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Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.]
| Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Oxford, : Academic, c2007 |
| Descrizione fisica | 1 online resource (567 p.) |
| Disciplina | 615.1 |
| Soggetto topico |
Clinical pharmacology
Drugs |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-72891-4
9786610728916 0-08-046642-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Title page; Copyright page; Table of contents; Preface to the First Edition; Preface to the Second Edition; Contributors; CHAPTER 1. Introduction to Clinical Pharmacology; BACKGROUND; PHARMACOKINETICS; PART I: PHARMACOKINETICS; CHAPTER 2. Clinical Pharmacokinetics; THE TARGET CONCENTRATION STRATEGY; CONCEPTS UNDERLYING CLINICAL PHARMACOKINETICS; MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS; CHAPTER 3. Compartmental Analysis of Drug Distribution; PHYSIOLOGICAL SIGNIFICANCE OF DRUG DISTRIBUTION VOLUMES; PHYSIOLOGICAL BASIS OF MULTICOMPARTMENTAL MODELS OF DRUG DISTRIBUTION
CLINICAL CONSEQUENCES OF DIFFERENT DRUG DISTRIBUTION PATTERNSANALYSIS OF EXPERIMENTAL DATA; CHAPTER 4. Drug Absorption and Bioavailability; DRUG ABSORPTION; BIOAVAILABILITY; KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION; CHAPTER 5. Effects of Renal Disease on Pharmacokinetics; EFFECTS OF RENAL DISEASE ON DRUG ELIMINATION; EFFECTS OF RENAL DISEASE ON DRUG DISTRIBUTION; EFFECTS OF RENAL DISEASE ON DRUG ABSORPTION; CHAPTER 6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy; KINETICS OF INTERMITTENT HEMODIALYSIS; KINETICS OF CONTINUOUS RENAL REPLACEMENT THERAPY CLINICAL CONSIDERATIONSCHAPTER 7. Effect of Liver Disease on Pharmacokinetics; HEPATIC ELIMINATION OF DRUGS; EFFECTS OF LIVER DISEASE ON PHARMACOKINETICS; USE OF THERAPEUTIC DRUGS IN PATIENTS WITH LIVER DISEASE; CHAPTER 8. Noncompartmental versus Compartmental Approaches to Pharmacokinetic Analysis; INTRODUCTION; KINETICS, PHARMACOKINETICS, AND PHARMACOKINETIC PARAMETERS; NONCOMPARTMENTAL ANALYSIS; COMPARTMENTAL ANALYSIS; NONCOMPARTMENTAL VERSUS COMPARTMENTAL MODELS; CONCLUSION; CHAPTER 9. Distributed Models of Drug Kinetics; INTRODUCTION; CENTRAL ISSUES DRUG MODALITY I: DELIVERY ACROSS A PLANAR - TISSUE INTERFACEDRUG MODALITY II: DELIVERY FROM A POINT SOURCE - DIRECT INTERSTITIAL INFUSION; SUMMARY; CHAPTER 10. Population Pharmacokinetics; INTRODUCTION; ANALYSIS OF PHARMACOKINETIC DATA; POPULATION PHARMACOKINETICS; MODEL APPLICATIONS; CONCLUSIONS; PART II: DRUG METABOLISM AND TRANSPORT; CHAPTER 11. Pathways of Drug Metabolism; INTRODUCTION; PHASE I BIOTRANSFORMATIONS; PHASE II BIOTRANSFORMATIONS (CONJUGATIONS); ADDITIONAL EFFECTS ON DRUG METABOLISM; CHAPTER 12. Methods of Analysis of Drugs and Drug Metabolites; INTRODUCTION CHOICE OF ANALYTICAL METHODOLOGYCHROMATOGRAPHIC SEPARATIONS; ABSORPTION AND EMISSION SPECTROSCOPY; IMMUNOAFFINITY ASSAYS; MASS SPECTROMETRY; EXAMPLES OF CURRENT ASSAY METHODS; CHAPTER 13. Clinical Pharmacogenetics; INTRODUCTION; HIERARCHY OF PHARMACOGENETIC INFORMATION; IDENTIFICATION AND SELECTION OF OUTLIERS IN A POPULATION; EXAMPLES OF IMPORTANT GENETIC POLYMORPHISMS; CONCLUSIONS AND FUTURE DIRECTIONS; CHAPTER 14. Equilibrative and Concentrative Transport Mechanisms; INTRODUCTION; MECHANISMS OF TRANSPORT ACROSS BIOLOGICAL MEMBRANES; DESCRIPTION OF SELECTED MEMBRANE PROTEIN TRANSPORTERS ROLE OF TRANSPORTERS IN PHARMACOKINETICS AND DRUG ACTION |
| Record Nr. | UNINA-9910458649003321 |
| Amsterdam ; ; Oxford, : Academic, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.]
| Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Oxford, : Academic, c2007 |
| Descrizione fisica | 1 online resource (567 p.) |
| Disciplina | 615.1 |
| Soggetto topico |
Clinical pharmacology
Drugs |
| ISBN |
1-280-72891-4
9786610728916 0-08-046642-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Title page; Copyright page; Table of contents; Preface to the First Edition; Preface to the Second Edition; Contributors; CHAPTER 1. Introduction to Clinical Pharmacology; BACKGROUND; PHARMACOKINETICS; PART I: PHARMACOKINETICS; CHAPTER 2. Clinical Pharmacokinetics; THE TARGET CONCENTRATION STRATEGY; CONCEPTS UNDERLYING CLINICAL PHARMACOKINETICS; MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS; CHAPTER 3. Compartmental Analysis of Drug Distribution; PHYSIOLOGICAL SIGNIFICANCE OF DRUG DISTRIBUTION VOLUMES; PHYSIOLOGICAL BASIS OF MULTICOMPARTMENTAL MODELS OF DRUG DISTRIBUTION
CLINICAL CONSEQUENCES OF DIFFERENT DRUG DISTRIBUTION PATTERNSANALYSIS OF EXPERIMENTAL DATA; CHAPTER 4. Drug Absorption and Bioavailability; DRUG ABSORPTION; BIOAVAILABILITY; KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION; CHAPTER 5. Effects of Renal Disease on Pharmacokinetics; EFFECTS OF RENAL DISEASE ON DRUG ELIMINATION; EFFECTS OF RENAL DISEASE ON DRUG DISTRIBUTION; EFFECTS OF RENAL DISEASE ON DRUG ABSORPTION; CHAPTER 6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy; KINETICS OF INTERMITTENT HEMODIALYSIS; KINETICS OF CONTINUOUS RENAL REPLACEMENT THERAPY CLINICAL CONSIDERATIONSCHAPTER 7. Effect of Liver Disease on Pharmacokinetics; HEPATIC ELIMINATION OF DRUGS; EFFECTS OF LIVER DISEASE ON PHARMACOKINETICS; USE OF THERAPEUTIC DRUGS IN PATIENTS WITH LIVER DISEASE; CHAPTER 8. Noncompartmental versus Compartmental Approaches to Pharmacokinetic Analysis; INTRODUCTION; KINETICS, PHARMACOKINETICS, AND PHARMACOKINETIC PARAMETERS; NONCOMPARTMENTAL ANALYSIS; COMPARTMENTAL ANALYSIS; NONCOMPARTMENTAL VERSUS COMPARTMENTAL MODELS; CONCLUSION; CHAPTER 9. Distributed Models of Drug Kinetics; INTRODUCTION; CENTRAL ISSUES DRUG MODALITY I: DELIVERY ACROSS A PLANAR - TISSUE INTERFACEDRUG MODALITY II: DELIVERY FROM A POINT SOURCE - DIRECT INTERSTITIAL INFUSION; SUMMARY; CHAPTER 10. Population Pharmacokinetics; INTRODUCTION; ANALYSIS OF PHARMACOKINETIC DATA; POPULATION PHARMACOKINETICS; MODEL APPLICATIONS; CONCLUSIONS; PART II: DRUG METABOLISM AND TRANSPORT; CHAPTER 11. Pathways of Drug Metabolism; INTRODUCTION; PHASE I BIOTRANSFORMATIONS; PHASE II BIOTRANSFORMATIONS (CONJUGATIONS); ADDITIONAL EFFECTS ON DRUG METABOLISM; CHAPTER 12. Methods of Analysis of Drugs and Drug Metabolites; INTRODUCTION CHOICE OF ANALYTICAL METHODOLOGYCHROMATOGRAPHIC SEPARATIONS; ABSORPTION AND EMISSION SPECTROSCOPY; IMMUNOAFFINITY ASSAYS; MASS SPECTROMETRY; EXAMPLES OF CURRENT ASSAY METHODS; CHAPTER 13. Clinical Pharmacogenetics; INTRODUCTION; HIERARCHY OF PHARMACOGENETIC INFORMATION; IDENTIFICATION AND SELECTION OF OUTLIERS IN A POPULATION; EXAMPLES OF IMPORTANT GENETIC POLYMORPHISMS; CONCLUSIONS AND FUTURE DIRECTIONS; CHAPTER 14. Equilibrative and Concentrative Transport Mechanisms; INTRODUCTION; MECHANISMS OF TRANSPORT ACROSS BIOLOGICAL MEMBRANES; DESCRIPTION OF SELECTED MEMBRANE PROTEIN TRANSPORTERS ROLE OF TRANSPORTERS IN PHARMACOKINETICS AND DRUG ACTION |
| Record Nr. | UNINA-9910784647603321 |
| Amsterdam ; ; Oxford, : Academic, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.]
