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Aging : How Science Works
| Aging : How Science Works |
| Autore | Carlberg Carsten |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cham : , : Springer, , 2024 |
| Descrizione fisica | 1 online resource (184 pages) |
| Altri autori (Persone) |
UlvenStine M
VelleuerEunike |
| ISBN | 3-031-61257-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Abbreviations -- 1 Human Genome, Development, Evolution and Aging -- 1.1 The Human Genome and Its Variation -- 1.2 Principles of Development and Aging -- 1.3 Evolutionary Perspective on Aging -- 1.4 Hallmarks of Aging -- Bibiliography -- 2 Principles of Gene Expression and Epigenetics -- 2.1 Gene Regulation -- 2.2 Chromatin Structure and Epigenetics -- 2.3 Information Storage by Chromatin Modifications -- 2.4 Epigenetics Enables Gene Expression -- Bibliography -- 3 Epigenetics, Memory and Aging -- 3.1 Transgenerational Epigenetics -- 3.2 Epigenetics of Aging -- 3.3 Epigenetics and Time: The Circadian Clock -- Bibliography -- 4 Biochemistry of Aging -- 4.1 Principles of Metabolism -- 4.2 Aging and Conserved Nutrient Sensing Pathways -- 4.3 Neuroendocrine Regulation of Energy Metabolism and Aging -- Bibliography -- 5 Molecular and Cellular Basis of Aging -- 5.1 Mitochondria and Endoplasmatic Reticulum Dysfunctions -- 5.2 Apoptosis, Autophagy and the Loss of Proteostasis -- 5.3 Stem Cell Exhaustion and Cellular Senescence -- 5.4 Long- and Short-Lived Cells -- Bibliography -- 6 Immunity and Aging -- 6.1 Innate and Adaptive Immunity -- 6.2 Relation of Epigenetics and Immunity -- 6.3 Inflammation and Aging -- 6.4 The Aging Immune System -- 6.5 The Microbiome in Aging -- Bibliography -- 7 Chronic Diseases and Aging -- 7.1 The Global Burden of Diseases -- 7.2 The Metabolic Syndrome: Obesity, T2D and CVD -- 7.3 Cancer -- 7.4 Neurodegenerative Diseases -- Bibliography -- 8 Premature Aging -- 8.1 DNA Repair Mechanisms -- 8.2 Premature Aging Syndromes Associated with Genomic Instability -- 8.3 Laminopathies -- Bibliography -- 9 Healthy Aging and Longevity -- 9.1 Impact of Energy Balance and Dietary Macronutrient Composition -- 9.2 Impact of Physical Activity -- 9.3 Aging Clocks -- 9.4 The Socio-Economic Need of Healthy Aging.
Bibliography -- Glossary. |
| Record Nr. | UNINA-9910874669703321 |
Carlberg Carsten
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| Cham : , : Springer, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer
| Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer |
| Autore | Carlberg Carsten |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (179 pages) |
| Disciplina | 616.994071 |
| Soggetto topico |
Carcinogenesis
Cancer - Etiology Càncer Etiologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-75699-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1 Introduction to Cancer -- 1.1 The Global Burden of Cancer -- 1.2 Categorization and Diagnosis of Tumors -- 1.3 Crucial Transitions in Cancer -- 1.4 Causes of Cancer -- 1.5 Cancer Prevention -- Further Reading -- 2 Oncogenes and Signal Transduction -- 2.1 Cellular Transformation -- 2.2 Activating Oncogenes in Signal Transduction Pathways -- 2.3 Oncogenic Translocations and Amplifications -- 2.4 The Hallmarks of Cancer Concept -- Further Reading -- 3 Tumor Suppressor Genes and Cell Fate Control -- 3.1 p53 - A Master Example -- 3.2 Tumor Suppressors and Oncogenes in Cell Cycle Control -- 3.3 Tumor Suppressor Inhibition and Cancer Onset -- Further Reading -- 4 Multi-step Tumorigenesis and Genome Instability -- 4.1 Characteristics of Tumor Growth -- 4.2 Multi-step Tumorigenesis -- 4.3 Genome Instability -- 4.4 Cancer Driver Mutations and Genes -- Further Reading -- 5 Cancer Genomics -- 5.1 Human Genetic Variation and Cancer Susceptibility -- 5.2 The Cancer Genome -- 5.3 Cancer Genome Projects -- Further Reading -- 6 Cancer Epigenomics -- 6.1 Epigenetic Mechanisms of Cancer -- 6.2 DNA Methylation and Cancer -- 6.3 Chromatin Changes and Cancer -- 6.4 Epigenetic Reprogramming in Cancer -- Further Reading -- 7 Aging and Cancer -- 7.1 Central Role of Aging During Chronic Diseases -- 7.2 The Hallmarks of Aging -- 7.3 Epigenetics of Aging -- 7.4 Telomeres and Replicative Immortality -- Further Reading -- 8 Tumor Microenvironment -- 8.1 The Impact of the Wound Healing Program for Cancer -- 8.2 Cell Types of the Tumor Microenvironment -- 8.3 Inducing Angiogenesis -- 8.4 Tumor-Promoting Inflammation -- 8.5 Deregulating Cellular Energetics -- Further Reading -- 9 Metastasis and Cachexia -- 9.1 The Metastatic Cascade -- 9.2 Epithelial-Mesenchymal Transition -- 9.3 Metastatic Colonization.
