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Antiviral drugs : aspects of clinical use and recent advances / / edited by Patrick Arbuthnot
| Antiviral drugs : aspects of clinical use and recent advances / / edited by Patrick Arbuthnot |
| Autore | Arbuthnot Patrick |
| Pubbl/distr/stampa | IntechOpen, 2012 |
| Descrizione fisica | 1 online resource (208 pages) : illustrations |
| Disciplina | 616.925061 |
| Soggetto topico |
Antiviral agents
Virus diseases - Chemotherapy |
| Soggetto non controllato | Pharmacology |
| ISBN | 953-51-6885-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antiviral drugs |
| Record Nr. | UNINA-9910138348803321 |
Arbuthnot Patrick
|
||
| IntechOpen, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Gene therapy for viral infections / / Patrick Arbuthnot, Wits and South African Medical Research Council, Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa
| Gene therapy for viral infections / / Patrick Arbuthnot, Wits and South African Medical Research Council, Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa |
| Autore | Arbuthnot Patrick |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (391 p.) |
| Disciplina | 616.042 |
| Soggetto topico |
Gene therapy
Genetic vectors |
| ISBN | 9780124114524 (ProQuest Ebook Central) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Gene Therapy for Viral Infections; Copyright; Dedication; Contents; Acknowledgments; Chapter 1 - Essentials of Viruses and their Suitability for Treatment Using Gene Therapy; 1.1 GENE THERAPY; 1.2 ESSENTIALS OF VIRUSES; 1.3 VIRAL PATHOGENESIS OF DISEASE; 1.4 IMMUNE RESPONSES TO VIRUS INFECTIONS; 1.5 MUTATION OF VIRUSES; 1.6 CONTROL OF VIRAL INFECTION; 1.7 METHODS OF USING GENE THERAPY TO TREAT VIRAL INFECTIONS; REFERENCES; Chapter 2 - Harnessing RNAi to Silence Viral Gene Expression; 2.1 INTRODUCTION; 2.2 BIOGENESIS OF MIRS IN MAMMALIAN CELLS
2.3 EXPLOITING RNAI TO SILENCE VIRAL GENE EXPRESSIONTO COUNTER VIRAL INFECTIONS; REFERENCES; Chapter 3 - Engineering Sequence-Specific DNA Binding Proteins for Antiviral Gene Editing; 3.1 INTRODUCTION; 3.2 ZINC FINGER PROTEINS; 3.3 TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS; 3.4 HOMING ENDONUCLEASES; 3.5 CRISPR/CAS; 3.6 DELIVERY OF CUSTOMIZED SEQUENCE-SPECIFIC DNA BINDING PROTEINS FOR ANTIVIRAL THERAPEUTIC APPLICATION; 3.7 USE OF SITE-SPECIFIC DNA TARGETING FOR TREATMENT OF VIRAL INFECTIONS; 3.8 CONCLUSIONS; REFERENCES; Chapter 4 - Viral Vectors for Delivery of Antiviral Sequences 4.1 INTRODUCTION4.2 ADENO-ASSOCIATED VIRAL VECTORS; 4.3 ADENOVIRAL VECTORS; 4.4 LENTIVIRAL AND RETROVIRAL VECTORS; 4.5 USE OF VIRAL VECTORS FOR DEVELOPING TREATMENT VIRAL INFECTIONS; 4.6 CONCLUSIONS; REFERENCES; Chapter 5 - Delivery of Antiviral Nucleic Acids with Nonviral Vectors; 5.1 INTRODUCTION; 5.2 CONSIDERATIONS FOR OPTIMIZING NVV-MEDIATED DELIVERY OF THERAPEUTIC NUCLEIC ACIDS TO VIRUS-INFECTED CELLS; DELIVERED WITH NVVS; 5.4 CATEGORIES OF NVVS; 5.5 CONCLUSIONS; REFERENCES; Chapter 6 - Gene Therapy for Chronic Hepatitis B Virus Infection; 6.1 INTRODUCTION 6.2 GENE THERAPY FOR HBV INFECTIONOF HBV INFECTION; SILENCING HBV REPLICATION; 6.5 GENE EDITING FOR THE INACTIVATION OF VIRAL CCCDNA; 6.6 CONCLUSIONS; REFERENCES; Chapter 7 - Gene Therapy for Hepatitis C Virus Infection; 7.1 DISCOVERY OF HEPATITIS C VIRUS; OF HCV INFECTION; 7.3 HCV GENOME AND VIRAL REPLICATION; 7.4 MODELS OF HCV INFECTION; 7.5 CURRENT AND NEW HCV TREATMENT; 7.6 COUNTERING HCV WITH NUCLEIC ACIDS; 7.7 CONCLUSIONS; REFERENCES; Chapter 8 - Gene Therapy for HIV-1 Infection; IN RESEARCH ON HIV; 8.2 EPIDEMIOLOGY OF HIV-1 INFECTION; 8.3 PROTEINS ENCODED BY HIV-1 8.4 REPLICATION OF HIV-18.5 PATHOGENESIS OF AIDS; HIV-1 INFECTION; 8.7 MODELS OF HIV-1 REPLICATION; 8.8 GENE THERAPY FOR HIV-1 INFECTION; 8.9 CONCLUSIONS; REFERENCES; Chapter 9 - Gene Therapy for Respiratory Viral Infections; 9.1 INTRODUCTION; 9.2 RESPIRATORY SYNCYTIAL VIRUS; 9.3 INFLUENZA VIRUS; 9.4 SARS COV; VIRAL INFECTIONS; 9.6 CONCLUSIONS; REFERENCES; Chapter 10 - Gene Therapy for Infection with Hemorrhagic Fever Viruses; 10.1 INTRODUCTION; 10.2 FILOVIRIDAE; 10.3 DENGUE VIRUS; FEVER VIRUSES; 10.5 CONCLUSIONS; REFERENCES Chapter 11 - Gene Transfer for Prophylaxis and Therapy of Viral Infections |
