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Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity / / edited by Richard A. Anderson, Norah Spears
| Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity / / edited by Richard A. Anderson, Norah Spears |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (164 p.) |
| Disciplina | 616.994 |
| Soggetto topico |
Cancer
Cancer - Treatment - Complications Ovaries - Cancer - Diagnosis Ovaries - Cancer - Treatment |
| ISBN |
0-12-801601-9
0-12-801591-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Cancer Treatment and the Ovary; Copyright Page; Contents; List of Contributors; Foreword; Introduction; I. Clinical; 1 Ovarian Follicle Biology and the Basis for Gonadotoxicity; 1.1 Overview of Ovarian Function; 1.2 Ovarian Development; 1.3 Molecular Mechanisms Controlling Primordial Follicle Activation; 1.4 Local Control of Early Follicle Development; 1.5 Endocrine Control of Later Follicle Development; 1.6 Reproductive Lifespan and the Ovarian Primordial Follicle Reserve; 1.7 Germ Cell Sensitivity to Cell Death; 1.8 Conclusion; References
2 Relevant Cancer Diagnoses, Commonly Used Chemotherapy Agents and Their Biochemical Mechanisms of Action2.1 Introduction; 2.2 Impact of Radiotherapy on Future Female Fertility; 2.3 Impact of Chemotherapy on Future Female Fertility; 2.4 Mechanisms of Action of the Commonly Used Chemotherapy Drugs; 2.4.1 Alkylating Agents; 2.4.2 Antimetabolites; 2.4.3 Antitumour Antibiotics; 2.4.4 Mitotic Inhibitors; 2.4.5 Platinum Drugs; 2.4.6 Topoisomerase Inhibitors; 2.4.7 High-Dose Chemotherapy; 2.4.8 Targeted Therapies; References; 3 Clinical Assessment of Ovarian Toxicity; 3.1 Introduction 3.2 The Use of Chemotherapy-Related Amenorrhoea3.3 Biomarkers of the Ovarian Reserve; 3.4 AMH and Determination of Gonadotoxicity; 3.4.1 After Chemotherapy; 3.4.2 Prospective Analyses; 3.4.3 Measurement of AMH; 3.4.4 AMH in Paediatric Oncology; 3.4.5 AMH and Prediction of Reproductive Lifespan and Fertility; 3.5 Conclusion; Acknowledgement; References; 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment; 4.1 Introduction; 4.2 Risk Factors for Premature Ovarian Insufficiency After Chemotherapy; 4.2.1 Age; 4.2.2 Type of Chemotherapy 4.2.3 Combined Treatment Protocols4.2.3.1 Breast Cancer; 4.2.3.2 Hodgkin Lymphoma; 4.2.3.3 Non-Hodgkin Lymphoma; 4.2.3.4 Leukaemia; 4.2.3.5 Role of Gonadotropin-Releasing Hormone Analogues for the Preservation of Ovarian Function; 4.3 How do Chemotherapeutics Damage The Ovary?; 4.4 The Relevance of BRCA Mutations to Ovarian Damage After Chemotherapy; 4.5 Conclusion; References; II. Laboratory Models; 5 In Vivo Models of Ovarian Toxicity; 5.1 Introduction; 5.2 Rodent Models of Chemotherapy-Induced Follicular Depletion and Ovoprotection; 5.2.1 Chemotherapy-Induced Follicular Depletion 5.2.2 Cell-Type Specificity of Chemotherapy Toxicity5.2.3 Ovarian Toxicity Lessons from Ovoprotection Studies; 5.2.4 Rodent Studies of Ovarian Chemotherapy Toxicity Compared to Data from Clinical Studies; 5.2.5 Transgenerational Toxicity of Chemotherapy; 5.3 Primate Models of Chemotherapy-Induced Ovarian Toxicity and Ovoprotection; 5.4 Conclusion; References; 6 In Vitro Models of Ovarian Toxicity; 6.1 Introduction; 6.2 Why Use Culture Systems?; 6.3 What Culture Systems are Available?; 6.4 Human and other Primate Model Studies of Ovarian Chemotherapy Toxicity 6.5 Rodent Model Studies of Ovarian Chemotherapy Toxicity |
