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Cancer stem cells [[electronic resource] ] : identification and targets / / edited by Sharmila Bapat
| Cancer stem cells [[electronic resource] ] : identification and targets / / edited by Sharmila Bapat |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (274 p.) |
| Disciplina |
362.196/994
362.196994 616.99406 |
| Altri autori (Persone) | BapatSharmila |
| Soggetto topico |
Cancer cells
Stem cells |
| ISBN |
1-281-83137-9
9786611831370 0-470-39159-6 0-470-39156-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CANCER STEM CELLS; CONTENTS; Contributors; Preface; 1 Cancer Stem Cells: Similarities and Variations in the Theme of Normal Stem Cells; 1.1 Introduction; 1.2 Stem Cells in the Life of an Organism; 1.2.1 Stem Cells in Early Development and Fetal Life; 1.2.2 Stem Cells in the Adult Organism; 1.3 Cancer Stem Cells; 1.3.1 Activation of Stem Cells and Cancer; 1.3.2 Isolation and Identification of Cancer Stem Cells; 1.3.3 De Novo Generation of a New Organ (Tumor) by Transformed Stem Cells; 1.4 Self-Renewal and Differentiation in CSCs
1.5 CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem Cell Factors1.5.1 Stem Cell Intrinsic Factors: Genetic and Epigenetic Effects; 1.5.2 Stem Cell Extrinsic Effects: Niche Effects and Microenvironmental Signaling; 1.6 Conclusions and Future Perspectives; References; 2 Leukemic Stem Cells; 2.1 Introduction; 2.2 Dysregulation of Hematopoiesis in Leukemia; 2.2.1 Normal Hematopoietic Stem Cell Hierarchies; 2.2.2 Understanding Aberrant Hierarchies in Leukemia; 2.2.3 Types of Leukemia; 2.3 Identification and isolation of Cancer-Initiating Cells in Leukemia 2.4 Molecular Regulation of Aberrant Hierarchies2.4.1 Signaling Pathways Deregulated in Leukemia; 2.4.2 Self-Renewal of Normal and Leukemic Stem Cells; 2.4.3 Epigenetic Effects; 2.4.4 MicroRNA in Leukemia Development; 2.5 Conclusions and Future Perspectives; References; 3 Isolation and Characterization of Breast and Brain Cancer Stem Cells; 3.1 Introduction; 3.2 Breast Cancer Stem Cells; 3.2.1 Mammary Gland Architecture and Cell Types; 3.2.2 Breast Cancer; 3.2.3 Identification of Breast Cancer Stem Cells 3.2.4 Putative Breast Cancer Stem Cells that Exhibit the CD44(+) CD24(-/low)Lin(-) Marker Profile3.2.5 ESA(+) Subpopulation of CD24(-low)Lin(-) Cells Enriched by Tumorigenicity; 3.2.6 Tumorigenic Breast Cells Displaying Properties of Stem Cells; 3.2.7 In Vitro Propagation of Breast Cancer Stem Cells as Mammospheres; 3.3 Brain Cancer Stem Cells; 3.3.1 Brain Architecture and Cell Types; 3.3.2 Brain Cancers; 3.3.3 Brain Stem Cells; 3.3.4 Brain Cancer Stem Cells; 3.3.5 Brain Cancer-Derived Cells that Generate Tumor Spheres; 3.4 Conclusions and Future Perspectives; References 4 Cancer Stem Cell Side Populations4.1 Introduction; 4.2 Stem Cell Side Populations; 4.3 Side Populations in Normal Tissue; 4.4 Side Populations in Tumors; 4.5 Overcoming Side Population Limitations; 4.6 Conclusions and Future Perspectives; References; 5 Evidence for Cancer Stem Cells in Retinoblastoma; 5.1 Introduction; 5.2 Elusive Origins of Retinoblastoma; 5.3 Sources of Retinoblastoma Cells for Study; 5.4 Precedent for Cancer Stem Cells; 5.5 Side Populations in Retinoblastoma; 5.6 Immunoreactivity to Stem Cell Markers in Retinoblastoma; 5.7 Conclusions and Future Perspectives; References 6 Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer Stem Cells |
| Record Nr. | UNINA-9910144112903321 |
