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Current and Future Advances in Male Infertility : A Compendium for Clinicians and Researchers
Current and Future Advances in Male Infertility : A Compendium for Clinicians and Researchers
Autore Agarwal Ashok
Edizione [1st ed.]
Pubbl/distr/stampa Cham : , : Springer International Publishing AG, , 2024
Descrizione fisica 1 online resource (405 pages)
Altri autori (Persone) SalehRamadan
BoitrelleFlorence
ShahRupin
ISBN 3-031-62648-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Foreword -- Preface -- Contents -- About the Editors -- Part I: Declining Male Reproductive Health -- Chapter 1: Clinical Implications of the WHO 6th Edition on Human Semen Analysis -- Introduction -- Sperm Analysis as Part of the Initial Workup for Infertile Couples -- Basic Sperm Parameters -- Extended Examination -- Multiple Sperm Defect Indices -- Sperm DNA Fragmentation -- Sperm Fluorescence In Situ Hybridization (FISH) -- Leukocytospermia -- Anti-sperm Antibodies (ASAs) -- Seminal Biochemistry -- Ejaculate Fraction -- Advanced Tests -- Seminal Oxidative Stress -- Acrosome Reaction -- Sperm Chromatin Condensation -- Transmembrane Ion Flow -- CASA Systems -- Conclusion -- References -- Chapter 2: Endocrine-Disrupting Chemicals (EDCs) and Male Infertility -- Introduction -- Endocrine-Disrupting Chemicals (EDCs) -- Polychlorinated Biphenyls (PCBs) -- Dichlorodiphenyltrichloroethane (DDT) and Its Main Metabolite (DDE) -- Bisphenol A (BPA) -- Phthalates (DBP, DEHP) -- EDCs and Semen Quality -- Mechanism(s) of Action on EDCs on the Male Reproductive System -- Disorders Associated with EDCs in the Male -- Cryptorchidism -- Hypospadias -- Testicular Cancer -- Transgenerational Effects of EDCs -- Epigenetic Alterations to the Fetus -- Genetic Disruptions of Spermatogenesis -- Limitations of Research on EDCs -- Future Research on EDCs and Male Infertility -- Summary -- References -- Chapter 3: Lifestyle Modifications and Male Infertility -- Introduction -- Lifestyle Factors Affecting Male Infertility -- Obesity -- Diet -- Smoking -- Alcohol Consumption -- Caffeine -- Performance-Enhancing Drug Usage -- Recreational Substance Abuse -- Sport/Physical Activity -- Electromagnetic/Radiofrequency Exposure -- Heat Stress -- Psychological Stress and Anxiety -- Mechanisms by Which Lifestyle Factors Affect Male Fertility -- Seminal Oxidative Stress.
Direct Testicular Toxicity -- Germ Cell Changes -- Histopathological Changes -- Hormonal Mechanisms -- Nutritional Imbalances -- Genetic Mechanisms -- Effects of Lifestyle Changes on Semen Quality and Male Fertility -- Conclusion -- References -- Chapter 4: Impact of Testicular Cancer on Male Fertility -- Introduction -- Mechanisms of Infertility in TC -- Direct Parenchymal Damage and Replacement by the Tumor -- Correlative Etiologies -- Cryptorchidism -- Testicular Dysgenesis Syndrome -- Causative Mechanisms -- Endocrine Disruption and Hypogonadism -- Systemic Inflammation due to TC -- Antisperm Antibodies -- Elevated DNA Fragmentation -- Prior to the Treatment with Chemotherapy and/or Radiation Therapy -- Posttreatment with Radiation Therapy and/or Chemotherapy -- Relationship of Testicular Cancer Treatment and Infertility -- Orchidectomy/RPLND and Fertility -- Chemotherapy and Fertility -- Radiation Therapy and Fertility -- Sexual Dysfunction in Survivors of TC -- Contraception During Treatment: Paternity After Treatment -- Summary -- References -- Part II: Sperm Chromatin Integrity and Fertility -- Chapter 5: Impact of Sperm DNA Fragmentation on Natural and Assisted Conception -- Introduction -- Sperm DNA Natural Repair Mechanisms -- Origin of SDF -- Defective Sperm Chromatin Packaging -- Abortive Apoptosis -- Oxidative Stress-Mediated Damage -- Types of SDF -- What Causes SDF? -- Impact of SDF on Fertility Outcome -- Spontaneous Pregnancy Outcomes -- Outcomes of Assisted Reproductive Techniques -- Selecting a Test for SDF Evaluation -- Terminal Deoxynucleotidyl Transferase-Mediated Deoxyuridine Triphosphate Nick End Labeling (TUNEL) Assay -- Sperm Chromatin Structure Assay (SCSA) -- Sperm Chromatin Dispersion (SCD) Test -- Comet Assay -- Implementing SDF Test into Clinical Practice -- The SDF Test in the WHO Manual of Semen Analysis.