| Record Nr. | UNINA-9910788269803321 |
|
Arbuthnot Patrick
|
||
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Gene therapy for viral infections / / Patrick Arbuthnot, Wits and South African Medical Research Council, Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa
| Gene therapy for viral infections / / Patrick Arbuthnot, Wits and South African Medical Research Council, Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa |
| Autore | Arbuthnot Patrick |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (391 p.) |
| Disciplina | 616.042 |
| Soggetto topico |
Gene therapy
Genetic vectors |
| ISBN | 9780124114524 (ProQuest Ebook Central) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Gene Therapy for Viral Infections; Copyright; Dedication; Contents; Acknowledgments; Chapter 1 - Essentials of Viruses and their Suitability for Treatment Using Gene Therapy; 1.1 GENE THERAPY; 1.2 ESSENTIALS OF VIRUSES; 1.3 VIRAL PATHOGENESIS OF DISEASE; 1.4 IMMUNE RESPONSES TO VIRUS INFECTIONS; 1.5 MUTATION OF VIRUSES; 1.6 CONTROL OF VIRAL INFECTION; 1.7 METHODS OF USING GENE THERAPY TO TREAT VIRAL INFECTIONS; REFERENCES; Chapter 2 - Harnessing RNAi to Silence Viral Gene Expression; 2.1 INTRODUCTION; 2.2 BIOGENESIS OF MIRS IN MAMMALIAN CELLS
2.3 EXPLOITING RNAI TO SILENCE VIRAL GENE EXPRESSIONTO COUNTER VIRAL INFECTIONS; REFERENCES; Chapter 3 - Engineering Sequence-Specific DNA Binding Proteins for Antiviral Gene Editing; 3.1 INTRODUCTION; 3.2 ZINC FINGER PROTEINS; 3.3 TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS; 3.4 HOMING ENDONUCLEASES; 3.5 CRISPR/CAS; 3.6 DELIVERY OF CUSTOMIZED SEQUENCE-SPECIFIC DNA BINDING PROTEINS FOR ANTIVIRAL THERAPEUTIC APPLICATION; 3.7 USE OF SITE-SPECIFIC DNA TARGETING FOR TREATMENT OF VIRAL INFECTIONS; 3.8 CONCLUSIONS; REFERENCES; Chapter 4 - Viral Vectors for Delivery of Antiviral Sequences 4.1 INTRODUCTION4.2 ADENO-ASSOCIATED VIRAL VECTORS; 4.3 ADENOVIRAL VECTORS; 4.4 LENTIVIRAL AND RETROVIRAL VECTORS; 4.5 USE OF VIRAL VECTORS FOR DEVELOPING TREATMENT VIRAL INFECTIONS; 4.6 CONCLUSIONS; REFERENCES; Chapter 5 - Delivery of Antiviral Nucleic Acids with Nonviral Vectors; 5.1 INTRODUCTION; 5.2 CONSIDERATIONS FOR OPTIMIZING NVV-MEDIATED DELIVERY OF THERAPEUTIC NUCLEIC ACIDS TO VIRUS-INFECTED CELLS; DELIVERED WITH NVVS; 5.4 CATEGORIES OF NVVS; 5.5 CONCLUSIONS; REFERENCES; Chapter 6 - Gene Therapy for Chronic Hepatitis B Virus Infection; 6.1 INTRODUCTION 6.2 GENE THERAPY FOR HBV INFECTIONOF HBV INFECTION; SILENCING HBV REPLICATION; 6.5 GENE EDITING FOR THE INACTIVATION OF VIRAL CCCDNA; 6.6 CONCLUSIONS; REFERENCES; Chapter 7 - Gene Therapy for Hepatitis C Virus Infection; 7.1 DISCOVERY OF HEPATITIS C VIRUS; OF HCV INFECTION; 7.3 HCV GENOME AND VIRAL REPLICATION; 7.4 MODELS OF HCV INFECTION; 7.5 CURRENT AND NEW HCV TREATMENT; 7.6 COUNTERING HCV WITH NUCLEIC ACIDS; 7.7 CONCLUSIONS; REFERENCES; Chapter 8 - Gene Therapy for HIV-1 Infection; IN RESEARCH ON HIV; 8.2 EPIDEMIOLOGY OF HIV-1 INFECTION; 8.3 PROTEINS ENCODED BY HIV-1 8.4 REPLICATION OF HIV-18.5 PATHOGENESIS OF AIDS; HIV-1 INFECTION; 8.7 MODELS OF HIV-1 REPLICATION; 8.8 GENE THERAPY FOR HIV-1 INFECTION; 8.9 CONCLUSIONS; REFERENCES; Chapter 9 - Gene Therapy for Respiratory Viral Infections; 9.1 INTRODUCTION; 9.2 RESPIRATORY SYNCYTIAL VIRUS; 9.3 INFLUENZA VIRUS; 9.4 SARS COV; VIRAL INFECTIONS; 9.6 CONCLUSIONS; REFERENCES; Chapter 10 - Gene Therapy for Infection with Hemorrhagic Fever Viruses; 10.1 INTRODUCTION; 10.2 FILOVIRIDAE; 10.3 DENGUE VIRUS; FEVER VIRUSES; 10.5 CONCLUSIONS; REFERENCES Chapter 11 - Gene Transfer for Prophylaxis and Therapy of Viral Infections |
| Record Nr. | UNINA-9910816283703321 |
|
Arbuthnot Patrick
|
||
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||