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From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential
| From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential |
| Autore | Ribaudo Giovanni |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (234 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
SARS-CoV-2
benzoic acid derivatives gallic acid molecular docking reactivity parameters selenoxide elimination one-pot imine-enamine reaction mechanism DFT calculations selenium anti-inflammatory drugs QSAR pain management cyclooxygenase multitarget drug cannabinoid neuropathic pain clopidogrel NMR study oxone peroxymonosulfate sodium halide thienopyridine drug discovery precision medicine pharmacodynamics pharmacokinetics coronavirus SARS-CoV-2 COVID-19 3-chymotrypsin-like protease pyrimidonic pharmaceuticals molecular dynamics simulations binding free energy β-carrageenan antioxidant activity Box-Behken extraction Eucheuma gelatinae physic-chemistry rheology quercetin quercetin 3-O-glucuronide cisplatin nephrotoxicity cytoprotection lithium therapy neurocytology toxicology neuroprotection chemoinformatics big data methadone hydrochloride pharmaceutical solutions drug compounding high performance liquid chromatography stability study microbiology fucoidan alginate L-selectin E-selectin MCP-1 ICAM-1 THP-1 macrophage monocyte migration protein binding breast milk M/P ratio statistical modeling molecular descriptors chromatographic descriptors affinity chromatography anti-ACE anti-DPP-IV gastrointestinal digestion in silico molecular dynamics paramyosin seafood target fishing |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | From a Molecule to a Drug |
| Record Nr. | UNINA-9910585940503321 |
Ribaudo Giovanni
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Drug Research in China: Selected Papers from the 15-NASMD Conference
| Marine Drug Research in China: Selected Papers from the 15-NASMD Conference |
| Autore | Zhou Xuefeng |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (512 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Antarctic krill (Euphausia superba)
peptide antioxidant activity stability oyster plasma peptidome antimicrobial peptides cytotoxicity actinomycete piericidins absolute configuration Pestalotiopsis heterocornis heterocornols anti-inflammatory activity sponge-derived fungus sclerotides lipodepsipeptide Aspergillus sclerotiorum nasopharyngeal carcinoma AChE inhibitory vascular endothelial cell flavonoid oxidized low-density lipoprotein Nrf2 apoptosis butyrolactone I food allergy metabolism pharmacokinetics actinomycin X2 microbial pigments dyeing silk antibacterial properties PD-L1 virtual screening pharmacophore modeling ADME molecular dynamics xanthones ascidian-derived fungus Diaporthe sp anti-glioma activity antiaging Sonneratia apetala signaling pathway Caenorhabditis elegans mutants coral-derived fungi Aspergillus hiratsukae meroterpenoids antibacterial activity cytotoxic activity deep-sea-derived fungus Aspergillus puniceus isoquinoline alkaloid protein tyrosine phosphatase inhibitor antibacterial Aspergillus sp geodin semisynthesize insecticidal activity Arca inflata antitumor peptide MAPK signaling calmodulin colorectal cancer methicillin-resistant Staphylococcus aureus actinomycin D Streptomyces parvulus mechanism mangrove endophytic Pestalotiopsis Sdy-1 antitumor activity Wnt signaling β-catenin eremophilane sesquiterpenoids mangrove-derived fungus Penicillium sp Oceanapia sponge secondary metabolites biological activities drug design anticancer cyclic pentapeptide galaxamide analogues skipjack tuna (Katsuwonus pelamis) muscle angiotensin-I-converting enzyme (ACE) peptide molecular docking nitric oxide (NO) endothelin-1 (ET-1) Trichoderma longibrachiatum sesquiterpene glycoside antimicrobial activity marine fungi Aspergillus unguis depsides depsidones osteoclast differentiation soft-coral-derived fungus pyranodipyran derivatives tyrosyl DNA phosphodiesterase 1 inhibitory activities fluorescent properties butenolides enantiomers Aspergillus terreus pancreatic lipase NAFLD fucoxanthin adenosine monophosphate-activated protein kinase (AMPK) nuclear factor erythroid-2-related factor 2-mediated (Nrf2) Toll-like receptor 4-mediated (TLR4) Aspergillus flavipes HN4-13 emodin macroporous resin XAD-16 adsorption kinetics and isotherms enrichment tetramic acid derivatives deep-sea fungus clavipitacae Lecanicillium fusisporum chronic kidney disease fucoidan cognitive dysfunction neuroinflammation oxidative stress GSK3β-Nrf2-HO-1 signaling microglial polarization deep-sea actinomycetes aromatic acids oximes antihyperlipidemic phycocyanin microbiota transcriptome IL-17 pathway Hahella prodiginine chejuenlide genome mining LC-MS/MS CDK4/6 marine compounds pharmacophore construction ADMET mm-pbsa |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Drug Research in China |