The SDF Test in the Guidelines of Professional Societies -- Limitations of SDF Test -- Strategies to Reduce SDF -- Limiting Exposures and Lifestyle Change -- Control of Male Genital Tract Infections/Inflammation -- Varicocele Repair -- Antioxidant Supplementation -- Management of Persistently High SDF -- Use of Testicular Sperm -- Use of Sperm Selection Techniques -- Summary -- References -- Part III: Male Oxidative Stress Infertility (MOSI) -- Chapter 6: Pathophysiology of Seminal Oxidative Stress -- Introduction -- Role of Reactive Oxygen Species and Oxidative Stress in Male Infertility -- The Physiological Role of ROS in Sperm Cells -- Maturation -- Capacitation -- Acrosome Reaction -- Sperm-Oocyte Fusion -- Pathological Role of ROS in Sperm Cells -- Lipid Peroxidation -- Sperm DNA Fragmentation -- Apoptosis -- Mitochondrial Dysfunction -- ROS Sources in Seminal Plasma -- Redox Status in Semen -- Methods to Assess Redox Status -- Redox Biomarkers of Male Infertility -- Treatment of OS-Related Male Infertility -- Insights into Future Redox Biomarker Research -- Summary -- References -- Chapter 7: Management of Male Oxidative Stress Infertility (MOSI) -- Introduction -- Causes of OS and Male Infertility -- Intrinsic Causes -- Extrinsic Causes -- Diagnosis of MOSI -- Semen Analysis -- ROS Assays -- Total Antioxidant Capacity -- ROS-TAC Score -- Oxidative Reduction Potential -- Treatment of Male Oxidative Stress Infertility -- Empiric Medical Therapy -- Antioxidants -- Arginine -- Carnitines -- Coenzyme Q10 -- Folic Acid -- Glutathione -- Lycopene -- Selenium -- Vitamin A -- Vitamin C -- Vitamin E -- Zinc -- Lifestyle and Dietary Modification -- Obesity -- Antibiotics -- Varicocele Repair -- New Strategies -- Summary -- References -- Part IV: Genetics and Epigenetics of Male Infertility -- Chapter 8: Advances in Genetics of Male Infertility.
