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Advanced Statistical Methods in Data Science / / edited by Ding-Geng Chen, Jiahua Chen, Xuewen Lu, Grace Y. Yi, Hao Yu
| Advanced Statistical Methods in Data Science / / edited by Ding-Geng Chen, Jiahua Chen, Xuewen Lu, Grace Y. Yi, Hao Yu |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XVI, 222 p. 41 illus., 20 illus. in color.) |
| Disciplina | 519.50285 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Statistics
Quantitative research Statistical Theory and Methods Data Analysis and Big Data Statistics in Business, Management, Economics, Finance, Insurance |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: Data Analysis Based on Latent or Dependent Variable Models -- Chapter 1: A New Method for Robust Mixture Regression and Outlier Detection -- Chapter 2: The Mixture Gatekeeping Procedure Based on Weighted Multiple Testing Correction for Correlated Tests -- Chapter 3: Regularization in Regime-switching Gaussian Autoregressive Models -- Chapter 4: Modeling Zero Inflation and Over-dispersion in the Length of Hospital Stay for Patients with Ischaemic Heart Disease -- Chapter 5: Robust Optimal Interval Design for High-Dimensional Dose Finding in Multi-Agent Combination Trials -- Part II: Life Time Data Analysis -- Chapter 6: Group Selection in Semi-parametric Accelerated Failure Time Model -- Chapter 7: A Proportional Odds Model for Regression Analysis of Case I Interval-Censored Data -- Chapter 8: Empirical Likelihood Inference under Density Ratio Models Based on Type I Censored Samples: Hypothesis Testing and Quantile Estimation -- Chapter 9: Recent Development in the Joint Modeling of Longitudinal Quality of Life Measurements and Survival Data from Cancer Clinical Trials -- Part III: Applied Data Analysis -- Chapter 10: Confidence Weighting Procedures for Multiple Choice Tests -- Chapter 11: Improving the Robustness of Parametric Imputation -- Chapter 12: Maximum Smoothed Likelihood Estimation of the Centre of a Symmetric Distribution -- Chapter 13: Dividend Pay-out Problems with the Logarithmic Utility -- Chapter 14: Modeling the Common Risk among Equities: A Multivariate Time Series Model with an Additive GARCH Structure. |
| Record Nr. | UNINA-9910155548503321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biopharmaceutical Applied Statistics Symposium : Volume 3 Pharmaceutical Applications / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 3 Pharmaceutical Applications / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (426 pages) |
| Disciplina | 615.10727 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7820-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: Personalized Medicine -- 1 Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints -- 2 Uses of Mixture Normal Distribution in Genomics and Otherwise -- 3 Personalized Medicine – Design Considerations -- 4 Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncology Trials -- 5 High Dimensional Data in Genomics -- Part II: Novel Applications -- 6 Synergy or Additivity - The Importance of Defining the Primary Endpoint -- 7 Full Bayesian Adaptive Dose Finding using Toxicity Probability Interval (TPI) -- 8 Alpha-recycling for the Analyses of Primary and Secondary Endpoints of Clinical Trials -- 9 Expanded Interpretations of Results of Carcinogenicity Studies of Pharmaceuticals -- 1 Clinical Trials in Orphan Drug Development -- 11 Mediation Modeling in Randomized Trials with Non-normal Outcome Variables -- 12 Statistical Considerations in Using Images in Clinical Trials -- 13 Interesting Applications over 30 Years of Consulting -- 14 Uncovering Fraud, Misconduct and Other Data Quality Issues in Clinical Trials -- 15 Development and Evaluation of High Dimensional Prognostic Models -- 16 Design and Analysis of Biosimilar Studies. |
