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Standards of mouse model phenotyping [[electronic resource] /] / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown
| Standards of mouse model phenotyping [[electronic resource] /] / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (359 p.) |
| Disciplina | 599.353135 |
| Altri autori (Persone) |
Hrabé de AngelisMartin
ChambonPierre BrownStephen D. M |
| Soggetto topico |
Mice as laboratory animals
Mice - Genetics Transgenic mice Phenotype |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-30244-2
9786612302442 3-527-61194-0 3-527-60870-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Standards of Mouse Model Phenotyping; Foreword; Table of Contents; Preface; 1 Characterizing Hearing in Mice; 1.1 Introduction; 1.2 Behavioral Tests of Hearing; 1.3 Physiological Tests of Hearing; 1.4 Anatomy of the Ear; 1.5 Conclusions; Acknowledgements; 2 Molecular Phenotyping: Gene Expression Profiling; 2.1 Why this Screen? Medical and Biological Relevance; 2.2 Examples: Diseases of Mouse and Man; 2.3 Diagnostic Methods: History and State of the Art; 2.4 Technical Requirements for Screening Protocols (Short): First and Second Line Approaches; 2.5 Logistics (Whom, When, How Many, Why)
2.5.1 Choice of Platform2.5.2 Biological Samples; 2.6 Trouble Shooting; 2.6.1 Preparation of Hybridization Target; 2.6.2 Critical Issues of Chip Hybridization; 2.6.3 Image Processing and Array Design; 2.7 Short-term Outlook; 3 Screening for Bone and Cartilage Phenotypes in Mice; 3.1 Introduction; 3.1.1 The Skeleton; 3.1.2 Skeletal Development in the Embryo; 3.1.3 Growth and Maintenance of Bone and Cartilage; 3.1.4 Diseases Involving Cartilage and Bone; 3.1.5 The Mouse as a Model for Skeletal Diseases; 3.2 Screening Protocols; 3.2.1 Morphological Analysis; 3.2.1.1 Protocol 3.2.2 X-Ray Analysis3.2.2.1 General; 3.2.2.2 Imaging; 3.2.2.3 X-Ray Analysis; 3.2.2.4 Protocol; 3.2.3 DXA-Analysis; 3.2.3.1 General; 3.2.3.2 Advantages; 3.2.3.3 Disadvantages; 3.2.3.4 Small Animal Applications; 3.2.3.5 Precision and Accuracy; 3.2.3.6 Considerations; 3.2.3.7 Protocol; 3.2.4 Biochemical Bone Markers; 3.2.4.1 Clinical Utility of Biochemical Markers of Bone Turnover in Small Animals; 3.2.4.2 Mouse Markers of Bone Turnover/Metabolism and Hormonal Regulation; 3.2.4.3 Variability/Sensitivity/Sample Choice; 3.2.4.4 Which Markers Should be Used During the Screen? 3.2.5 Advanced Small Animal Imaging Techniques3.2.5.1 pQCT; 3.2.5.2 μCT; 3.2.5.3 μMRI; 3.2.5.4 Whole-mount Skeletal Preparations; 3.2.5.5 Histomorphometry; 3.2.5.6 Miscellaneous; 3.2.5.7 Order of the Tests; 3.3 Conclusion; List of Abbreviations; Appendix; μCT Volumetric Data Processing; MRI Principles; 4 Clinical Chemical Screen; 4.1 Introduction; 4.1.1 Relevance of the Screen; 4.1.2 Biology and Medical Application; 4.1.2.1 Biology of Clinical Chemical Parameters; 4.1.2.2 Medical Application; 4.2 Diseases in Mouse and Humans; 4.2.1 Diagnostic Impact of Clinical Chemistry 4.2.2 Clinical Chemistry in Selected Disorders4.2.2.1 Hypercholesterolemia; 4.2.2.2 Albuminuria; 4.2.2.3 Acute Myeloid Leukemia (AML); 4.3 Clinical Chemistry as Diagnostic Tool; 4.3.1 History; 4.3.2 State of the Art; 4.4 Technical Requirements and Screening Protocols; 4.4.1 Technical Requirements; 4.4.1.1 Blood Collection; 4.4.1.2 Sample Preparation; 4.4.1.3 Sample Analysis; 4.4.2 Screening Protocols; 4.4.2.1 Primary Screen; 4.4.2.2 Secondary Screen; 4.4.2.3 Tertiary Screen; 4.5 Logistics of the Screen; 4.5.1 General Considerations; 4.5.2 Lessons from ENU Mutants; 4.6 Trouble Shooting 4.6.1 Factors Interfering In Vivo |
