid -- Vitamin E -- Polyunsaturated Fatty Acids (PUFA) -- Vitamin D -- Vitamin B -- Niacin (Vitamin B3) -- Folic Acid (Vitamin B9) -- Vitamin B12 -- Vitamin B6 -- Vitamin B2 -- Nutritional Benefits of DASH DIET, Mediterranean Diet for the Prevention of Atherosclerosis, Hypertension, and Coronary Heart Disease -- Mediterranean Diet -- Closing Remarks -- References -- 4 Role of Vitamins in Health and Disease: A Vitamin B Perspective -- Introduction -- B Vitamins in Health and Disease -- Effects of B Vitamins on Metabolism and Related Disorders.
Effects of B Vitamins on Neurology and Mental Health -- Effects of B Vitamins on Hematology and Immunity -- Effects of B Vitamins on Bone Mineralization -- Effects of B Vitamins on Cancer Cells -- Conclusion -- Conflicts of Interest -- References -- 5 Discovering the Potential of Bee Bread from Malaysian Stingless Bee as Vitamins B1, B3, and B6-Rich Source for Health and Disease -- Introduction -- Hydrophilic Vitamins in Bee Bread -- Vitamin B1 (Thiamine) in Bee Bread for Health and Disease -- Vitamin B3 in Bee Bread for Health and Disease -- Vitamin B6 in Bee Bread for Health and Disease -- Conclusions -- References -- 6 The Protective Role of Vitamins in Skincare and Cosmeceutical Products: Mechanisms Involved to Re-engineer the Skin Towards a Healthy State -- Introduction -- Vitamin A and Retinoids -- Protective Role of Vitamin A Against Ultraviolet Radiation -- Functions of Vitamin A and Retinoids in Skin Care Products -- Future Possibility of Making Anti-ageing Products Containing Vitamin A -- Vitamin B3 -- Vitamin C -- Vitamin D -- Vitamin E -- Worldwide Sale of Skin Care and Cosmeceutical Products -- Summary and Future Directions -- References -- 7 Natural and Plant-Derived Vitamins: A Comprehensive Review of Biochemistry, Pharmacology and Nutritional Benefits in Health and Disease -- Introduction -- Vitamin A -- Biochemistry of Vitamin A -- Pharmacology of Vitamin A -- Dietary Sources and Physiological Functions of Vitamin A -- Vitamin B -- Thiamine (Vitamin B1) -- Source of Thiamine -- Pharmacology of Thiamine -- Consequences of Thiamine Deficiency -- Riboflavin (Vitamin B2) -- Sources of Riboflavin -- Pharmacology of Riboflavin -- Physiological Functions of Riboflavin -- Flavoproteins -- Physiological Functions of Flavoproteins in Health and Disease -- Clinical Consequences of Riboflavin Deficiency -- Niacin (Vitamin B3). Sources of Niacin -- Pharmacology of Niacin -- Clinical Implications of Niacin Deficiency -- Neurological Disorders -- Toxicity of Niacin -- Pantothenic Acid (Vitamin B5) -- Sources of Pantothenic Acid -- Physiological Functions of Pantothenic Acid -- Pharmacology of Pantothenic Acid -- Vitamin B6 -- Biosynthesis of Vitamin B6 -- Pharmacology -- Dietary Sources of Vitamin B6 -- Biotin (Vitamin B7) -- Biochemistry of Biotin -- Pharmacology of Biotin -- Intake and Food Sources of Biotin -- Usefulness of Biotin -- Folic Acid (Vitamin B9) -- Biochemistry of Folic Acid -- Pharmacology of Folic Acid -- Dietary Sources of Folic Acid -- Health Benefits of Folic Acid -- Vitamin B12 -- Biochemistry of Vitamin B12 -- Pharmacology of Vitamin B12 -- Dietary Sources of Vitamin B12 -- Ascorbic Acid (Vitamin C) -- Dietary Sources of Vitamin C -- Biochemistry of Vitamin C -- Pharmacology of Vitamin C -- Benefits of Vitamin C in Health and Disease -- Vitamin D -- Endogenous Formation: Photosynthesis of Vitamin D3 in Human Skin -- Biological Mechanism of Action of Vitamin D -- Clinical Applications