| Record Nr. | UNINA-9910300121003321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biopharmaceutical Applied Statistics Symposium : Volume 1 Design of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 1 Design of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XIV, 409 p. 54 illus., 28 illus. in color.) |
| Disciplina | 615.10727 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7829-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. A Statistical Approach to Clinical Trial Simulations -- 2. Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design -- 3. Adaptive Trial Design in Clinical Research -- 4. Best Practices and Recommendations for Trial Simulations Within the Context of Designing Adaptive Clinical Trials -- 5. Designing and Analyzing Recurrent Event Data Trials -- 6. Bayesian Methodologies for Response-Adaptive Allocation -- 7. Addressing High Placebo Response in Neuroscience Clinical Trials -- 8. Phase I Cancer Clinical Trial Design: Single and Combination Agents -- 9. Sample Size and Power for the Mixed Linear Model -- 10. Crossover Designs -- 11. Data monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures -- 12. Design and Data Analysis of Multiregional Clinical Trials (MRCT) – Theory and Practice -- 13. Multiregional Clinical Trials (MRCT) -- 14. Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines -- 15. Development and validation of Patient-reported Outcomes -- 16. Interim Analysis of Survival Trials: Group Sequential Analyses and Conditional Power. |
| Record Nr. | UNINA-9910300110403321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biopharmaceutical Applied Statistics Symposium : Volume 2 Biostatistical Analysis of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 2 Biostatistical Analysis of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (251 pages) |
| Disciplina | 614.35 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7826-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | On Statistical Approaches to Meta-analysis of Randomized Clinical Trials -- Collaborative Targeted Maximum Likelihood Estimation to Assess Causal Effects in Observational Studies -- Generalized Tests in Clinical Trials -- Discrete Time-to-event and Score-based Methods with Application to Composite Endpoint for Assessing Evidence of Disease Activity-Free -- Imputing Missing Data Using a Surrogate Biomarker: Analyzing the Incidence of Endometrial Hyperplasia -- Some Statistical Issues in Patient-reported Outcomes -- Network Meta-analysis -- Detecting Safety Signals Among Adverse Events in Clinical Trials -- Applied Meta-analysis using R -- Treatment of Missing Data in Comparative Effectiveness Research -- Missing Data -- Bayesian Subgroup Analysis with Examples -- Statistical Methods in Diagnostic Devices -- A Question-Based Approach to the Analysis of Safety Data -- Analysis of Two-stage Adaptive Seamless Trial Design -- Multiplicity Problems in Clinical Trials – A Regulatory Perspective. |
| Record Nr. | UNINA-9910300111803321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen
| Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico |
Medicine - Research - Statistical methods
Clinical trials - Methodology |
| ISBN |
0-429-17306-7
1-4822-1219-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
| Record Nr. | UNINA-9910787961903321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen
| Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico |
Medicine - Research - Statistical methods
Clinical trials - Methodology |
| ISBN |
0-429-17306-7
1-4822-1219-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
| Record Nr. | UNINA-9910800183903321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen
| Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen |
| Autore | Peace Karl E. <1941, > |
| Pubbl/distr/stampa | Boca Raton : , : Chapman and Hall/CRC Press, , 2011 |
| Descrizione fisica | 1 online resource (422 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | ChenDing-Geng |