| Principles of clinical pharmacology [[electronic resource] /] / Arthur J. Atkinson, Jr. ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Oxford, : Academic, c2007 |
| Descrizione fisica | 1 online resource (567 p.) |
| Disciplina | 615.1 |
| Soggetto topico |
Clinical pharmacology
Drugs |
| ISBN |
1-280-72891-4
9786610728916 0-08-046642-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Title page; Copyright page; Table of contents; Preface to the First Edition; Preface to the Second Edition; Contributors; CHAPTER 1. Introduction to Clinical Pharmacology; BACKGROUND; PHARMACOKINETICS; PART I: PHARMACOKINETICS; CHAPTER 2. Clinical Pharmacokinetics; THE TARGET CONCENTRATION STRATEGY; CONCEPTS UNDERLYING CLINICAL PHARMACOKINETICS; MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS; CHAPTER 3. Compartmental Analysis of Drug Distribution; PHYSIOLOGICAL SIGNIFICANCE OF DRUG DISTRIBUTION VOLUMES; PHYSIOLOGICAL BASIS OF MULTICOMPARTMENTAL MODELS OF DRUG DISTRIBUTION
CLINICAL CONSEQUENCES OF DIFFERENT DRUG DISTRIBUTION PATTERNSANALYSIS OF EXPERIMENTAL DATA; CHAPTER 4. Drug Absorption and Bioavailability; DRUG ABSORPTION; BIOAVAILABILITY; KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION; CHAPTER 5. Effects of Renal Disease on Pharmacokinetics; EFFECTS OF RENAL DISEASE ON DRUG ELIMINATION; EFFECTS OF RENAL DISEASE ON DRUG DISTRIBUTION; EFFECTS OF RENAL DISEASE ON DRUG ABSORPTION; CHAPTER 6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy; KINETICS OF INTERMITTENT HEMODIALYSIS; KINETICS OF CONTINUOUS RENAL REPLACEMENT THERAPY CLINICAL CONSIDERATIONSCHAPTER 7. Effect of Liver Disease on Pharmacokinetics; HEPATIC ELIMINATION OF DRUGS; EFFECTS OF LIVER DISEASE ON PHARMACOKINETICS; USE OF THERAPEUTIC DRUGS IN PATIENTS WITH LIVER DISEASE; CHAPTER 8. Noncompartmental versus Compartmental Approaches to Pharmacokinetic Analysis; INTRODUCTION; KINETICS, PHARMACOKINETICS, AND PHARMACOKINETIC PARAMETERS; NONCOMPARTMENTAL ANALYSIS; COMPARTMENTAL ANALYSIS; NONCOMPARTMENTAL VERSUS COMPARTMENTAL MODELS; CONCLUSION; CHAPTER 9. Distributed Models of Drug Kinetics; INTRODUCTION; CENTRAL ISSUES DRUG MODALITY I: DELIVERY ACROSS A PLANAR - TISSUE INTERFACEDRUG MODALITY II: DELIVERY FROM A POINT SOURCE - DIRECT INTERSTITIAL INFUSION; SUMMARY; CHAPTER 10. Population Pharmacokinetics; INTRODUCTION; ANALYSIS OF PHARMACOKINETIC DATA; POPULATION PHARMACOKINETICS; MODEL APPLICATIONS; CONCLUSIONS; PART II: DRUG METABOLISM AND TRANSPORT; CHAPTER 11. Pathways of Drug Metabolism; INTRODUCTION; PHASE I BIOTRANSFORMATIONS; PHASE II BIOTRANSFORMATIONS (CONJUGATIONS); ADDITIONAL EFFECTS ON DRUG METABOLISM; CHAPTER 12. Methods of Analysis of Drugs and Drug Metabolites; INTRODUCTION CHOICE OF ANALYTICAL METHODOLOGYCHROMATOGRAPHIC SEPARATIONS; ABSORPTION AND EMISSION SPECTROSCOPY; IMMUNOAFFINITY ASSAYS; MASS SPECTROMETRY; EXAMPLES OF CURRENT ASSAY METHODS; CHAPTER 13. Clinical Pharmacogenetics; INTRODUCTION; HIERARCHY OF PHARMACOGENETIC INFORMATION; IDENTIFICATION AND SELECTION OF OUTLIERS IN A POPULATION; EXAMPLES OF IMPORTANT GENETIC POLYMORPHISMS; CONCLUSIONS AND FUTURE DIRECTIONS; CHAPTER 14. Equilibrative and Concentrative Transport Mechanisms; INTRODUCTION; MECHANISMS OF TRANSPORT ACROSS BIOLOGICAL MEMBRANES; DESCRIPTION OF SELECTED MEMBRANE PROTEIN TRANSPORTERS ROLE OF TRANSPORTERS IN PHARMACOKINETICS AND DRUG ACTION |
| Record Nr. | UNINA-9910813758003321 |
| Amsterdam ; ; Oxford, : Academic, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||