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Effects of persistent and bioactive organic pollutants on human health [[electronic resource] /] / David O. Carpenter
| Effects of persistent and bioactive organic pollutants on human health [[electronic resource] /] / David O. Carpenter |
| Autore | Carpenter David O |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, Inc., 2013 |
| Descrizione fisica | 1 online resource (610 p.) |
| Disciplina | 615.9/5 |
| Soggetto topico |
Bioactive compounds - Toxicology
Organic compounds - Toxicology Persistent pollutants - Health aspects |
| ISBN |
1-118-67954-7
1-118-67965-2 1-118-67949-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Copyright page; Contents; Contributors; CHAPTER 1: Introduction: Why Should We Care about Organic Chemicals and Human Health?; References; CHAPTER 2: Sources of Human Exposure; Introduction; Human Exposure Pathways; Direct or Nondietary; Dietary; Chemicals of Concern; POPs; Pesticides; Benzene; Perfluoroalkyl Substances (PFASs); Conclusions and Recommendations; References; CHAPTER 3: The Burden of Cancer from Organic Chemicals; Introduction; The Global Burden of Cancer; Childhood Cancers; Exposure to Organic Chemicals: Contributions to the Global Burden of Cancer
OccupationalOutdoor Air Pollution; Indoor Air Pollution; Water Pollution; Consumer Products; Food Contaminants; Pesticides; 2,4-Dichlorophenoxyacetic Acid (2,4-D): Health Impacts of a Widely Used Organic Chemical Herbicide; Linking Chemicals to Specific Cancer Sites; Examples of Individual Organic Chemicals; Sources of Exposure Information; Estimating the Percentage of Cancers Attributable to Occupational and Environmental Exposures: Methodological and Conceptual Difficulties; Efforts to Estimate Attributable Fractions; Causes: Genes or Environment?; Conclusion: Opportunities for Prevention ReferencesCHAPTER 4: Carcinogenicity and Mechanisms of Persistent Organic Pollutants; Introduction; Many POPs Are Complete Carcinogens in Animal Studies; Aspects of Cancer Induction; Carcinogenesis Is a Multistep Process; Compounds May Require Metabolic Bioactivation to Reactive Intermediates and/or By-Products to Act as Carcinogens: Example Lower-Chlorinated Biphenyls; Direct versus Indirect Action; Cancer-Initiating Activity of POPs; Cancer Initiation Is Based on Genotoxic Events; Initiating and Genotoxic Activity of POPs In Vitro and In Vivo; Genotoxicity of Individual Pesticides Tumor-Promoting Activities of Environmental PollutantsPromoting Activity of Individual POPs; Mechanisms of Tumor Promotion by Environmental Pollutants; Progression in Carcinogenesis; Summary and Conclusion; Acknowledgments; References; CHAPTER 5: Diabetes and the Metabolic Syndrome; Introduction; Why Is There an Epidemic of T2D?; Human Evidence Linking POPs and T2D; Earlier Evidence; Recent Evidence: Cross-Sectional Studies; Recent Evidence: Prospective Studies; Human Evidence Linking POPs and Metabolic Syndrome; Mismatch of Time Trend: Issues Related to Inverted U-Shaped Associations Polybrominated Biphenyl Ethers (PBDEs) and T2DThrifty Gene Hypothesis and POPs; POPs and Glycemic Control among Diabetic Patients; Dietary Interventions in T2D; Summary; References; CHAPTER 6: Mechanistic Basis for Elevation in Risk of Diabetes Caused by Persistent Organic Pollutants; Introduction; Diabetes; POPs: Novel Diabetogenic Factors; POPs and Diabetes: Mechanistic Basis; AhR; CAR and SXR; Challenges and Perspectives; References; CHAPTER 7: Cardiovascular Disease and Hypertension; Introduction; Animal Studies and Laboratory Evidence Standardized Mortality Ratios (SMRs) for Heart Disease |
| Record Nr. | UNINA-9910141811103321 |
Carpenter David O
|
||