| Record Nr. | UNINA-9910595071903321 |
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Zhou Xuefeng
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications
| Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| Autore | Carvalho Violeta |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
protein biomarker
microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 |
| ISBN | 3-0365-6099-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639996703321 |
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Carvalho Violeta
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy
| Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy |
| Autore | Ruvo Menotti |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (278 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
porcine deltacoronavirus
nucleocapsid monoclonal antibodies neurodegenerative disorders affibody molecules blood–brain barrier receptor-mediated transcytosis transferrin receptor AL amyloidosis CD38 anti-CD38 MoAb Daratumumab Isatuximab myeloma BCMA bispecific T-cell engager antibody-drug conjugates chimeric antigen receptor T-cells belantamab mafodotin idecabtagene vicleucel JNJ-68284528 Mabs Antibody-Drug Conjugate cancer therapy drug targeting payload cross-linking antibody fragment Fab scFv E. coli YKL-40 CHI3L1 monoclonal antibody phage display lung metastasis prostate-specific membrane antigen in vivo imaging prostate cancer glutamate carboxypeptidase II NAALADase immunization antibody protocol guinea pig cDNA chimeric antigen receptor (CAR T) universal CAR T modular CAR T universal immune receptor CAR adaptor adoptive immunotherapy split CAR bispecific polyspecificity pharmacokinetics solubility aggregation viscosity developability stability affinity specificity protein engineering self-association non-specific binding immunogenicity antibody fragments single chain amyloid oligomer neurotoxicity NUsc1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557613003321 |
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Ruvo Menotti
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutraceutical, Nutrition Supplements and Human Health
| Nutraceutical, Nutrition Supplements and Human Health |
| Autore | Siddiqui Rafat A |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (348 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
Lactobacillus salivarius
otitis probiotic bacteriocin prevention Morus nigra L. black mulberry nutraceutical pharmacological properties coenzyme Q10 (CoQ10) bioavailability intestinal absorption neuroprotection fenugreek protein hydrolysate antiproliferative apoptosis antioxidant Caco2 cells catechins green tea extract herbal dietary supplements hepatotoxicity microbiome Streptococcus agalactiae GBS pregnancy cachexia plum cancer muscle wasting myoblasts protein synthesis graviola weight loss obesity blood glucose food composition metabolic syndrome natural products Carica papaya Bifidobacterium breve M-16V infant health clinical efficacy probiotics gut microbiota Autism spectrum disorder dietary supplements pediatric physician communication frankincense Boswellia boswellic acid lupeolic acid AKBA cytokine breast cancer pentacyclic triterpenic acid triterpenoid chorioallantoic membrane assay Platycodon grandiflorus root BMI body fat mass abdominal fat area wild rice metabolomics atherosclerosis LDL-r-KO mice cytokines 16S rDNA plasma feces proteins carbohydrates functional food curcumin formulated curcumin pharmacokinetics aurora kinase A hepatocellular carcinoma Dietary Supplement Label Database food description food classification FoodEx2 quelites supplementation arsenic vitamin K diet supplement age-related diseases vitamin K-dependent proteins pathological calcification inflammation skeletal muscles Bifidobacterium breve B-3 muscle mass mitochondria |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557507803321 |
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Siddiqui Rafat A
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pharmacogenomics and Personalized Medicine
