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Mesenchymal stem cell therapy / / Lucas G. Chase, Mohan C. Vemuri, editors
| Mesenchymal stem cell therapy / / Lucas G. Chase, Mohan C. Vemuri, editors |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Humana Press, 2013 |
| Descrizione fisica | 1 online resource (457 p.) |
| Disciplina | 616.02774 |
| Altri autori (Persone) |
ChaseLucas G
VemuriMohan C |
| Collana | Stem cell biology and regenerative medicine |
| Soggetto topico | Mesenchymal stem cells |
| ISBN |
1-283-93458-2
1-62703-200-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Scaling-up Ex-vivo Expansion of Mesenchymal Stem/Stromal Cells for Cellular Therapies -- Mesenchymal Stromal Cell Mechanisms of Immunomodulation and Homing -- Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? -- The Biology of Mesenchymal Stem Cells in Health and Disease and its Relevance to MSC-based Cell Delivery Therapies -- Pulmonary Clinical Applications for Mesenchymal Stem Cells -- Stem Cell Therapy for Bone Disorders -- Mesenchymal Stem Cell Therapies for Bone and Tendon Conditions -- Mesenchymal Stromal Cells (MSC) and the Repair of Cartilage Tissue -- Mesenchymal Stem Cells and Haematopoietic Stem Cell Culture -- Mesenchymal Stem Cells for Treatment and Prevention of Graft-Versus-Host Disease and Graft Failure after Hematopoietic Stem Cell Transplantation and Future Challenges -- Mesenchymal Stromal Cell Therapy in Crohn’s Disease -- Application of Mesenychymal Stem Cells in Amyotrophic Lateral Sclerosis -- Mesenchymal Stem Cell Therapy for Heart Disease -- Advances in Lentivector-based Cell Therapy with Mesenchymal Stem Cells -- Genetically Engineered Mesenchymal Stem Cells for Cell and Gene Therapy -- Optimal Tissue Sources of Mesenchymal Stromal Cells for Clinical Trials -- Regulatory Considerations Applicable to Manufacturing of Human Placenta-derived Mesenchymal Stromal Cells (MSC) Used in Clinical Trials in Australia and Comparison to USA and European Regulatory Frameworks -- Mesenchymal Stem Cell Therapy for Peripheral Vascular Diseases -- Mesenchymal Stromal Cells in the Clinic: What do the clinical trials say?. |
| Record Nr. | UNINA-9910437829403321 |
| New York, : Humana Press, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Stem Cell Manufacturing [[electronic resource]]
| Stem Cell Manufacturing [[electronic resource]] |
| Autore | Cabral Joaquim M. S |
| Pubbl/distr/stampa | Oxford, : Elsevier Science, 2015 |
| Descrizione fisica | 1 online resource (342 p.) |
| Disciplina | 616.02774 |
| Altri autori (Persone) |
da SilvaClaudia Lobato
ChaseLucas G DiogoMaria Margarida |
| Soggetto topico | Stem cells |
| ISBN |
0-444-63266-2
0-444-63265-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; STEM CELL MANUFACTURING; STEM CELL MANUFACTURING; Copyright; CONTENTS; LIST OF CONTRIBUTORS; INTRODUCTION; 1 - Genetic Engineering in Stem Cell Biomanufacturing ; 1.1 INTRODUCTION; 1.2 GENETIC MANIPULATION APPROACHES IN HUMAN PLURIPOTENT STEM CELLS; 1.2.1 Transgenic Approaches; 1.2.2 Knock-In and Knock-Out Approaches; 1.2.2.1 Zinc-Finger Nucleases; 1.2.2.2 Transcription Activator-Like Effector Nucleases; 1.2.2.3 Clustered Regularly Interspaced Short Palindromic Repeat/Cas9; 1.2.3 Bacterial Artificial Chromosomes; 1.3 APPLICATIONS