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer stem cells [[electronic resource] ] : identification and targets / / edited by Sharmila Bapat
| Cancer stem cells [[electronic resource] ] : identification and targets / / edited by Sharmila Bapat |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (274 p.) |
| Disciplina |
362.196/994
362.196994 616.99406 |
| Altri autori (Persone) | BapatSharmila |
| Soggetto topico |
Cancer cells
Stem cells |
| ISBN |
1-281-83137-9
9786611831370 0-470-39159-6 0-470-39156-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CANCER STEM CELLS; CONTENTS; Contributors; Preface; 1 Cancer Stem Cells: Similarities and Variations in the Theme of Normal Stem Cells; 1.1 Introduction; 1.2 Stem Cells in the Life of an Organism; 1.2.1 Stem Cells in Early Development and Fetal Life; 1.2.2 Stem Cells in the Adult Organism; 1.3 Cancer Stem Cells; 1.3.1 Activation of Stem Cells and Cancer; 1.3.2 Isolation and Identification of Cancer Stem Cells; 1.3.3 De Novo Generation of a New Organ (Tumor) by Transformed Stem Cells; 1.4 Self-Renewal and Differentiation in CSCs
1.5 CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem Cell Factors1.5.1 Stem Cell Intrinsic Factors: Genetic and Epigenetic Effects; 1.5.2 Stem Cell Extrinsic Effects: Niche Effects and Microenvironmental Signaling; 1.6 Conclusions and Future Perspectives; References; 2 Leukemic Stem Cells; 2.1 Introduction; 2.2 Dysregulation of Hematopoiesis in Leukemia; 2.2.1 Normal Hematopoietic Stem Cell Hierarchies; 2.2.2 Understanding Aberrant Hierarchies in Leukemia; 2.2.3 Types of Leukemia; 2.3 Identification and isolation of Cancer-Initiating Cells in Leukemia 2.4 Molecular Regulation of Aberrant Hierarchies2.4.1 Signaling Pathways Deregulated in Leukemia; 2.4.2 Self-Renewal of Normal and Leukemic Stem Cells; 2.4.3 Epigenetic Effects; 2.4.4 MicroRNA in Leukemia Development; 2.5 Conclusions and Future Perspectives; References; 3 Isolation and Characterization of Breast and Brain Cancer Stem Cells; 3.1 Introduction; 3.2 Breast Cancer Stem Cells; 3.2.1 Mammary Gland Architecture and Cell Types; 3.2.2 Breast Cancer; 3.2.3 Identification of Breast Cancer Stem Cells 3.2.4 Putative Breast Cancer Stem Cells that Exhibit the CD44(+) CD24(-/low)Lin(-) Marker Profile3.2.5 ESA(+) Subpopulation of CD24(-low)Lin(-) Cells Enriched by Tumorigenicity; 3.2.6 Tumorigenic Breast Cells Displaying Properties of Stem Cells; 3.2.7 In Vitro Propagation of Breast Cancer Stem Cells as Mammospheres; 3.3 Brain Cancer Stem Cells; 3.3.1 Brain Architecture and Cell Types; 3.3.2 Brain Cancers; 3.3.3 Brain Stem Cells; 3.3.4 Brain Cancer Stem Cells; 3.3.5 Brain Cancer-Derived Cells that Generate Tumor Spheres; 3.4 Conclusions and Future Perspectives; References 4 Cancer Stem Cell Side Populations4.1 Introduction; 4.2 Stem Cell Side Populations; 4.3 Side Populations in Normal Tissue; 4.4 Side Populations in Tumors; 4.5 Overcoming Side Population Limitations; 4.6 Conclusions and Future Perspectives; References; 5 Evidence for Cancer Stem Cells in Retinoblastoma; 5.1 Introduction; 5.2 Elusive Origins of Retinoblastoma; 5.3 Sources of Retinoblastoma Cells for Study; 5.4 Precedent for Cancer Stem Cells; 5.5 Side Populations in Retinoblastoma; 5.6 Immunoreactivity to Stem Cell Markers in Retinoblastoma; 5.7 Conclusions and Future Perspectives; References 6 Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer Stem Cells |
| Record Nr. | UNINA-9910830418203321 |