Introduction -- Chromosomal Alterations -- Epigenetic Factors -- Advances in Genetic Testing for Male Infertility -- Chromosomal Alteration Testing -- Gene Panel Testing and Next-Generation Sequencing Approaches -- Impact of Genetic Mutations on Male Infertility Management -- Congenital Hypogonadotropic Hypogonadism (cHH) -- Congenital Absent Vas Deferens (CAVD) -- Teratozoospermia and Asthenozoospermia -- Impaired Sperm Capacitation and Fertilizing Capacity -- Quantitative Spermatogenic Disturbances -- Gene Therapy -- Conclusion -- References -- Chapter 9: Epigenetic Alterations in Male Infertility -- Narrative Review -- Introduction -- Epigenetic Mechanisms -- DNA Methylation (CpG Sites) -- Histone Modification -- Chromatin Remodelling -- Small Non-coding RNAs -- Epigenetics and Sperm -- Epigenetics in Spermatogenesis -- Factors Contributing to Epigenetic Changes in Sperm -- Techniques to Assess Sperm Epigenetics -- Epigenetic Alterations in Male Infertility -- Impact on Fertility -- Impact on Semen Parameters -- Impact on ART Outcomes -- Epigenetic Inheritance and Impact on Offspring Health -- Insights into the Future Research of Epigenetic Alterations in Male Infertility -- SWOT (Strengths, Weaknesses, Opportunities and Threats) Analysis of the Current Research on Epigenetics -- Prospects for Future Research on Epigenetics -- Summary -- References -- Part V: Varicocele Revisited -- Chapter 10: New Insights into the Pathophysiology of Varicocele in Male Infertility -- Introduction -- Animal Models to Study the Pathophysiology of Varicoceles -- Laboratory Finding Associated with the Pathophysiology of Varicoceles -- Anatomic Hypotheses of Origin of Varicoceles -- Scrotal Hyperthermia -- Hormonal Disturbances -- Hypoperfusion of the Testis -- Metabolic Reflux to the Testis -- Genetics of Varicocele Pathophysiology -- Sperm Proteomics.
Effect of Varicocele on Testicular Function -- Varicocele and Conventional Semen Analysis -- Varicocele and Oxidative Stress -- Varicocele and Antisperm Antibodies -- Varicocele and Sperm Vitality -- Varicocele and Sperm Capacitation -- Varicocele and Sperm Binding to Zona Pellucida -- Varicocele and Sperm DNA Fragmentation -- Summary -- References -- Chapter 11: Clinical Dilemmas and Controversies in Varicocele Management -- Controversies in Diagnosis -- Clinical Versus Ultrasonographic Diagnosis and Grading -- Guidelines for Varicocele Diagnosis -- Controversies in Counseling -- Evaluating the Real Impact of Varicocele on Male Fertility -- Clinical Varicocele in the Context of Normal Conventional Semen Parameters -- Role of Varicocele Repair (VR) in the Context of ART -- Varicocele and Hypogonadism -- Varicocele and NOA -- Varicocele in Adolescence -- Varicocele and Scrotal Pain -- Controversies in Therapy -- Indications for Intervention -- Other Indications -- Elevated SDF -- Prior to ART -- NOA and Prior to Sperm Retrieval -- Hypogonadism -- Intervention: Which Technique to Select? -- Reference Technique (Subinguinal Microsurgical Varicocelectomy) -- Subclinical Varicocele: To Treat or Not to Treat? -- Bilateral Versus Unilateral VR -- Age of the Couple -- Role of Medical and AOX-Based Therapy -- Controversies in Posttreatment Evaluation -- Role of Ultrasound in Post-VR Evaluation -- Optimal Duration to Assess Post-VR Changes in Semen Parameters -- Managing Recurrent and Persistent Varicocele -- Future Perspectives -- Clinical Case Scenario -- Answer -- Clinical Case Scenario 2 -- Answer -- Summary -- References -- Part VI: Management of Male Accessory Gland Infection (MAGI) -- Chapter 12: Challenges in the Diagnosis and Treatment of Male Accessory Gland Infection (MAGI) -- Introduction -- Microbiological Investigations in MAGI.
Diagnostic Workup of MAGI.
Record Nr. UNINA-9910878974203321
Agarwal Ashok  
Cham : , : Springer International Publishing AG, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Human Semen Analysis : From the WHO Manual to the Clinical Management of Infertile Men
Human Semen Analysis : From the WHO Manual to the Clinical Management of Infertile Men
Autore Agarwal Ashok
Edizione [1st ed.]
