Antibiotics : current innovations and future trends / / edited by Sergio Sánchez, Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico, and Arnold L. Demain, Research Institute for Scientists Emeriti (RISE), Drew University, Madison, NJ, USA |
Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
Descrizione fisica | 1 online resource (450 p.) |
Disciplina | 615.329 |
Soggetto topico |
Antibiotics industry
Antibiotics Antibiotics - Analysis |
Soggetto genere / forma | Electronic books. |
ISBN | 1-908230-55-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: What is an Antibiotic?; Introduction; The etymology of the word antibiotic; Disinfectants and related compounds; Chemotherapeutic agents, magic bullets and selective toxicity; The long shadow of Selman Waksman and synthetic antibiotics; Antibiotic resistance and the emergence of 'antibacterial' as a synonym for 'antibiotic'; Selective toxicity, lexicography and the evolving definition of antibiotic; Why worry about definitions?; Summary; 2: Main Applications of Antibiotics; Introduction
Antibiotics for treatment of infectious diseasesFurther discussion; Conclusion and future perspectives; 3: Microorganisms Producing Antibiotics; The antibiotic producers and antibiotic functions; The numbers of antibiotic-producing microbes; Chemical diversity; Biodiversity; The way ahead; Epilogue; 4: The Need for New Antibiotics; The antibiotic crisis; Antibiotic resistance; Emergence of new diseases; Lack of new drugs; Why drug discovery has dropped; Lack of new antibiotics; Natural products versus synthetics as drugs; Possible solutions to the problem; 5: Tackling Antibiotic Resistance IntroductionPreparation of new vaccines against resistant bacterial strains; Search for new antibiotics; Newly approved antibiotics and antibiotics in the pipeline; Search for new antibiotics from non-traditional or less traditional sources; Microbial genome sequences - search for genes specifying biosynthesis of antibiotics; Forgotten antibiotics to be revitalized; New antibiotic targets; Discussion and conclusions; 6: Eradication of Dormant Pathogens; Persisters and infectious disease; Mechanisms of persister formation; Persister eradication; 7: Toxicity of Antibacterial Drugs Class effectsHas genomics been misleading?; Collateral damage; What is 'safe enough'?; Into the future: prophylaxis and precision medicine; Conclusions; 8: Overuse of Antibiotics: Non-medical Applications; Introduction; Antibiotic resistance - evolution and drivers; Problem: overuse of antibiotics in agriculture; Overuse of antibiotics leads to environmental contamination; Antibiotic overuse in international travel and trade; Conclusion; 9: Antibiotics for Emerging and Re-emerging Diseases; Introduction; Antiparasitic antibiotics; Antiviral antibiotics; Anti-pathogenic E. coli antibiotics Conclusions10: Endophytes as a Potential Source of New Antibiotics; Introduction; Endophyte definition; Distribution in the plant; Biological properties; Pharmaceutical importance of endophytes; Endophytes as producers of the same metabolites as the host plant; Antibiotics from endophytic microorganisms; Potential agricultural uses of endophytic secondary metabolites; Volatile organic compounds are potentially important for biocontrol and control of fruit post-harvest diseases; Compounds with antibiotic activity chemically derived from natural endophytic secondary metabolites Current situation and compounds undergoing clinical evaluation |
Record Nr. | UNINA-9910460088503321 |
Norfolk, England : , : Caister Academic Press, , [2015] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Antibiotics : current innovations and future trends / / edited by Sergio Sánchez, Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico, and Arnold L. Demain, Research Institute for Scientists Emeriti (RISE), Drew University, Madison, NJ, USA |
Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
Descrizione fisica | 1 online resource (450 p.) |
Disciplina | 615.329 |
Soggetto topico |
Antibiotics industry
Antibiotics Antibiotics - Analysis |
ISBN | 1-908230-55-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: What is an Antibiotic?; Introduction; The etymology of the word antibiotic; Disinfectants and related compounds; Chemotherapeutic agents, magic bullets and selective toxicity; The long shadow of Selman Waksman and synthetic antibiotics; Antibiotic resistance and the emergence of 'antibacterial' as a synonym for 'antibiotic'; Selective toxicity, lexicography and the evolving definition of antibiotic; Why worry about definitions?; Summary; 2: Main Applications of Antibiotics; Introduction
