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Biomolecular networks [[electronic resource] ] : methods and applications in systems biology / / Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang
| Biomolecular networks [[electronic resource] ] : methods and applications in systems biology / / Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang |
| Autore | Chen Luonan <1962-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (420 p.) |
| Disciplina | 572.80285 |
| Altri autori (Persone) |
WangRui-Sheng
ZhangXiang-Sun <1943-> |
| Collana | Wiley series on bioinformatics |
| Soggetto topico |
Molecular biology - Data processing
Computational biology Bioinformatics Biological systems - Research - Data processing |
| ISBN |
1-282-18602-7
9786612186028 0-470-48806-9 0-470-48805-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
BIOMOLECULAR NETWORKS; CONTENTS; PREFACE; ACKNOWLEDGMENTS; LIST OF ILLUSTRATIONS; ACRONYMS; 1 Introduction; 1.1 Basic Concepts in Molecular Biology; 1.1.1 Genomes, Genes, and DNA Replication Process; 1.1.2 Transcription Process for RNA Synthesis; 1.1.3 Translation Process for Protein Synthesis; 1.2 Biomolecular Networks in Cells; 1.3 Network Systems Biology; 1.4 About This Book; I GENE NETWORKS; 2 Transcription Regulation: Networks and Models; 2.1 Transcription Regulation and Gene Expression; 2.1.1 Transcription and Gene Regulation; 2.1.2 Microarray Experiments and Databases
2.1.3 ChIP-Chip Technology and Transcription Factor Databases2.2 Networks in Transcription Regulation; 2.3 Nonlinear Models Based on Biochemical Reactions; 2.4 Integrated Models for Regulatory Networks; 2.5 Summary; 3 Reconstruction of Gene Regulatory Networks; 3.1 Mathematical Models of Gene Regulatory Network; 3.1.1 Boolean Networks; 3.1.2 Bayesian Networks; 3.1.3 Markov Networks; 3.1.4 Differential Equations; 3.2 Reconstructing Gene Regulatory Networks; 3.2.1 Singular Value Decomposition; 3.2.2 Model-Based Optimization; 3.3 Inferring Gene Networks from Multiple Datasets 3.3.1 General Solutions and a Particular Solution of Network Structures for Multiple Datasets3.3.2 Decomposition Algorithm; 3.3.3 Numerical Validation; 3.4 Gene Network-Based Drug Target Identification; 3.4.1 Network Identification Methods; 3.4.2 Linear Programming Framework; 3.5 Summary; 4 Inference of Transcriptional Regulatory Networks; 4.1 Predicting TF Binding Sites and Promoters; 4.2 Inference of Transcriptional Interactions; 4.2.1 Differential Equation Methods; 4.2.2 Bayesian Approaches; 4.2.3 Data Mining and Other Methods; 4.3 Identifying Combinatorial Regulations of TFs 4.4 Inferring Cooperative Regulatory Networks4.4.1 Mathematical Models; 4.4.2 Estimating TF Activity; 4.4.3 Linear Programming Models; 4.4.4 Numerical Validation; 4.5 Prediction of Transcription Factor Activity; 4.5.1 Matrix Factorization; 4.5.2 Nonlinear Models; 4.6 Summary; II PROTEIN INTERACTION NETWORKS; 5 Prediction of Protein-Protein Interactions; 5.1 Experimental Protein-Protein Interactions; 5.2 Prediction of Protein-Protein Interactions; 5.2.1 Association Methods; 5.2.2 Maximum-Likelihood Estimation; 5.2.3 Deterministic Optimization Approaches 5.3 Protein Interaction Prediction Based on Multidomain Pairs5.3.1 Cooperative Domains, Strongly Cooperative Domains, Superdomains; 5.3.2 Inference of Multidomain Interactions; 5.3.3 Numerical Validation; 5.3.4 Reconstructing Complexes by Multidomain Interactions; 5.4 Domain Interaction Prediction Methods; 5.4.1 Statistical Method; 5.4.2 Domain Pair Exclusion Analysis; 5.4.3 Parsimony Explanation Approaches; 5.4.4 Integrative Approaches; 5.5 Summary; 6 Topological Structure of Biomolecular Networks; 6.1 Statistical Properties of Biomolecular Networks 6.2 Evolution of Protein Interaction Networks |
| Record Nr. | UNINA-9910143084903321 |
Chen Luonan <1962->
|
||
