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Immunology : a short course / / Richard Coico, Geoffrey Sunshine
| Immunology : a short course / / Richard Coico, Geoffrey Sunshine |
| Autore | Coico Richard |
| Edizione | [Seventh edition.] |
| Pubbl/distr/stampa | West Sussex, England : , : Wiley Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (xxiii, 406 pages) : illustrations (chiefly color) |
| Disciplina | 616.079 |
| Soggetto topico |
Immunology
Immunochemistry Immunity Allergy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-39687-1
1-118-39689-8 1-118-39690-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview of the immune system -- Innate immunity -- Adaptive immunity -- Immunogens and antigens -- Antibody structure and function -- Antigen-antobody interactions, immune assays, and experimental systems -- The genetic basis of antibody structure -- Biology of the B lymphocyte -- How T cells recognize antigen : the role of the major histocompatibility complex -- Biology of the T lymphocyte -- Activation and function of T cells -- Cytokines -- Tolerance and autoimmunity -- Complement -- Hypersensitivity : type I -- Hypersensitivity : types II and III -- Hypersensitivity : type IV -- Immunodeficiency disorders and neoplasias of the lymphoid system -- Transplantation -- Tumor immunology -- Resistance and immununization to infectious diseases. |
| Record Nr. | UNINA-9910460793103321 |
Coico Richard
|
||
| West Sussex, England : , : Wiley Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Immunology [[e-book] ] : a short course / / Richard Coico, Geoffrey Sunshine
| Immunology [[e-book] ] : a short course / / Richard Coico, Geoffrey Sunshine |
| Autore | Coico Richard |
| Edizione | [Seventh edition.] |
| Pubbl/distr/stampa | Chichester : , : Wiley Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (xxiii, 406 pages) : illustrations |
| Disciplina | 616.079 |
| Soggetto topico |
Allergy and Immunology
Immune System Diseases Immune System Processes Immunity |
| ISBN |
1-118-39690-1
1-118-39689-8 1-118-39687-1 |
| Classificazione |
616.07/9
491.8 QW 504 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | und |
| Nota di contenuto | Overview of the immune system -- Innate immunity -- Adaptive immunity -- Immunogens and antigens -- Antibody structure and function -- Antigen-antobody interactions, immune assays, and experimental systems -- The genetic basis of antibody structure -- Biology of the B lymphocyte -- How T cells recognize antigen : the role of the major histocompatibility complex -- Biology of the T lymphocyte -- Activation and function of T cells -- Cytokines -- Tolerance and autoimmunity -- Complement -- Hypersensitivity : type I -- Hypersensitivity : types II and III -- Hypersensitivity : type IV -- Immunodeficiency disorders and neoplasias of the lymphoid system -- Transplantation -- Tumor immunology -- Resistance and immununization to infectious diseases. |
| Record Nr. | UNINA-9910795818603321 |
|
Coico Richard
|
||
| Chichester : , : Wiley Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immunology : A Short Course
| Immunology : A Short Course |
| Autore | Coico Richard |
| Edizione | [7th ed.] |
| Pubbl/distr/stampa | New York : , : John Wiley & Sons, Incorporated, , 2015 |
| Descrizione fisica | 1 online resource (433 pages) |
| Disciplina | 616.07/9 |
| Altri autori (Persone) | SunshineGeoffrey |
| Soggetto topico | Immune System Processes |
| ISBN |
9781118396902
1118396901 9781118396919 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title Page -- Copyright Page -- Contents in Brief -- Contents -- About the Authors -- Contributors -- Preface and Acknowledgments -- How to Use Your Textbook -- About the Companion Website -- Chapter 1 Overview of the Immune System -- Introduction -- Innate and Adaptive Immunity -- Innate Immunity -- Adaptive Immunity -- Clonal Selection Theory -- Active, Passive, and Adoptive Immunization -- Major Characteristics of the Adaptive Immune Response -- Cells Involved in the Adaptive Immune Response -- Humoral and Cellular Immunity -- Humoral Immunity -- Cell-Mediated Immunity -- Generation of Diversity in the Immune Response -- Benefits of Immunology -- Damaging Effects of the Immune Response -- The Future of Immunology -- The Short Course Begins Here -- References and Bibliography -- Chapter 2 Innate Immunity -- Introduction -- Physical and Chemical Barriers of Innate Immunity -- Origin, Differentiation, and Characterizationof Cells of the Innate Immune System -- Pattern Recognition: The Hallmark of Innate Immune Responses -- Pattern Recognition Receptors -- Complement -- Intracellular and Extracellular Killing of Microorganisms -- Inflammation -- Hallmark Signs of Inflammation -- Localized Inflammatory Responses -- Chronic Inflammation -- Fever -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 3 Adaptive Immunity -- Cells and Organs Involved in Adaptive Immunity -- The Lymphatic Organs -- Lymphocyte Migration and Recirculation -- The Fate of Antigen after Penetration -- Frequency of Antigen-Specific Naïve Lymphocytes -- Interrelationship between Innate and Adaptive Immunity -- Review Questions -- Answers to Review Questions -- Chapter 4 Immunogens and Antigens -- Introduction -- Requirements for Immunogenicity -- Foreignness -- High Molecular Weight -- Chemical Complexity -- Degradability.