of Vitamin D -- Vitamin E -- α-Tocopherol Synthesis and Regulations -- Pharmacology of Vitamin E -- Food Sources of Vitamin E -- Benefits of Vitamin E in Health and Disease -- Vitamin K -- Dietary Source of Vitamin K -- Physiological Functions and Pharmacokinetics of Vitamin K -- Sequelae of Vitamin K Deficiency -- Toxicity of Vitamin K -- Conclusions and Relevance -- References -- 8 Unraveling the Mechanisms of Hydrophilic Vitamins in Alzheimer's and Parkinson's: Preclinical and Clinical Evidence -- Introduction -- Neuroprotective Mechanisms of Vitamin C in Neurodegenerative Diseases -- Vitamin C and Alzheimer's Disease -- Vitamin C and Parkinson's Disease -- Neuroprotective Mechanisms of Vitamin B Complex in Neurodegenerative Diseases -- Vitamin B in Alzheimer's Disease. Vitamin B Complex in Parkinson's Disease -- Conclusion and Future Perspectives -- References -- Part II Functionality of B Vitamins in Health and Disease -- 9 The Interplay of Thiamine and Cardiovascular Diseases -- Introduction -- Thiamine Metabolism and Signal Transduction -- Thiamine Absorption and Transport -- The Role of Thiamine in Metabolic Processes -- Thiamine Deficiency and Cardiovascular Diseases -- Thiamine Deficiency and Diabetes Mellitus -- Thiamine Deficiency and Heart Failure -- References -- 10 Vitamin B7 (Biotin) and Its Role in Hair, Skin and Nail Health -- Introduction -- Vitamin B7 [Biotin]-Overview -- Sources of Biotin -- Biotin's Involvement in Essential Metabolic Processes -- Biotin and Hair Health -- Structure and Growth Cycle of Hair -- Biotin and Hair Loss -- How Biotin Contributes to Hair Strength, Texture, and Growth -- Biotin and Skin Health -- Skin's Crucial Role as a Protective Barrier: -- Biotin's Significance in Sustaining Healthy Skin Cells -- Potential Benefits of Biotin for Promoting a Youthful and Glowing Complexion -- Biotin and Nail Health -- Recognizing the Signs of Biotin Deficiency (Hair Thinning, Skin Rash, Brittle Nails) -- Hair Thinning and Hair Loss -- Skin Rash (Dermatitis) -- Brittle Nails (Onychoschizia) -- Conjunctivitis (Eye Inflammation) -- Neurological Symptoms (Rare) -- Biotin Supplementation -- Consultation with Healthcare Professionals Before Starting Biotin Supplementation -- Conclusion -- References -- 11 Role of Vitamin B12 in Cardiovascular Disease -- Introduction -- Vitamin B12 in Different Types of CVD -- Vitamin B12 Deficiency Induced Anemia and Heart Failure -- Vitamin B12 Deficiency in Pediatric/Adolescent Populations -- Role of Vitamin B12 in CVD Risk in Diabetes -- Conclusion -- References -- 12 Association of Vitamin B12 with Bone Mineral Density -- Introduction. Biochemistry and Physiology of Vitamin B12 -- Evidence from Different Experimental and Observational Studies -- Conclusions -- References -- 13 Mechanistic Effects of Vitamin B6 and B12 on Inflammation and Cancer -- Introduction -- The Link Between Inflammation and Cancer -- Vitamin B6 -- The Mechanistic Role of Vitamin B6 in Inflammation and Cancer -- Inflammatory Mediators and Inflammasome Pathways -- Oxidative Stress Pathways -- Vitamin B6 and Advanced Glycation End Products (AGEs) -- Hydrogen Sulphide, Trans-Sulphuration, and Vitamin B6 Relationship -- Sphingosine-1-Phosphate and Vitamin B6 -- Telomere Length and Vitamin B6 -- Vitamin B6 as an Immunomodulatory Agent in Cancer -- Vitamin B12 -- Vitamin B12 and One-Carbon Metabolism -- Vitamin B12 Status on Inflammation and Cancer -- Involvement of Vitamin B12 in DNA Methylation and Cancer -- Conclusion -- References -- 14 The Interweaving of B9- and B12-Dependent Reactions and Their Clinical Implications -- Introduction -- Discovery -- Structure and Absorption of Folate -- Structure and Absorption of Vitamin B12 -- Metabolic Processes -- The Homocysteine-Methionine Axis -- The Folate Shuttle -- Clinical Applications -- Genetics and Epigenetics -- The Circulatory System -- The Epithelial Tissues -- The Nervous System -- The Vascular System -- Malignancies -- Conclusions -- References -- 15 The Role of Folic Acid in the Regulation of Homocysteine Levels and Cardiovascular Disease -- Introduction -- The Mechanism of Folic Acid and Homocysteine Regulation -- Structural and Functional Effects of Homocysteine Engender Cardiovascular Implications -- Lowering Blood Homocysteine Levels Through Supplementation -- Changes in Lifestyle and Dietary Sources -- Elevated Homocysteine Levels Engender Cardiovascular Implications -- Elevated Blood Pressure -- High Cholesterol -- Physical Inactivity -- Obesity. Stress and Anxiety. |
| Record Nr. | UNINA-9910864183403321 |
Shah Anureet K
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| Cham : , : Springer International Publishing AG, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lipophilic Vitamins in Health and Disease
| Lipophilic Vitamins in Health and Disease |
| Autore | Tappia Paramjit S |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing AG, , 2024 |
| Descrizione fisica | 1 online resource (411 pages) |
| Altri autori (Persone) |
ShahAnureet K
DhallaNaranjan S |
| Collana | Advances in Biochemistry in Health and Disease Series |
| ISBN | 3-031-55489-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Contributors -- Part I General Aspects of Lipophilic Vitamins -- 1 The Cardio-protective Effect of Fat-Soluble Vitamins on Anti-cancer Drug Induced Cardiotoxicity -- Introduction -- Chemotherapy Drugs Inducing Possible Mitochondrial Damage -- Disruption to the Sarcomere Structure -- Vitamin D3's Cytoprotective Effect Through Various Signaling Pathway -- Synergistic Effect of Pirfenidone and Vitamin D -- Safety Efficacy of High-Dose Vitamin D Supplementation -- Synergistic Effect of Eicosapentaenoic Acid and Vitamin E -- Synergistic Effect of Hesperidin and Vitamin E -- Vitamin E's Protective Effect on Cisplatin Induced Cardiotoxicity -- Conclusion and Discussion -- Strengths and Limitations -- References -- 2 Fat Soluble Vitamins in the Ocular, Cardiac, and Infectious Diseases: Myths and Misconceptions -- Fat Soluble Vitamins -- The Role of Fat-Soluble Vitamins in Eye Health and Disease -- The Role of Fat-Soluble Vitamins in Cardiovascular Diseases (CVD) -- More Concentrations on Vitamin D -- Myths and Misconceptions About Fat-Soluble Vitamins -- Conclusions -- References -- 3 The Effects of Lipophilic Vitamins on Women's Heart Health -- Cardiovascular Disease in Women -- The Beneficial Effect of Vitamins a and D on Women's Heart Health -- Vitamin E and Women's Heart Health -- Vitamin K and Women's Heart Health -- Clinical Studies and Epidemiological Evidence of the Effect of Lipophilic Vitamins on Women's Heart Health -- Potential Risks and Considerations -- References -- 4 Mitigation of Dementia and Alzheimer's Disease with Lipophilic Vitamins and Their Derivatives: Preclinical and Clinical Evidence -- Introduction -- Overview of Pre-clinical Studies -- Supportive Evidence from Clinical Studies -- Nanotechnological Interventions in Promoting the Systemic Delivery of Vitamins.
