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Creatine and creatine phosphate [[electronic resource] ] : scientific and clinical perspectives / / [edited by] Michael A. Conway and Joseph F. Clark
| Creatine and creatine phosphate [[electronic resource] ] : scientific and clinical perspectives / / [edited by] Michael A. Conway and Joseph F. Clark |
| Pubbl/distr/stampa | San Diego, CA, : Academic Press, c1996 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina | 612.01575 |
| Altri autori (Persone) |
ConwayMichael A
ClarkJoseph F |
| Soggetto topico |
Creatine - Metabolism
Creatine - Physiological effect Phosphocreatine - Metabolism Phosphocreatine - Physiological effect |
| ISBN |
1-281-03708-7
9786611037086 0-08-053008-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Creatine and Creatine Phosphate: Scientific and Clinical Perspectives; Copyright Page; Contents; List of Contributors; A Brief Review of the Sections; Preface; Acknowledgements; Section I: Basic Biochemistry of Creatine and Creatine Phosphate; Chapter 1. Old and New Ideas on the Roles of Phosphagens and their Kinases; 1. Historical introduction to phosphagen kinases; 2. Physiological functions of phosphagen kinases; 3. Use of creatine kinase by the biochemist and physiologist; 4. The phosphoglycerate kinase-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) method
5. Comparison of the free ADP concentration estimated by different methods6. Determination of the amount of ADP irreversibly bound to structural protein in the domestic fowl pectoral muscle; References; Chapter 2. Creatine Phosphate Shuttle Pathway in Tissues with Dynamic Energy Demand; 1. Creatine phosphate shuttle hypothesis: cytosolic and mitochondrial CK serve as components of the shuttle; 2. CK in specialized cells: biochemical, physiological and immunological characterization; 3. Subcellular localization of CK; 4. Structure-function analysis of CK; 5. Targeted modification of CK 6. Future applications7. Summary; Acknowledgements; References; Chapter 3. Experimental Observations of Creatine and Creatine Phosphate Metabolism; 1. Introduction; 2. NMR studies of ATP and creatine phosphate in the heart; 3. Creatine phosphate metabolism investigated with ß-guanidinopropionic acid; 4. Creatine phosphate in skeletal muscle; 5. Creatine transport; 6. Summary; References; Chapter 4. An Introduction to the Cellular Creatine Kinase System in Contractile Tissue; 1. Introduction; 2. The creatine kinase system in different muscle types; 3. Skeletal muscle; 4. Cardiac muscle 5. Smooth muscle6. Summary; References; Chapter 5. Cardiac Energetics: Compartmentation of Creatine Kinase and Regulation of Oxidative Phosphorylation; 1. Introduction; 2. The role of the outer mitochondrial membrane in restricting ADP diffusion and controlling respiration; 3. Metabolic oscillations in cytoplasm as a feedback signal; References; Chapter 6. The Role of the Creatine Kinase/Creatine Phosphate System Studied by Molecular Biology; 1. Introduction; 2. Transgenic knock-out; 3. Muscle performance; 4. Graded CK knock-out; 5. Transgenic overexpression; 6. Summary; Acknowledgements ReferencesSection II: Biochemical Basis for a Therapeutic Role of Creatine and Creatine Phosphate; Chapter 7. Molecular and Cellular Mechanisms of Action for the Cardioprotective and Therapeutic Role of Creatine Phosphate; 1. Introduction; 2. Pharmacological effects of exogenous PCr; 3. Calcium dependence of the anti-ischaemic effect of PCr; 4. Protection of the heart from oxidative damage; 5. Effects of PCr on phospholipid metabolism; 6. Other biochemical effects related to the uptake of PCr; 7. Pharmacokinetics of PCr uptake by different tissues; 8. Direct effect of PCr on the cell membrane 9. The zwitterionic mechanism of action of PCr |
| Record Nr. | UNINA-9910784649903321 |
