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Targeting STAT3 and STAT5 in Cancer
| Targeting STAT3 and STAT5 in Cancer |
| Autore | Moriggl Richard |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (578 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
multiple myeloma
STAT3 S3I-1757 nanoparticle CD38 siRNA/RNAi polyethylenimine PEI lipopolyplex siRNA delivery glioma glioblastoma STAT5 AKT ERK1/2 prolactin androgens prostate cancer knockout escape mechanisms stem/progenitor cells cell hierarchy cancer CD4+ T cells CD8+ T cells myeloid cells immune check point hepatitis C virus (HCV) cirrhosis hepatocellular carcinoma (HCC) endoplasmic reticulum (ER) stress oxidative stress (OS) unfolded protein response (UPR) microRNA-122 (miR-122) nuclear factor erythroid 2-related factor 2 (NRF2) signal transducer and activator of transcription 3 (STAT3) hepatocyte nuclear factor 4 alpha (HNF4A) solid cancers cell cycle apoptosis inflammation mitochondria stemness tumor suppression melanoma autoimmune disease immunotherapy tumor-immune cell interactions breast cancer PD-L1 M2 macrophages NK cells STAT3 inhibitor XIII hedging transaction costs dynamic programming risk management post-decision state variable cancer progression cancer-stem cell cytokine therapy resistance metastasis immunosuppression tumor microenvironment proliferation tyrosine kinase 2 JAK family of protein tyrosine kinases signal transducer and activator of transcription cytokine receptor signaling gain-of-function mutation tumorigenesis ADAM17 interleukin-6 trans-signaling epidermal growth factor receptor (EGF-R) shedding metalloprotease tumor necrosis factor alpha (TNFα) inflammation associated cancer colon cancer lung cancer SH2 domain mutations autosomal-dominant hyper IgE syndrome inflammatory hepatocellular adenomas T-cell large granular lymphocytic leukemia T-cell prolymphocytic leukemia growth hormone insensitivity syndrome nuclear pore complex nuclear transport receptors nucleocytoplasmic shuttling targeting tumor-associated macrophages adoptive T cell therapy immune suppression STAT transcription factors JAK STAT T-PLL T-cell leukemia meta-analysis STAT5B signaling small-molecule inhibitors cancer models companion animals comparative oncology pharmacological inhibitor STAT5 signaling chemotherapy resistance myeloid leukemia heat shock proteins chaperones stabilization targeted therapy ovarian cancer hematopoietic cancers therapeutic targeting pharmacological inhibitors mTOR Bone Marrow Failure Syndromes lymphocytes lymphoma T-cells RHOA NGS MPN JAK2 V617F neoplastic stem cells |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557623503321 |
Moriggl Richard
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targeting the Microbiome for Disease Diagnosis and Therapy : New Frontiers for Personalized Medicine
| Targeting the Microbiome for Disease Diagnosis and Therapy : New Frontiers for Personalized Medicine |
| Autore | Laterza Lucrezia |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (280 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Graves-Basedow's diseases
Hashimoto's thyroiditis autoimmunity gut microbiota irritable bowel syndrome microbiota microbiome food components nutrients hematopoietic stem cell transplantation fecal microbiota transplantation aGvHD antibiotic-resistant bacteria cystic fibrosis rabbits intestinal dysbiosis feces microbiome beta-blocker hemodialysis next-generation sequencing propensity score matching methods violin plots random sampling analytical reproducibility fecal matter transplantation data disease subtypes personalized medicine maltodextrin dip test gallstone disease 16S rDNA gene diversity blood biochemical characteristics mesothelioma 16S RNA sequencing species probiotics and gut disease probiotics and acute diverticulitis probiotics and diverticular disease probiotics mechanism of action IgA Nephropathy rifaximin α1KI-CD89Tg mice children intermittent hypoxemia obstructive sleep apnea tonsil weight status oral microbiota rheumatology diseases biomarkers artificial intelligence machine learning rheumatoid arthritis Sjogren's syndrome systemic lupus erythematosus endometrial cancer endometrial microbiome gut microbiome dysbiosis estrogen metabolism estrobolome inflammation antitumour treatment prebiotics probiotics schizophrenia depression anxiety functional genes thymoma genera driver mutation cardiovascular diseases critically ill intestinal permeability recurrent cystitis |
| ISBN | 3-0365-5611-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Targeting the Microbiome for Disease Diagnosis and Therapy |
| Record Nr. | UNINA-9910637781403321 |
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Laterza Lucrezia
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Alcohol Hangover : Causes, Consequences, and Treatment
