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Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910144228403321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910830717703321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Methanol: The Basic Chemical and Energy Feedstock of the Future : Asinger's Vision Today / / edited by Martin Bertau, Heribert Offermanns, Ludolf Plass, Friedrich Schmidt, Hans-Jürgen Wernicke
| Methanol: The Basic Chemical and Energy Feedstock of the Future : Asinger's Vision Today / / edited by Martin Bertau, Heribert Offermanns, Ludolf Plass, Friedrich Schmidt, Hans-Jürgen Wernicke |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (699 p.) |
| Disciplina |
615.9
615.9/02 615.902 621.042 |
| Soggetto topico |
Renewable energy resources
Energy systems Chemical engineering Renewable and Green Energy Energy Systems Industrial Chemistry/Chemical Engineering |
| ISBN | 3-642-39709-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Fossil Feedstocks: What Comes After? -- Asinger's Vision "Technical Photosynthesis" -- Methanol Generation -- Substance Property Data of Methanol -- Methanol Utilisation Technologies -- Methanol Generation Economics: Economical Evaluation of the State-of-the-art of Methanol Production Technologies. |
| Record Nr. | UNINA-9910299622203321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Rare earth chemistry / / ed. by Rainer Pöttgen, Thomas Jüstel, Cristian A. Strassert
| Rare earth chemistry / / ed. by Rainer Pöttgen, Thomas Jüstel, Cristian A. Strassert |
| Pubbl/distr/stampa | Berlin ; ; Boston : , : De Gruyter, , [2020] |
| Descrizione fisica | 1 online resource (XV, 654 p.) |
| Disciplina | 546/.41 |
| Collana | De Gruyter STEM |
| Soggetto topico |
Rare earths
SCIENCE / Chemistry / Inorganic |
| ISBN |
9781523154333
1523154330 9783110653724 3110653729 9783110654929 311065492X |
| Classificazione | VH 8045.0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Frontmatter -- Preface -- Contents -- List of contributors -- 1. The elements -- 1.1 Discovery of the rare-earth elements -- 1.2 Rare-earth minerals and rare-earth mining -- 1.3 Rare earth resources and processing -- 1.4 Rare earth metal production and refinement -- 1.5 Recycling aspects – magnets -- 1.6 Recycling aspects – phosphors -- 1.7 The structures of the elements -- 1.8 Electronic properties of the lanthanide ions -- 2. Reactivity and compounds -- 2.1 Halides of trivalent lanthanides -- 2.2 Lanthanide compounds with tetrahedral oxoanions -- 2.3 Lanthanide compounds with low valence -- 2.4 Intermetallic compounds -- 2.5 Polyoxometalates -- 2.6 Coordination chemistry -- 2.7 Organometallic rare-earth chemistry -- 3. Characterization and properties -- 3.1 Analysis of rare-earth metals and their species -- 3.2 Rare earth toxicology -- 3.3 Rare earths magnetism – condensed matter -- 3.4 Rare earth magnetism – molecules -- 3.5 Optical characterization -- 3.6 Solid-state NMR and Mößbauer spectroscopy -- 3.7 Rare-earth ion spin dynamics as a source of structural information -- 3.8 Electrical and dielectric properties -- 4. Materials and applications -- 4.1 Optical materials – molecules -- 4.2 Optical materials – microcrystalline powders -- 4.3 Optical materials – ceramics -- 4.4 Crystal growth of rare-earth doped and rare-earth containing materials -- 4.5 Medical applications of rare earth compounds -- 4.6 Rare earth-based scintillators -- 4.7 Rare earth metals in heterogeneous catalysis -- 4.8 Materials for solid state cooling -- 4.9 Rare earth metal-based hydride materials -- 4.10 Lanthanide nanoparticles and their biological applications -- 4.11 Rare-earth-based hybrid materials -- 4.12 Rare earth based superconducting materials -- 4.13 Rare-earth-containing glasses -- 4.14 Bioinorganic chemistry of the elements -- 4.15 Economic aspects -- Subject Index -- Formula Index |
| Record Nr. | UNINA-9911007109403321 |
| Berlin ; ; Boston : , : De Gruyter, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Rohstoffwirtschaft und gesellschaftliche Entwicklung : Die nächsten 50 Jahre / / herausgegeben von Peter Kausch, Jörg Matschullat, Martin Bertau, Helmut Mischo
| Rohstoffwirtschaft und gesellschaftliche Entwicklung : Die nächsten 50 Jahre / / herausgegeben von Peter Kausch, Jörg Matschullat, Martin Bertau, Helmut Mischo |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer Spektrum, , 2016 |
| Descrizione fisica | 1 online resource (244 p.) |
| Disciplina | 553 |
| Soggetto topico |
Geology, Economic
Mines and mineral resources Geotechnical engineering Economic Geology Mineral Resources Geotechnical Engineering & Applied Earth Sciences |
| ISBN | 3-662-48855-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto | Metalle für Europas Industrie - ob die Öffentlichkeit sie will oder nicht?- Innovationen in Abbau und Verarbeitung Seltener Erden -- Antworten auf die Kritikalität von Materialien: Historische Beispiele -- Globale Angebotskonzentration von mineralischen Rohstoffen und Zwischenprodukten -- Phosphatrecycling aus Klärschlammaschen - warum Phosphorsäure der einzige Weg ist -- Recycling von seltenen Metallen und deren Verbindungen -- Metalle: Aktivatoren von Kreislaufwirtschaft und Recycling 4.0 -- Magnetische Materialien - Schlüsselkomponenten für neue Energietechnologien -- Forschung für Nachhaltigkeit -- Energiekosten und Investitionsentwicklung in einem Unternehmen der Metallindustrie -- Veränderung in der Rohstoffbasis in der Petrochemie und die Auswirkungen auf Europa -- Methanol - der Schlüssel zur Energie- und Rohstoffwende -- EIT RawMaterials: Einführung in eine neue Wissens- und Innovationsgemeinschaft -- Demografie und Rohstoffe - Wechselseitige Einflüsse -- Ressourcentechnologien 2065 -- Ansatzpunkte einer globalen ökologischen Wende: Ressourcen- und Schadensentkopplung -- Mittel- und langfristige Energie- und Rohstoffherausforderungen - die nächsten 50 Jahre. |
| Record Nr. | UNINA-9910483601503321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer Spektrum, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||