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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (520 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
intrinsically disordered proteins
epiproteome disordered protein platform molecular recognition feature post-translational modifications physiological homeostasis stress response RIN4 p53 molecular machines intrinsically disordered protein membrane-less organelle neurodegenerative disease p300 HAT acetylation post-translational modification protein aggregation Tau fibrillation intrinsically disorder proteins disorder-to-order regions protein–RNA interactions unstructured proteins conformational plasticity disordered protein folding ribosomal protein spectroscopy protein stability temperature response protein thermostability salt bridges meta strategy dual threshold significance voting decision tree based artificial neural network protein intrinsic disorder intrinsic disorder intrinsic disorder prediction intrinsically disordered region protein conformation transcriptome RNA sequencing Microarray differentially regulated genes gene ontology analysis functional analysis intrinsically disordered structural disorder correlated mutations co-evolution evolutionary couplings residue co-variation interaction surface residue contact network dehydron homodimer hydrogen bond inter-subunit interaction ion pair mutual synergistic folding solvent-accessible surface area stabilization center MLL proteins MLL4 lncRNA HOTAIR MEG3 leukemia histone lysine methyltransferase RNA binding protein hydration wide-line 1H NMR secretion immune extracellular protein-protein interaction structural domain evolution transcription factors DNA-protein interactions Sox2 sequential DNA loading smFRET DNA conformational landscape sequential DNA bending transcription factor dosage oligomer N-terminal prion protein copper binding prion disease mutations Nuclear pore complex FG-Nups phosphorylation coarse-grained CABS model MC simulations statistical force fields protein structure intrinsically disordered proteins (IDPs) neurodegenerative diseases aggregation drugs drug discovery plant virus eIF4E VPg potyvirus molten globule fluorescence anisotropy protein hydrodynamics |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis
| Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis |
| Autore | Locatelli Marcello |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (308 p.) |
| Soggetto non controllato |
alginate
heavy metals high-speed counter-current chromatography (HSCCC) microwave processing phytochemicals microNIR antioxidant activity in-line monitoring Wuyi Rock tea metabolomics seawater optimization walnut septum color analysis metabolite profiling rosuvastatin dispersive liquid-liquid microextraction antioxidant mouse melanoma B16 cells nails extraction sample preparation quality MAE Panax notoginseng physicochemical properties flow injection ionic liquids branched-chain keto acids Semen Cuscutae near-infrared spectroscopy volatile organic compounds odor SFE single-drop microextraction experimental design cluster analysis therapeutic drug monitoring Thymus algeriensis metformin tyrosinase gas chromatography-olfactometry Ajuga genevensis phytosterols serum diabetes GHB polyphenols ultrasound assisted extraction microextraction oolong tea alkaloid minor ginsenosides inductively coupled plasma-mass spectrometry wood stir bar sorptive extraction HPLC-Q-TOF/MS GHB glucuronide Hericium erinaceuns mycelium endogenous values cultivars Tieguanyin tea cultivar SIRT1 modification HPLC-MS/MS fluid bed process steamed Panax notoginseng dry extract UPLC-QTOF MS flavonoids blood-enriching activity UPLC-QqQ MS HPLC-PDA neurodegenerative disease biological activity rare earth elements response surface methodology solid-phase microextraction Ultra-Turrax extraction bovine hide ultra-high-performance liquid chromatography tandem mass spectrometry gel strength hematopoiesis genistein muscle Lycium ruthenicun hemostatic activity flavonoid ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry HILIC surfactant saponins pigments chlorogenic acids daidzein Fe3O4 LC-MS Asphodeline lutea actinidin total polyphenolic content stir cake sorptive extraction gelatin ruthenicunoid A |
| ISBN | 3-03921-085-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346663903321 |
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Locatelli Marcello
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches
| Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches |
| Autore | Moro Enrico |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (301 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
mucopolysaccharidosis IIIB
quantitative proteomics NAGLU lysosomes Gaucher disease bone involvement enzyme replacement therapy substrate reduction therapy Osteoimmunology RANK/RANKL Osteopontin MIP-1β mucolipidosis II sortilin TGF-beta cathepsin D Fabry disease alpha-galactosidase A endocytosis lysosome IGF2R/M6P clathrin chloroquine lysosomal diseases precision medicine pharmacological chaperones gene therapy Pompe disease lysosomal targeting autophagy muscle satellite cells rhGAA glycogen lysosomal α-glucosidase GAA biomarker Gaucher Disease Wnt/β-catenin Dkk1 Wnt3a iPSC neuronopathy Krabbe disease Twitcher mouse psychosine visual system visual cortex astrogliosis mucopolysaccharidosis type I Hurler syndrome hematopoietic stem cell transplantations animal models experimental therapies axon guidance lysosomal storage disorders neuronal circuit α-galactosidase A A4GALT globotriaosylceramide (Gb3) globotriaosyl-sphingosine (lysoGb3) pharmacological chaperone therapy exosomes endocytic pathways neurodegenerative disease Parkinson disease lysosomal storage disorder viral vectors newborn screening variant interpretation second tier test tandem mass spectrometry lyso-Gb3 dried blood spot GLA gene globotriaosylsphingosine biomarkers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lysosomal Storage Disorders |
| Record Nr. | UNINA-9910557545503321 |
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Moro Enrico
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metals and neurodegeneration: Restoring the balance
| Metals and neurodegeneration: Restoring the balance |
| Autore | Katja M. Kanninen |