| Record Nr. | UNINA-9910797335903321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity / / edited by Richard A. Anderson, Norah Spears
| Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity / / edited by Richard A. Anderson, Norah Spears |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (164 p.) |
| Disciplina | 616.994 |
| Soggetto topico |
Cancer
Cancer - Treatment - Complications Ovaries - Cancer - Diagnosis Ovaries - Cancer - Treatment |
| ISBN |
0-12-801601-9
0-12-801591-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Cancer Treatment and the Ovary; Copyright Page; Contents; List of Contributors; Foreword; Introduction; I. Clinical; 1 Ovarian Follicle Biology and the Basis for Gonadotoxicity; 1.1 Overview of Ovarian Function; 1.2 Ovarian Development; 1.3 Molecular Mechanisms Controlling Primordial Follicle Activation; 1.4 Local Control of Early Follicle Development; 1.5 Endocrine Control of Later Follicle Development; 1.6 Reproductive Lifespan and the Ovarian Primordial Follicle Reserve; 1.7 Germ Cell Sensitivity to Cell Death; 1.8 Conclusion; References
2 Relevant Cancer Diagnoses, Commonly Used Chemotherapy Agents and Their Biochemical Mechanisms of Action2.1 Introduction; 2.2 Impact of Radiotherapy on Future Female Fertility; 2.3 Impact of Chemotherapy on Future Female Fertility; 2.4 Mechanisms of Action of the Commonly Used Chemotherapy Drugs; 2.4.1 Alkylating Agents; 2.4.2 Antimetabolites; 2.4.3 Antitumour Antibiotics; 2.4.4 Mitotic Inhibitors; 2.4.5 Platinum Drugs; 2.4.6 Topoisomerase Inhibitors; 2.4.7 High-Dose Chemotherapy; 2.4.8 Targeted Therapies; References; 3 Clinical Assessment of Ovarian Toxicity; 3.1 Introduction 3.2 The Use of Chemotherapy-Related Amenorrhoea3.3 Biomarkers of the Ovarian Reserve; 3.4 AMH and Determination of Gonadotoxicity; 3.4.1 After Chemotherapy; 3.4.2 Prospective Analyses; 3.4.3 Measurement of AMH; 3.4.4 AMH in Paediatric Oncology; 3.4.5 AMH and Prediction of Reproductive Lifespan and Fertility; 3.5 Conclusion; Acknowledgement; References; 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment; 4.1 Introduction; 4.2 Risk Factors for Premature Ovarian Insufficiency After Chemotherapy; 4.2.1 Age; 4.2.2 Type of Chemotherapy 4.2.3 Combined Treatment Protocols4.2.3.1 Breast Cancer; 4.2.3.2 Hodgkin Lymphoma; 4.2.3.3 Non-Hodgkin Lymphoma; 4.2.3.4 Leukaemia; 4.2.3.5 Role of Gonadotropin-Releasing Hormone Analogues for the Preservation of Ovarian Function; 4.3 How do Chemotherapeutics Damage The Ovary?; 4.4 The Relevance of BRCA Mutations to Ovarian Damage After Chemotherapy; 4.5 Conclusion; References; II. Laboratory Models; 5 In Vivo Models of Ovarian Toxicity; 5.1 Introduction; 5.2 Rodent Models of Chemotherapy-Induced Follicular Depletion and Ovoprotection; 5.2.1 Chemotherapy-Induced Follicular Depletion 5.2.2 Cell-Type Specificity of Chemotherapy Toxicity5.2.3 Ovarian Toxicity Lessons from Ovoprotection Studies; 5.2.4 Rodent Studies of Ovarian Chemotherapy Toxicity Compared to Data from Clinical Studies; 5.2.5 Transgenerational Toxicity of Chemotherapy; 5.3 Primate Models of Chemotherapy-Induced Ovarian Toxicity and Ovoprotection; 5.4 Conclusion; References; 6 In Vitro Models of Ovarian Toxicity; 6.1 Introduction; 6.2 Why Use Culture Systems?; 6.3 What Culture Systems are Available?; 6.4 Human and other Primate Model Studies of Ovarian Chemotherapy Toxicity 6.5 Rodent Model Studies of Ovarian Chemotherapy Toxicity |
| Record Nr. | UNINA-9910811681603321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||