| The Alcohol Hangover : Causes, Consequences, and Treatment |
| Autore | Verster Joris |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
hangover
alcohol internet attention executive function working memory sleep daytime activity symptoms sex differences presence severity cognitive control automatism Simon Nogo task response selection response inhibition nutrients zinc nicotinic acid bootstrapping frequency tolerance alcohol hangover scale (AHS) alcohol use disorders identification test (AUDIT) dependence symptoms of AUDIT (DS-AUDIT) heavy drinking study design naturalistic study randomized controlled trial blinding mobile technology physical performance hiking walking water consumption Samaria Gorge sensitivity subjective intoxication blood alcohol concentration catastrophising veisalgia acute hangover scale distraction stimulus-response binding distractor-response binding theory of event coding measurement scale single item assessment definition treatment prevention SJP-001 naproxen fexofenadine mood performance assessment at home mobile testing executive functions cognition awareness of impairment driving residual alcohol cognitive effort decision making model-based model-free ethanol acetaldehyde acetate oxidative stress malondialdehyde 8-isoprostane cytokines C-reactive protein hangover treatment inflammation liver function stress neuroticism BAC hangover resistance causes consequences treatments |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Alcohol Hangover |
| Record Nr. | UNINA-9910557141803321 |
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Verster Joris
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Benefits of Plant Extracts for Human Health
| The Benefits of Plant Extracts for Human Health |
| Autore | Proestos Charalampos |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
gut microbiota
natural products diabetes mellitus complications mechanisms pepper fermentation hyperglycemia angiotensin I-converting enzyme (ACE) inhibition antioxidant Berberis food preservative alkaloid human health andrographolide reversed-phase liquid chromatography quantitative analysis method validation anti-inflammatory activity phenolic acids emulsions antioxidants health properties multidrug resistance doxorubicin MRSA quorum sensing biofilm rice bran polyphenols oxidative stress inflammation anti-inflammatory Sideritis raeseri subsp. raeseri essential oil antimicrobial antiproliferative activity Euphorbia hirta L. bioactive compounds in vitro α-amylase inhibition streptozotocin-induced diabetic mice Jujube hydrolysis anti-inflammation lung NF-κB Nrf2 HO-1 Kadsura spp fruit parts phenolics antioxidant capacity in vitro health properties bud-derivatives botanicals UV-Visible spectroscopic fingerprint chemometrics targeted chromatographic fingerprint tomato pomace extraction platelet ultrasound functional ingredient |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557428003321 |
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Proestos Charalampos
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Immunology and Biology of Brain Tumors
| The Immunology and Biology of Brain Tumors |
| Autore | Graner Michael |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (88 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
vaccine therapy
oncoantigen tumor associate antigen tumor angiogenesis high-grade glioma pituitary neuroendocrine tumors VEGF Treg TAM PD-1 PD-L1 tumor microenvironment (TME) glioblastoma multiforme (GBM) GBM-associated macrophages (GAMs) exosomes oncomiR-21 STAT3 inhibitor glioma diffusion tensor imaging generalized q-ball imaging treatment-related effects multiple resections adrenal insufficiency Addison’s disease bevacizumab cerebral radiation necrosis craniopharyngioma inflammation checkpoint inhibitors Interleukin-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557665403321 |
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Graner Michael
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Impact of Alcoholic Beverages on Human Health
| The Impact of Alcoholic Beverages on Human Health |
| Autore | Anderson Peter |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (242 p.) |
| Soggetto topico | Public health & preventive medicine |
| Soggetto non controllato |
alcoholism