| Hoboken, NJ, : John Wiley & Sons, Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Effects of persistent and bioactive organic pollutants on human health / / David O. Carpenter
| Effects of persistent and bioactive organic pollutants on human health / / David O. Carpenter |
| Autore | Carpenter David O |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, Inc., 2013 |
| Descrizione fisica | 1 online resource (610 p.) |
| Disciplina | 615.9/5 |
| Soggetto topico |
Bioactive compounds - Toxicology
Organic compounds - Toxicology Persistent pollutants - Health aspects |
| ISBN |
1-118-67954-7
1-118-67965-2 1-118-67949-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Copyright page; Contents; Contributors; CHAPTER 1: Introduction: Why Should We Care about Organic Chemicals and Human Health?; References; CHAPTER 2: Sources of Human Exposure; Introduction; Human Exposure Pathways; Direct or Nondietary; Dietary; Chemicals of Concern; POPs; Pesticides; Benzene; Perfluoroalkyl Substances (PFASs); Conclusions and Recommendations; References; CHAPTER 3: The Burden of Cancer from Organic Chemicals; Introduction; The Global Burden of Cancer; Childhood Cancers; Exposure to Organic Chemicals: Contributions to the Global Burden of Cancer
OccupationalOutdoor Air Pollution; Indoor Air Pollution; Water Pollution; Consumer Products; Food Contaminants; Pesticides; 2,4-Dichlorophenoxyacetic Acid (2,4-D): Health Impacts of a Widely Used Organic Chemical Herbicide; Linking Chemicals to Specific Cancer Sites; Examples of Individual Organic Chemicals; Sources of Exposure Information; Estimating the Percentage of Cancers Attributable to Occupational and Environmental Exposures: Methodological and Conceptual Difficulties; Efforts to Estimate Attributable Fractions; Causes: Genes or Environment?; Conclusion: Opportunities for Prevention ReferencesCHAPTER 4: Carcinogenicity and Mechanisms of Persistent Organic Pollutants; Introduction; Many POPs Are Complete Carcinogens in Animal Studies; Aspects of Cancer Induction; Carcinogenesis Is a Multistep Process; Compounds May Require Metabolic Bioactivation to Reactive Intermediates and/or By-Products to Act as Carcinogens: Example Lower-Chlorinated Biphenyls; Direct versus Indirect Action; Cancer-Initiating Activity of POPs; Cancer Initiation Is Based on Genotoxic Events; Initiating and Genotoxic Activity of POPs In Vitro and In Vivo; Genotoxicity of Individual Pesticides Tumor-Promoting Activities of Environmental PollutantsPromoting Activity of Individual POPs; Mechanisms of Tumor Promotion by Environmental Pollutants; Progression in Carcinogenesis; Summary and Conclusion; Acknowledgments; References; CHAPTER 5: Diabetes and the Metabolic Syndrome; Introduction; Why Is There an Epidemic of T2D?; Human Evidence Linking POPs and T2D; Earlier Evidence; Recent Evidence: Cross-Sectional Studies; Recent Evidence: Prospective Studies; Human Evidence Linking POPs and Metabolic Syndrome; Mismatch of Time Trend: Issues Related to Inverted U-Shaped Associations Polybrominated Biphenyl Ethers (PBDEs) and T2DThrifty Gene Hypothesis and POPs; POPs and Glycemic Control among Diabetic Patients; Dietary Interventions in T2D; Summary; References; CHAPTER 6: Mechanistic Basis for Elevation in Risk of Diabetes Caused by Persistent Organic Pollutants; Introduction; Diabetes; POPs: Novel Diabetogenic Factors; POPs and Diabetes: Mechanistic Basis; AhR; CAR and SXR; Challenges and Perspectives; References; CHAPTER 7: Cardiovascular Disease and Hypertension; Introduction; Animal Studies and Laboratory Evidence Standardized Mortality Ratios (SMRs) for Heart Disease |
| Record Nr. | UNINA-9910828658403321 |
|
Carpenter David O
|
||
| Hoboken, NJ, : John Wiley & Sons, Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||