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Isolation and Identification of Bioactive Secondary Metabolites
| Isolation and Identification of Bioactive Secondary Metabolites |
| Autore | Seca Ana Maria Loureiro da |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (272 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
coumarins
Lycium metabolomic HPLC-MS orbitrap secondary metabolites endemic plants olive leaves supercritical fluid extraction antioxidants hyperuricemia plant-based functional food xanthine oxidase adenosine deaminase uric acid transporter bioactive compound Piper pseudoarboreum bioassay-guided fractionation leishmanicidal activity alkamides (E)-piplartine Wedelia chinensis organic farming phytotoxic substances vanillic acid gallic acid Origanum subspecies morphological traits glandular trichomes essential oil composition rosmarinic acid sensory evaluation colored potato tubers total phenols anthocyanins saccharides nutrition microelements plants fungi food supplements cardiovascular diseases neurodegenerative diseases Alzheimer's disease metabolic syndrome apocarotenoid caffeic acid derivative flavonoid Lactuca sativa lignan megastigmane sesquiterpene lactone 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid black chokeberry anthocyanin simulated moving bed antioxidant activity neuroprotection Artemisia clinical trials health effects adverse effects anticancer antiparasitic artemisinin santonin achillin tehranolide Aglaomorpha quercifolia GC-MS profile rhizome leaves n-hexane extract fatty acids terpenoids linolenic acid hop-16-ene cardiac glycosides secondary plant metabolites natural product isolation hyrcanoside deglucohyrcanoside ouabain cymarin digitoxin anticancer activity Na+/K+-ATPase inhibitors corn salad leafy vegetables phytochemicals liquid chromatography mass spectrometry celastrol Celastraceae antimicrobial activity mechanism of action Bacillus subtilis |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576883103321 |
Seca Ana Maria Loureiro da
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Kinetoplastid Genomics and Beyond
| Kinetoplastid Genomics and Beyond |
| Autore | Requena Jose M |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (251 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
trypanosomatids
yeasts trypanosomatids genome cell cycle phases S-phase duration DNA replication replication origins neglected tropical diseases Leishmania Trypanosoma cruzi Trypanosoma brucei drug discovery in vitro models in vivo models genomics drug resistance Leishmania infantum proteome post-translational modifications (PTMs) proteogenomics mass spectrometry Retrotransposon Hot Spot (RHS) multigene family chromosome distribution recombination gene mosaic structure evolution nuclear protein Leishmania braziliensis reverse genetics CRISPR–Cas9 gene targeting phenotyping heat shock proteins Trypanosoma cruzi strain sequencing methods genome plasticity gene expression trans-sialidases mucins SENP Ulp2 SUMO CRISPR protease genome repeats 3′UTR multigenic family Leishmania donovani whole-genome sequencing (WGS) transcriptome artemisinin drug resistance Leishmania viruses phylogeny coevolution endosymbiont protozoan viruses transcriptome assembly transcriptional regulation ontology network co-expression network taxonomic analysis database contamination kleptoplastidy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557679003321 |
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Requena Jose M
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Lassa Fever : Viral Replication, Disease Pathogenesis, and Host Immune Modulations
| Lassa Fever : Viral Replication, Disease Pathogenesis, and Host Immune Modulations |
| Autore | Ly Hinh |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (132 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Lassa virus disease (LVD)
vaccine breadth mimicry B cell anergy conserved antigens Fc-gamma receptors conformational antigens broadly-neutralizing antibodies focused immunity dominant and subdominant epitopes cross-restriction Lassa virus Z protein late domain PPXY budding release matrix protein phosphorylation arenavirus mass spectrometry viral glycoprotein viral entry viral fusion fusion protein Lassa virus vaccine ML29 vaccine STAT-1-/- mice Mopeia virus interfering particles Lassa fever LASV virus–host interactions entry replication Lassa vaccine replication-deficient MVA vector VLP formation single-dose efficacy cell-mediated immunity arenaviruses viral hemorrhagic fevers animal models mammarenavirus vaccine virulence pathogenesis innate immunity adaptive immunity COVID-19 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Lassa Fever |
| Record Nr. | UNINA-9910674050303321 |
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Ly Hinh
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Bioactive Natural Product Studies—A Southern Hemisphere Perspective
| Marine Bioactive Natural Product Studies—A Southern Hemisphere Perspective |
| Autore | Urban Sylvia |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (142 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Sinularia
