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Microdrops and digital microfluidics / / Jean Berthier
| Microdrops and digital microfluidics / / Jean Berthier |
| Autore | Berthier Jean <1952-> |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Norwich, NY, : William Andrew Pub., c2008 |
| Descrizione fisica | 1 online resource (463 p.) |
| Disciplina | 629.8/042 |
| Collana | Micro & nano technologies |
| Soggetto topico |
Atomizers
Microfluidics - Equipment and supplies Spraying - Equipment and supplies Electrostatic atomization - Methodology Microelectromechanical systems |
| ISBN |
9780080947396
0080947395 9780815518358 0815518358 9781282169807 1282169807 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Digital microfluidics in today's microfluidics -- Theory of wetting -- The physics of droplets -- Electrowetting theory -- EWOD microsystems -- Biological applications of EWOD -- Chemical applications -- Acoustic methods for manipulating droplets -- Introduction to droplet microfluidics and multiphase microflows -- Epilog. |
| Altri titoli varianti | Micro drops and digital microfluidics |
| Record Nr. | UNINA-9911006575503321 |
Berthier Jean <1952->
|
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| Norwich, NY, : William Andrew Pub., c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Microfluidics for biotechnology / / Jean Berthier, Pascal Silberzan
| Microfluidics for biotechnology / / Jean Berthier, Pascal Silberzan |
| Autore | Berthier Jean <1952-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boston : , : Artech House, , ©2010 |
| Descrizione fisica | 1 online resource (502 p.) |
| Disciplina | 660.6 |
| Altri autori (Persone) | SilberzanPascal |
| Collana | Integrated microsystems series |
| Soggetto topico |
Biotechnology
Microfluidics |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-59693-444-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Microfluidics for Biotechnology Second Edition; Contents; Preface; Acknowledgements; Chapter 1 Dimensionless Numbers in Microfluidics; 1.1 Introduction; 1.2 Microfluidic Scales; 1.3 Buckingham's Pi Theorem; 1.4 Scaling Numbers and Characteristic Scales; 1.4.1 Micro- to Nanoscales; 1.4.2 Hydrodynamic Characteristic Times; 1.4.3 Newtonian Fluids; 1.4.4 Non-Newtonian Fluids; 1.4.5 Droplets and Digital Microfluidics; 1.4.6 Multiphysics; 1.4.7 Specific Dimensionless Numbers and Composite Groups; References; Chapter 2 Microflows; 2.1 Introduction
2.1.1 On the Importance of Microfluidics in Biotechnology2.1.2 From Single Continuous Flow to Droplets; 2.2 Single-Phase Microflows; 2.2.1 Navier-Stokes (NS) Equations; 2.2.2 Non-Newtonian Rheology; 2.2.3 Laminarity of Microflows; 2.2.4 Stokes Equation; 2.2.5 Hagen-Poiseuille Flow; 2.2.6 Pressure Drop and Friction Factor; 2.2.7 Bernoulli's Approach; 2.2.8 Modeling: Lumped Parameters Model; 2.2.9 Microfluidic Networks: Worked Example 1-Microfluidic Flow Inside a Microneedle; 2.2.10 Microfluidic Networks: Worked Example 2-Plasma Extraction from Blood 2.2.11 Hydrodynamic Entrance Length: Establishment of the Flow2.2.12 Distributing a Uniform Flow into a Microchamber; 2.2.13 The Example of a Protein Reactor; 2.2.14 Recirculation Regions; 2.2.15 Inertial Effects at Medium Reynolds Numbers: Dean Flow; 2.2.16 Microflows in Flat Channels: Helle-Shaw Flows; 2.3 Conclusion; References; Chapter 3 Interfaces, Capillarity, and Microdrops; 3.1 Introduction; 3.2 Interfaces and Surface Tension; 3.2.1 The Notion of Interface; 3.2.2 Surface Tension; 3.3 Laplace Law and Applications; 3.3.1 Curvature Radius and Laplace's Law 3.3.2 Examples of the Application of Laplace's Law3.4 Partial or Total Wetting; 3.5 Contact Angle: Young's Law; 3.5.1 Young's Law; 3.5.2 Young's Law for Two Liquids and a