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Fundamentals of early clinical drug development [[electronic resource] ] : from synthesis design to formulation / / edited by Ahmed F. Abdel-Magid and Stéphane Caron
| Fundamentals of early clinical drug development [[electronic resource] ] : from synthesis design to formulation / / edited by Ahmed F. Abdel-Magid and Stéphane Caron |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2006 |
| Descrizione fisica | 1 online resource (341 p.) |
| Disciplina |
615.1
615.19 615/.1 |
| Altri autori (Persone) |
Abdel-MagidAhmed F. <1947->
CaronStéphane |
| Soggetto topico |
Clinical pharmacology
Pharmaceutical technology Drugs - Testing |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-54982-3
9786610549825 0-470-04340-7 0-470-04339-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Reflections on process research II / Edward J.J. Grabowski -- Development and scale-up of a heterocyclic cross-coupling for the synthesis of 5-(2-(3-methyl-3H-imidazol-4-yl)thieno(3,2-b)pyridin-7-yl)amino-2-methyl-1H-indol / John A. Ragan -- Large-scale enantioselective preparation of 2E,7E, 5S,6R, 5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic acid, a key fragment for the formal total synthesis of the anti-tumor agent cryptophycin 52 / James Aikins ... [et al.] -- Efforts toward a commercially viable route and process to the synthesis of HIV PI GW640385X / John C. Roberts ... [et al.] -- Development of an asymmetric synthesis of ABT-100 / Albert W. Kruger ... [et al.] -- Asymmetric hydrogenation: a new route to pregabalin / Rex Jennings ... [et al.] -- Responsibilities of the process chemist: beyond synthetic organic chemistry / Stéphane Caron -- Outsourcing: the challenge of science, speed, and quality / Simone Andler-Burzlaff, Jason Bertola, and Roger E. Marti -- Automation and the changing face of process research in the pharmaceutical industry / Edward J. Delaney ... [et al.] -- Large scale synthesis: an engineering perspective / Joseph H. Childers, Jr. -- Synthesis and application of radioisotopes in pharmaceutical research and development / Larry E. Weaner and David C. Hoerr -- Selection of the drug form in exploratory development / George J. Quallich -- Strategies to control particle size of active pharmaceutical ingredients / David J. am Ende and Peter R. Rose -- Challenges in early formulation: turning drug substance into drug product / Mark H. Kleinman and Beeah Lee -- Intellectual property and early development / Maria I. Shchuka. |
| Record Nr. | UNINA-9910143557703321 |
| Hoboken, N.J., : Wiley-Interscience, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fundamentals of early clinical drug development [[electronic resource] ] : from synthesis design to formulation / / edited by Ahmed F. Abdel-Magid and Stéphane Caron
| Fundamentals of early clinical drug development [[electronic resource] ] : from synthesis design to formulation / / edited by Ahmed F. Abdel-Magid and Stéphane Caron |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2006 |
| Descrizione fisica | 1 online resource (341 p.) |
| Disciplina |
615.1
615.19 615/.1 |
| Altri autori (Persone) |
Abdel-MagidAhmed F. <1947->
CaronStéphane |
| Soggetto topico |
Clinical pharmacology
Pharmaceutical technology Drugs - Testing |
| ISBN |
1-280-54982-3
9786610549825 0-470-04340-7 0-470-04339-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Reflections on process research II / Edward J.J. Grabowski -- Development and scale-up of a heterocyclic cross-coupling for the synthesis of 5-(2-(3-methyl-3H-imidazol-4-yl)thieno(3,2-b)pyridin-7-yl)amino-2-methyl-1H-indol / John A. Ragan -- Large-scale enantioselective preparation of 2E,7E, 5S,6R, 5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic acid, a key fragment for the formal total synthesis of the anti-tumor agent cryptophycin 52 / James Aikins ... [et al.] -- Efforts toward a commercially viable route and process to the synthesis of HIV PI GW640385X / John C. Roberts ... [et al.] -- Development of an asymmetric synthesis of ABT-100 / Albert W. Kruger ... [et al.] -- Asymmetric hydrogenation: a new route to pregabalin / Rex Jennings ... [et al.] -- Responsibilities of the process chemist: beyond synthetic organic chemistry / Stéphane Caron -- Outsourcing: the challenge of science, speed, and quality / Simone Andler-Burzlaff, Jason Bertola, and Roger E. Marti -- Automation and the changing face of process research in the pharmaceutical industry / Edward J. Delaney ... [et al.] -- Large scale synthesis: an engineering perspective / Joseph H. Childers, Jr. -- Synthesis and application of radioisotopes in pharmaceutical research and development / Larry E. Weaner and David C. Hoerr -- Selection of the drug form in exploratory development / George J. Quallich -- Strategies to control particle size of active pharmaceutical ingredients / David J. am Ende and Peter R. Rose -- Challenges in early formulation: turning drug substance into drug product / Mark H. Kleinman and Beeah Lee -- Intellectual property and early development / Maria I. Shchuka. |
| Record Nr. | UNINA-9910830297703321 |
| Hoboken, N.J., : Wiley-Interscience, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron
| Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2020] |
| Descrizione fisica | 1 online resource (XII, 856 S.) : graph. Darst |
| Disciplina | 547.2 |
| Soggetto topico | Organic compounds - Synthesis |
| ISBN |
1-119-44890-5
1-119-44888-3 1-119-44891-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Aliphatic nucleophilic substitution -- Addition to carbon-heteroatom multiple bonds -- Addition to carbon-carbon multiple bonds -- Nucleophilic aromatic substitution -- Electrophilic aromatic substitution -- Selected catalytic reactions -- Rearrangements -- Eliminations -- Reductions -- Oxidations -- Selected free radical reactions -- Synthesis of "nucleophilic" organometallic reagents -- Synthesis of common aromatic heterocycles -- Access to chirality -- Biocatalysis -- Green chemistry -- Continuous chemistry -- General solvent properties -- Practical chemistry concepts: tips for the practicing chemist or things they don't teach you in school. |
| Record Nr. | UNINA-9910555055103321 |
| Hoboken, New Jersey : , : Wiley, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron
| Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2020] |
| Descrizione fisica | 1 online resource (XII, 856 S.) : graph. Darst |
| Disciplina | 547.2 |
| Soggetto topico | Organic compounds - Synthesis |
| ISBN |
1-119-44890-5
1-119-44888-3 1-119-44891-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Aliphatic nucleophilic substitution -- Addition to carbon-heteroatom multiple bonds -- Addition to carbon-carbon multiple bonds -- Nucleophilic aromatic substitution -- Electrophilic aromatic substitution -- Selected catalytic reactions -- Rearrangements -- Eliminations -- Reductions -- Oxidations -- Selected free radical reactions -- Synthesis of "nucleophilic" organometallic reagents -- Synthesis of common aromatic heterocycles -- Access to chirality -- Biocatalysis -- Green chemistry -- Continuous chemistry -- General solvent properties -- Practical chemistry concepts: tips for the practicing chemist or things they don't teach you in school. |
| Record Nr. | UNINA-9910828724403321 |
| Hoboken, New Jersey : , : Wiley, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical synthetic organic chemistry [[electronic resource] ] : reactions, principles, and techniques / / edited by Stéphane Caron
| Practical synthetic organic chemistry [[electronic resource] ] : reactions, principles, and techniques / / edited by Stéphane Caron |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2011 |
| Descrizione fisica | 1 online resource (xii, 856 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | CaronStéphane |
| Soggetto topico | Organic compounds - Synthesis |
| ISBN |
9786613176608