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer stem cells : identification and targets / / edited by Sharmila Bapat
| Cancer stem cells : identification and targets / / edited by Sharmila Bapat |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (274 p.) |
| Disciplina |
362.196/994
362.196994 616.99406 |
| Altri autori (Persone) | BapatSharmila |
| Soggetto topico |
Cancer cells
Stem cells |
| ISBN |
1-281-83137-9
9786611831370 0-470-39159-6 0-470-39156-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CANCER STEM CELLS; CONTENTS; Contributors; Preface; 1 Cancer Stem Cells: Similarities and Variations in the Theme of Normal Stem Cells; 1.1 Introduction; 1.2 Stem Cells in the Life of an Organism; 1.2.1 Stem Cells in Early Development and Fetal Life; 1.2.2 Stem Cells in the Adult Organism; 1.3 Cancer Stem Cells; 1.3.1 Activation of Stem Cells and Cancer; 1.3.2 Isolation and Identification of Cancer Stem Cells; 1.3.3 De Novo Generation of a New Organ (Tumor) by Transformed Stem Cells; 1.4 Self-Renewal and Differentiation in CSCs
1.5 CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem Cell Factors1.5.1 Stem Cell Intrinsic Factors: Genetic and Epigenetic Effects; 1.5.2 Stem Cell Extrinsic Effects: Niche Effects and Microenvironmental Signaling; 1.6 Conclusions and Future Perspectives; References; 2 Leukemic Stem Cells; 2.1 Introduction; 2.2 Dysregulation of Hematopoiesis in Leukemia; 2.2.1 Normal Hematopoietic Stem Cell Hierarchies; 2.2.2 Understanding Aberrant Hierarchies in Leukemia; 2.2.3 Types of Leukemia; 2.3 Identification and isolation of Cancer-Initiating Cells in Leukemia 2.4 Molecular Regulation of Aberrant Hierarchies2.4.1 Signaling Pathways Deregulated in Leukemia; 2.4.2 Self-Renewal of Normal and Leukemic Stem Cells; 2.4.3 Epigenetic Effects; 2.4.4 MicroRNA in Leukemia Development; 2.5 Conclusions and Future Perspectives; References; 3 Isolation and Characterization of Breast and Brain Cancer Stem Cells; 3.1 Introduction; 3.2 Breast Cancer Stem Cells; 3.2.1 Mammary Gland Architecture and Cell Types; 3.2.2 Breast Cancer; 3.2.3 Identification of Breast Cancer Stem Cells 3.2.4 Putative Breast Cancer Stem Cells that Exhibit the CD44(+) CD24(-/low)Lin(-) Marker Profile3.2.5 ESA(+) Subpopulation of CD24(-low)Lin(-) Cells Enriched by Tumorigenicity; 3.2.6 Tumorigenic Breast Cells Displaying Properties of Stem Cells; 3.2.7 In Vitro Propagation of Breast Cancer Stem Cells as Mammospheres; 3.3 Brain Cancer Stem Cells; 3.3.1 Brain Architecture and Cell Types; 3.3.2 Brain Cancers; 3.3.3 Brain Stem Cells; 3.3.4 Brain Cancer Stem Cells; 3.3.5 Brain Cancer-Derived Cells that Generate Tumor Spheres; 3.4 Conclusions and Future Perspectives; References 4 Cancer Stem Cell Side Populations4.1 Introduction; 4.2 Stem Cell Side Populations; 4.3 Side Populations in Normal Tissue; 4.4 Side Populations in Tumors; 4.5 Overcoming Side Population Limitations; 4.6 Conclusions and Future Perspectives; References; 5 Evidence for Cancer Stem Cells in Retinoblastoma; 5.1 Introduction; 5.2 Elusive Origins of Retinoblastoma; 5.3 Sources of Retinoblastoma Cells for Study; 5.4 Precedent for Cancer Stem Cells; 5.5 Side Populations in Retinoblastoma; 5.6 Immunoreactivity to Stem Cell Markers in Retinoblastoma; 5.7 Conclusions and Future Perspectives; References 6 Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer Stem Cells |
| Record Nr. | UNINA-9910877356203321 |
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||