Haptens -- Further Requirements for Immunogenicity -- Primary and Secondary Responses -- Antigenicity and Antigen-Binding Site -- Epitopes Recognized by B Cells and T Cells -- Major Classes of Antigens -- Binding of Antigen with Antigen-Specific Antibodies or T Cells -- Cross-Reactivity -- Adjuvants -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 5 Antibody Structure and Function -- Introduction -- Isolation and Characterization of Immunoglobulins -- Structure of Light and Heavy Chains -- Domains -- Hinge Region -- Variable Region -- Immunoglobulin Variants -- Isotypes -- Allotypes -- Idiotypes -- Structural Features of IgG -- Biologic Properties of IgG -- Agglutination and Formation of Precipitate -- Passage through the Placenta and Absorption in Neonates -- Opsonization -- Antibody-Dependent Cell-Mediated Cytotoxicity -- Activation of Complement -- Neutralization of Toxins -- Immobilization of Bacteria -- Neutralization of Viruses -- Structural Features of IgM -- Biologic Properties of IgM -- Complement Fixation -- Neonatal Immunity and First Line of Humoral Defense -- Agglutination -- Isohemagglutinins -- Structural and Biologic Properties of IgA -- Biologic Properties of IgA -- Role in Mucosal Infections -- Bactericidal Activity -- Antiviral Activity -- Structural and Biologic Properties of IgD -- Structural and Biologic Properties of IgE -- Importance of IgE in Parasitic Infections and Hypersensitivity Reactions -- Kinetics of the Antibody Response Following Immunization -- Primary Response -- Secondary Response -- The Immunoglobulin Superfamily -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 6 Antigen-Antibody Interactions, Immune Assays, and Experimental Systems -- Introduction -- Antigen-Antibody Interactions. Primary Interactions Between Antibody and Antigen -- Association Constant -- Affinity and Avidity -- Secondary Interactions between Antibody and Antigen -- Agglutination Reactions -- Precipitation Reactions -- Immunoassays -- Direct-Binding Immunoassays -- Solid-Phase Immunoassays -- Immunofluorescence -- Direct Immunofluorescence -- Indirect Immunofluorescence -- Flow Cytometry -- Immunoabsorption and Immunoadsorption -- Cellular Assays -- Assays of Lymphocyte Function -- B-Cell and T-Cell Proliferation Assays -- Antibody Production by B Cells -- Effector Cell Assays for T Cells and Natural Killer Cells -- Cell Culture -- Primary Cell Cultures and Cloned Lymphoid Cell Lines -- B-Cell Hybridomas and Monoclonal Antibodies -- T-Cell Hybridomas -- Genetically Engineered Molecules and Receptors -- Experimental Animal Models -- Inbred Strains -- Adoptive Transfer -- SCID Mice -- Thymectomized and Congenitally Athymic (Nude) Mice -- Transgenic Mice and Gene Targeting -- Transgenic Mice -- Knockout and Knock-in Mice -- Analysis of Gene Expression -- Microarrays to Assess Gene Expression -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 7 The Genetic Basis of Antibody Structure -- Introduction -- A Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression -- Genetic Events in Synthesis of Ig Chains -- Organization and Rearrangement of Light-Chain Genes -- κ-Chain Synthesis -- λ-Chain Synthesis -- Organization and Rearrangement of Heavy-Chain Genes -- Allelic Exclusion and the Regulation of Ig Gene Expression -- Class or Isotype Switching -- Generation of Antibody Diversity -- Presence of Multiple V Genes in the Germline -- VJ and VDJ Combinatorial Association -- Random Assortment of H and L Chains -- Junctional Diversity -- Somatic Hypermutation -- Somatic Gene Conversion. Role of Activation-Induced Cytidine Deaminase