Antibiotics for treatment of infectious diseasesFurther discussion; Conclusion and future perspectives; 3: Microorganisms Producing Antibiotics; The antibiotic producers and antibiotic functions; The numbers of antibiotic-producing microbes; Chemical diversity; Biodiversity; The way ahead; Epilogue; 4: The Need for New Antibiotics; The antibiotic crisis; Antibiotic resistance; Emergence of new diseases; Lack of new drugs; Why drug discovery has dropped; Lack of new antibiotics; Natural products versus synthetics as drugs; Possible solutions to the problem; 5: Tackling Antibiotic Resistance IntroductionPreparation of new vaccines against resistant bacterial strains; Search for new antibiotics; Newly approved antibiotics and antibiotics in the pipeline; Search for new antibiotics from non-traditional or less traditional sources; Microbial genome sequences - search for genes specifying biosynthesis of antibiotics; Forgotten antibiotics to be revitalized; New antibiotic targets; Discussion and conclusions; 6: Eradication of Dormant Pathogens; Persisters and infectious disease; Mechanisms of persister formation; Persister eradication; 7: Toxicity of Antibacterial Drugs Class effectsHas genomics been misleading?; Collateral damage; What is 'safe enough'?; Into the future: prophylaxis and precision medicine; Conclusions; 8: Overuse of Antibiotics: Non-medical Applications; Introduction; Antibiotic resistance - evolution and drivers; Problem: overuse of antibiotics in agriculture; Overuse of antibiotics leads to environmental contamination; Antibiotic overuse in international travel and trade; Conclusion; 9: Antibiotics for Emerging and Re-emerging Diseases; Introduction; Antiparasitic antibiotics; Antiviral antibiotics; Anti-pathogenic E. coli antibiotics Conclusions10: Endophytes as a Potential Source of New Antibiotics; Introduction; Endophyte definition; Distribution in the plant; Biological properties; Pharmaceutical importance of endophytes; Endophytes as producers of the same metabolites as the host plant; Antibiotics from endophytic microorganisms; Potential agricultural uses of endophytic secondary metabolites; Volatile organic compounds are potentially important for biocontrol and control of fruit post-harvest diseases; Compounds with antibiotic activity chemically derived from natural endophytic secondary metabolites Current situation and compounds undergoing clinical evaluation |
Record Nr. | UNINA-9910787002203321 |
Norfolk, England : , : Caister Academic Press, , [2015] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Antibiotics : current innovations and future trends / / edited by Sergio Sánchez, Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF, Mexico, and Arnold L. Demain, Research Institute for Scientists Emeriti (RISE), Drew University, Madison, NJ, USA |
Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
Descrizione fisica | 1 online resource (450 p.) |
Disciplina | 615.329 |
Soggetto topico |
Antibiotics industry
Antibiotics Antibiotics - Analysis |
ISBN | 1-908230-55-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: What is an Antibiotic?; Introduction; The etymology of the word antibiotic; Disinfectants and related compounds; Chemotherapeutic agents, magic bullets and selective toxicity; The long shadow of Selman Waksman and synthetic antibiotics; Antibiotic resistance and the emergence of 'antibacterial' as a synonym for 'antibiotic'; Selective toxicity, lexicography and the evolving definition of antibiotic; Why worry about definitions?; Summary; 2: Main Applications of Antibiotics; Introduction