evolution fermentation frugivory Homo primate yeast alcohol patterns of drinking disease mortality dose response monotonous protective effects curvilinear alcohol control policy injury review risk morbidity policy intervention public health alcohol industry Canada body weight obesity eating dietary intake drinking pattern labelling health warning labels effectiveness implementation burden of disease death disability infectious diseases non-communicable diseases injuries global no-alcohol products low-alcohol products production consumption health impact gut liver cirrhosis hepatocellular carcinoma microbiome acetaldehyde oxidative stress inflammation one carbon metabolism lipid metabolism DNA damage cancer carcinogenesis communicable diseases HIV tuberculosis pneumonia severe acute respiratory syndrome coronavirus 2 alcohol drinking binge drinking cardiovascular diseases ischaemic heart disease hypertension stroke fetal fetal alcohol spectrum disorder pregnancy risk assessment hepatotoxicity dose-response relationship margin of exposure epidemiological methods brain addiction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585942003321 |
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Anderson Peter
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Impact of the COVID-19 Emergency on the Quality of Life of the General Population
| The Impact of the COVID-19 Emergency on the Quality of Life of the General Population |
| Autore | Roccella Michele |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (822 p.) |
| Soggetto topico |
Technology: general issues
History of engineering & technology |
| Soggetto non controllato |
COVID-19
pandemic anxiety psychopathological symptomatology mood post-traumatic stress disorder (PTSD) emergency autism children diagnosis intervention parents remote depression EPDS pregnancy SARS-CoV-2 psychiatry infectious disease healthcare personnel psychopathological symptoms mental health neurological psychological inflammation COVID-19 pandemic ERT lysosomal storage disease psychological impact antibodies serological test SLE GAD-7 PHQ-9 ISI quarantine burnout health professionals stress prevention virus' transmission fear of contagion breathing difficulty healthy adolescents emotion awareness state anxiety risk perception of COVID-19 meaning-based resources psychological well-being resilience emergency services adversity lockdown personality public health coping psychological distress public Ireland physical activity (PA) undergraduates university students chronic pain triggers well-being occupational balance social distancing home confinement coronavirus interpersonal violence sense of coherence Covid-19 psychiatric patients worry risk perception mental illness attitudes knowledge practices spirituality Indonesia quality of life stress disorder living together emotional bond coronavirus disease psychological health general population somatic symptoms Quality of Life gender differences WHOQOL-BREF health health psychology Italy public mental health physical activity Kosovo restrictions 15D vaccination community pharmacists DASS-21 emotional distress chronic diseases Hashimoto's disease frailty telemedicine gerontechnology wearable sensors shelter-in-place measures resting heart rate sleep duration activity pattern consultation comprehensive health care pandemics dentist fear insomnia preventive behavior fear of Covid-19 Athens Insomnia Scale psychological coping students general self-reported health gender cross-national study primary healthcare access to healthcare treatment effectiveness perceived control over time COVID-19 fear vitality emotion general anxiety disorder-7 (GAD-7) older adults short health anxiety inventory (SHAI) state-trait anxiety inventory (STAI) stomatognathic system COVID-19 confinement prospective memory working memory psychological wellbeing emotions Egyptian coping strategies STAI BDI-II avoidance-oriented coping college students coping styles emotion-oriented coping life satisfaction perceived stress task-oriented coping satisfaction with life fear of COVID-19 elderly population parental distress executive functioning multiple sclerosis elder abuse risk factors postural control balance detraining falls inactivity ageing type of personality type D personality TMD orofacial pain masticatory COVID-19 emergency preventive measures Chile nursing psychological discomfort pregnant adverse childhood experiences ACEs psychological flexibility wellbeing help-seeking family physician primary care healthy lifestyle pandemic COVID-19 neurodegenerative diseases public health strategies healthy lifestyle behaviors telerehabilitation Autism Spectrum Disorder parenting stress depressive symptoms economic crisis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566456903321 |
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Roccella Michele
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Interplay of Microbiome and Immune Response in Health and Diseases
| The Interplay of Microbiome and Immune Response in Health and Diseases |
| Autore | Barceló-Coblijn Gwendolyn |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (206 p.) |
| Soggetto non controllato |
gastrointestinal diseases