in Generating Antibody Diversity -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 8 Biology of the B Lymphocyte -- Introduction -- Development of B Lymphocytes -- Overview -- Sites of Early B-Cell Differentiation -- Pro-B and Pre-B Cells: First Ig Rearrangements -- Immature B Cells -- Transitional B cells -- Mature B Cells -- Plasma Cells -- Memory B Cells -- Sites of Antibody Synthesis -- Interaction of Antigen, B Cells, and Helper T Cells in the Lymph Node -- Events in the Germinal Center -- Antibody Synthesis in Mucosal Tissue -- Thymus-Independent Antibody Responses -- B-Cell Membrane Proteins -- Stage-Specific Markers -- Antigen-Binding Molecules: Membrane Immunoglobulin -- Signal Transduction Molecules Associated with Membrane Immunoglobulin -- Molecules Involved in T-B Cell Interactions -- Homing -- Intracellular Signaling in B Cells -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 9 How T Cells Recognize Antigen: The Role of the Major Histocompatibility Complex -- Introduction -- How The MHC Got Its Name -- MHC Role in Antigen Presentation -- Different MHC Molecules Are Expressed by Distinct Host Cells and Interact with Different Sets of T Cells -- MHC Class I -- MHC Class II -- Variability of MHC Class I and MHC Class II Molecules -- Structure of MHC Class I and Class II Molecules -- MHC Class I -- Structure of MHC Class II Molecules -- Antigen Processing and Presentation: How MHC Molecules Bind Peptides and Create Ligands That Interact with T Cells -- Exogenous Antigens and Generation of MHC Class II-Peptide Complexes -- Endogenous Antigens: Generation of MHC Class I-Peptide Complexes -- Cross-Presentation: Exogenous Antigens Presented in the MHC Class I Pathway. Which Antigens Trigger Which T-Cell Responses? -- MHC Molecules Bind Peptides Derived from Self-Molecules -- Inability to Respond to an Antigen -- Other Types of Antigen That Activate T-Cell Responses -- Superantigens -- Lipids and Glycolipids -- Multiple Antigens Activate γδ T Cells -- Genes of the HLA Region -- Nomenclature of Polymorphic MHC Molecules -- Regulation of Expression of MHC Genes -- Codominant Expression -- Coordinate Regulation -- Inheritance of MHC Genes -- MHC in Other Species -- Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 10 Biology of the T Lymphocyte -- Introduction -- The Antigen-Specific T-Cell Receptor -- Molecules That Interact with Antigen -- The T-Cell Receptor Complex -- Co-Receptors -- Other Important Molecules Expressed on the T-Cell Surface -- γδ T Cells -- Genes Coding for T-Cell Receptors -- Generation of T-Cell Receptor Diversity -- T-Cell Differentiation in the Thymus -- The Thymus as Primary Organ for T-Cell Differentiation -- Key Steps in Thymic Differentiation -- Early T-Cell Receptor Gene Rearrangements: Double-Negative Cells and Splitting Off of γδ T Cells -- Pre-T Cells -- Double-Positive Cells -- Thymic Selection -- Leaving the Thymus -- Generation of the T-Cell Repertoire -- Characteristics of αβ T Cells Emerging from the Thymus -- Further Differentiation of CD4+ and CD8+ T Cells Outside the Thymus -- Differentiation of Other Cell Types in the Thymus -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 11 Activation and Function of T Cells -- Introduction -- A Two-Signal Model for the Activation of T Cells -- Dendritic Cells Are the Key APC for Naïve T Cells -- Activation of CD4+ T Cells. Paired Interactions at the Surface of the APC and CD4+ T Cell. |
| Record Nr. | UNINA-9910964455203321 |
|
Coico Richard
|
||
| New York : , : John Wiley & Sons, Incorporated, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||