Pubbl/distr/stampa Cham : , : Springer International Publishing AG, , 2024
Descrizione fisica 1 online resource (380 pages)
Altri autori (Persone) BoitrelleFlorence
SalehRamadan
ShahRupin
ISBN 9783031553370
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Foreword -- Preface -- Contents -- About the Editors -- Part I: WHO Manual for Human Semen Analysis -- 1: Historical View: From First to the Sixth WHO Manual -- Introduction -- Major Advances in Each of the WHO Editions -- What Is New in the Sixth Edition of the WHO Manual of Semen Analysis? -- Practical Considerations and Expert Opinion -- References -- Part II: Basic Semen Examinations in Clinical Practice -- 2: Role of Semen Examination in the Couple's Fertility Assessment -- Introduction -- Semen Analysis in the Initial Work-Up of the Infertile Couple -- Basic Semen Parameters -- Extended Tests -- Advanced Tests -- Conclusions -- References -- 3: Macroscopic Semen Parameters -- Introduction -- Physiology of Human Ejaculate -- Macroscopic Parameters of Semen: Methodological Considerations -- Collection of Semen Samples -- Liquefaction of Semen -- Viscosity of Semen -- Semen Colour -- Hemospermia -- Semen Odour -- Semen pH -- Semen Volume -- Summary -- References -- 4: Sperm Concentration and Total Sperm Count -- Introduction -- Physiology: Methodology of Sperm Concentration and Total Sperm Count Testing -- Explaining the Test -- Significance of Sperm Count -- Natural Variation -- More Than One Test May Be Required -- Special Measures If Count Is Very Low -- Sperm Count/Concentration and Diagnosis of Fertility and Infertility -- Reference Ranges Employed by the WHO Manual -- Sperm Count/Concentration and Etiological Diagnosis of Male Reproductive Functions and Dysfunction -- Causes Implied in Sperm Count/Concentration Decreasing -- Sperm Count/Concentration Planning of Further Investigations -- Sperm Count/Concentration and Non-ART Management: Treatment and Treatment Response Monitoring -- Management of Oligozoospermic Patient Using Hormonal Treatment -- Management of Oligozoospermic Patient Using Antioxidants.
Management of Oligozoospermic Patient with Varicocelectomy -- Sperm Count/Concentration and ART Management: Guide ART Choice -- ART for Oligozoospermia -- IUI -- IVF/ICSI -- Cryopreservation -- Surgical Sperm Retrieval -- Two Clinical Scenarios -- Case 1 -- Case 2 -- References -- 5: Sperm Motility -- Introduction -- Physiology: Methodology of Sperm Motility Testing -- Sperm Motility and Diagnosis of Fertility and Infertility -- Sperm Motility and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Flagellar/Ciliary Defects and Sperm Motility -- Energy-Driven Concept of Sperm Motility -- Sperm Motility and Lifestyle and Environmental Factors -- The Role of Ion Channels in Sperm Motility -- Genetic Contribution to Sperm Motility -- Role of Sexual Abstinence -- Drugs Affecting Sperm Motility -- Heat Exposure and Sperm Motility -- Psychological Stress Affecting Sperm Motility -- Infection and Sperm Motility -- Sperm Motility and Planning Further Investigations -- Oxidative Stress Evaluation -- Genetic Testing -- Structural Sperm Abnormalities -- Ion Transport Channels -- Mitochondrial Gene Mutations -- Antisperm Antibody (ASA) Testing -- Microbiological Investigation -- Sperm Motility and Non-ART Management: Treatment and Treatment Response Monitoring -- Varicocele Repair for Isolated Asthenozoospermia -- Sperm Motility and ART Management: Guide to ART Choice -- Threshold for IUI in Male Factor Infertility -- Thresholds for IVF -- In Vitro Enhancement of Motility -- Absolute Asthenozoospermia Vs. Absolute Necrozoospermia -- Flagellar Dyskinesia and Primary Ciliary Dyskinesia (PCD) -- Clinical Scenarios -- Case Scenario 1 -- Case Scenario 2 -- Clinical Decision Tree -- ART Management of Male Factor Infertility (Oligoasthenospermia): After Non-ART management has failed (A and B) -- A. Considerations for IUI for Oligoasthenospermia.
