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Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 572.65 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85417-0
9786610854172 3-527-60718-8 3-527-60709-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9910143963203321 |
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 572.65 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| ISBN |
1-280-85417-0
9786610854172 3-527-60718-8 3-527-60709-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9910830125203321 |
|
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering the genetic code : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 660.6/3 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| ISBN |
9786610854172
9781280854170 1280854170 9783527607181 3527607188 9783527607099 3527607099 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9911019363303321 |
|
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||