| Pubbl/distr/stampa | Frontiers Media SA, 2016 |
| Descrizione fisica | 1 electronic resource (132 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
Brain
neurodegenerative disease Neurons Metals Iron Copper Alzheimer's disease Zinc Manganese |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Metals and neurodegeneration |
| Record Nr. | UNINA-9910136796903321 |
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Katja M. Kanninen
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| Frontiers Media SA, 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metformin: Beyond Diabetes
| Metformin: Beyond Diabetes |
| Autore | Bost Frederic |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (134 p.) |
| Soggetto topico |
Medicine
Endocrinology |
| Soggetto non controllato |
metformin
cancer diabetes neurodegenerative disease mitochondria gut microbiota PCOS (polycystic ovarian syndrome) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Metformin |
| Record Nr. | UNINA-9910557670903321 |
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Bost Frederic
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondrial Dysfunction in Aging and Diseases of Aging
| Mitochondrial Dysfunction in Aging and Diseases of Aging |
| Autore | Haas Richard H |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto non controllato |
age-related diseases
sphingolipids glaucoma ALS neurodegeneration mitochondrial dysfunction adaptive immunity senescence de-emergence innate immunity cell danger response mitochondrial transfer axonal transport cytokines mitochondrial age-related macular degeneration prevention heart failure purinergic signaling autophagy Alzheimer's disease diabetic retinopathy proteostasis 1 immunosenescence Miro1 ROS metabolism optic nerve polypharmacy eIF2? Parkin coenzyme Q10 neurodegenerative disease DNA damage skin exercise nucleotide metabolism pasteur effect stress response inflammation retina drug-induced mitochondrial toxicity neuroinflammation exosomes reactive oxygen species 25(OH)D cardiomyopathy crabtree effect insulin resistance cardiovascular disease ageing genetic mutations metabokines mitochondria multiple sclerosis aerobic healing cycle SOD1 mitophagy PINK1 type 2 diabetes integrated cell stress response morbidity and mortality ultraviolet photoageing cancer aging 25(OH)2D lysosome NAD+ Parkinson's disease |
| ISBN | 3-03921-328-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367756303321 |
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Haas Richard H
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Chaperones and Neurodegeneration
| Molecular Chaperones and Neurodegeneration |
| Autore | Cintia Roodveldt |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
molecular chaperone
therapeutics neurodegenerative disease heat-shock response protein misfolding neuroprotection neurodegeneration heat-shock protein proteostasis amyloid protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910261132603321 |
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Cintia Roodveldt
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nanomaterials for Biomedical and Biotechnological Applications
| Nanomaterials for Biomedical and Biotechnological Applications |
| Autore | Ferraro Angelo |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (266 p.) |
| Soggetto topico |
Technology: general issues
Biotechnology |
| Soggetto non controllato |
neurodegenerative disease
cerium oxide nanoparticles Parkinson's disease oxidative stress physicochemical properties blood-brain barrier synthesis methods magnetic driving magnetic nanoparticles actuation system drug targeting chitosan clay nanocomposite films papain covalent immobilization wine magnetic gels drug release magnetic hyperthermia magnetic lipogels supramolecular hydrogels self-assembly nanoparticle functionalization organic and inorganic nanoparticles ophthalmic applications clinical trials orthopedic nanomedicine nanomodified surfaces animal model immune response Chlorella vulgaris microwave-synthesized magnetite particles response surface methodology harvesting process optimization optimization economic analysis plant design and process engineering cubic particles COVID-19 nanotechnology vaccines sanitizers biosensors restricted access media nanofibers microfibers on-line extraction biological samples column-switching chromatography theranostic nanomaterials boron nitride neutron capture reaction nuclear medicine drug delivery antibiotics antimicrobial resistance gold nanoparticles ciprofloxacin Enterococcus faecalis liver and kidney infections colorectal cancer biomarkers cytotoxic medication genetic pathways epigenetic changes prognostic phytomedicine rheumatoid arthritis methotrexate anti-arthritic activity nanoemulsion hemocompatibility MTT assay stability studies |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585937903321 |
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Ferraro Angelo
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Neuroprotection
| Natural Products and Neuroprotection |
| Autore | Angeloni Cristina |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (338 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Vitamin D
Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson's disease terpenes, rotenone thymol Alzheimer's disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood-brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients' autonomy beneficence nonmaleficence medical liability Parkinson's disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557705603321 |
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Angeloni Cristina
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neuronal Development and Degeneration
| Neuronal Development and Degeneration |
| Autore | Zhang Wenbo |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (161 p.) |
| Soggetto topico |
Science: general issues
Neurosciences |
| Soggetto non controllato |
neuronal development
degeneration retina brain neurodegenerative disease |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557207603321 |
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Zhang Wenbo
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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