Antibiotics for treatment of infectious diseasesFurther discussion; Conclusion and future perspectives; 3: Microorganisms Producing Antibiotics; The antibiotic producers and antibiotic functions; The numbers of antibiotic-producing microbes; Chemical diversity; Biodiversity; The way ahead; Epilogue; 4: The Need for New Antibiotics; The antibiotic crisis; Antibiotic resistance; Emergence of new diseases; Lack of new drugs; Why drug discovery has dropped; Lack of new antibiotics; Natural products versus synthetics as drugs; Possible solutions to the problem; 5: Tackling Antibiotic Resistance IntroductionPreparation of new vaccines against resistant bacterial strains; Search for new antibiotics; Newly approved antibiotics and antibiotics in the pipeline; Search for new antibiotics from non-traditional or less traditional sources; Microbial genome sequences - search for genes specifying biosynthesis of antibiotics; Forgotten antibiotics to be revitalized; New antibiotic targets; Discussion and conclusions; 6: Eradication of Dormant Pathogens; Persisters and infectious disease; Mechanisms of persister formation; Persister eradication; 7: Toxicity of Antibacterial Drugs Class effectsHas genomics been misleading?; Collateral damage; What is 'safe enough'?; Into the future: prophylaxis and precision medicine; Conclusions; 8: Overuse of Antibiotics: Non-medical Applications; Introduction; Antibiotic resistance - evolution and drivers; Problem: overuse of antibiotics in agriculture; Overuse of antibiotics leads to environmental contamination; Antibiotic overuse in international travel and trade; Conclusion; 9: Antibiotics for Emerging and Re-emerging Diseases; Introduction; Antiparasitic antibiotics; Antiviral antibiotics; Anti-pathogenic E. coli antibiotics Conclusions10: Endophytes as a Potential Source of New Antibiotics; Introduction; Endophyte definition; Distribution in the plant; Biological properties; Pharmaceutical importance of endophytes; Endophytes as producers of the same metabolites as the host plant; Antibiotics from endophytic microorganisms; Potential agricultural uses of endophytic secondary metabolites; Volatile organic compounds are potentially important for biocontrol and control of fruit post-harvest diseases; Compounds with antibiotic activity chemically derived from natural endophytic secondary metabolites Current situation and compounds undergoing clinical evaluation |
Record Nr. | UNINA-9910824528303321 |
Norfolk, England : , : Caister Academic Press, , [2015] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Manual of industrial microbiology and biotechnology [[electronic resource] /] / editors in chief, Richard H. Baltz, Julian E. Davies, Arnold L. Demain ; editors, Alan T. Bull ... [et al.] |
Edizione | [3rd ed.] |
Pubbl/distr/stampa | Washington, DC, : ASM Press, 2010 |
Descrizione fisica | 1 online resource (786 p.) |
Disciplina | 660.6/2 |
Altri autori (Persone) |
BaltzRichard H
DaviesJulian E DemainA. L <1927-> (Arnold L.) |
Soggetto topico |
Biotechnology
Industrial microbiology |
ISBN |
1-68367-128-7
1-283-03441-7 9786613034410 1-61344-262-9 1-55581-682-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
CONTENTS; Editors /; Contributors /; Preface /; SECTION 1 ____________________________; ISOLATION AND SCREENING FOR SECONDARY METABOLITES AND ENZYMES /; Isolation; 1. New Approaches to Microbial Isolation /; 2. Selectie Isolation of Actinobacteria /; Identity/Dereplication; 3. Taxonomic Characterization of Prokaryotic Microorganisms /; Screening; 4. Enzymes from Extreme Environments /; 5. Cell-Based Screening Methods for Anti-Infective Compounds /; 6. Metabolomics for the Discovery of Novel Compounds /; 7 Strategies for Accessing Microbial Secondary Metabolites /
Section II ________________________FERMENTATION AND CELL CULTURE /; 8. Miniaturization of Fermentations /; 9. Solid-Phase Fermentation: Aerobic and Anaerobic /; 10. Bacterial Cultivation for Production of Proteins and Other Biological Products /; 11. Heterologous Protein Expression in Yeasts and Filamentous Fungi; 12. Mammalian Cell Culture for Biopharmaceutical Production /; 13. Manufacture of Mammalian Cell Biopharmaceuticals /; 14. Plant Cell Culture /; 15. Insect Cell Culture /; Section III; GENETICS, STRAIN IMPROVEMENT, AND RECOMBINANT PROTEINS / 16. Genetic Engineering of Corynebacteria /17. Genetic Manipulation of Clostridium /; 18. Genetic Manipulation of Myxobacteria /; 19. Strain Improvement of Escherichia coli To Enhance Recombinant Protein Production /; 20. Genetic Engineering Tools for Saccharomyces cerevisiae /; 21 Protein Expression in Nonconventional Yeasts /; 22. Genetics, Genetic Manipulation, and Approaches to Strain Improvement of Filamentous Fungi /; 23. Genetic Manipulation of Mammalian Cells for Protein Expression /; Section IV ___________________________________; GENETIC ENGINEERING