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Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910143509103321 |
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910830844403321 |
|
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910841118203321 |
|
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||