| Record Nr. | UNINA-9910144698703321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Standards of mouse model phenotyping [[electronic resource] /] / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown
| Standards of mouse model phenotyping [[electronic resource] /] / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (359 p.) |
| Disciplina | 599.353135 |
| Altri autori (Persone) |
Hrabé de AngelisMartin
ChambonPierre BrownStephen D. M |
| Soggetto topico |
Mice as laboratory animals
Mice - Genetics Transgenic mice Phenotype |
| ISBN |
1-282-30244-2
9786612302442 3-527-61194-0 3-527-60870-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Standards of Mouse Model Phenotyping; Foreword; Table of Contents; Preface; 1 Characterizing Hearing in Mice; 1.1 Introduction; 1.2 Behavioral Tests of Hearing; 1.3 Physiological Tests of Hearing; 1.4 Anatomy of the Ear; 1.5 Conclusions; Acknowledgements; 2 Molecular Phenotyping: Gene Expression Profiling; 2.1 Why this Screen? Medical and Biological Relevance; 2.2 Examples: Diseases of Mouse and Man; 2.3 Diagnostic Methods: History and State of the Art; 2.4 Technical Requirements for Screening Protocols (Short): First and Second Line Approaches; 2.5 Logistics (Whom, When, How Many, Why)
2.5.1 Choice of Platform2.5.2 Biological Samples; 2.6 Trouble Shooting; 2.6.1 Preparation of Hybridization Target; 2.6.2 Critical Issues of Chip Hybridization; 2.6.3 Image Processing and Array Design; 2.7 Short-term Outlook; 3 Screening for Bone and Cartilage Phenotypes in Mice; 3.1 Introduction; 3.1.1 The Skeleton; 3.1.2 Skeletal Development in the Embryo; 3.1.3 Growth and Maintenance of Bone and Cartilage; 3.1.4 Diseases Involving Cartilage and Bone; 3.1.5 The Mouse as a Model for Skeletal Diseases; 3.2 Screening Protocols; 3.2.1 Morphological Analysis; 3.2.1.1 Protocol 3.2.2 X-Ray Analysis3.2.2.1 General; 3.2.2.2 Imaging; 3.2.2.3 X-Ray Analysis; 3.2.2.4 Protocol; 3.2.3 DXA-Analysis; 3.2.3.1 General; 3.2.3.2 Advantages; 3.2.3.3 Disadvantages; 3.2.3.4 Small Animal Applications; 3.2.3.5 Precision and Accuracy; 3.2.3.6 Considerations; 3.2.3.7 Protocol; 3.2.4 Biochemical Bone Markers; 3.2.4.1 Clinical Utility of Biochemical Markers of Bone Turnover in Small Animals; 3.2.4.2 Mouse Markers of Bone Turnover/Metabolism and Hormonal Regulation; 3.2.4.3 Variability/Sensitivity/Sample Choice; 3.2.4.4 Which Markers Should be Used During the Screen? 3.2.5 Advanced Small Animal Imaging Techniques3.2.5.1 pQCT; 3.2.5.2 μCT; 3.2.5.3 μMRI; 3.2.5.4 Whole-mount Skeletal Preparations; 3.2.5.5 Histomorphometry; 3.2.5.6 Miscellaneous; 3.2.5.7 Order of the Tests; 3.3 Conclusion; List of Abbreviations; Appendix; μCT Volumetric Data Processing; MRI Principles; 4 Clinical Chemical Screen; 4.1 Introduction; 4.1.1 Relevance of the Screen; 4.1.2 Biology and Medical Application; 4.1.2.1 Biology of Clinical Chemical Parameters; 4.1.2.2 Medical Application; 4.2 Diseases in Mouse and Humans; 4.2.1 Diagnostic Impact of Clinical Chemistry 4.2.2 Clinical Chemistry in Selected Disorders4.2.2.1 Hypercholesterolemia; 4.2.2.2 Albuminuria; 4.2.2.3 Acute Myeloid Leukemia (AML); 4.3 Clinical Chemistry as Diagnostic Tool; 4.3.1 History; 4.3.2 State of the Art; 4.4 Technical Requirements and Screening Protocols; 4.4.1 Technical Requirements; 4.4.1.1 Blood Collection; 4.4.1.2 Sample Preparation; 4.4.1.3 Sample Analysis; 4.4.2 Screening Protocols; 4.4.2.1 Primary Screen; 4.4.2.2 Secondary Screen; 4.4.2.3 Tertiary Screen; 4.5 Logistics of the Screen; 4.5.1 General Considerations; 4.5.2 Lessons from ENU Mutants; 4.6 Trouble Shooting 4.6.1 Factors Interfering In Vivo |