1.3.1 Genetic Labeling for Cell Identification and Cell Tracking1.3.2 Gene Alteration for Directed Differentiation; 1.3.3 Gene Disruption for Functional Investigation; 1.3.4 Gene Correction for Function Restoration; 1.4 DELIVERY METHODS; 1.4.1 Transfection; 1.4.2 Nucleofection; 1.4.3 Viral Transduction; 1.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 2 - Biomechanics in Stem Cell Manufacturing; 2.1 INTRODUCTION; 2.2 CELLULAR BIOMECHANICS; 2.2.1 Biomechanical Cues; 2.2.2 Shear Forces and Differentiated Cells; 2.2.3 Shear Forces and Pluripotent Stem Cells 2.3 SCALE UP TOWARD PRODUCTION-LEVEL BIOREACTORS2.4 BIOMANUFACTURING CELLS FOR THERAPIES; 2.4.1 Pluripotent Stem Cells; 2.4.2 Cardiomyocytes; 2.4.3 Endothelial Cells; 2.5 CONCLUSION; REFERENCES; 3 - Bioreactor Engineering Fundamentals for Stem Cell Manufacturing ; 3.1 INTRODUCTION; 3.2 STIRRED BIOREACTOR BASICS; 3.3 SPECIAL FEATURES OF STIRRED BIOREACTORS FOR HMSC CULTURE ON MICROCARRIERS; 3.3.1 Introduction; 3.3.2 Preparing the Bioreactor for Culture; 3.3.3 Medium and Medium Exchange; 3.3.4 Microcarrier Selection; 3.3.5 Cell and Microcarrier Concentrations; 3.3.6 Attachment Protocol 3.3.7 Use of Coatings to Enhance Attachment3.3.8 The Minimum Speed for Suspension, NJS and Associated Mean Specific Energy Dissipation Rate, εT;̄ 3.3.8.1 General Aspects; 3.3.8.2 NJS Considerations in hMSC Culture; 3.3.9 Oxygen Demand, Mass Transfer, and Optimum Dissolved Oxygen; 3.3.9.1 General Considerations; 3.3.9.2 Application to hMSC Culture; 3.3.10 Fluid Dynamically Generated Stresses and Cell Proliferation; 3.3.10.1 General Considerations; 3.3.10.2 Application to hMSC Culture; 3.3.11 Fluid Dynamically Generated Stresses and Their Application to Cell Harvesting; 3.4 FUTURE ISSUES 3.4.1 Increasing Cell Density3.4.2 Oxygen Demand and Mass Transfer at Higher Cell Density-Sparging and Higher Agitator Speeds; 3.4.3 Carbon Dioxide, Osmolality, and pH; 3.4.4 Human-Induced and Embryonic Pluripotent Stem Cells; 3.5 CONCLUSIONS; NOMENCLATURE; REFERENCES; 4 - Microcarrier Culture Systems for Stem Cell Manufacturing ; 4.1 OVERVIEW; 4.1.1 Historical Perspective; 4.2 MICROCARRIER TECHNOLOGY; 4.2.1 Types of Microcarriers; 4.2.2 Properties of Microcarriers Required for Cell Culturing; 4.2.3 Advantages of Using Microcarrier Culture Systems for Cell Manufacturing 4.3 SCALABLE CULTURE SYSTEMS FOR ADHERENT STEM CELLS |
| Record Nr. | UNINA-9910798524903321 |
Cabral Joaquim M. S
|
||
| Oxford, : Elsevier Science, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Stem Cell Manufacturing
| Stem Cell Manufacturing |
| Autore | Cabral Joaquim M. S |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Oxford, : Elsevier Science, 2015 |
| Descrizione fisica | 1 online resource (342 p.) |
| Disciplina | 616.02774 |
| Altri autori (Persone) |
da SilvaClaudia Lobato
ChaseLucas G DiogoMaria Margarida |
| Soggetto topico | Stem cells |
| ISBN |
0-444-63266-2