B. ART Considerations for Severe Oligoasthenospermia -- ART Considerations for Absolute Necrozoospermia -- ART Considerations for Absolute Asthenozoospermia -- Non-ART Management of Asthenospermia -- References -- 6: Sperm Vitality -- Introduction -- Physiology: Methodology of Sperm Vitality Testing -- Tests for Sperm Vitality Assessment -- Sperm Vitality and Diagnosis of Fertility and Infertility -- Sperm Vitality and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Ageing -- Tobacco -- Alcohol -- Overweight and Metabolic Syndrome -- Endocrinopathies -- Medications -- Radiofrequencies and Radiations -- Environmental and Occupational Pollutants -- Genital Infections -- Systemic Infections -- Urological Disease -- Varicocele -- Sperm Vitality and Planning of Further Investigations -- Sperm Vitality and Non-ART Management: Treatment and Treatment Response Monitoring -- Modifiable Risk Factors Corrections -- Repeated Ejaculation -- Antibiotic Therapy -- Varicocele Correction -- Antioxidants -- Timing for Reassessment -- Sperm Vitality and ART Management: Guide ART Choice -- Two Clinical Scenarios -- Clinical Scenario #1 -- How Should the Patient Be Managed? -- Clinical Scenario #2 -- How Should the Patient Be Managed? -- References -- 7: Sperm Morphology -- Introduction -- Physiology: Methodology of Sperm morphology Testing -- Sperm Morphology and Diagnosis of Fertility and Infertility -- Sperm Morphology and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Tobacco and Cannabis -- Alcohol Consumption -- Overweight/Obesity -- Environmental and Occupational Pollutants -- Varicocele -- Infections -- Testicular Cancer -- Diabetes -- Genetic Causes -- Sperm Morphological Abnormalities -- Globozoospermia -- Macrozoospermia -- Microcephalic and Thin Heads -- Tapered Sperm Head.
Pinhead/Acephalic/Decapitated Spermatozoa -- Excess Residual Cytoplasm -- Sperm Tail Abnormalities -- Sperm Morphology and Planning of Further Investigations -- Sperm Morphology and Non-ART Management: Treatment and Treatment Response Monitoring -- Sperm Morphology and ART Management: Guiding ART Choices -- Have We Become Too Strict? -- Testicular Versus Ejaculated Sperm -- The Correlation of Sperm Morphological Profile and Particular Clinical Conditions -- Definition and Types of Multiple Sperm Defects -- The Clinical Importance of Reporting All of the Morphological Abnormalities -- Two Clinical Scenarios -- Case 1 -- Case 2 -- References -- 8: Sperm Agglutination -- Introduction -- Physiology: Methodology of Sperm Agglutinates Testing -- Direct Antiglobulin Test -- Mixed Antiglobulin Reaction (MAR) Test -- The Immunobead Test (IB) -- Indirect Antiglobulin Test -- Limitation of the Test -- ASAB and Male Reproductive Function and Dysfunction -- Risk Factors of ASAB Formation -- Varicocele -- Vasectomy -- Infection -- Other Uncommon Risk Factors for ASAB Formation -- Potential Targets of ASAB -- ASAB and Diagnosis of Fertility and Infertility -- Reference Ranges Used by the WHO Manual of Semen Analysis -- Scoring of Agglutination -- ASAB and Planning of Further Investigations -- Management of ASAB -- ASAB and ART Outcome -- Clinical Scenarios -- Case 1 -- Case 2 -- Future Perspectives -- References -- 9: Leukocytospermia and Bacteriospermia -- Introduction -- Relationship of Bacteriospermia and Leukocytospermia -- Impact of Bacteriospermia on Male Reproductive Function -- Impact of Leukocytospermia on Male Fertility Potential -- Clinical Significance of Leukocytospermia -- Types of Round Cells -- Methods for Identifying Seminal Leukocytes -- Peroxidase Tests -- Ortho-Toluidine Test -- Endtz Test -- Immunochemistry -- Seminal Granulocyte Elastase Test.
