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Corynebacterium diphtheriae and Related Toxigenic Species : Genomics, Pathogenicity and Applications / / edited by Andreas Burkovski
| Corynebacterium diphtheriae and Related Toxigenic Species : Genomics, Pathogenicity and Applications / / edited by Andreas Burkovski |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (302 p.) |
| Disciplina | 579.135 |
| Soggetto topico |
Medical microbiology
Bacteriology Epidemiology Parasitology Microbial genetics Microbial genomics Medical Microbiology Microbial Genetics and Genomics |
| ISBN | 94-007-7624-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Diphtheria and Its Etiological Agents -- Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis - General Aspects -- Comparative Genomics and Pathogenicity Islands of Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis -- Corynephages: Infections of the Infectors -- Toxin Structure, Delivery and Action -- Iron Acquisition and Iron-Dependent Gene expression in Corynebacterium diphtheria -- Assembly and Function of Corynebacterium diphtheria -- Toxigenic Corynebacteria: Adhesion, Invasion and Host Response -- Detection Methods for Laboratory Diagnosis of Diphtheria -- Diphtheria Surveillance -- History of diphtheria Vaccine Development -- Antimicrobial Susceptibility and Treatment -- Sialidases of Corynebacteria and Their Biotechnological Application -- Molecular Genetic Tools for Research in Corynebacterium diphtheria -- Diphtheria Toxin Based Molecules as Therapeutic Approaches. |
| Record Nr. | UNINA-9910298302003321 |
| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski
| Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
| Descrizione fisica | 1 online resource (210 p.) |
| Disciplina | 579.373 |
| Soggetto topico | Corynebacterium glutamicum - Metabolism |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-910190-06-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: Trends in Corynebacterium glutamicum Research and Application; From glutamate producer to a biotechnology workhorse; Systems biology; Corynebacterium glutamicum as a synthetic biology platform; Corynebacterium glutamicum-based green technology; 2: Proteomics of Corynebacterium glutamicum; Introduction; Understanding Corynebacterium glutamicum physiology with proteomics: application examples; Methods of Corynebacterium glutamicum proteomics; Conclusion and outlook
3: Developing Interpretation of Intracellular Metabolism of Corynebacterium glutamicum by Using Flux Analysis TechnologyIntroduction; Understanding the physiology of Corynebacterium glutamicum lysine production and glutamate production through conventional metabolic flux analysis; Fractional 13C enrichment-based metabolic flux analysis; Improvement in metabolic flux analysis precision; Conclusion; 4: Growth and Production Capabilities of Corynebacterium glutamicum: Interrogating a Genome-scale Metabolic Network Model; Introduction; The metabolic network of Corynebacterium glutamicum Stoichiometric modelling fundamentalsModel validation; Predicting production capabilities for amino acids; Uncertainties in metabolic network models; Metabolic flux analysis; Conclusions; 5: Metabolic Engineering of Corynebacterium glutamicum for Alternative Carbon Source Utilization; Introduction; Engineering of Corynebacterium glutamicum for alternative carbon sources; Complex carbon sources; Summary and outlook; 6: Manipulation of Nitrogen Metabolism and Alternative Nitrogen Sources for Corynebacterium glutamicum; Ammonium assimilation in Corynebacterium glutamicum Regulation of nitrogen metabolismManipulation of nitrogen metabolism for amino acid production; Overexpression, deletion and heterologous expression of glutamate dehydrogenase; Overexpression of glutamine synthetases; Influence of glutamate synthase on L-glutamate biosynthesis; Changing ammonium assimilation and amino acid production by manipulation of α-ketoglutarate supply; Influence of ammonium and glutamate transport systems on amino acid production; Manipulation of nitrogen regulation: influences on metabolite pools; Assimilation of alternative nitrogen sources; Concluding remarks 7: Transport, Degradation and Assimilation of Aromatic Compounds and their Regulation in Corynebacterium glutamicum Introduction; What do the Corynebacterium glutamicum genomes predict for degradation and assimilation of aromatic compounds?; Corynebacterium glutamicum grows on various aromatic compounds; Physiological adaptation of Corynebacterium glutamicum growing on aromatic compounds compared with carbohydrates; Uptake and transport of aromatic compounds in Corynebacterium glutamicum; Aromatic compounds degraded via protocatechuate branch of the β-ketoadipate pathway Aromatic compounds degraded via the catechol branch of the β-ketoadipate pathway |
| Record Nr. | UNINA-9910460499903321 |
| Norfolk, England : , : Caister Academic Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski
| Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
| Descrizione fisica | 1 online resource (210 p.) |
| Disciplina | 579.373 |
| Soggetto topico | Corynebacterium glutamicum - Metabolism |
| ISBN | 1-910190-06-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: Trends in Corynebacterium glutamicum Research and Application; From glutamate producer to a biotechnology workhorse; Systems biology; Corynebacterium glutamicum as a synthetic biology platform; Corynebacterium glutamicum-based green technology; 2: Proteomics of Corynebacterium glutamicum; Introduction; Understanding Corynebacterium glutamicum physiology with proteomics: application examples; Methods of Corynebacterium glutamicum proteomics; Conclusion and outlook
