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Antibody fc [[electronic resource]] : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody fc [[electronic resource]] : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (376 p.) |
| Disciplina | 616.07/93 |
| Altri autori (Persone) | NimmerjahnFalk |
| Soggetto topico |
Fc receptors
Immune response Anti-antibodies |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910452543403321 |
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910779973903321 |
|
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910820381203321 |
|
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||