Challenges and Opportunities in the Management of Neurodegenerative Diseases with Nanotechnology Delivery Systems -- References -- 5 Lipid-Soluble Vitamins: Their Roles in Cardiovascular Health and Diseases -- Introduction -- Vitamin A -- Overview -- Conversion of Carotenoids into Vitamin A -- Biochemical Reactions that Utilize Vitamin A -- Vitamin D -- Overview -- Biosynthesis of Vitamin D -- Biochemical Reactions -- Vitamin E -- Overview -- Biosynthesis -- Biochemical Reactions -- Vitamin K -- Overview -- Biosynthesis -- Biochemical Reactions and Cardiovascular Health -- Conclusion -- References -- 6 Interactions Between Gut Microbiota and Lipophilic Vitamins in Health and Disease -- Introduction -- Interactions of Fat-Soluble Vitamins with the Gut Microbiome to Maintain Physiological Homeostasis: Cellular and Molecular Insights -- Vitamin A -- Vitamin D -- Vitamin E -- Vitamin K -- Diseases Implicated for Gut Microbiome/lipophilic Vitamin Interaction Axis: A Pharmacological Overview -- Inflammatory Bowel Disease -- Neurological Complications -- Cancer Immunotherapy & -- Beyond -- Ageing -- Limitations in Current Understanding -- Future Perspectives -- Conclusion -- References -- Part II Vitamin E and Associated Metabolites in Health and Disease -- 7 The Potential Role of Tocotrienols Against Cardiovascular Diseases -- Introduction -- Structural and Chemical Differences Between Tocotrienol and Tocopherol Molecules that May Give Rise to Their Distinct Properties -- Dietary Sources -- Potential Role of Tocotrienols Against Cardiovascular Diseases: Inflammation and Immune Response -- Potential Role of Tocotrienols Against Cardiovascular Diseases: Cholesterol Metabolism and Homeostasis -- Concluding Remarks -- References -- 8 Recent Progress on the Skeletal Research of Tocotrienol -- Introduction -- Deposition of Tocotrienol in the Bone. Effects of Tocotrienol on Osteocytes and Wnt -- Effects of Tocotrienol on Mevalonate Pathway -- Effects of Tocotrienol on Bone in Humans -- Effects of Tocotrienol on Other Aspects of Bone Remodelling -- Research Gaps -- Conclusion -- References -- 9 Importance of Vitamin E and Its Metabolism for Health and Disease -- Introduction -- Metabolism of Vitamin E -- Diseases with Vitamin E Relevance -- Ataxia with Vitamin E Deficiency -- Cardiovascular Diseases -- Non-alcoholic Fatty Liver Disease -- Skin Health and Atopic Diseases -- Conclusions and Outlook -- References -- 10 Beneficial Effects of Vitamin E Combined with Antioxidants in Cardiovascular System Disorders: Experimental Evidence -- Introduction -- Metabolism and Functions of Vitamin E -- Vitamin E: Action in the Cell Membrane and Interaction with Intracellular Binding Proteins -- Vitamin E and Cardiovascular Function -- Beneficial Effects of Combined Treatment with Vitamin E and Other Antioxidants in the Cardiovascular System -- Conclusions -- References -- 11 Vitamin E for the Prevention and Treatment of Cardiovascular Disease -- Introduction -- Antioxidant Mechanism of Action of Vitamin E -- Vitamin E in Different Types of CVD -- Consideration for Other Classes of Vitamin E in CVD -- Role of Vitamin E in CVD in Diabetes -- Conclusion -- References -- 12 Vitamin E (Tocopherol): Implications in Cardiovascular Health and Neuroprotection -- Introduction -- Tocopherol Versus Tocotrienols -- Vitamin E as a Cofactor/Co-Enzyme in Various Metabolism -- Vitamin E-as an Antioxidant Property Against Lipid Peroxidation -- Scavenging Avenger of Vitamin E -- Vitamin E in Cell Membrane Protection -- Vitamin E in Primary Cardiac Prevention -- Vitamin E in Secondary RCT -- Vitamin E in Cardiac Muscle Recovery. Vitamin E-as a Neurodegenerative Agent and in Randomized Clinical Trials of Various Neurodegenerative Diseases -- Alzheimer's Diseases-Aging -- Pathogenesis of AD -- Proofs that Oxidative Damage Induced Damage of the Brain in AD Patients -- Vitamin-E Against AD -- Vitamin E in AD-Induced Animal Experimentation -- Clinical Trials with Vitamin E in AD Patients -- Neuroplasticity -- Parkinson's Disease -- Seizure's -- Purkinje Neurons Versus Vit-E -- Conclusion -- References -- Part III Functional Aspects of Vitamins A, D and K -- 13 Retinoids and the Vitamin a Receptor STRA6 in Health