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Practical process research and development [[electronic resource] ] : a guide for organic chemists / / Neal G. Anderson
| Practical process research and development [[electronic resource] ] : a guide for organic chemists / / Neal G. Anderson |
| Autore | Anderson Neal G |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston, : Academic Press, 2012 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina | 541/.39 |
| Altri autori (Persone) | AndersonNeal G |
| Soggetto topico | Chemical processes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-73506-7
0-12-386538-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY
REFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS III. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES Chapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS VII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS VI. TEMPERATURE CONTROL |
| Record Nr. | UNINA-9910461560403321 |
Anderson Neal G
|
||
| Amsterdam ; ; Boston, : Academic Press, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical process research and development [[electronic resource] ] : a guide for organic chemists / / Neal G. Anderson
| Practical process research and development [[electronic resource] ] : a guide for organic chemists / / Neal G. Anderson |
| Autore | Anderson Neal G |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston, : Academic Press, 2012 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina | 541/.39 |
| Altri autori (Persone) | AndersonNeal G |
| Soggetto topico | Chemical processes |
| ISBN |
1-283-73506-7
0-12-386538-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY
REFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS III. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES Chapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS VII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS VI. TEMPERATURE CONTROL |
| Record Nr. | UNINA-9910790145503321 |
|
Anderson Neal G
|
||
| Amsterdam ; ; Boston, : Academic Press, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical process research and development : a guide for organic chemists / / Neal G. Anderson
| Practical process research and development : a guide for organic chemists / / Neal G. Anderson |
| Autore | Anderson Neal G |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston, : Academic Press, 2012 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina | 541/.39 |
| Altri autori (Persone) | AndersonNeal G |
| Soggetto topico | Chemical processes |
| ISBN |
1-283-73506-7
0-12-386538-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY
REFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS III. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES Chapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS VII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS VI. TEMPERATURE CONTROL |
| Record Nr. | UNINA-9910826948203321 |
|
Anderson Neal G
|
||
| Amsterdam ; ; Boston, : Academic Press, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||