Is the Threshold of 1 × 106 WBC/ml Semen Reliable for Defining Leukocytospermia? -- Management of Leukocytospermia in the Context of Male Infertility -- Follow-Up of Leukocytospermia Cases -- Role of Assisted Reproductive Techniques in the Treatment of Infertile Men with Leukocytospermia -- Swim-Up -- Glass Wool Filtration -- Mechanical Filtration -- Density Gradient Centrifugation -- Microfluidics -- Impact of Leukocytospermia on ART Outcome -- Decisional Tree/Clinical Guide for Non-ART and ART Management of Leukocytospermia is presented in  Figs. 9.1 and 9.2, Respectively -- Clinical Scenarios -- Clinical Scenario 1 -- Clinical Scenario 2 -- References -- Part III: Extended Examinations in Clinical Practice -- 10: Sperm DNA Fragmentation -- Introduction -- Pathophysiology of SDF and Methodology of SDF Testing -- Relationship Between Sperm DNA Test Results and Reproductive Outcomes -- SDF and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- SDF and Further Investigations -- SDF: Non-ART Management -- SDF and ART Management: Guide ART Choice -- Short Abstinence -- Advanced Sperm Processing Techniques -- Use of Testicular Sperm for ICSI in Men with High Levels of Sperm DNA Fragmentation -- Two Case Scenarios -- References -- 11: Genetic Screening for Sperm Aneuploidy by Fluorescent In Situ Hybridization (FISH) in Severe Cases of Male Infertility -- Introduction -- Chromosomal Content in Sperm, How to Measure It -- How Sperm Ploidy Is Related with Male Fertility -- Baseline Sperm Aneuploidies in Normozoospermic and Fertile Controls -- Sperm Aneuploidies in Infertile Males -- Sperm Aneuploidies in Low Quality Sperm Samples -- Reproductive Outcomes in ART from Men Presenting Sperm Aneuploidies -- Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Patients with Increased Sperm Aneuploidy.
Solving Reproductive Problems Linked with Sperm Aneuploidy.
Record Nr. UNINA-9910874655903321
Agarwal Ashok  
Cham : , : Springer International Publishing AG, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Proteomics in Human Reproduction : Biomarkers for Millennials / / by Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui
Proteomics in Human Reproduction : Biomarkers for Millennials / / by Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui
Autore Agarwal Ashok
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (XV, 124 p. 9 illus.)
Disciplina 572.6
Collana SpringerBriefs in Reproductive Biology
Soggetto topico Reproductive medicine
Proteomics
Bioinformatics
Reproductive Medicine
ISBN 3-319-48418-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Proteomics -- Proteomics and Male Infertility -- Role of Proteomics in Female Infertility -- Proteomics in Assisted Reproduction -- Challenges of Proteomic Studies in Human Reproduction -- What Does the Future Hold? -- Conclusions.
Record Nr. UNINA-9910155274903321
Agarwal Ashok  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Strategies to Ameliorate Oxidative Stress During Assisted Reproduction / / by Ashok Agarwal, Damayanthi Durairajanayagam, Gurpriya Virk, Stefan S. Du Plessis
Strategies to Ameliorate Oxidative Stress During Assisted Reproduction / / by Ashok Agarwal, Damayanthi Durairajanayagam, Gurpriya Virk, Stefan S. Du Plessis
Autore Agarwal Ashok
Edizione [1st ed. 2014.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (67 p.)
Disciplina 616.69206
Collana SpringerBriefs in Reproductive Biology
Soggetto topico Reproductive medicine
Embryology
Reproductive Medicine
ISBN 3-319-10259-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Sources of ROS in ART -- Antioxidant Strategies -- Role of Combined Antioxidants -- Conclusion.
Record Nr. UNINA-9910298338703321
Agarwal Ashok  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui