Blombäck's Essential Guide to Blood Coagulation : A Practical Guide to Diagnosis and Treatment of Hemostatic Disorders

• Autore: Antovic Jovan P
• Pubblicazione: Newark : , : John Wiley & Sons, Incorporated, , 2025; ©2025
• Edizione: 3rd ed.
• Descrizione fisica: 1 online resource (258 pages)
• Disciplina: 616.157
• Altri autori: MagnussonMaria
• Nota di contenuto: Cover -- Title Page -- Copyright Page -- Dedication -- Contents -- Contributors -- Preface -- Abbreviations -- PART 1 General hemostasis -- CHAPTER 1 Overview of normal hemostasis -- CHAPTER 2 Sampling instructions and preanalytical issues in hemostasis -- Points to note prior to blood sampling -- Sampling time and patient preparation -- Referrals for coagulation analyses -- Sampling -- Preparation before sampling -- Sampling technique -- Sample handling -- Centrifugation -- Storage -- Selected References -- CHAPTER 3 Laboratory investigation -- Nomenclature -- Screening analyses -- cB/B-platelet particle concentration/platelet count (PLT) -- p/B/cB-prothrombin time (PT [INR]) -- Spontaneous increase or decrease in PT (INR) -- Point-of-care cB-PT (INR) -- P-activated partial thromboplastin time (APTT) -- Point-of-care cB-APTT -- Point-of-care cB-ACT -- P-fibrin D-dimer (DDI) and S-fibrin(ogen) degradation products (FDP) -- Point-of-care cB/P-fibrin-D-dimer -- P-fibrinogen -- Point-of-care cB-fibrinogen -- B-bleeding time according to Ivy (BT) -- S-soluble fibrin (SF) and fibrin monomers (FM) -- P-antithrombin (AT) -- P-anti-factor Xa analysis (aFXa)/anti-Xa analysis (aXa) -- P-anti-factor IIa analysis (aFIIa)/direct thrombin inhibition assays (DTI) -- P-thrombin time (TT) -- Special analyses -- Coagulation factors -- Protein C anticoagulant system -- Antiphospholipid syndrome -- Thrombotic microangiopathies -- Fibrinolysis -- Markers of coagulation activation (hypercoagulation markers) -- Platelet assays -- B-platelet indices (MPV, PDW) -- B-immature platelet fraction (IPF) -- B/PRP-platelet light transmission aggregometry (LTA) -- B-platelet flow cytometry -- PRP-platelet transmission electron microscopy (PTEM) -- B-multiple impedance aggregometry (Multiplate®) -- Point-of-care B-VerifyNowTM. ; Point-of-care B-platelet function analyzer (PFA-100/INNOVANCE® PFA-200) -- Genetic testing -- Genetic testing for hemophilia A and B -- Genetic testing for VWD -- Genetic testing for other hereditary bleeding disorders including platelet defects -- Genetic testing for thrombophilia -- Global hemostatic assays -- Endogenous thrombin potential (ETP) -- Overall hemostatic potential (OHP) -- Viscoelastic testing -- Useful assays in research studies -- P-tissue factor (TF) -- P/S-extracellular vesicles (EVs) -- P/S-neutrophil extracellular traps (NETs) -- Fibrin structure -- P-C1-esterase inhibitor -- P-protein C inhibitor -- P-APC-protein C inhibitor (PCI) complex -- P-thrombin activatable fibrinolysis inhibitor (TAFI) -- P-tissue factor pathway inhibitor (TFPI) -- P-thrombomodulin (TM) -- P-plasmin-plasmin inhibitor complex (PAP) -- P-plasminogen activator, tissue type (t-PA) -- P-t-PA/PAI-1 complex -- Other nonhemostatic variables of importance -- S-cytokines -- P-complement -- S-lipoprotein(a) (Lp[a]), P-apolipoprotein -- Selected References -- PART 2 Bleeding disorders -- CHAPTER 4 Clinical and laboratory investigation of increased bleeding tendency -- Introduction -- Clinical investigation -- Bleeding history -- Family history -- Other medical conditions -- Concomitant medications -- Physical examination -- Laboratory investigations -- Laboratory investigations -- Screening assays -- Confirmatory assays -- Genetic testing -- Nondetectable conditions in laboratory tests despite positive bleeding history -- Selected References -- Hereditary bleeding disorders -- CHAPTER 5 Hemophilia -- Introduction -- Bleeding symptoms in hemophilia -- Treatment -- Prophylaxis -- Nonfactor replacement therapy -- Immune tolerance induction -- Antibodies against emicizumab -- Treatment of bleeding events -- Pain relievers. ; Clinical follow-up of patients with bleeding disorders -- Selected References -- CHAPTER 6 Von Willebrand disease -- Introduction -- Classification -- Diagnosis -- Management -- On-demand treatment -- Prophylaxis -- Surgery -- Pain treatment -- Follow-up -- Selected References -- CHAPTER 7 Rare bleeding disorders including inherited platelet function defects -- Inherited platelet function defects -- Background -- Diagnosis -- Management -- Very rare coagulation factor deficiencies -- Fibrinogen deficiency -- Factor II (prothrombin) deficiency -- Factor V deficiency -- Combined factor V and factor VIII defect -- Factor VII deficiency -- Factor X deficiency -- Factor XI deficiency (hemophilia C) -- Factor XIII deficiency -- Vitamin K-dependent coagulation factor deficiency (VKDCFD) -- Vascular bleeding disorders -- Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu) -- Ehlers-Danlos syndrome (EDS) -- Bleeding disorder of unknown cause (BDUC) -- Background -- Diagnosis -- Management -- Selected References -- CHAPTER 8 Specific issues of