Solid; 3.5.3 Generalization of Young's Law-Neumann's Construction; 3.6 Capillary Force and Force on a Triple Line; 3.6.1 Introduction; 3.6.2 Capillary Force Between Two Parallel Plates; 3.6.3 Capillary Rise in a Tube-Jurin's Law; 3.6.4 Capillary Rise Between Two Parallel Vertical Plates; 3.6.5 Capillary Pumping; 3.6.6 Force on a Triple Line; 3.6.7 Examples of Capillary Forces in Microsystems; 3.7 Pinning and Canthotaxis 3.7.1 Theory3.7.2 Pinning of an Interface Between Pillars; 3.7.3 Droplet Pinning on a Surface Defect; 3.7.4 Pinning of a Microdroplet-Quadruple Contact Line; 3.7.5 Pinning in Microwells; 3.8 Microdrops; 3.8.1 Shape of Microdrops; 3.8.2 Drops on Inhomogeneous Surfaces; 3.9 Conclusions; References; Chapter 4 Digital, Two-Phase, and Droplet Microfluidics; 4.1 Introduction; 4.2 Digital Microfluidics; 4.2.1 Introduction; 4.2.2 Theory of Electrowetting; 4.2.3 EWOD Microsystems; 4.2.4 Conclusion; 4.3 Multiphase Microflows; 4.3.1 Introduction; 4.3.2 Droplet and Plug Flow in Microchannels |
| Record Nr. | UNINA-9910458231503321 |
|
Berthier Jean <1952->
|
||
| Boston : , : Artech House, , ©2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microfluidics for biotechnology / / Jean Berthier, Pascal Silberzan
| Microfluidics for biotechnology / / Jean Berthier, Pascal Silberzan |
| Autore | Berthier Jean <1952-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boston : , : Artech House, , ©2010 |
| Descrizione fisica | 1 online resource (502 p.) |
| Disciplina | 660.6 |
| Altri autori (Persone) | SilberzanPascal |
| Collana | Integrated microsystems series |
| Soggetto topico |
Biotechnology
Microfluidics |
| ISBN | 1-59693-444-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Microfluidics for Biotechnology Second Edition; Contents; Preface; Acknowledgements; Chapter 1 Dimensionless Numbers in Microfluidics; 1.1 Introduction; 1.2 Microfluidic Scales; 1.3 Buckingham's Pi Theorem; 1.4 Scaling Numbers and Characteristic Scales; 1.4.1 Micro- to Nanoscales; 1.4.2 Hydrodynamic Characteristic Times; 1.4.3 Newtonian Fluids; 1.4.4 Non-Newtonian Fluids; 1.4.5 Droplets and Digital Microfluidics; 1.4.6 Multiphysics; 1.4.7 Specific Dimensionless Numbers and Composite Groups; References; Chapter 2 Microflows; 2.1 Introduction
2.1.1 On the Importance of Microfluidics in Biotechnology2.1.2 From Single Continuous Flow to Droplets; 2.2 Single-Phase Microflows; 2.2.1 Navier-Stokes (NS) Equations; 2.2.2 Non-Newtonian Rheology; 2.2.3 Laminarity of Microflows; 2.2.4 Stokes Equation; 2.2.5 Hagen-Poiseuille Flow; 2.2.6 Pressure Drop and Friction Factor; 2.2.7 Bernoulli's Approach; 2.2.8 Modeling: Lumped Parameters Model; 2.2.9 Microfluidic Networks: Worked Example 1-Microfluidic Flow Inside a Microneedle; 2.2.10 Microfluidic Networks: Worked Example 2-Plasma Extraction from Blood 2.2.11 Hydrodynamic Entrance Length: Establishment of the Flow2.2.12 Distributing a Uniform Flow into a Microchamber; 2.2.13 The Example of a Protein Reactor; 2.2.14 Recirculation Regions; 2.2.15 Inertial Effects at Medium Reynolds Numbers: Dean Flow; 2.2.16 Microflows in Flat Channels: Helle-Shaw Flows; 2.3 Conclusion; References; Chapter 3 Interfaces, Capillarity, and Microdrops; 3.1 Introduction; 3.2 Interfaces and Surface Tension; 3.2.1 The Notion of Interface; 3.2.2 Surface Tension; 3.3 Laplace Law and Applications; 3.3.1 Curvature Radius and Laplace's Law 3.3.2 Examples of the Application of Laplace's Law3.4 Partial or Total Wetting; 3.5 Contact Angle: Young's Law; 3.5.1 Young's Law; 3.5.2 Young's Law for Two Liquids and a Solid; 3.5.3 Generalization of Young's Law-Neumann's Construction; 3.6 Capillary Force and Force on a Triple Line; 3.6.1 Introduction; 3.6.2 Capillary Force Between Two Parallel Plates; 3.6.3 Capillary Rise