| Pharmacogenomics and Personalized Medicine |
| Autore | Cecchin Erika |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (208 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
CYP2C9
VKORC1 warfarin warfarin initiation phase of therapy INR pharmacogenetics study pharmacogenomics pharmacogenetics genotype phenotype alleles precision medicine pharmacotranscriptomics high-throughput analysis childhood acute lymphoblastic leukemia clopidogrel acenocoumarol CDSS implementation azathioprine inflammatory bowel disease glutathione-S transferase pharmacokinetics nucleoside analogs microRNAs gene expression drug resistance AML cisplatin nephrotoxicity kidney injury genetic polymorphisms pre-emptive panel breast cancer subtype miRNA pathway crosstalk network precision drugs ovarian cancer platinum resistance focal copy number alterations whole exome sequencing personalized medicine human genetics pharmacology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557287703321 |
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Cecchin Erika
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Precision Medicine : Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy
| Precision Medicine : Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy |
| Autore | Turgeon Jacques |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Soggetto topico |
Medicine
Clinical & internal medicine |
| Soggetto non controllato |
fibromyalgia (FM)
myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) microRNA miRNome pharmacogenomics pharmacoepigenomics SM2miR Pharmaco-miR repoDB ME/CFS Common Data Elements (CDEs) dihydropyrimidine dehydrogenase DPYD 5-fluorouracil fluoropyrimidine therapeutic drug monitoring orthotopic liver transplant busulfan glutathione S-transferase genetic polymorphism limited sampling strategy pharmacokinetics clinical pharmacogenetics pharmacogenetic testing adverse drug reactions genotype phenotype pharmacogene barriers to pharmacogenetics implementation Sub-Saharan Africa chronic low back pain (cLBP) genetics personalized treatment polymorphism CYP450 tacrolimus CYP3A5 liver transplant pharmacogenomic minority data collection drug biomarker pharmacogenetics pharmacogenetic test personalized medicine gene expression infliximab adalimumab ulcerative colitis Crohn disease inflammatory bowel disease |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Precision Medicine |
| Record Nr. | UNINA-9910585940803321 |
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Turgeon Jacques
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Preclinical Evaluation of Lipid-Based Nanosystems
| Preclinical Evaluation of Lipid-Based Nanosystems |
| Autore | Silva Ana Catarina |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (351 p.) |
| Soggetto topico | Technology: general issues |
| Soggetto non controllato |
nanostructured lipid carriers (NLC)
formulation optimization rivastigmine quality by design (QbD) nasal route nose-to-brain N-alkylisatin liposome urokinase plasminogen activator PAI-2 SerpinB2 breast cancer liposomes target delivery nanosystem FZD10 protein colon cancer therapy supersaturation silica-lipid hybrid spray drying lipolysis lipid-based formulation fenofibrate mesoporous silica oral drug delivery hyaluronic acid drug release light activation stability mobility biocorona dissolution enhancement phospholipids solid dosage forms porous microparticles nanoemulsion(s) phase-behavior DoE D-optimal design vegetable oils non-ionic surfactants efavirenz flaxseed oil nanostructured lipid carriers nanocarrier docohexaenoic acid neuroprotection neuroinflammation fluconazole Box‒Behnken design nanotransfersome ulcer index zone of inhibition rheological behavior ex vivo permeation nanomedicine cancer doxorubicin melanoma drug delivery ultrasound contrast agents phospholipid coating ligand distribution cholesterol acoustic response microbubble lipid phase dialysis ammonia intoxication cyanocobalamin vitamin B12 atopic dermatitis psoriasis transferosomes lipid vesicles skin topical delivery oligonucleotide self-emulsifying drug delivery systems hydrophobic ion pairing intestinal permeation enhancers Caco-2 monolayer clarithromycin solid lipid nanoparticles optimization permeation pharmacokinetics follicular targeting dexamethasone alopecia areata lipomers lipid polymer hybrid nanocapsules biodistribution skin ethyl cellulose |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557544303321 |
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Silva Ana Catarina
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Progress and Recent Advances in Solid Organ Transplantation
| Progress and Recent Advances in Solid Organ Transplantation |
| Autore | Thongprayoon Charat |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (188 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
living donation
nephrectomy hand-assisted laparoscopic nephrectomy body composition complications simultaneous pancreas-kidney transplantation immunosuppression graft order sequence outcome survival kidney transplantation hydrogen diarrhea small intestinal bacterial overgrowth sickle cell disease sickle cell transplantation outcomes big data tacrolimus metabolism C/D ratio cholesterol dyslipidemia LDL-C liver transplantation hematuria chronic kidney disease tocilizumab clazakizumab desensitization anti-HLA alloantibody post traumatic growth psychiatric morbidity network analysis ESAS MINI CPC DCPR distress demoralization alexithymia anxiety antibody-mediated rejection recurrent primary disease renal transplantation pancreas transplantation cold ischemia time delayed graft function Eurotransplant Senior Program end-stage renal disease intensive care unit bioimpedance analysis drug dosing lean body mass index pharmacokinetics tacrolimus C/D ratio mineral bone disorder parathyroidectomy parathyroid hormone osteoporosis bone fractures Contrast-enhanced ultrasound kidney perfusion kidney function kidney donation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576885203321 |
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Thongprayoon Charat
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Qualitative and Quantitative Analysis of Bioactive Natural Products 2018
| Qualitative and Quantitative Analysis of Bioactive Natural Products 2018 |
| Autore | Marcotullio Maria Carla |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (374 p.) |
| Soggetto non controllato |
Scorzonera
capsaicinoids artificial neural network cerebral ischemia reperfusion injury antioxidant activity quality evaluation chemometrics secondary metabolites identification antioxidant capacity Moroccan region volatile compounds HPLC-Q-Exactive-Orbitrap-MS quantitative analysis amino acids content HPLC-ELSD antioxidant autophagy quantification sugars 1-triacontanol hemp seed oil Alzheimer’s disease macrodiolides extraction recycling preparative high performance liquid chromatography HPLC methods GC-MS Myristica fragrans Rossa da inverno sel. Rojo Duro onion cultivar fruit powders decursin food traceability ionic liquids separation optimisation Spondias spp C-glycosylflavone wine UPLC-MS scutellarein saffron carotenoids red cabbage hydrodistillation Ginkgo biloba Extract (GBE) gas chromatography organic acids olive leaves crocins CBD oil Bolbostemma paniculatum UPLC-ESI-MS/MS geographical origin HPLC traditional Chinese medicine decoction liquid chromatography bioactive natural compounds Podospermum metabolic profiling SPME-GC/MS LTQ-Orbitrap oral administration UPLC bioactive compounds Erigeron breviscapus extract terrain conditions nutmeg antibacterial activity method validation ShenFu prescription decoction chili decursinol angelate statistical evaluations stereoselective and simultaneous analysis curcuminoids Talaromyces pinophilus talarodiolide HPLC-Q-TOF-MS/MS Olea europaea L. triterpenes chromatogram-bioactivity correlation essential oil stability Staphylococcus aureus Iris lactea Pall. var. chinensis (Fisch.) Koidz endothelial function anthocyanins HPLC analysis liquid chromatography-mass spectrometry nodakenin turmerone UHPLC-MS/MS Quercus acuta leaf Curcuma longa UHPLC analysis ginseng berry extract geographical variation qualitative analysis Sorbus free radical-scavenging ginsenosides flavonoids biostimulant GC/MS terpenes aleuritolic acid phenolic compounds apoptosis response surface methodology phenolic acids pharmacokinetics mass spectrometry scutellarin multivariate statistical analysis phenolics MODDE experimental design proanthocyanidins UFLC-QQQ-MS rice cannabidiol odor-activity values UPLC-QTOF-MS turmeric decursinol |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346662303321 |
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Marcotullio Maria Carla
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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