| San Diego, CA, : Academic Press, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Creatine and creatine phosphate : scientific and clinical perspectives / / [edited by] Michael A. Conway and Joseph F. Clark
| Creatine and creatine phosphate : scientific and clinical perspectives / / [edited by] Michael A. Conway and Joseph F. Clark |
| Pubbl/distr/stampa | San Diego, CA, : Academic Press, c1996 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina | 612.01575 |
| Altri autori (Persone) |
ConwayMichael A
ClarkJoseph F |
| Soggetto topico |
Creatine - Metabolism
Creatine - Physiological effect Phosphocreatine - Metabolism Phosphocreatine - Physiological effect |
| ISBN |
1-281-03708-7
9786611037086 0-08-053008-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Creatine and Creatine Phosphate: Scientific and Clinical Perspectives; Copyright Page; Contents; List of Contributors; A Brief Review of the Sections; Preface; Acknowledgements; Section I: Basic Biochemistry of Creatine and Creatine Phosphate; Chapter 1. Old and New Ideas on the Roles of Phosphagens and their Kinases; 1. Historical introduction to phosphagen kinases; 2. Physiological functions of phosphagen kinases; 3. Use of creatine kinase by the biochemist and physiologist; 4. The phosphoglycerate kinase-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) method
5. Comparison of the free ADP concentration estimated by different methods6. Determination of the amount of ADP irreversibly bound to structural protein in the domestic fowl pectoral muscle; References; Chapter 2. Creatine Phosphate Shuttle Pathway in Tissues with Dynamic Energy Demand; 1. Creatine phosphate shuttle hypothesis: cytosolic and mitochondrial CK serve as components of the shuttle; 2. CK in specialized cells: biochemical, physiological and immunological characterization; 3. Subcellular localization of CK; 4. Structure-function analysis of CK; 5. Targeted modification of CK 6. Future applications7. Summary; Acknowledgements; References; Chapter 3. Experimental Observations of Creatine and Creatine Phosphate Metabolism; 1. Introduction; 2. NMR studies of ATP and creatine phosphate in the heart; 3. Creatine phosphate metabolism investigated with ß-guanidinopropionic acid; 4. Creatine phosphate in skeletal muscle; 5. Creatine transport; 6. Summary; References; Chapter 4. An Introduction to the Cellular Creatine Kinase System in Contractile Tissue; 1. Introduction; 2. The creatine kinase system in different muscle types; 3. Skeletal muscle; 4. Cardiac muscle 5. Smooth muscle6. Summary; References; Chapter 5. Cardiac Energetics: Compartmentation of Creatine Kinase and Regulation of Oxidative Phosphorylation; 1. Introduction; 2. The role of the outer mitochondrial membrane in restricting ADP diffusion and controlling respiration; 3. Metabolic oscillations in cytoplasm as a feedback signal; References; Chapter 6. The Role of the Creatine Kinase/Creatine Phosphate System Studied by Molecular Biology; 1. Introduction; 2. Transgenic knock-out; 3. Muscle performance; 4. Graded CK knock-out; 5. Transgenic overexpression; 6. Summary; Acknowledgements ReferencesSection II: Biochemical Basis for a Therapeutic Role of Creatine and Creatine Phosphate; Chapter 7. Molecular and Cellular Mechanisms of Action for the Cardioprotective and Therapeutic Role of Creatine Phosphate; 1. Introduction; 2. Pharmacological effects of exogenous PCr; 3. Calcium dependence of the anti-ischaemic effect of PCr; 4. Protection of the heart from oxidative damage; 5. Effects of PCr on phospholipid metabolism; 6. Other biochemical effects related to the uptake of PCr; 7. Pharmacokinetics of PCr uptake by different tissues; 8. Direct effect of PCr on the cell membrane 9. The zwitterionic mechanism of action of PCr |
| Record Nr. | UNINA-9910810781603321 |
| San Diego, CA, : Academic Press, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||