3: Developing Interpretation of Intracellular Metabolism of Corynebacterium glutamicum by Using Flux Analysis TechnologyIntroduction; Understanding the physiology of Corynebacterium glutamicum lysine production and glutamate production through conventional metabolic flux analysis; Fractional 13C enrichment-based metabolic flux analysis; Improvement in metabolic flux analysis precision; Conclusion; 4: Growth and Production Capabilities of Corynebacterium glutamicum: Interrogating a Genome-scale Metabolic Network Model; Introduction; The metabolic network of Corynebacterium glutamicum Stoichiometric modelling fundamentalsModel validation; Predicting production capabilities for amino acids; Uncertainties in metabolic network models; Metabolic flux analysis; Conclusions; 5: Metabolic Engineering of Corynebacterium glutamicum for Alternative Carbon Source Utilization; Introduction; Engineering of Corynebacterium glutamicum for alternative carbon sources; Complex carbon sources; Summary and outlook; 6: Manipulation of Nitrogen Metabolism and Alternative Nitrogen Sources for Corynebacterium glutamicum; Ammonium assimilation in Corynebacterium glutamicum Regulation of nitrogen metabolismManipulation of nitrogen metabolism for amino acid production; Overexpression, deletion and heterologous expression of glutamate dehydrogenase; Overexpression of glutamine synthetases; Influence of glutamate synthase on L-glutamate biosynthesis; Changing ammonium assimilation and amino acid production by manipulation of α-ketoglutarate supply; Influence of ammonium and glutamate transport systems on amino acid production; Manipulation of nitrogen regulation: influences on metabolite pools; Assimilation of alternative nitrogen sources; Concluding remarks 7: Transport, Degradation and Assimilation of Aromatic Compounds and their Regulation in Corynebacterium glutamicum Introduction; What do the Corynebacterium glutamicum genomes predict for degradation and assimilation of aromatic compounds?; Corynebacterium glutamicum grows on various aromatic compounds; Physiological adaptation of Corynebacterium glutamicum growing on aromatic compounds compared with carbohydrates; Uptake and transport of aromatic compounds in Corynebacterium glutamicum; Aromatic compounds degraded via protocatechuate branch of the β-ketoadipate pathway Aromatic compounds degraded via the catechol branch of the β-ketoadipate pathway |
| Record Nr. | UNINA-9910787343103321 |
| Norfolk, England : , : Caister Academic Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski
| Corynebacterium glutamicum : from systems biology to biotechnological applications / / edited by Andreas Burkovski |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2015] |
| Descrizione fisica | 1 online resource (210 p.) |
| Disciplina | 579.373 |
| Soggetto topico | Corynebacterium glutamicum - Metabolism |
| ISBN | 1-910190-06-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current Books of Interest; Preface; 1: Trends in Corynebacterium glutamicum Research and Application; From glutamate producer to a biotechnology workhorse; Systems biology; Corynebacterium glutamicum as a synthetic biology platform; Corynebacterium glutamicum-based green technology; 2: Proteomics of Corynebacterium glutamicum; Introduction; Understanding Corynebacterium glutamicum physiology with proteomics: application examples; Methods of Corynebacterium glutamicum proteomics; Conclusion and outlook
3: Developing Interpretation of Intracellular Metabolism of Corynebacterium glutamicum by Using Flux Analysis TechnologyIntroduction; Understanding the physiology of Corynebacterium glutamicum lysine production and glutamate production through conventional metabolic flux analysis; Fractional 13C enrichment-based metabolic flux analysis; Improvement in metabolic flux analysis precision; Conclusion; 4: Growth and Production Capabilities of Corynebacterium glutamicum: Interrogating a Genome-scale Metabolic Network Model; Introduction; The metabolic network of Corynebacterium glutamicum Stoichiometric modelling fundamentalsModel validation; Predicting production capabilities for amino acids; Uncertainties in metabolic network models; Metabolic flux analysis; Conclusions; 5: Metabolic Engineering of Corynebacterium glutamicum for Alternative Carbon Source Utilization; Introduction; Engineering of Corynebacterium glutamicum for alternative carbon sources; Complex carbon sources; Summary and outlook; 6: Manipulation of Nitrogen Metabolism and Alternative Nitrogen Sources for Corynebacterium glutamicum; Ammonium assimilation in Corynebacterium glutamicum Regulation of nitrogen metabolismManipulation of nitrogen metabolism for amino acid production; Overexpression, deletion and heterologous expression of glutamate dehydrogenase; Overexpression of glutamine synthetases; Influence of glutamate synthase on L-glutamate biosynthesis; Changing ammonium assimilation and amino acid production by manipulation of α-ketoglutarate supply; Influence of ammonium and glutamate transport systems on amino acid production; Manipulation of nitrogen regulation: influences on metabolite pools; Assimilation of alternative nitrogen sources; Concluding remarks 7: Transport, Degradation and Assimilation of Aromatic Compounds and their Regulation in Corynebacterium glutamicum Introduction; What do the Corynebacterium glutamicum genomes predict for degradation and assimilation of aromatic compounds?; Corynebacterium glutamicum grows on various aromatic compounds; Physiological adaptation of Corynebacterium glutamicum growing on aromatic compounds compared with carbohydrates; Uptake and transport of aromatic compounds in Corynebacterium glutamicum; Aromatic compounds degraded via protocatechuate branch of the β-ketoadipate pathway Aromatic compounds degraded via the catechol branch of the β-ketoadipate pathway |
| Record Nr. | UNINA-9910828520003321 |
| Norfolk, England : , : Caister Academic Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||