hemostasis in children - focus on bleeding -- Developmental hemostasis -- Bleeding in children -- Vitamin K deficiency bleeding -- Coagulation factor deficiencies -- Hemophilia A and B -- Rare hereditary coagulation factor disorders -- Acquired coagulation factor deficiencies -- Platelet function defects and thrombocytopenia -- Platelet function defects -- Thrombocytopenia -- Selected References -- CHAPTER 9 Hereditary bleeding disorders and aging -- Cardiovascular disease (CVD) -- Atrial fibrillation -- Atherosclerotic cardiovascular disease (ASCVD) -- Management of incident coronary artery disease -- Cancer -- Chronic kidney disease -- Selected references -- CHAPTER 10 Paradigm change - new treatment for hereditary bleeding disorders -- Coagulation factor concentrates -- Nonfactor replacement therapy. ; Factor VIII-mimicking agents -- Rebalancing agents -- Gene therapy -- Selected References -- Acquired bleeding disorders -- CHAPTER 11 Acquired inhibitors of coagulation factors -- Acquired hemophilia -- Background -- Diagnosis -- Management -- Treatment of bleeding -- Eradication of antibodies -- Follow-up -- Relapse -- Acquired von Willebrand disease -- Background -- Diagnosis -- Management -- Selected References -- Critical Bleedings -- CHAPTER 12 Critical bleeding in trauma and surgery -- Background -- Pathophysiology, resuscitation, and surgical management of traumatic bleeding -- Judicious volume replacement aimed at maintaining adequate circulating blood volume -- A blood product transfusion strategy aimed at preventing and treating coagulopathy -- Avoiding acidosis, hypothermia, and hypocalcemia -- Surgical control of the bleeding -- Management of acute bleeding in surgery -- Treatment protocols -- Pediatric considerations -- Selected References -- CHAPTER 13 Gastrointestinal bleeding -- Background -- Diagnosis -- Disease history and symptom assessment -- Physical examination -- Acute management -- Immediate actions -- Early pharmacological treatment -- Diagnostic-therapeutic procedures -- Endoscopy -- Angiography -- Surgery -- Secondary prophylaxis after GI bleeding -- Considerations regarding hemostasis in GI bleeding -- Selected References -- CHAPTER 14 Intracranial bleeding -- Intracerebral hemorrhage -- Background -- Causes and risk factors -- Diagnosis -- Management -- Subarachnoid hemorrhage -- Background -- Causes and risk factors -- Diagnosis -- Management -- Traumatic brain injury -- Background -- Management -- Selected References -- CHAPTER 15 Obstetric massive bleeding -- Background -- Management -- Specific treatments -- Follow-up -- Selected References. ; CHAPTER 16 Bleedings associated with anticoagulant and antiplatelet treatment (including reversal of antithrombotic treatment) -- Background -- Antiplatelet drugs -- Anticoagulant therapy -- Combination of anticoagulant and antiplatelet therapies -- Management -- Selected References -- PART 3 Thromboembolic disorders -- Venous thrombosis -- CHAPTER 17 Venous thromboembolism -- Background -- Risk factor review -- Diagnosis -- Clinical signs and symptoms -- Differential diagnoses from clinical assessment -- Assessing probability for incident VTE -- Diagnostic imaging -- Management -- VTE severity assessment -- Clinical symptoms -- Location and size -- Echocardiography -- Biomarkers -- Bleeding risk -- Short-term prognostic stratification -- Treatment -- Follow-up and secondary prevention -- Further investigations to consider -- Hereditary thrombophilia -- Antiphospholipid syndrome (APS) -- Malignancy screening -- Rare underlying causes -- Hyperhomocysteinemia -- Myeloproliferative neoplasms -- Paroxysmal nocturnal hemoglobinuria -- Continued follow-up -- Selected References -- CHAPTER 17.1 Cerebral venous thrombosis -- Background -- Causes and risk factors -- Diagnosis -- Clinical presentation -- Imaging -- Blood tests -- Management -- Selected References -- Anticoagulation -- Endovascular and surgical treatment -- Papillary edema -- Selected References -- CHAPTER 17.2 Splanchnic vein thrombosis -- Background -- Diagnosis -- Imaging -- Laboratory tests -- Pathology -- Endoscopy -- Management -- Treatment of acute/recent portal vein thrombosis without liver cirrhosis (nontumoral) -- Treatment of chronic portal vein thrombosis without liver cirrhosis -- Treatment of portal vein thrombosis in liver cirrhosis -- Treatment of Budd-Chiari syndrome -- Selected References -- CHAPTER 18 Specific issues of hemostasis in children - focus on thrombosis. ; Background.
• Sommario/riassunto: New edition of a concise, comprehensive, easy-to-read pocket book distilling the most clinically up-to-date information on thrombotic and bleeding disorders In a concise manner, Blombäck's Essential Guide to Blood Coagulation distills the most clinically up-to-date information on thrombotic and bleeding disorders, including the latest treatment.
• Titolo autorizzato: Blombäck's Essential Guide to Blood Coagulation
• ISBN: 1-394-22315-3; 1-394-22313-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9911027077003321
• Lo trovi qui: Univ. Federico II