OF SECONDARY METABOLITE SYNTHESIS 24. Glycosylation of Secondary Metabolites To Produce Novel Compounds /25. Metabolic Engineering of Escherichia coli for the Production of a Precursor to Artemisinin, an Antimalarial Drug /; 26. Heterologous Production of Polyketides in Streptomyces coelicolor and Escerichia coli /; 27. Genetic Engineering of Acidic Lipopeptide Antibiotics /; 28. Genetic Engineering To Regulate Production of Secondary Metabolites in Streptomyces clavuligerus /; 29. Genetic Engineering of Myxobacterial Natural Product Biosynthetic Genes /; Section V _______________________________________ TRIAL ENZYMES, BIOCATALYSIS, AND ENZYME EVOLUTION /30. Tools for Enzyme Discovery /; 31. Enzyme Engineering: Combining Computational Approaches with Directed Evolution /; 32. Enzyme Engineering by Directed Evolution; 33. Industrial Applications of Enzymes as Catalysts /; 34. Biomass-Conerting Enzymes and Their Bioenergy Applications /; 35. The Use of Enzymes for Nonaqueous Organic Transformations /; 36. Enzyme Promiscuity and Evolution of New Protein Functions; 37. Enzyme Production in Escherichia coli; 38. Bioprocess Development /; Section VI _______________________________________ MICROBIAL FUELS (BIOFUELS) AND FINE CHEMICALS / |
Record Nr. | UNINA-9910574099003321 |
Washington, DC, : ASM Press, 2010 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Manual of industrial microbiology and biotechnology [[electronic resource] /] / editors in chief, Richard H. Baltz, Julian E. Davies, Arnold L. Demain ; editors, Alan T. Bull ... [et al.] |
Edizione | [3rd ed.] |
Pubbl/distr/stampa | Washington, DC, : ASM Press, 2010 |
Descrizione fisica | 1 online resource (786 p.) |
Disciplina | 660.6/2 |
Altri autori (Persone) |
BaltzRichard H
DaviesJulian E DemainA. L <1927-> (Arnold L.) |
Soggetto topico |
Biotechnology
Industrial microbiology |
ISBN |
1-68367-128-7
1-283-03441-7 9786613034410 1-61344-262-9 1-55581-682-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
CONTENTS; Editors /; Contributors /; Preface /; SECTION 1 ____________________________; ISOLATION AND SCREENING FOR SECONDARY METABOLITES AND ENZYMES /; Isolation; 1. New Approaches to Microbial Isolation /; 2. Selectie Isolation of Actinobacteria /; Identity/Dereplication; 3. Taxonomic Characterization of Prokaryotic Microorganisms /; Screening; 4. Enzymes from Extreme Environments /; 5. Cell-Based Screening Methods for Anti-Infective Compounds /; 6. Metabolomics for the Discovery of Novel Compounds /; 7 Strategies for Accessing Microbial Secondary Metabolites /
Section II ________________________FERMENTATION AND CELL CULTURE /; 8. Miniaturization of Fermentations /; 9. Solid-Phase Fermentation: Aerobic and Anaerobic /; 10. Bacterial Cultivation for Production of Proteins and Other Biological Products /; 11. Heterologous Protein Expression in Yeasts and Filamentous Fungi; 12. Mammalian Cell Culture for Biopharmaceutical Production /; 13. Manufacture of Mammalian Cell Biopharmaceuticals /; 14. Plant Cell Culture /; 15. Insect Cell Culture /; Section III; GENETICS, STRAIN IMPROVEMENT, AND RECOMBINANT PROTEINS / 16. Genetic Engineering of Corynebacteria /17. Genetic Manipulation of Clostridium /; 18. Genetic Manipulation of Myxobacteria /; 19. Strain Improvement of Escherichia coli To Enhance Recombinant Protein Production /; 20. Genetic Engineering Tools for Saccharomyces cerevisiae /; 21 Protein Expression in Nonconventional Yeasts /; 22. Genetics, Genetic Manipulation, and Approaches to Strain Improvement of Filamentous Fungi /; 23. Genetic Manipulation of Mammalian Cells for Protein Expression /; Section IV ___________________________________; GENETIC ENGINEERING OF SECONDARY METABOLITE SYNTHESIS 24. Glycosylation of Secondary Metabolites To Produce Novel Compounds /25. Metabolic Engineering of Escherichia coli for the Production of a Precursor to Artemisinin, an Antimalarial Drug /; 26. Heterologous Production of Polyketides in Streptomyces coelicolor and Escerichia coli /; 27. Genetic Engineering of Acidic Lipopeptide Antibiotics /; 28. Genetic Engineering To Regulate Production of Secondary Metabolites in Streptomyces clavuligerus /; 29. Genetic Engineering of Myxobacterial Natural Product Biosynthetic Genes /; Section V _______________________________________ TRIAL ENZYMES, BIOCATALYSIS, AND ENZYME EVOLUTION /30. Tools for Enzyme Discovery /; 31. Enzyme Engineering: Combining Computational Approaches with Directed Evolution /; 32. Enzyme Engineering by Directed Evolution; 33. Industrial Applications of Enzymes as Catalysts /; 34. Biomass-Conerting Enzymes and Their Bioenergy Applications /; 35. The Use of Enzymes for Nonaqueous Organic Transformations /; 36. Enzyme Promiscuity and Evolution of New Protein Functions; 37. Enzyme Production in Escherichia coli; 38. Bioprocess Development /; Section VI _______________________________________ MICROBIAL FUELS (BIOFUELS) AND FINE CHEMICALS / |