0-444-63265-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; STEM CELL MANUFACTURING; STEM CELL MANUFACTURING; Copyright; CONTENTS; LIST OF CONTRIBUTORS; INTRODUCTION; 1 - Genetic Engineering in Stem Cell Biomanufacturing ; 1.1 INTRODUCTION; 1.2 GENETIC MANIPULATION APPROACHES IN HUMAN PLURIPOTENT STEM CELLS; 1.2.1 Transgenic Approaches; 1.2.2 Knock-In and Knock-Out Approaches; 1.2.2.1 Zinc-Finger Nucleases; 1.2.2.2 Transcription Activator-Like Effector Nucleases; 1.2.2.3 Clustered Regularly Interspaced Short Palindromic Repeat/Cas9; 1.2.3 Bacterial Artificial Chromosomes; 1.3 APPLICATIONS
1.3.1 Genetic Labeling for Cell Identification and Cell Tracking1.3.2 Gene Alteration for Directed Differentiation; 1.3.3 Gene Disruption for Functional Investigation; 1.3.4 Gene Correction for Function Restoration; 1.4 DELIVERY METHODS; 1.4.1 Transfection; 1.4.2 Nucleofection; 1.4.3 Viral Transduction; 1.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 2 - Biomechanics in Stem Cell Manufacturing; 2.1 INTRODUCTION; 2.2 CELLULAR BIOMECHANICS; 2.2.1 Biomechanical Cues; 2.2.2 Shear Forces and Differentiated Cells; 2.2.3 Shear Forces and Pluripotent Stem Cells 2.3 SCALE UP TOWARD PRODUCTION-LEVEL BIOREACTORS2.4 BIOMANUFACTURING CELLS FOR THERAPIES; 2.4.1 Pluripotent Stem Cells; 2.4.2 Cardiomyocytes; 2.4.3 Endothelial Cells; 2.5 CONCLUSION; REFERENCES; 3 - Bioreactor Engineering Fundamentals for Stem Cell Manufacturing ; 3.1 INTRODUCTION; 3.2 STIRRED BIOREACTOR BASICS; 3.3 SPECIAL FEATURES OF STIRRED BIOREACTORS FOR HMSC CULTURE ON MICROCARRIERS; 3.3.1 Introduction; 3.3.2 Preparing the Bioreactor for Culture; 3.3.3 Medium and Medium Exchange; 3.3.4 Microcarrier Selection; 3.3.5 Cell and Microcarrier Concentrations; 3.3.6 Attachment Protocol 3.3.7 Use of Coatings to Enhance Attachment3.3.8 The Minimum Speed for Suspension, NJS and Associated Mean Specific Energy Dissipation Rate, εT;̄ 3.3.8.1 General Aspects; 3.3.8.2 NJS Considerations in hMSC Culture; 3.3.9 Oxygen Demand, Mass Transfer, and Optimum Dissolved Oxygen; 3.3.9.1 General Considerations; 3.3.9.2 Application to hMSC Culture; 3.3.10 Fluid Dynamically Generated Stresses and Cell Proliferation; 3.3.10.1 General Considerations; 3.3.10.2 Application to hMSC Culture; 3.3.11 Fluid Dynamically Generated Stresses and Their Application to Cell Harvesting; 3.4 FUTURE ISSUES 3.4.1 Increasing Cell Density3.4.2 Oxygen Demand and Mass Transfer at Higher Cell Density-Sparging and Higher Agitator Speeds; 3.4.3 Carbon Dioxide, Osmolality, and pH; 3.4.4 Human-Induced and Embryonic Pluripotent Stem Cells; 3.5 CONCLUSIONS; NOMENCLATURE; REFERENCES; 4 - Microcarrier Culture Systems for Stem Cell Manufacturing ; 4.1 OVERVIEW; 4.1.1 Historical Perspective; 4.2 MICROCARRIER TECHNOLOGY; 4.2.1 Types of Microcarriers; 4.2.2 Properties of Microcarriers Required for Cell Culturing; 4.2.3 Advantages of Using Microcarrier Culture Systems for Cell Manufacturing 4.3 SCALABLE CULTURE SYSTEMS FOR ADHERENT STEM CELLS |
| Record Nr. | UNINA-9910814782103321 |
|
Cabral Joaquim M. S
|
||
| Oxford, : Elsevier Science, 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||