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Antiviral drugs : aspects of clinical use and recent advances / / edited by Patrick Arbuthnot
| Antiviral drugs : aspects of clinical use and recent advances / / edited by Patrick Arbuthnot |
| Autore | Arbuthnot Patrick |
| Pubbl/distr/stampa | IntechOpen, 2012 |
| Descrizione fisica | 1 online resource (208 pages) : illustrations |
| Disciplina | 616.925061 |
| Soggetto topico |
Antiviral agents
Virus diseases - Chemotherapy |
| Soggetto non controllato | Pharmacology |
| ISBN | 953-51-6885-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antiviral drugs |
| Record Nr. | UNINA-9910138348803321 |
Arbuthnot Patrick
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| IntechOpen, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910464383103321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910786928003321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910817216603321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||