in a Tube-Jurin's Law; 3.6.4 Capillary Rise Between Two Parallel Vertical Plates; 3.6.5 Capillary Pumping; 3.6.6 Force on a Triple Line; 3.6.7 Examples of Capillary Forces in Microsystems; 3.7 Pinning and Canthotaxis 3.7.1 Theory3.7.2 Pinning of an Interface Between Pillars; 3.7.3 Droplet Pinning on a Surface Defect; 3.7.4 Pinning of a Microdroplet-Quadruple Contact Line; 3.7.5 Pinning in Microwells; 3.8 Microdrops; 3.8.1 Shape of Microdrops; 3.8.2 Drops on Inhomogeneous Surfaces; 3.9 Conclusions; References; Chapter 4 Digital, Two-Phase, and Droplet Microfluidics; 4.1 Introduction; 4.2 Digital Microfluidics; 4.2.1 Introduction; 4.2.2 Theory of Electrowetting; 4.2.3 EWOD Microsystems; 4.2.4 Conclusion; 4.3 Multiphase Microflows; 4.3.1 Introduction; 4.3.2 Droplet and Plug Flow in Microchannels |
| Record Nr. | UNINA-9910791476103321 |
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Berthier Jean <1952->
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| Boston : , : Artech House, , ©2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Open microfluidics / / Jean Berthier, Kenneth A. Brakke, and Erwin Berthier
| Open microfluidics / / Jean Berthier, Kenneth A. Brakke, and Erwin Berthier |
| Autore | Berthier Jean <1952-> |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; Beverly, Massachusetts : , : John Wiley & Sons, Inc. : , : Scrivener Publishing LLC, , 2016 |
| Descrizione fisica | 1 online resource (330 p.) |
| Disciplina | 532.05 |
| Collana | THEi Wiley ebooks |
| Soggetto topico |
Microfluidics
Capillaries - Physiology |
| ISBN |
1-118-72082-2
1-118-72086-5 1-118-72093-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910134877403321 |
|
Berthier Jean <1952->
|
||
| Hoboken, New Jersey ; ; Beverly, Massachusetts : , : John Wiley & Sons, Inc. : , : Scrivener Publishing LLC, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Open microfluidics / / Jean Berthier, Kenneth A. Brakke, and Erwin Berthier
| Open microfluidics / / Jean Berthier, Kenneth A. Brakke, and Erwin Berthier |
| Autore | Berthier Jean <1952-> |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; Beverly, Massachusetts : , : John Wiley & Sons, Inc. : , : Scrivener Publishing LLC, , 2016 |
| Descrizione fisica | 1 online resource (330 p.) |
| Disciplina | 532.05 |
| Collana | THEi Wiley ebooks |
| Soggetto topico |
Microfluidics
Capillaries - Physiology |
| ISBN |
1-118-72082-2
1-118-72086-5 1-118-72093-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910825021503321 |
|
Berthier Jean <1952->
|
||
| Hoboken, New Jersey ; ; Beverly, Massachusetts : , : John Wiley & Sons, Inc. : , : Scrivener Publishing LLC, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The physics of microdroplets [[electronic resource] /] / Jean Berthier and Kenneth A. Brakke
| The physics of microdroplets [[electronic resource] /] / Jean Berthier and Kenneth A. Brakke |
| Autore | Berthier Jean <1952-> |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, Inc |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina | 532/.05 |
| Altri autori (Persone) | BrakkeKenneth A |
| Soggetto topico |
Microdroplets
Microfluidics Capillarity |
| ISBN |
1-280-67921-2
9786613656148 1-118-40133-6 1-118-40132-8 1-118-40130-1 |
| Classificazione | TEC008070 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Preface xviii Acknowledgements xxi Introduction 1 1. Fundamentals of Capillarity 5 1.1 Abstract 5 -- 1.2 Interfaces and Surface Tension 5 -- 1.3 Laplace's Law and Applications 13 -- 1.4 Measuring the Surface Tension of Liquids 48 -- 1.5 Minimization of the Surface Energy and Minimal Surfaces 59 -- 1.6 References 61 -- 2. Minimal Energy and Stability Rubrics 65 -- 2.1 Abstract 65 -- 2.2 Spherical Shapes as Energy Minimizers 66 -- 2.3 Symmetrization and the Rouloids 70 -- 2.4 Increasing Pressure and Stability 75 -- 2.5 The Double-Bubble Instability 78 -- 2.6 Conclusion 81 -- 2.7 References 82 -- 3. Droplets: Shape, Surface and Volume 83 -- 3.1 Abstract 83 -- 3.2 The Shape of Micro-drops 84 -- 3.3 Electric Bonds Number 85 -- 3.4 Shape, Surface Area and Volume of Sessile Droplets 85 -- 3.5 Conclusion 103 -- 3.6 References 103 -- 4. Sessile Droplets 105 -- 4.1 Abstract 105 -- 4.2 Droplet Self-motion Under the Effect of a Contrast or Gradient of Wettability 105 -- 4.3 Contact Angle Hysteresis 112 -- 4.4 Pinning and Canthotaxis 115 -- 4.5 Sessile Droplet on a Non-ideally Planar Surface 122 -- 4.6 Droplet on Textured or Patterned Substrates 123 -- 4.7 References 140 -- 5. Droplets Between Two Non-parallel Planes: from Tapered Planes to Wedges 143 -- 5.1 Abstract 143 -- 5.2 Droplet Self-motion Between Two Non-parallel Planes 143 -- 5.3 Droplet in a Corner 151 -- 5.4 Conclusion 159 -- 5.5 References 159 -- 6. Microdrops in Microchannels and Microchambers 161 -- 6.1 Abstract 161 -- 6.2 Droplets in Micro-wells 161 -- 6.3 Droplets in Microchannels 167 -- 6.4 Conclusion 180 -- 6.5 References 180 -- 7. Capillary Effects: Capillary Rise, Capillary Pumping, and Capillary Valve 183 -- 7.1 Abstract 183 -- 7.2 Capillary Rise 183 -- 7.3 Capillary Pumping 195 -- 7.4 Capillary Valves 202 -- 7.5 Conclusions 207 -- 7.6 References 207 -- 8. Open Microfluidics 209 -- 8.1 Abstract 209 -- 8.2 Droplet Pierced by a Wire 210 -- 8.3 Liquid Spreading Between Solid Structures - Spontaneous Capillary Flow 216 -- 8.4 Liquid Wetting Fibers 239 -- 8.5 Conclusions 247 -- 8.6 References 248 -- 8.7 Appendix: Calculation of the Laplace Pressure for a Droplet on a Horizontal Cylindrical Wire 250 -- 9. Droplets, particles and Interfaces 251 -- 9.1 Abstract 251 -- 9.2 Neumann's Construction for liquid Droplets 251 -- 9.3 The Difference Between Liquid Droplets and Rigid Spheres at an Interface 252 -- 9.4 Liquid Droplet Deposited at a Liquid Surface 253 -- 9.5 Immiscible Droplets in Contact and Engulfment 258 -- 9.6 Non-deformable (Rigid) Sphere at an Interface 262 -- 9.7 Droplet Evaporation and Capillary Assembly 275 -- 9.8 Conclusion 288 -- 9.9 References 290 -- 10. Digital Microfluidics 293 -- 10.1 Abstract 293 -- 10.2 Electrowetting and EWOD 293 -- 10.3 Droplet Manipulation with EWOD 304 -- 10.4 Examples of EWOD in Biotechnology - Cell Manipulation 333 -- 10.5 Examples of Electrowetting for Optics-Tunable Lenses and Electrofluidic Display 335 -- 10.6 Conclusion 336 -- 10.7 References 337 -- 11. Capillary Self-assembly for 3D Microelectronics 341 -- 11.1 Abstract 341 -- 11.2 Ideal Case: Total Pinning on the Chip and Pad Edges 342 -- 11.3 Real Case: Spreading and Wetting 352 -- 11.4 The Importance of Pinning and Confinement 355 -- 11.5 Conclusion 357 -- 11.6 Appendix A: Shift Energy and Restoring Force 358 -- 11.7 Appendix B: Twist Energy and Restoring Torque 359 -- 11.8 Appendix C: Lift Energy and Restoring Force 361 -- 11.9 References 362 -- 12. Epilogue 365 -- Index 367. |
| Record Nr. | UNINA-9910139087903321 |
|
Berthier Jean <1952->
|
||
| Hoboken, N.J., : John Wiley & Sons, Inc | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The physics of microdroplets / / Jean Berthier and Kenneth A. Brakke
| The physics of microdroplets / / Jean Berthier and Kenneth A. Brakke |
| Autore | Berthier Jean <1952-> |
| Edizione | [1st edition] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, Inc |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina | 532/.05 |
| Altri autori (Persone) | BrakkeKenneth A |
| Soggetto topico |
Microdroplets
Microfluidics Capillarity |
| ISBN |
9786613656148
9781280679216 1280679212 9781118401330 1118401336 9781118401323 1118401328 9781118401309 1118401301 |