9.4 Cachexia -- Further Reading -- 10 Cancer Immunity -- 10.1 Outline of Cancer Immunity -- 10.2 Recognition of Tumor Antigens -- 10.3 Monoclonal Antibodies in Cancer Immunotherapy -- 10.4 Immune Cell Therapies -- Further Reading -- 11 Architecture of Cancer Therapies -- 11.1 Classical Cancer Treatments -- 11.2 Targeted Therapies -- 11.3 Precision Oncology -- Further Reading -- Glossary. |
| Record Nr. | UNINA-9910490024603321 |
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Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Human Epigenetics: How Science Works / / by Carsten Carlberg, Ferdinand Molnár
| Human Epigenetics: How Science Works / / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XVI, 153 p. 69 illus. in color.) |
| Disciplina | 573.21 |
| Soggetto topico |
Gene expression
Molecular biology Nutrition Cancer research Immunology Gene Expression Molecular Medicine Nutrition Cancer Research |
| ISBN | 3-030-22907-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Chromatin and gene expression -- DNA methylation -- Histone modifications -- Chromatin modifying proteins and RNAs -- Embryogenesis and cellular differentiation -- Population epigenetics and aging -- Cancer epigenetics -- Neuroepigenetics -- Nutritional epigenetics -- Epigenetics of immune function -- Epigenome-environment interactions and their therapy. |
| Record Nr. | UNINA-9910349442303321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Human Epigenomics [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár
| Human Epigenomics [[electronic resource] /] / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XIX, 223 p. 120 illus. in color.) |
| Disciplina | 616.042 |
| Soggetto topico |
Human genetics
Molecular biology Human Genetics Molecular Medicine |
| ISBN | 981-10-7614-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics. . |
| Record Nr. | UNINA-9910298425103321 |
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Carlberg Carsten
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of Gene Regulation / / by Carsten Carlberg, Ferdinand Molnár
| Mechanisms of Gene Regulation / / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [2nd ed. 2016.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XVI, 211 p. 82 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene expression
Proteins Gene Expression Protein Structure |
| ISBN | 94-017-7741-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. |
| Record Nr. | UNINA-9910253876003321 |
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Carlberg Carsten
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| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of Gene Regulation / / by Carsten Carlberg, Ferdinand Molnár
| Mechanisms of Gene Regulation / / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (XV, 210 p. 83 illus., 64 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene expression
Proteins Gene Expression Protein Structure |
| ISBN | 94-007-7905-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. |
| Record Nr. | UNINA-9910298306003321 |
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Carlberg Carsten
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| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of Gene Regulation: How Science Works / / by Carsten Carlberg, Ferdinand Molnár
| Mechanisms of Gene Regulation: How Science Works / / by Carsten Carlberg, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XVI, 149 p. 71 illus., 70 illus. in color.) |
| Disciplina | 572.865 |
| Soggetto topico |
Medicine - Research
Biology - Research Biochemistry Genetics Biomedical Research Genetics and Genomics |
| ISBN | 3-030-52321-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs. |
| Record Nr. | UNINA-9910424631003321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Immunology : How Science Works / / by Carsten Carlberg, Eunike Velleuer
| Molecular Immunology : How Science Works / / by Carsten Carlberg, Eunike Velleuer |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (228 pages) |
| Disciplina | 616.079 |
| Soggetto topico |
Immunology
Autoimmunity Inflammation Immunogenetics Tumors - Immunological aspects Translational Immunology Tumour Immunology Immunologia Immunitat cel·lular Malalties autoimmunitàries |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-031-04025-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Cells and tissues of the immune system -- 2 Innate immunity and inflammation -- 3 Adaptive immunity and antigen receptor diversity -- 4 B cell immunity: BCRs, antibodies and their effector functions -- 5 Antigen-presenting cells and the major histocompatibility complex -- 6 T cell immunity: TCRs and their effector functions -- 7 Immunity to bacterial pathogens and the microbiome -- 8 Immunity to viral pathogens and the virome -- 9 Tolerance and transplantation immunology -- 10 Immunological hypersensitivities: Allergy and autoimmunity -- 11 Cancer immunology. |
| Record Nr. | UNINA-9910574060003321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Medicine : How Science Works / / by Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár
| Molecular Medicine : How Science Works / / by Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (708 pages) : illustrations |
| Disciplina | 612 |
| Soggetto topico |
Medicine - Research
Biology - Research Genomics Cancer Immunology Nutrition Physiology Biomedical Research Cancers |
| ISBN |
9783031271335
9783031271328 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease. |
| Record Nr. | UNINA-9910698649303321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrigenomics / / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár
| Nutrigenomics / / by Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár |
| Autore | Carlberg Carsten |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (XXI, 222 p. 103 illus., 101 illus. in color.) |
| Disciplina | 612.3 |
| Soggetto topico |
Molecular biology
Clinical nutrition Molecular Medicine Clinical Nutrition |
| ISBN | 3-319-30415-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Nutrition and common diseases -- Human genomic variation -- Sensing nutrition -- Nutrigenomics: Adapting the human genome to dietary changes and personalized nutrition -- Nutritional epigenomics -- Nutritional signaling and aging -- Chronic inflammation and metabolic stress -- Obesity -- Glucose homeostasis, insulin resistance and β cell failure -- Diabetes -- Hypertension, atherosclerosis and dyslipidemias -- Metabolic syndrome. . |
| Record Nr. | UNINA-9910253874903321 |
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Carlberg Carsten
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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