and Disease -- Introduction: The Importance of Vitamin a -- Vitamin a Metabolism -- Retinoid Signalling -- Retinoids in Cancer -- Retinoids in Development -- Retinoids in Skin -- STRA6 as the Receptor for RBP -- STRA6 in Disease (I): The Mathew Wood Syndrome -- STRA6 in Disease (II): Cancer -- STRA6 in Disease (III): Insulin Resistance -- Conclusions -- References -- 14 A Vitamin Treatment for Motor Neurone Disease -- Introduction -- Amyotrophic Lateral Sclerosis -- Retinoic Acid and the Retinoic Acid Receptor -- Retinoids as a Potential Therapeutic for Amyotrophic Lateral Sclerosis -- Conclusions -- References -- 15 Vitamin D and Its Role on Inflammation, Oxidative Stress and Cardiovascular Disease -- Introduction -- Vitamin D -- Biosynthesis -- Mechanism of Action -- Oxidative Stress, Inflammation and Cardiovascular Conditions -- Vitamin D, Inflammation and Oxidative Stress -- Vitamin D and Cardiovascular Risk -- Conclusion -- References -- 16 Vitamin D and Immune Function: Unraveling the Connections -- Introduction -- Vitamin D and Health -- Recommended Levels of Vitamin D -- Vitamin D and Immunity -- Vitamin D and Immune Cells -- Vitamin D and the Innate Immune System -- Vitamin D and the Adaptive Immune System. Vitamin D and Its Connection in Autoimmune Diseases and Immune-Related Disorders -- Type I Diabetes (TID) -- Psoriasis -- Multiple Sclerosis (MS) -- Rheumatoid Arthritis (RA) -- Systemic Lupus Erythematosus (SLE) -- Miscellaneous -- Conclusion -- Conflicts of Interest -- References -- 17 Maternal Vitamin D Levels During Gestation and Impact on Offspring's Risk of Non-communicable Diseases in Adulthood -- Background -- Why Vitamin D Matters? -- Vitamin D Level During Pregnancy and Infancy -- Vitamin D Effect on Fetal Growth and Neonatal Anthropomorphic Features -- Vitamin D Effect on Immune Response During Pregnancy -- Vitamin D Level During Adolescence -- Maternal Vitamin D Deficiency and Risk of Communicable Disease in Adulthood -- Vitamin D Metabolism During Pregnancy -- Vitamin D Supplementation During Gestation -- Fetal Programming and Vitamin D -- Conclusion -- References -- 18 Unveiling the Link of Vitamin D and Diverse Cardiovascular Disorders: Current Status and Future Prospective -- Introduction -- Vitamin D: Its Physiological Role and Deficiency -- Link Between Vitamin D and Various Cardiovascular Disorders -- Role of Vitamin D in Cardiomyopathy -- Role of Vitamin D in Pulmonary Arterial Hypertension -- Role of Vitamin D in Myocardial Infarction -- Role of Vitamin D in Cardiac Fibrosis and Remodeling -- Role of Vitamin D in Heart Failure -- Role of Vitamin D in Arrhythmias -- Role of Vitamin D in Endothelial Dysfunction -- Role of Vitamin D in Other Disorders -- Major Challenges and Future Directions -- Conclusion -- References -- 19 Environmental Pollution-Induced Vitamin D Deficiency and Its Impact on the Outcomes of Pregnancy -- Introduction -- Vitamin D -- Vitamin D Synthesis and Metabolism -- Vitamin D Metabolism in Pregnant Women -- Vitamin D and Calcium Metabolism in Pregnancy -- Physiological Effects Concerning Calcium and Phosphate. Environmental Pollution and Vitamin D Deficiency During Pregnancy. |
| Record Nr. | UNINA-9910857781403321 |
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Tappia Paramjit S
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| Cham : , : Springer International Publishing AG, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modulation of Oxidative Stress in Heart Disease [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S. Dhalla, Madhu Dikshit, Nirmal K. Ganguly
| Modulation of Oxidative Stress in Heart Disease [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S. Dhalla, Madhu Dikshit, Nirmal K. Ganguly |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XIII, 686 p. 114 illus., 100 illus. in color.) |
| Disciplina | 571.9453 |
| Soggetto topico |
Oxidative stress
Cardiovascular system Cardiology Cell physiology Biochemistry Biomedical engineering Oxidative Stress Cardiovascular Biology Cell Physiology Biochemistry, general Biomedical Engineering/Biotechnology Estrès (Psicologia) Malalties del cor |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-13-8946-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910373918403321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oxidative Stress in Heart Diseases [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S Dhalla, Nirmal K Ganguly, Madhu Dikshit
| Oxidative Stress in Heart Diseases [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S Dhalla, Nirmal K Ganguly, Madhu Dikshit |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XIII, 596 p. 66 illus.) |
| Disciplina | 571.6 |
| Soggetto topico |
Cell biology
Cardiology Biochemistry Biomedical engineering Health promotion Cell physiology Cell Biology Biochemistry, general Biomedical Engineering/Biotechnology Health Promotion and Disease Prevention Cell Physiology Estrès oxidatiu Malalties del cor |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-13-8273-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | I. Role of Oxidative Stress in Heart Diseases -- 1. J.L Johnson. Laboratory of cardiovascular pathology, School of Clinical Sciences, University of Bristol, Bristol. UK -- 2. M.A.Srivastava, Department of Physiology, McGill University, Canada -- 3. P. Balakumar. Pharmacology Unit, AIMST University, Semeling 08100 Bedong, Kedah Darul Aman, Malaysia -- 4. K. B Pasumarthi. Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada -- 5. B. Turan. Department of Biophysics, Ankara University, Faculty of Medicine, Ankara,Turkey -- 6. Z. Xie. Marshall Institute of Interdisciplinary Research, Marshall University, Huntington,WV, USA -- 7. T. L. Haas. Angiogenesis Research Group, School of Health Sciences, York University,Toronto, Canada -- 8. A. Kukol. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK -- 9. N.S.Dhalla, Cardiovascular Research Institute, University of Manitoba, Winnipeg, Canada -- 10. A.K.Srivastava. Cell Signalling laboratory, McGill University, Canada -- 11. S.Chakraborti, University of Kalyani, Kalyani 741235, West Bengal, India -- 12. S.Goswami, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India -- 13. C.C.Kartha, Rajiv Gandhi Institute of Biotechnology, Thiruvanatapuram, India -- 14. S.K.Malick, Department of Pharmacology. AIIMS, New Delhi, India -- 15. S.Chatterjee, Anna University, Chennai, India -- 16. N.Mahapatra, IIT-Madras, Chennai, India -- 17. R. Bhunya, Department of Biochemistry and Biophysicvs, University of kalyani, West Bengal, India -- 18. S.Nandi, North Est Hill University, Meghalaya, India -- 19. N.K.Ganguly, Sir gangaram Hospital, New Delhi -- 20. M.Dixit, CSIR-CDR, -Lucknow, India -- 21. A.D.Abell, University of Adelaide, Australia -- 22. Chava Kimchi Sarfaty, Centre for Biologics Evaluation and Research, Foodand Drug Administration, Bethesda, Maryland, USA -- 23. B. Furhman, Technion Faculty of Medicine and Ramban Medical Center, Hiafa, Israel -- 24. R.F.Gerlach, Department of Physiology, University of Sao Paulo, Brazil -- 25.T.L.Haas, School of Kinesiology and Health Sciences, York University, Toronto, Canada -- 26. B. Mittal, Department of Genetics. Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttap Pradesh, India -- 27. Richard Schulz, Department of Pedfiatrics, University of Alberta, Canada -- 28. Bodh J Jugdutt, Mackenzie Haeth Sciences Centre, Division of Cardiology, University of Alberta, Canada -- 29. Vibha Rani, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India -- 34. Veena Dhawan, Department of Experimental Medicine and Biotechnology,PGIMER,Chandigarh, India -- 30. Surekha Rani, Department of Genetics, Osmania University, Hyderabad, Telengana State, India. |
| Record Nr. | UNINA-9910373919303321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pathophysiological Aspects of Proteases [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S. Dhalla
| Pathophysiological Aspects of Proteases [[electronic resource] /] / edited by Sajal Chakraborti, Naranjan S. Dhalla |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XV, 671 p. 88 illus., 71 illus. in color.) |
| Disciplina | 612 |
| Soggetto topico |
Human physiology
Molecular biology Pharmaceutical technology Cancer research Human Physiology Molecular Medicine Pharmaceutical Sciences/Technology Cancer Research |