| Collana | Chapman & Hall/CRC biostatistics series |
| Soggetto topico |
Clinical trials
Drugs - Testing |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-14207-2
1-58488-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Contents; Preface; Chapter 1: Overview of Clinical Trial Methodology; Chapter 2: Overview of the Drug Development Processand Regulation of Clinical Trials; Chapter 3: Ethical Considerations in the Designand Conduct of Clinical Trials; Chapter 4: Sample Size Considerations in ClinicalTrials Pre-Market Approval; Chapter 5: Sequential, Group Sequential, StochasticCurtailment, and Adaptive DesignProcedures in Clinical Trials; Chapter 6: Biostatistical Aspects of the Protocol; Chapter 7: The Statistical Analysis Plan; Chapter 8: Pooling of Data from Multicenter Clinical Trials
Chapter 9: Validity of Statistical InferenceChapter 10: Bioequivalence Clinical Trials; Chapter 11: Dose and Frequency Determinationfrom Phase II Clinical Trials in StressTest-Induced Angina; Chapter 12: Confirmation of Clinically Optimal Dosingin the Treatment of Duodenal Ulcers:A Phase III Dose Comparison Trial; Chapter 13: Pivotal Proof-of-Efficacy Clinical Trialsin the Prevention of NANSAID-InducedGastric Ulceration; Chapter 14: Clinical Trials in the Treatmentof Alzheimer's Disease Based uponEnrichment Designs; Chapter 15: A Clinical Trial to Establish Reductionof CHD Risk Chapter 16: Pivotal Proof-of-Efficacy Clinical Trialsin the Treatment of Panic DisorderChapter 17: Combination Clinical Trials; Chapter 18: Monitoring Clinical Trials for Adverse Events; Index; Back cover |
| Record Nr. | UNINA-9910458853903321 |
Peace Karl E. <1941, >
|
||
| Boca Raton : , : Chapman and Hall/CRC Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen
| Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen |
| Autore | Peace Karl E. <1941, > |
| Pubbl/distr/stampa | Boca Raton : , : Chapman and Hall/CRC Press, , 2011 |
| Descrizione fisica | 1 online resource (422 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | ChenDing-Geng |
| Collana | Chapman & Hall/CRC biostatistics series |
| Soggetto topico |
Clinical trials
Drugs - Testing |
| ISBN |
0-429-14207-2
1-58488-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Contents; Preface; Chapter 1: Overview of Clinical Trial Methodology; Chapter 2: Overview of the Drug Development Processand Regulation of Clinical Trials; Chapter 3: Ethical Considerations in the Designand Conduct of Clinical Trials; Chapter 4: Sample Size Considerations in ClinicalTrials Pre-Market Approval; Chapter 5: Sequential, Group Sequential, StochasticCurtailment, and Adaptive DesignProcedures in Clinical Trials; Chapter 6: Biostatistical Aspects of the Protocol; Chapter 7: The Statistical Analysis Plan; Chapter 8: Pooling of Data from Multicenter Clinical Trials
Chapter 9: Validity of Statistical InferenceChapter 10: Bioequivalence Clinical Trials; Chapter 11: Dose and Frequency Determinationfrom Phase II Clinical Trials in StressTest-Induced Angina; Chapter 12: Confirmation of Clinically Optimal Dosingin the Treatment of Duodenal Ulcers:A Phase III Dose Comparison Trial; Chapter 13: Pivotal Proof-of-Efficacy Clinical Trialsin the Prevention of NANSAID-InducedGastric Ulceration; Chapter 14: Clinical Trials in the Treatmentof Alzheimer's Disease Based uponEnrichment Designs; Chapter 15: A Clinical Trial to Establish Reductionof CHD Risk Chapter 16: Pivotal Proof-of-Efficacy Clinical Trialsin the Treatment of Panic DisorderChapter 17: Combination Clinical Trials; Chapter 18: Monitoring Clinical Trials for Adverse Events; Index; Back cover |
| Record Nr. | UNINA-9910785026803321 |
|
Peace Karl E. <1941, >
|
||
| Boca Raton : , : Chapman and Hall/CRC Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen
| Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen |
| Autore | Peace Karl E. <1941, > |
| Pubbl/distr/stampa | Boca Raton : , : Chapman and Hall/CRC Press, , 2011 |