1-118-09357-7 1-118-09355-0 1-283-17660-2 1-118-09356-9 |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface. Chapter 1: Aliphatic Nucleophilic Substitution ( Jade D. Nelson ). Chapter 2: Addition to Carbon-Heteroatom Multiple Bonds ( Rajappa Vaidyanathan and Carrie Brockway Wager ). Chapter 3: Addition to Carbon Carbon Multiple Bonds ( John A. Ragan ). Chapter 4: Nucleophilic Aromatic Substitution ( Stephane Caron and Arun Ghosh ). Chapter 5: Electrophilic Aromatic Substitution ( Stephane Caron ). Chapter 6: Selected Metal-mediated cross-coupling reactions ( Stephane Caron, Arun Ghosh, Sally Gut Ruggeri, Nathan D. Ide, Jade D. Nelson, and John A. Ragan ). Chapter 7: Rearrangements ( David H. B. Ripin ). Chapter 8: Eliminations ( Sally Gut Ruggeri ). Chapter 9: Reductions ( Sally Gut Ruggeri, Stephane Caron, Pascal Dube, Nathan D. Ide, Kristin E. Price, John A. Ragan, and Shu Yu ). Chapter 10: Oxidations ( David H. Brown Ripin ). Chapter 11: Selected Free Radical Reactions ( Nathan D. Ide ). Chapter 12: Synthesis of "Nucleophilic" Organometallic Reagents ( David H. Brown Ripin ). Chapter 13: Synthesis of Common Aromatic Heterocycles ( Stephane Caron ). Chapter 14: Access to Chirality ( Robert W. Dugger ). Chapter 15: Synthetic Route Development of Selected Contemporary Pharmaceutical Drugs ( Stephane Caron ). Chapter 16: Green Chemistry ( Juan C. Colberg ). Chapter 17: Naming Carbocycles and Heterocycles ( Heather N. Frost and David H. B. Ripin ). Chapter 18: pKa ( David H. Brown Ripin ). Chapter 19: General Solvent Properties ( Stephane Caron ). Chapter 20: Practical Chemistry Concepts Tips for the Practicing Chemist or Things They Don't Teach You in School ( Sally Gut Ruggeri ). |
| Record Nr. | UNINA-9910791599703321 |
| Hoboken, N.J., : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron
| Practical synthetic organic chemistry : reactions, principles, and techniques / / edited by Stéphane Caron |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2011 |
| Descrizione fisica | 1 online resource (xii, 856 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | CaronStéphane |
| Soggetto topico | Organic compounds - Synthesis |
| ISBN |
9786613176608
1-118-09357-7 1-118-09355-0 1-283-17660-2 1-118-09356-9 |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface. Chapter 1: Aliphatic Nucleophilic Substitution ( Jade D. Nelson ). Chapter 2: Addition to Carbon-Heteroatom Multiple Bonds ( Rajappa Vaidyanathan and Carrie Brockway Wager ). Chapter 3: Addition to Carbon Carbon Multiple Bonds ( John A. Ragan ). Chapter 4: Nucleophilic Aromatic Substitution ( Stephane Caron and Arun Ghosh ). Chapter 5: Electrophilic Aromatic Substitution ( Stephane Caron ). Chapter 6: Selected Metal-mediated cross-coupling reactions ( Stephane Caron, Arun Ghosh, Sally Gut Ruggeri, Nathan D. Ide, Jade D. Nelson, and John A. Ragan ). Chapter 7: Rearrangements ( David H. B. Ripin ). Chapter 8: Eliminations ( Sally Gut Ruggeri ). Chapter 9: Reductions ( Sally Gut Ruggeri, Stephane Caron, Pascal Dube, Nathan D. Ide, Kristin E. Price, John A. Ragan, and Shu Yu ). Chapter 10: Oxidations ( David H. Brown Ripin ). Chapter 11: Selected Free Radical Reactions ( Nathan D. Ide ). Chapter 12: Synthesis of "Nucleophilic" Organometallic Reagents ( David H. Brown Ripin ). Chapter 13: Synthesis of Common Aromatic Heterocycles ( Stephane Caron ). Chapter 14: Access to Chirality ( Robert W. Dugger ). Chapter 15: Synthetic Route Development of Selected Contemporary Pharmaceutical Drugs ( Stephane Caron ). Chapter 16: Green Chemistry ( Juan C. Colberg ). Chapter 17: Naming Carbocycles and Heterocycles ( Heather N. Frost and David H. B. Ripin ). Chapter 18: pKa ( David H. Brown Ripin ). Chapter 19: General Solvent Properties ( Stephane Caron ). Chapter 20: Practical Chemistry Concepts Tips for the Practicing Chemist or Things They Don't Teach You in School ( Sally Gut Ruggeri ). |
| Record Nr. | UNINA-9910809996003321 |
| Hoboken, N.J., : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||