| ISBN | 981-10-6141-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Protease mediated viral infection -- Role of proteases in cancer pathology especially in breast cancer, as well as role of proteases as posible targets for drug development for cancer -- The multifunctional post-prolinedipeptidyl peptidase, DPP9, in EGF signaling, immunity and cancer biology -- Translating the knowledge of functional dynamics towards designing inhibitors of BACE1, a key aspartate protease in Alzheimer's disease -- Cysteine Dependent Aspartate Specific Proteases in Coronary Artery Disease -- Matrix metalloproteases: Potential role in Type 2 Diabetic Nephropathy -- Matrix-metalloproteinases in Breast Carcinoma, Immunohistology and Prognosis -- Matrix metalloproteinases in parasitic infections -- Role of proteases in cancer metastasis -- Proteolytic activation of kinase growth factors in the pathophysiology of cancer -- Involvement of m-Calpain in Colorectal Adenocarcinomas -- Proteases in Cancer: Potential Therapeutic Targets -- MMPs in Oral Squamous Cell Carcinoma -- Matrix metalloproteinase silencing: a therapeutic approach to treat cardiovascular pathology -- Proteases and Breast cancer -- Matrix metalloproteinases (MMPs) in cancer initiation and progression -- Neutrophil Serine protease in health and disease -- Proteases in disease pathology -- PAR1 mediated apoptosis and tumor regression of breast cancer cells by V. cholerae hemagglutinin protease -- Protein-protease interactions : an overview of the process from an ‘in silico’ perspective -- The functional relevance of Deubiquitinases in life and disease -- Physiological and pathological functions of mitochondrial proteases -- Proteases of parasitic helminths: their metabolic role in establishment of infection in the host -- Cysteine proteases of parasitic helminths -- Targeting proteases in urine for bladder cancer diagnosis. |
| Record Nr. | UNINA-9910253960203321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pathophysiology of Obesity-Induced Health Complications [[electronic resource] /] / edited by Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla
| Pathophysiology of Obesity-Induced Health Complications [[electronic resource] /] / edited by Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XVI, 345 p. 40 illus., 31 illus. in color.) |
| Disciplina | 616.39807 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Human physiology
Human Physiology |
| ISBN | 3-030-35358-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Prevalence, consequences, causes and management of obesity -- Adipocytes Under Environmental Assault: Targets for Obesity? -- Obesity and its Complications Pathogenesis -- Extracellular Vesicles and Circulating miRNAs - Exercise -Induced Mitigation of Obesity and Associated Metabolic Diseases -- Pathophysiology of Obesity Induced Hyperglycemia and Insulin Resistance -- Obesity and Osteoarthritis: Are Adipokines Bridging Metabolism, Inflammation, and Biomechanics -- Understanding the Initiation and Progression of Diet-Induced Obesity and Associated Pathophysiology: Lessons Learned from a Rat Model -- Immune Modulation and Macrophage Polarization in Pathogenesis of Pancreatic Dysfunction in Obesity -- Association Between Obesity and Poor Sleep: A Review of Epidemiological Evidence -- Exploration of the Bidirectionality of Obesity and Depression by means of the Neuropsychological Model of Obesity Genesis -- Obesity-Induced Non-Alcoholic Fatty Liver Disease (NAFLD): role of hyperhomocystenemia -- Mechanisms of Obesity Related Kidney Disease -- Consequences of Maternal Obesity on Neonatal Outcomes and Cardio-Metabolic Health in Infancy -- The Developmental Mechanisms of Obesity by Maternal Obesity -- Diet Induced Maternal Hypercholesterolemia and In Utero Fetal Programming -- Modified Denouement in Bariatric Surgery due to Genetic Polymorphism -- Anti-Inflammatory Components from Functional Foods for Obesity -- Attenuation of Obesity-Associated Oxidative Stress by Cucurbita maxima Seed Oil in High Fat Diet Induced Obese Rats -- Pathophysiology of Obesity-Related Non-Communicable Chronic Diseases and Advancements in Preventive Strategies. |
| Record Nr. | UNINA-9910373946103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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