sterile inflammation Staphylococcus spp etiopathogenesis colitis Escherichia coli bacteriophages atopic dermatitis intravenous immunoglobulin G adaptive immunity 16S rRNA gene vaginal microbiota modularity innate immunity gut-liver axis disease activity immune system cytokines commensals Staphylococcus aureus dysbiosis fecal transplantation TLR mimicry etanercept dextran sulfate sodium CAR T-cell 3-dihydroxy-4-methoxyBenzaldehyde chemo free treatment Staphylococcus epidermis rheumatoid arthritis microbiome co-occurrence network immune epigenetics 2 autoimmunity superoxide dismutase precision medicine metabolism adoptive cell transfer (ACT) gut barrier antibiotics checkpoint inhibitors probiotics microbiota Candida albicans Enterococcus faecalis chronic liver diseases TCR anaerobic bacteria HSV2 bacteriocins methotrexate microbial interactions T cells virus mice lymphoid malignancies HPV macrophages anti-TNF-? inflammation chondroitin sulfate disaccharide immunotherapy genomics immuno-oncology diet aerobic bacteria immunological niche melanin health chemokines gut microbiota cutaneous immunity HIV TIL cancer global network |
| ISBN | 3-03921-647-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367747303321 |
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Barceló-Coblijn Gwendolyn
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Potential of Dietary Antioxidants
| The Potential of Dietary Antioxidants |
| Autore | Dini Irene |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (552 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
Trichoderma spp
EVOO olive pomace olive vegetation water Olea europea var Leccino HRMS-Orbitrap phenolic identification antioxidant activity grape seed oil fatty acid novel extraction tocopherol supercritical fluid microwave assisted ultrasound assisted Soxhlet olive mill wastewater olive oil Olive Pâté antioxidants nutraceutical Q Exactive Orbitrap LC-MS/MS Clery strawberry food processing Polyphenols multi-methodological evaluation HS-GC/MS analysis PCA antioxidant HepG2 cells EVOO extract IOC methods LDLR PCSK9 tomatoes NMR spectroscopy FT-ICR mass spectrometry ripening stage phenolics metabolomics phytochemicals cardoon multipurpose plant chlorogenic acid fatty acids herbal treatment organic zinc lamb Haemonchus contortus antioxidant enzymes lipid peroxidation mineral status paraxanthine caffeine CYP1A2 phenotyping human saliva differential pulse voltammetry egg flavonoids inductively coupled plasma mass spectrometry (ICP-MS) metallome quercetin walnut by-products antitussive ROS NOx IL-6 CXC-R1 histopathological analysis sustainable agriculture onion skin traditional varieties flavonols dietary antioxidants Helichrysum medicinal plants infusions phenolic compounds antioxidative potential polyphenols flavonids endogenous antioxidant enzymes reduced glutathione oxidized glutathione catalase superoxide dismutase interleukin 6 tumor necrosis factor endurance sports Ficus carica oxidative stress protection stress hormones epidermal skin barrier nutricosmetics brown rice fermentation germination stress bioactive compounds untargeted metabolomics functional food health benefits lovage elicitation phenolic acids potential anti-inflammatory potential anticancer properties antioxidative activity bioactive peptides peptidomics mass spectrometry soybean plant-based foods LDL CVD lipid oxidation dietary fiber cholesterol hyperlipidemia microalgae spirulina inflammation lipopolysaccharide dairy cows fattening bulls leukocytes spices condiments extra-virgin olive oil antiviral properties antioxidant properties nutricosmetic grape seed pomace polyunsaturated fatty acids polyphenol resveratrol rutin HPLC GC coumarins green synthesis DFT red algae antioxidant and antimicrobial ability lipoperoxidation salmon anticancer marigold sage bearberry eucalyptus yarrow apples pomegranate mitochondrial DNA DNA damage apoptosis oral cancer arbutin melanin pigment melasma skin lightening cosmetic hyperpigmentation tyrosinase nuclear factor erythroid 2-related factor 2 (Nrf2) Brassicaceae light wavelength reactive oxygen species (ROS) oxidative stress antioxidant proteins Moringa leaf extract nanoencapsulation rabbit physiology reproduction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595076603321 |
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Dini Irene
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Retina in Health and Disease
| The Retina in Health and Disease |
| Autore | Ptito Maurice |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (465 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
eye
retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer's disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557336603321 |
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Ptito Maurice
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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