Alcyoniidae anticancer activity lobane cembrane diterpene conotoxins ShK toxin ion channels docking molecular dynamics potential of mean force free energy perturbation bioactivity biosynthesis brominated secondary metabolites choline ester indole sea cucumber viscera saponins mass spectrometry MALDI ESI HPCPC triterpene glycosides structure elucidation bioactive compounds marine invertebrate Echinodermata holothurian Cnemidocarpa stolonifera taurine amide PC3 cell line immunofluorescence assay thiaplidiaquinone Aplidium ascidian thiazinoquinone apoptosis Jurkat cytotoxicity malaria farnesyltransferase synthesis thiaplakortone regioisomer tricyclic natural product scaffold X-ray crystal Plasmodium falciparum antiplasmodial cephalostatin mandelalide methicillin resistant Staphylococcus aureus MRSA PK bisindole alkaloids salternamide A (SA) HIF-1α PI3K/Akt/mTOR p42/p44 MAPK STAT3 cell death |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557573903321 |
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Urban Sylvia
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Marine Glycoconjugates: Trends and Perspectives
| Marine Glycoconjugates: Trends and Perspectives |
| Autore | Stonik Valentin A |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (272 p.) |
| Soggetto non controllato |
functions
feather star Aeromonas glycosylceramides sghC1qDC O-antigen colony formation Bcl-2 proteins phospholipids sterol glycoconjugates Anthenea aspera glycosides Anneissia japonica cancer therapy secondary metabolites Echinoderm Apostichopus japonicus microalgae urease activity triterpene glycosides cytotoxic activity Alexandrium minutum Acremonium striatisporum betaine lipid signal transduction thermal adaptation Psolus fabricii O-polysaccharide oncolytic vaccinia virus N-Acetyllactosamine (LacNAc) l-perosamine differential scanning calorimetry Lethasterias fusca polyhydroxysteroids AMPK glycoprotein NMR spectroscopy glucose metabolism anti-biofilm activity ERK fish pathogen marine antiproliferative compounds lectin immunospecificity in vivo studies apoptosis distribution steroidal glycosides natural products biological activities Aphrocallistes vastus lectin marine fungi cell adhesion in vitro studies mass spectrometry psolusosides starfish sea cucumber glycosaminoglycan lipopolysaccharide (LPS) glycolipids fatty acids structures Akt diterpene glycosides body components structure mitophagy marine lectins crinoid cancer asterosaponins |
| ISBN | 3-03928-559-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Marine Glycoconjugates |
| Record Nr. | UNINA-9910404078503321 |
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Stonik Valentin A
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Membrane–Peptide Interactions : From Basics to Current Applications
| Membrane–Peptide Interactions : From Basics to Current Applications |
| Autore | Santos Nuno C |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (302 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
tachyplesin
host defense peptide anticancer antimicrobial antibiofilm peptide-membrane interaction structure-activity model membranes nuclear magnetic resonance solution structure accelerated molecular dynamics alamethicin membrane peptaibol cell-penetrating peptide peptide–lipid interaction lipid model systems molecular dynamics NMR membrane biophysics antimicrobial peptides non-lytic peptides bacterial membranes calcium hydroxide chemokine human beta defensin-3-C15 human dental pulp cell Streptococcus gordonii lipoprotein luffa sponge phosphopeptide mass spectrometry Matrix-assisted laser desorption ionization solid-phase extraction surface plasmon resonance melittin liposomes peptide–lipid interactions anti-microbial peptides pore-forming peptides ESKAPE pathogens Staphylococcus aureus KR12 LL-37 lipopeptide critical aggregation concentration CD spectroscopy biofilm cytotoxicity organisms sequence analysis machine learning feature selection sesame protein ACE inhibitory peptides simulated gastrointestinal digestion amino acid sequence molecular docking chionodracines circular dichroism membrane affinity cell-penetrating peptides circular dichroism spectroscopy atomic force microscopy mycolic acid Langmuir monolayer drug–peptide conjugates metastasis model of B16F10 melanoma Pisum sativum defensin 1 (Psd1) anti-metastatic activity glucosylceramide (GlcCer) cyclin F anti-inflammatory peptide cell permeable peptide heparin-binding peptide collagen-induced arthritis inducible nitric oxide interferon gamma interleukin-6 Enbrel |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
MembraneâPeptide Interactions
Membrane–Peptide Interactions |
| Record Nr. | UNINA-9910557551603321 |
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Santos Nuno C
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metabolism and Metabolomics of Liver in Health and Disease
| Metabolism and Metabolomics of Liver in Health and Disease |
| Autore | Wahli Walter |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (268 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis Fibrosis Liver biopsy Genomics Metabolomics Proteomics Transcriptomics nicotinamide NAFLD steatosis heat stress primary mouse hepatocytes metabolic profile GC-MS multivariate statistical analysis arachidonic acid docosahexaenoic acid inflammation fibrosis lipidomics mass spectrometry in vitro HepaRG sodium saccharin reference toxicants de novo lipogenesis carbohydrate response element-binding protein ChREBP diabetes glucose production glycogen glycolysis glycogen storage disease type I hexosamine pentose phosphate pathway acupuncture imflammation lipid metabolism oxidative stress metabolomics quantitative profiling 1H-NMR spectroscopy liver bile acids metabolomics rat plasma tandem mass spectrometry liquid chromatography acetaminophen hepatotoxicity biomarker premalignant alcoholic liver disease cholestasis cirrhosis NAFL NASH standard operating procedures urine blood feces tissue cells liver function nonalcoholic fatty liver liquid chromatography-mass spectrometry nuclear magnetic resonance spectroscopy metabolic pathway non-alcoholic fatty liver disease non-alcoholic steatohepatitis transcription factors metabolic stress lipid homeostasis glucose homeostasis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557148103321 |
