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Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer
| Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer |
| Autore | Carlberg Carsten |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (179 pages) |
| Disciplina | 616.994071 |
| Soggetto topico |
Carcinogenesis
Cancer - Etiology Càncer Etiologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-75699-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1 Introduction to Cancer -- 1.1 The Global Burden of Cancer -- 1.2 Categorization and Diagnosis of Tumors -- 1.3 Crucial Transitions in Cancer -- 1.4 Causes of Cancer -- 1.5 Cancer Prevention -- Further Reading -- 2 Oncogenes and Signal Transduction -- 2.1 Cellular Transformation -- 2.2 Activating Oncogenes in Signal Transduction Pathways -- 2.3 Oncogenic Translocations and Amplifications -- 2.4 The Hallmarks of Cancer Concept -- Further Reading -- 3 Tumor Suppressor Genes and Cell Fate Control -- 3.1 p53 - A Master Example -- 3.2 Tumor Suppressors and Oncogenes in Cell Cycle Control -- 3.3 Tumor Suppressor Inhibition and Cancer Onset -- Further Reading -- 4 Multi-step Tumorigenesis and Genome Instability -- 4.1 Characteristics of Tumor Growth -- 4.2 Multi-step Tumorigenesis -- 4.3 Genome Instability -- 4.4 Cancer Driver Mutations and Genes -- Further Reading -- 5 Cancer Genomics -- 5.1 Human Genetic Variation and Cancer Susceptibility -- 5.2 The Cancer Genome -- 5.3 Cancer Genome Projects -- Further Reading -- 6 Cancer Epigenomics -- 6.1 Epigenetic Mechanisms of Cancer -- 6.2 DNA Methylation and Cancer -- 6.3 Chromatin Changes and Cancer -- 6.4 Epigenetic Reprogramming in Cancer -- Further Reading -- 7 Aging and Cancer -- 7.1 Central Role of Aging During Chronic Diseases -- 7.2 The Hallmarks of Aging -- 7.3 Epigenetics of Aging -- 7.4 Telomeres and Replicative Immortality -- Further Reading -- 8 Tumor Microenvironment -- 8.1 The Impact of the Wound Healing Program for Cancer -- 8.2 Cell Types of the Tumor Microenvironment -- 8.3 Inducing Angiogenesis -- 8.4 Tumor-Promoting Inflammation -- 8.5 Deregulating Cellular Energetics -- Further Reading -- 9 Metastasis and Cachexia -- 9.1 The Metastatic Cascade -- 9.2 Epithelial-Mesenchymal Transition -- 9.3 Metastatic Colonization.
9.4 Cachexia -- Further Reading -- 10 Cancer Immunity -- 10.1 Outline of Cancer Immunity -- 10.2 Recognition of Tumor Antigens -- 10.3 Monoclonal Antibodies in Cancer Immunotherapy -- 10.4 Immune Cell Therapies -- Further Reading -- 11 Architecture of Cancer Therapies -- 11.1 Classical Cancer Treatments -- 11.2 Targeted Therapies -- 11.3 Precision Oncology -- Further Reading -- Glossary. |
| Record Nr. | UNINA-9910490024603321 |
Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Human Epigenetics: How Science Works [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár
| Human Epigenetics: How Science Works [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XVI, 153 p. 69 illus. in color.) |
| Disciplina | 573.21 |
| Soggetto topico |
Gene expression
Molecular biology Nutrition Cancer research Immunology Gene Expression Molecular Medicine Nutrition Cancer Research |
| ISBN | 3-030-22907-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Chromatin and gene expression -- DNA methylation -- Histone modifications -- Chromatin modifying proteins and RNAs -- Embryogenesis and cellular differentiation -- Population epigenetics and aging -- Cancer epigenetics -- Neuroepigenetics -- Nutritional epigenetics -- Epigenetics of immune function -- Epigenome-environment interactions and their therapy. |
| Record Nr. | UNINA-9910349442303321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Human Epigenomics [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár
| Human Epigenomics [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XIX, 223 p. 120 illus. in color.) |
| Disciplina | 616.042 |
| Soggetto topico |
Human genetics
Molecular biology Human Genetics Molecular Medicine |
| ISBN | 981-10-7614-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics. . |
| Record Nr. | UNINA-9910298425103321 |
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Carlberg Carsten
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of gene regulation : how science works / / Carsten Carlberg and Ferdinand Molnár
| Mechanisms of gene regulation : how science works / / Carsten Carlberg and Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2020] |
| Descrizione fisica | 1 online resource (XVI, 149 p. 71 illus., 70 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico | Gene expression |
| ISBN | 3-030-52321-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs. |
| Record Nr. | UNINA-9910424631003321 |
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Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of Gene Regulation [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár
| Mechanisms of Gene Regulation [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [2nd ed. 2016.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XVI, 211 p. 82 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene expression
Proteins Gene Expression Protein Structure |
| ISBN | 94-017-7741-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. |
| Record Nr. | UNINA-9910253876003321 |
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Carlberg Carsten
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| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of Gene Regulation [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár
| Mechanisms of Gene Regulation [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (XV, 210 p. 83 illus., 64 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene expression
Proteins Gene Expression Protein Structure |
| ISBN | 94-007-7905-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. |
| Record Nr. | UNINA-9910298306003321 |
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Carlberg Carsten
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| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular immunology : how science works / / Carsten Carlberg and Eunike Velleuer
| Molecular immunology : how science works / / Carsten Carlberg and Eunike Velleuer |
| Autore | Carlberg Carsten |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (228 pages) |
| Disciplina | 616.079 |
| Soggetto topico | Molecular immunology |
| ISBN | 3-031-04025-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910574060003321 |
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Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular medicine : how science works / / Carsten Carlberg, Eunike Velleuer, and Ferdinand Molnár
| Molecular medicine : how science works / / Carsten Carlberg, Eunike Velleuer, and Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [First edition, 2023.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2023] |
| Descrizione fisica | 1 online resource (708 pages) : illustrations |
| Disciplina | 612 |
| Soggetto topico |
Human physiology
Molecular biology |
| ISBN |
9783031271335
9783031271328 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease. |
| Record Nr. | UNINA-9910698649303321 |
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Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrigenomics [[electronic resource] /] / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár
| Nutrigenomics [[electronic resource] /] / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XXI, 222 p. 103 illus., 101 illus. in color.) |
| Disciplina | 612.3 |
| Soggetto topico |
Molecular biology
Clinical nutrition Molecular Medicine Clinical Nutrition |
| ISBN | 3-319-30415-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Nutrition and common diseases -- Human genomic variation -- Sensing nutrition -- Nutrigenomics: Adapting the human genome to dietary changes and personalized nutrition -- Nutritional epigenomics -- Nutritional signaling and aging -- Chronic inflammation and metabolic stress -- Obesity -- Glucose homeostasis, insulin resistance and β cell failure -- Diabetes -- Hypertension, atherosclerosis and dyslipidemias -- Metabolic syndrome. . |
| Record Nr. | UNINA-9910253874903321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrigenomics: How Science Works [[electronic resource] /] / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár
| Nutrigenomics: How Science Works [[electronic resource] /] / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XXI, 181 p. 70 illus., 69 illus. in color.) |
| Disciplina | 612.3 |
| Soggetto topico |
Gene expression
Molecular biology Nutrition Genetics Cell biology Gene Expression Molecular Medicine Nutrition Genetics and Genomics Cell Biology |
| ISBN | 3-030-36948-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1.Nutrition and common diseases -- 1.1.Evolution of human nutrition -- 1.2.Principles of metabolism -- 1.3.Dietary molecules -- 1.4.Nutrition and metabolic diseases -- 1.5.Nutrition and cancer -- 1.6.Impact of physical activity -- 2.Human genomic variation -- 2.1.Migration and evolutionary challenges of Homo sapiens -- 2.2.Diversity of human populations -- 2.3.Genetic variants of the human genome -- 2.4.Haplotype blocks and GWAS -- 2.5.The 1000 Genomes Project -- 3.Sensing nutrition -- 3.1.Nutrient-sensing mechanisms -- 3.2.Nuclear receptors as nutrient sensors -- 3.3.Functions and actions of PPARs -- 3.4 Integration of lipid metabolism by LXRs and FXR -- 3.5.Coordination of the immune response by VDR -- 3.6.Circadian control of metabolic processes -- 4.Interference of the human genome with nutrients -- 4.1.Human genetic adaptions -- 4.2.Genetic adaption to dietary changes -- 4.3 Regulatory SNPs and quantitative traits -- 4.4.Nutrigenomic analysis -- 4.5 Personal omics profiles -- 5.Nutritional epigenetics -- 5.1.Epigenetic mechanisms -- 5.2.Intermediary metabolism and epigenetic signaling -- 5.3.Nutrition-triggered transgenerational epigenetic inheritance -- 5.4.Population epigenetics -- 6.Nutritional signaling and aging -- 6.1 Aging and conserved nutrient-sensing pathways -- 6.2.Neuroendocrine regulation of aging -- 6.3.Principles of insulin signaling -- 6.4.Central role of FOXO transcription factors -- 6.5.Caloric restriction from yeast to mammals -- 6.6.Cellular energy status sensing by sirtuins and AMPK -- 7.Chronic inflammation and metabolic stress -- 7.1 Central role of monocytes and macrophages -- 7.2.Acute and chronic inflammation -- 7.3.Reverse cholesterol transport and inflammation -- 7.4.Sensing metabolic stress via the ER -- 8.Obesity -- 8.1 Definition of obesity -- 8.2 Adipogenesis -- 8.3.Inflammation in adipose tissue -- 8.4.Energy homeostasis and hormonal regulation of food uptake -- 8.5.Genetics of obesity -- 9.Insulin resistance and diabetes -- 9.1.Glucose homeostasis -- 9.2.Insulin resistance in skeletal muscle and liver -- 9.3.β cell failure -- 9.4.Definition of diabetes -- 9.5.Disturbed glucose homeostasis in T2D and its treatment -- 9.6.Genetics and epigenetics of T2D -- 10.Heart disease and the metabolic syndrome -- 10.1.Hypertension -- 10.2.Mechanisms of atherosclerosis -- 10.3.Lipoproteins and dyslipidemias -- 10.4.Whole body’s perspective of the metabolic syndrome -- 10.5.Metabolic syndrome in key metabolic organs -- 10.6.Genetics and epigenetics of the metabolic syndrome. |
| Record Nr. | UNINA-9910380741803321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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