| Record Nr. | UNINA-9910830451103321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Standards of mouse model phenotyping / / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown
| Standards of mouse model phenotyping / / edited by Martin Hrabede Angelis, Pierre Chambon, and Steve Brown |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (359 p.) |
| Disciplina | 599.353135 |
| Altri autori (Persone) |
Hrabe de AngelisMartin
ChambonPierre BrownStephen D. M |
| Soggetto topico |
Mice as laboratory animals
Mice - Genetics Transgenic mice Phenotype |
| ISBN |
1-282-30244-2
9786612302442 3-527-61194-0 3-527-60870-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Standards of Mouse Model Phenotyping; Foreword; Table of Contents; Preface; 1 Characterizing Hearing in Mice; 1.1 Introduction; 1.2 Behavioral Tests of Hearing; 1.3 Physiological Tests of Hearing; 1.4 Anatomy of the Ear; 1.5 Conclusions; Acknowledgements; 2 Molecular Phenotyping: Gene Expression Profiling; 2.1 Why this Screen? Medical and Biological Relevance; 2.2 Examples: Diseases of Mouse and Man; 2.3 Diagnostic Methods: History and State of the Art; 2.4 Technical Requirements for Screening Protocols (Short): First and Second Line Approaches; 2.5 Logistics (Whom, When, How Many, Why)
2.5.1 Choice of Platform2.5.2 Biological Samples; 2.6 Trouble Shooting; 2.6.1 Preparation of Hybridization Target; 2.6.2 Critical Issues of Chip Hybridization; 2.6.3 Image Processing and Array Design; 2.7 Short-term Outlook; 3 Screening for Bone and Cartilage Phenotypes in Mice; 3.1 Introduction; 3.1.1 The Skeleton; 3.1.2 Skeletal Development in the Embryo; 3.1.3 Growth and Maintenance of Bone and Cartilage; 3.1.4 Diseases Involving Cartilage and Bone; 3.1.5 The Mouse as a Model for Skeletal Diseases; 3.2 Screening Protocols; 3.2.1 Morphological Analysis; 3.2.1.1 Protocol 3.2.2 X-Ray Analysis3.2.2.1 General; 3.2.2.2 Imaging; 3.2.2.3 X-Ray Analysis; 3.2.2.4 Protocol; 3.2.3 DXA-Analysis; 3.2.3.1 General; 3.2.3.2 Advantages; 3.2.3.3 Disadvantages; 3.2.3.4 Small Animal Applications; 3.2.3.5 Precision and Accuracy; 3.2.3.6 Considerations; 3.2.3.7 Protocol; 3.2.4 Biochemical Bone Markers; 3.2.4.1 Clinical Utility of Biochemical Markers of Bone Turnover in Small Animals; 3.2.4.2 Mouse Markers of Bone Turnover/Metabolism and Hormonal Regulation; 3.2.4.3 Variability/Sensitivity/Sample Choice; 3.2.4.4 Which Markers Should be Used During the Screen? 3.2.5 Advanced Small Animal Imaging Techniques3.2.5.1 pQCT; 3.2.5.2 μCT; 3.2.5.3 μMRI; 3.2.5.4 Whole-mount Skeletal Preparations; 3.2.5.5 Histomorphometry; 3.2.5.6 Miscellaneous; 3.2.5.7 Order of the Tests; 3.3 Conclusion; List of Abbreviations; Appendix; μCT Volumetric Data Processing; MRI Principles; 4 Clinical Chemical Screen; 4.1 Introduction; 4.1.1 Relevance of the Screen; 4.1.2 Biology and Medical Application; 4.1.2.1 Biology of Clinical Chemical Parameters; 4.1.2.2 Medical Application; 4.2 Diseases in Mouse and Humans; 4.2.1 Diagnostic Impact of Clinical Chemistry 4.2.2 Clinical Chemistry in Selected Disorders4.2.2.1 Hypercholesterolemia; 4.2.2.2 Albuminuria; 4.2.2.3 Acute Myeloid Leukemia (AML); 4.3 Clinical Chemistry as Diagnostic Tool; 4.3.1 History; 4.3.2 State of the Art; 4.4 Technical Requirements and Screening Protocols; 4.4.1 Technical Requirements; 4.4.1.1 Blood Collection; 4.4.1.2 Sample Preparation; 4.4.1.3 Sample Analysis; 4.4.2 Screening Protocols; 4.4.2.1 Primary Screen; 4.4.2.2 Secondary Screen; 4.4.2.3 Tertiary Screen; 4.5 Logistics of the Screen; 4.5.1 General Considerations; 4.5.2 Lessons from ENU Mutants; 4.6 Trouble Shooting 4.6.1 Factors Interfering In Vivo |
| Record Nr. | UNINA-9910877058303321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||