| Descrizione fisica | 1 online resource (422 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | ChenDing-Geng |
| Collana | Chapman & Hall/CRC biostatistics series |
| Soggetto topico |
Clinical trials
Drugs - Testing |
| ISBN |
0-429-14207-2
1-58488-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Contents; Preface; Chapter 1: Overview of Clinical Trial Methodology; Chapter 2: Overview of the Drug Development Processand Regulation of Clinical Trials; Chapter 3: Ethical Considerations in the Designand Conduct of Clinical Trials; Chapter 4: Sample Size Considerations in ClinicalTrials Pre-Market Approval; Chapter 5: Sequential, Group Sequential, StochasticCurtailment, and Adaptive DesignProcedures in Clinical Trials; Chapter 6: Biostatistical Aspects of the Protocol; Chapter 7: The Statistical Analysis Plan; Chapter 8: Pooling of Data from Multicenter Clinical Trials
Chapter 9: Validity of Statistical InferenceChapter 10: Bioequivalence Clinical Trials; Chapter 11: Dose and Frequency Determinationfrom Phase II Clinical Trials in StressTest-Induced Angina; Chapter 12: Confirmation of Clinically Optimal Dosingin the Treatment of Duodenal Ulcers:A Phase III Dose Comparison Trial; Chapter 13: Pivotal Proof-of-Efficacy Clinical Trialsin the Prevention of NANSAID-InducedGastric Ulceration; Chapter 14: Clinical Trials in the Treatmentof Alzheimer's Disease Based uponEnrichment Designs; Chapter 15: A Clinical Trial to Establish Reductionof CHD Risk Chapter 16: Pivotal Proof-of-Efficacy Clinical Trialsin the Treatment of Panic DisorderChapter 17: Combination Clinical Trials; Chapter 18: Monitoring Clinical Trials for Adverse Events; Index; Back cover |
| Record Nr. | UNINA-9910799965803321 |
|
Peace Karl E. <1941, >
|
||
| Boca Raton : , : Chapman and Hall/CRC Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen
| Clinical trial methodology / / Karl E. Peace, Ding-Geng (Din) Chen |
| Autore | Peace Karl E. <1941-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Boca Raton, : Chapman and Hall/CRC Press, c2011 |
| Descrizione fisica | 1 online resource (422 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | ChenDing-Geng |
| Collana | Chapman & Hall/CRC biostatistics series |
| Soggetto topico |
Clinical trials
Drugs - Testing |
| ISBN |
1-04-017070-6
0-429-14207-2 1-58488-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Contents; Preface; Chapter 1: Overview of Clinical Trial Methodology; Chapter 2: Overview of the Drug Development Processand Regulation of Clinical Trials; Chapter 3: Ethical Considerations in the Designand Conduct of Clinical Trials; Chapter 4: Sample Size Considerations in ClinicalTrials Pre-Market Approval; Chapter 5: Sequential, Group Sequential, StochasticCurtailment, and Adaptive DesignProcedures in Clinical Trials; Chapter 6: Biostatistical Aspects of the Protocol; Chapter 7: The Statistical Analysis Plan; Chapter 8: Pooling of Data from Multicenter Clinical Trials
Chapter 9: Validity of Statistical InferenceChapter 10: Bioequivalence Clinical Trials; Chapter 11: Dose and Frequency Determinationfrom Phase II Clinical Trials in StressTest-Induced Angina; Chapter 12: Confirmation of Clinically Optimal Dosingin the Treatment of Duodenal Ulcers:A Phase III Dose Comparison Trial; Chapter 13: Pivotal Proof-of-Efficacy Clinical Trialsin the Prevention of NANSAID-InducedGastric Ulceration; Chapter 14: Clinical Trials in the Treatmentof Alzheimer's Disease Based uponEnrichment Designs; Chapter 15: A Clinical Trial to Establish Reductionof CHD Risk Chapter 16: Pivotal Proof-of-Efficacy Clinical Trialsin the Treatment of Panic DisorderChapter 17: Combination Clinical Trials; Chapter 18: Monitoring Clinical Trials for Adverse Events; Index; Back cover |
| Record Nr. | UNINA-9910973584603321 |
|
Peace Karl E. <1941->
|
||
| Boca Raton, : Chapman and Hall/CRC Press, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