| Classificazione | TEC008070 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Preface xviii Acknowledgements xxi Introduction 1 1. Fundamentals of Capillarity 5 1.1 Abstract 5 -- 1.2 Interfaces and Surface Tension 5 -- 1.3 Laplace's Law and Applications 13 -- 1.4 Measuring the Surface Tension of Liquids 48 -- 1.5 Minimization of the Surface Energy and Minimal Surfaces 59 -- 1.6 References 61 -- 2. Minimal Energy and Stability Rubrics 65 -- 2.1 Abstract 65 -- 2.2 Spherical Shapes as Energy Minimizers 66 -- 2.3 Symmetrization and the Rouloids 70 -- 2.4 Increasing Pressure and Stability 75 -- 2.5 The Double-Bubble Instability 78 -- 2.6 Conclusion 81 -- 2.7 References 82 -- 3. Droplets: Shape, Surface and Volume 83 -- 3.1 Abstract 83 -- 3.2 The Shape of Micro-drops 84 -- 3.3 Electric Bonds Number 85 -- 3.4 Shape, Surface Area and Volume of Sessile Droplets 85 -- 3.5 Conclusion 103 -- 3.6 References 103 -- 4. Sessile Droplets 105 -- 4.1 Abstract 105 -- 4.2 Droplet Self-motion Under the Effect of a Contrast or Gradient of Wettability 105 -- 4.3 Contact Angle Hysteresis 112 -- 4.4 Pinning and Canthotaxis 115 -- 4.5 Sessile Droplet on a Non-ideally Planar Surface 122 -- 4.6 Droplet on Textured or Patterned Substrates 123 -- 4.7 References 140 -- 5. Droplets Between Two Non-parallel Planes: from Tapered Planes to Wedges 143 -- 5.1 Abstract 143 -- 5.2 Droplet Self-motion Between Two Non-parallel Planes 143 -- 5.3 Droplet in a Corner 151 -- 5.4 Conclusion 159 -- 5.5 References 159 -- 6. Microdrops in Microchannels and Microchambers 161 -- 6.1 Abstract 161 -- 6.2 Droplets in Micro-wells 161 -- 6.3 Droplets in Microchannels 167 -- 6.4 Conclusion 180 -- 6.5 References 180 -- 7. Capillary Effects: Capillary Rise, Capillary Pumping, and Capillary Valve 183 -- 7.1 Abstract 183 -- 7.2 Capillary Rise 183 -- 7.3 Capillary Pumping 195 -- 7.4 Capillary Valves 202 -- 7.5 Conclusions 207 -- 7.6 References 207 -- 8. Open Microfluidics 209 -- 8.1 Abstract 209 -- 8.2 Droplet Pierced by a Wire 210 -- 8.3 Liquid Spreading Between Solid Structures - Spontaneous Capillary Flow 216 -- 8.4 Liquid Wetting Fibers 239 -- 8.5 Conclusions 247 -- 8.6 References 248 -- 8.7 Appendix: Calculation of the Laplace Pressure for a Droplet on a Horizontal Cylindrical Wire 250 -- 9. Droplets, particles and Interfaces 251 -- 9.1 Abstract 251 -- 9.2 Neumann's Construction for liquid Droplets 251 -- 9.3 The Difference Between Liquid Droplets and Rigid Spheres at an Interface 252 -- 9.4 Liquid Droplet Deposited at a Liquid Surface 253 -- 9.5 Immiscible Droplets in Contact and Engulfment 258 -- 9.6 Non-deformable (Rigid) Sphere at an Interface 262 -- 9.7 Droplet Evaporation and Capillary Assembly 275 -- 9.8 Conclusion 288 -- 9.9 References 290 -- 10. Digital Microfluidics 293 -- 10.1 Abstract 293 -- 10.2 Electrowetting and EWOD 293 -- 10.3 Droplet Manipulation with EWOD 304 -- 10.4 Examples of EWOD in Biotechnology - Cell Manipulation 333 -- 10.5 Examples of Electrowetting for Optics-Tunable Lenses and Electrofluidic Display 335 -- 10.6 Conclusion 336 -- 10.7 References 337 -- 11. Capillary Self-assembly for 3D Microelectronics 341 -- 11.1 Abstract 341 -- 11.2 Ideal Case: Total Pinning on the Chip and Pad Edges 342 -- 11.3 Real Case: Spreading and Wetting 352 -- 11.4 The Importance of Pinning and Confinement 355 -- 11.5 Conclusion 357 -- 11.6 Appendix A: Shift Energy and Restoring Force 358 -- 11.7 Appendix B: Twist Energy and Restoring Torque 359 -- 11.8 Appendix C: Lift Energy and Restoring Force 361 -- 11.9 References 362 -- 12. Epilogue 365 -- Index 367. |
| Record Nr. | UNINA-9910808250103321 |
|
Berthier Jean <1952->
|
||
| Hoboken, N.J., : John Wiley & Sons, Inc | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||