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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene / / by Amita Kashyap, D. Bujamma, Naresh Babu M



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Autore: Kashyap Amita Visualizza persona
Titolo: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene / / by Amita Kashyap, D. Bujamma, Naresh Babu M Visualizza cluster
Pubblicazione: Singapore : , : Springer Singapore : , : Imprint : Springer, , 2015
Edizione: 1st ed. 2015.
Descrizione fisica: 1 online resource (79 p.)
Disciplina: 006.3
502.85
519
570285
Soggetto topico: Computational intelligence
Bioinformatics
Cancer research
Biomedical engineering
Health informatics
Applied mathematics
Engineering mathematics
Computational Intelligence
Computational Biology/Bioinformatics
Cancer Research
Biomedical Engineering and Bioengineering
Health Informatics
Mathematical and Computational Engineering
Persona (resp. second.): BujammaD
Babu MNaresh
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references.
Nota di contenuto: Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References.
Sommario/riassunto: Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
Titolo autorizzato: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene  Visualizza cluster
ISBN: 981-4585-08-4
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910299705703321
Lo trovi qui: Univ. Federico II
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Serie: SpringerBriefs in Forensic and Medical Bioinformatics, . 2196-8845