Record Nr. | UNINA-9910830202103321 |
Washington, DC, : ASM Press, 2010 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Manual of industrial microbiology and biotechnology [[electronic resource] /] / editors in chief, Richard H. Baltz, Julian E. Davies, Arnold L. Demain ; editors, Alan T. Bull ... [et al.] |
Edizione | [3rd ed.] |
Pubbl/distr/stampa | Washington, DC, : ASM Press, 2010 |
Descrizione fisica | 1 online resource (786 p.) |
Disciplina | 660.6/2 |
Altri autori (Persone) |
BaltzRichard H
DaviesJulian E DemainA. L <1927-> (Arnold L.) |
Soggetto topico |
Biotechnology
Industrial microbiology |
ISBN |
1-68367-128-7
1-283-03441-7 9786613034410 1-61344-262-9 1-55581-682-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
CONTENTS; Editors /; Contributors /; Preface /; SECTION 1 ____________________________; ISOLATION AND SCREENING FOR SECONDARY METABOLITES AND ENZYMES /; Isolation; 1. New Approaches to Microbial Isolation /; 2. Selectie Isolation of Actinobacteria /; Identity/Dereplication; 3. Taxonomic Characterization of Prokaryotic Microorganisms /; Screening; 4. Enzymes from Extreme Environments /; 5. Cell-Based Screening Methods for Anti-Infective Compounds /; 6. Metabolomics for the Discovery of Novel Compounds /; 7 Strategies for Accessing Microbial Secondary Metabolites /
Section II ________________________FERMENTATION AND CELL CULTURE /; 8. Miniaturization of Fermentations /; 9. Solid-Phase Fermentation: Aerobic and Anaerobic /; 10. Bacterial Cultivation for Production of Proteins and Other Biological Products /; 11. Heterologous Protein Expression in Yeasts and Filamentous Fungi; 12. Mammalian Cell Culture for Biopharmaceutical Production /; 13. Manufacture of Mammalian Cell Biopharmaceuticals /; 14. Plant Cell Culture /; 15. Insect Cell Culture /; Section III; GENETICS, STRAIN IMPROVEMENT, AND RECOMBINANT PROTEINS / 16. Genetic Engineering of Corynebacteria /17. Genetic Manipulation of Clostridium /; 18. Genetic Manipulation of Myxobacteria /; 19. Strain Improvement of Escherichia coli To Enhance Recombinant Protein Production /; 20. Genetic Engineering Tools for Saccharomyces cerevisiae /; 21 Protein Expression in Nonconventional Yeasts /; 22. Genetics, Genetic Manipulation, and Approaches to Strain Improvement of Filamentous Fungi /; 23. Genetic Manipulation of Mammalian Cells for Protein Expression /; Section IV ___________________________________; GENETIC ENGINEERING OF SECONDARY METABOLITE SYNTHESIS 24. Glycosylation of Secondary Metabolites To Produce Novel Compounds /25. Metabolic Engineering of Escherichia coli for the Production of a Precursor to Artemisinin, an Antimalarial Drug /; 26. Heterologous Production of Polyketides in Streptomyces coelicolor and Escerichia coli /; 27. Genetic Engineering of Acidic Lipopeptide Antibiotics /; 28. Genetic Engineering To Regulate Production of Secondary Metabolites in Streptomyces clavuligerus /; 29. Genetic Engineering of Myxobacterial Natural Product Biosynthetic Genes /; Section V _______________________________________ TRIAL ENZYMES, BIOCATALYSIS, AND ENZYME EVOLUTION /30. Tools for Enzyme Discovery /; 31. Enzyme Engineering: Combining Computational Approaches with Directed Evolution /; 32. Enzyme Engineering by Directed Evolution; 33. Industrial Applications of Enzymes as Catalysts /; 34. Biomass-Conerting Enzymes and Their Bioenergy Applications /; 35. The Use of Enzymes for Nonaqueous Organic Transformations /; 36. Enzyme Promiscuity and Evolution of New Protein Functions; 37. Enzyme Production in Escherichia coli; 38. Bioprocess Development /; Section VI _______________________________________ MICROBIAL FUELS (BIOFUELS) AND FINE CHEMICALS / |
Record Nr. | UNINA-9910876969803321 |
Washington, DC, : ASM Press, 2010 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|