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomolecular networks [[electronic resource] ] : methods and applications in systems biology / / Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang
| Biomolecular networks [[electronic resource] ] : methods and applications in systems biology / / Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang |
| Autore | Chen Luonan <1962-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (420 p.) |
| Disciplina | 572.80285 |
| Altri autori (Persone) |
WangRui-Sheng
ZhangXiang-Sun <1943-> |
| Collana | Wiley series on bioinformatics |
| Soggetto topico |
Molecular biology - Data processing
Computational biology Bioinformatics Biological systems - Research - Data processing |
| ISBN |
1-282-18602-7
9786612186028 0-470-48806-9 0-470-48805-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
BIOMOLECULAR NETWORKS; CONTENTS; PREFACE; ACKNOWLEDGMENTS; LIST OF ILLUSTRATIONS; ACRONYMS; 1 Introduction; 1.1 Basic Concepts in Molecular Biology; 1.1.1 Genomes, Genes, and DNA Replication Process; 1.1.2 Transcription Process for RNA Synthesis; 1.1.3 Translation Process for Protein Synthesis; 1.2 Biomolecular Networks in Cells; 1.3 Network Systems Biology; 1.4 About This Book; I GENE NETWORKS; 2 Transcription Regulation: Networks and Models; 2.1 Transcription Regulation and Gene Expression; 2.1.1 Transcription and Gene Regulation; 2.1.2 Microarray Experiments and Databases
2.1.3 ChIP-Chip Technology and Transcription Factor Databases2.2 Networks in Transcription Regulation; 2.3 Nonlinear Models Based on Biochemical Reactions; 2.4 Integrated Models for Regulatory Networks; 2.5 Summary; 3 Reconstruction of Gene Regulatory Networks; 3.1 Mathematical Models of Gene Regulatory Network; 3.1.1 Boolean Networks; 3.1.2 Bayesian Networks; 3.1.3 Markov Networks; 3.1.4 Differential Equations; 3.2 Reconstructing Gene Regulatory Networks; 3.2.1 Singular Value Decomposition; 3.2.2 Model-Based Optimization; 3.3 Inferring Gene Networks from Multiple Datasets 3.3.1 General Solutions and a Particular Solution of Network Structures for Multiple Datasets3.3.2 Decomposition Algorithm; 3.3.3 Numerical Validation; 3.4 Gene Network-Based Drug Target Identification; 3.4.1 Network Identification Methods; 3.4.2 Linear Programming Framework; 3.5 Summary; 4 Inference of Transcriptional Regulatory Networks; 4.1 Predicting TF Binding Sites and Promoters; 4.2 Inference of Transcriptional Interactions; 4.2.1 Differential Equation Methods; 4.2.2 Bayesian Approaches; 4.2.3 Data Mining and Other Methods; 4.3 Identifying Combinatorial Regulations of TFs 4.4 Inferring Cooperative Regulatory Networks4.4.1 Mathematical Models; 4.4.2 Estimating TF Activity; 4.4.3 Linear Programming Models; 4.4.4 Numerical Validation; 4.5 Prediction of Transcription Factor Activity; 4.5.1 Matrix Factorization; 4.5.2 Nonlinear Models; 4.6 Summary; II PROTEIN INTERACTION NETWORKS; 5 Prediction of Protein-Protein Interactions; 5.1 Experimental Protein-Protein Interactions; 5.2 Prediction of Protein-Protein Interactions; 5.2.1 Association Methods; 5.2.2 Maximum-Likelihood Estimation; 5.2.3 Deterministic Optimization Approaches 5.3 Protein Interaction Prediction Based on Multidomain Pairs5.3.1 Cooperative Domains, Strongly Cooperative Domains, Superdomains; 5.3.2 Inference of Multidomain Interactions; 5.3.3 Numerical Validation; 5.3.4 Reconstructing Complexes by Multidomain Interactions; 5.4 Domain Interaction Prediction Methods; 5.4.1 Statistical Method; 5.4.2 Domain Pair Exclusion Analysis; 5.4.3 Parsimony Explanation Approaches; 5.4.4 Integrative Approaches; 5.5 Summary; 6 Topological Structure of Biomolecular Networks; 6.1 Statistical Properties of Biomolecular Networks 6.2 Evolution of Protein Interaction Networks |
| Record Nr. | UNINA-9910823650003321 |
|
Chen Luonan <1962->
|
||
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||