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Wahli Walter
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metabolomic Applications in Animal Science
| Metabolomic Applications in Animal Science |
| Autore | Tomonaga Shozo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (265 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Technology, engineering, agriculture |
| Soggetto non controllato |
albumen
breed chicken feed metabolome yolk arachidonic acid omega-3 fatty acids lipidomics mass spectrometry dietary fat fatty acid metabolism pork meat skeletal muscle fiber type cooking beef Wagyu Holstein captive giraffes urine metabolomics 1H-NMR NMR metabotype transition ketosis cattle chemometrics spectral correction authentication biomarker feeding meat quality traits metabolite postmortem aging processing chickens heat stress lipid peroxidation orotic acid feed efficiency biomarkers SNPs GWAS RFI pigs pathways metabolic profile transition period livestock methyl donor one-carbon metabolism negative energy balance pasture legumes phytoestrogens flavonoids coumestans polyphenols proanthocyanidins metabolic profiling biosynthesis linear model transcriptomics horse metabolomic metabolism exercise saliva anabolic practices testosterone plasma CE-TOFMS intramuscular fat meat quality porcine |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557407903321 |
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Tomonaga Shozo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metabolomics Data Processing and Data Analysis—Current Best Practices
| Metabolomics Data Processing and Data Analysis—Current Best Practices |
| Autore | Hanhineva Kati |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (276 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
metabolic networks
mass spectral libraries metabolite annotation metabolomics data mapping nontarget analysis liquid chromatography mass spectrometry compound identification tandem mass spectral library forensics wastewater gut microbiome meta-omics metagenomics metabolomics metabolic reconstructions genome-scale metabolic modeling constraint-based modeling flux balance host–microbiome metabolism global metabolomics LC-MS spectra processing pathway analysis enrichment analysis mass spectrometry liquid chromatography MS spectral prediction metabolite identification structure-based chemical classification rule-based fragmentation combinatorial fragmentation time series PLS NPLS variable selection bootstrapped-VIP data repository computational metabolomics reanalysis lipidomics data processing triplot multivariate risk modeling environmental factors disease risk chemical classification in silico workflows metabolome mining molecular families networking substructures mass spectrometry imaging metabolomics imaging biostatistics ion selection algorithms liquid chromatography high-resolution mass spectrometry data-independent acquisition all ion fragmentation targeted analysis untargeted analysis R programming full-scan MS/MS processing R-MetaboList 2 liquid chromatography–mass spectrometry (LC/MS) fragmentation (MS/MS) data-dependent acquisition (DDA) simulator in silico untargeted metabolomics liquid chromatography–mass spectrometry (LC-MS) experimental design sample preparation univariate and multivariate statistics metabolic pathway and network analysis LC–MS metabolic profiling computational statistical unsupervised learning supervised learning |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557354403321 |
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Hanhineva Kati
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metabolomics in Neurodegenerative Disease
| Metabolomics in Neurodegenerative Disease |
| Autore | Green Brian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (184 p.) |
| Soggetto non controllato |
glutamic acid
direct mass spectrometry neurodegeneration 6-OHDA targeted mass spectrometry mitochondrial dysfunction myo-inositol metabolomics bile acids subacute mild traumatic brain injury age-related macular degeneration metabolic pathways energy metabolism midbrain Alzheimer's disease biomarkers 1H NMR Parkinson's disease dementia GC-MS pathogenesis tricarboxylic acid cycle micro-dialysis 13C-labeled succinate metabolism lipidomics dementia with Lewy bodies fatty acid prodromal Parkinson's disease malonate cerebral ischemia mass spectrometry retinal pigment epithelium excitotoxicity endothelin-1 reperfusion C. elegans Streptomyces venezuelae ?-synuclein aggregates natural product fatty acid metabolism imaging mass spectrometry LC-MS drusen cerebral palsy plasma Parkinson's disease |
| ISBN | 3-03928-041-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404087203321 |
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Green Brian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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