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Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
| Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, [England] : , : Academic Press, , 2014 |
| Descrizione fisica | 1 online resource (279 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Alternative treatment
Cancer - Treatment |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-802527-1
0-12-802215-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest 3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure 5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family 3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis 3.2.2. Autophagy |
| Record Nr. | UNINA-9910459571803321 |
| London, [England] : , : Academic Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
| Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, [England] : , : Academic Press, , 2014 |
| Descrizione fisica | 1 online resource (279 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Alternative treatment
Cancer - Treatment |
| ISBN |
0-12-802527-1
0-12-802215-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest 3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure 5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family 3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis 3.2.2. Autophagy |
| Record Nr. | UNINA-9910787265603321 |
| London, [England] : , : Academic Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
| Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, [England] : , : Academic Press, , 2014 |
| Descrizione fisica | 1 online resource (279 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Alternative treatment
Cancer - Treatment |
| ISBN |
0-12-802527-1
0-12-802215-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest 3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure 5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family 3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis 3.2.2. Autophagy |
| Record Nr. | UNINA-9910827756703321 |
| London, [England] : , : Academic Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
| Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier Science, , 2015 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Chemoprevention
Cancer - Diet therapy Phytochemicals - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-803877-2
0-12-803876-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action References |
| Record Nr. | UNINA-9910461754703321 |
| Waltham, MA : , : Elsevier Science, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
| Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier Science, , 2015 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Chemoprevention
Cancer - Diet therapy Phytochemicals - Therapeutic use |
| ISBN |
0-12-803877-2
0-12-803876-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action References |
| Record Nr. | UNINA-9910797589003321 |
| Waltham, MA : , : Elsevier Science, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
| Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier Science, , 2015 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.994061 |
| Collana | Enzymes |
| Soggetto topico |
Cancer - Chemoprevention
Cancer - Diet therapy Phytochemicals - Therapeutic use |
| ISBN |
0-12-803877-2
0-12-803876-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action References |
| Record Nr. | UNINA-9910828715703321 |
| Waltham, MA : , : Elsevier Science, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||