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Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases
| Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases |
| Autore | Tikkanen Ritva |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (276 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Rabdosia inflexa
inflammation gastric ulcer cytokines MAPK NF-κB extracellular signal-regulated kinases 1/2 hyperoxia bronchopulmonary dysplasia HPAECs angiogenesis cell cycle SIRT1 oxidative stress psoriasis antimicrobial peptide cecropin A tight junction protein MEK/ERK signaling porcine intestinal epithelial cell extracellular signal-regulated kinase 5 (ERK5) Kv4.2 PC12 cells infantile myofibromatosis receptor tyrosine kinases platelet-derived growth factor receptor protein kinase inhibitors sunitinib erlotinib FR180204 U0126 targeted therapy apoptosis ERK1/2 JNKs mitochondrial dysfunction neurodegeneration neuro-inflammation p38 MAPKs Parkinson's disease mitogen-activated protein kinases (MAPKs) MAPK kinetics osteoclast differentiation bone remodeling DAPK ERK p38 JNK mitogen-activated protein kinase pathway (MAPK pathway) protein tyrosine phosphatase interacting protein 51 (PTPIP51) protein-protein interaction (PPI) cancer signaling SR CR Compatibility T2DM metabolic profiling MAPK/PI3K/Akt signaling pathway reactive oxygen species PTPN6 SRC DOK4 MKK4 MKK7 p53 DUSP1 SIRT2 atherosclerosis aortic valve sclerosis aortic valve stenosis naphthalimide-metal complex conjugates N-heterocyclic carbene mitochondria ROS p38 MAPK cancer FGF-induced signaling FRS2 phosphorylation downregulation |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Mitogen Activated Protein Kinases |
| Record Nr. | UNINA-9910557405603321 |
Tikkanen Ritva
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer
| Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer |
| Autore | Mortier Erwan |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (202 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
cytokine
oncology inflammation inhibitor therapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557210203321 |
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Mortier Erwan
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modulating Glial Cells Phenotype: New Findings and Therapies
| Modulating Glial Cells Phenotype: New Findings and Therapies |
| Autore | Javier Ramos Alberto |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (178 p.) |
| Soggetto topico |
Science: general issues
Neurosciences |
| Soggetto non controllato |
aging
inflammation microglia astroglia therapies |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Modulating Glial Cells Phenotype |
| Record Nr. | UNINA-9910557477503321 |
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Javier Ramos Alberto
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modulators of Oxidative Stress : Chemical and Pharmacological Aspects
| Modulators of Oxidative Stress : Chemical and Pharmacological Aspects |
| Autore | Saso Luciano |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (298 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ascorbic acid
deferoxamine N-acetylcysteine ischemia/reperfusion cardiac fibroblasts reactive oxygen species photobiomodulation reactive oxygen species (ROS) nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) cancer diabetes wound healing glucose pentose phosphate pathway NADPH redox balance glycogen glycolysis stress resistance insulin resistance immunomodulation inflammation olive tree oxidative stress secoirioids sirtuin 3 high fat diet sex differences mice metabolic stress antioxidants ADHD Nrf2 NRF2-KEAP1 ROS cancer metabolism antioxidant cancer therapy chemoresistance radioresistance sepsis MitoVitE mitochondria gene expression cytokines mRNA vitamin C folic acid one-carbon metabolism C2C12 cells metabolomics mass spectrometry type 2 diabetes dipeptidyl peptidase-4 inhibitors biomarkers ER stress Ezetimibe ischemia-reperfusion ionizing radiation liver hydroperoxide epigenetics miR7/MAFG/Nrf2 axe |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Modulators of Oxidative Stress |
| Record Nr. | UNINA-9910557769603321 |
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Saso Luciano
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
| Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides |
| Autore | Rubattu Speranza |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto non controllato |
postmortem biochemistry
medulla animal models remodeling BNP PCSK9 guanylyl cyclase/natriuretic peptide receptor-A cardiorenal syndrome forensic medicine preserved ejection fraction kidney renin-angiotensin-aldosterone system atrial fibrillation vasopressor congestive heart failure atrial natriuretic peptide gene-knockout obesity heart failure angiogenesis adipose tissue vascular LDL receptor metabolic syndrome linkage analysis cardiometabolic disease cardiomyocyte cardiac dysfunction cardiac hypertrophy insulin lipid metabolism cGMP Idiopathic Pulmonary Arterial Hypertension (IPAH) Natriuretic Peptide Clearance Receptor (NPR-C) signaling gene-duplication renin–angiotensin system natriuretic peptides angiotensin receptor–neprilysin inhibitor cardiac remodelling ARNi NT-proBNP inflammation pulmonary arterial hypertension vascular homeostasis endothelial cell Atrial Natriuretic peptide natriuretic peptide vasodilator stroke genetic variants arterial hypertension fibroblast MANP hypertension guanylyl cyclase receptor A |
| ISBN | 3-03921-583-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular Basis of Cardiovascular Diseases |
| Record Nr. | UNINA-9910367751403321 |
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Rubattu Speranza
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Biology of Selenium in Health and Disease
| Molecular Biology of Selenium in Health and Disease |
| Autore | Tsuji Petra A |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (384 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
selenoproteome
selenoprotein hierarchy nonradioactive isotopes SEC-ICP MS glutathione peroxidase thioredoxin reductase SECIS translation regulation autoimmune thyroid disease diabetes mellitus Graves' disease Hashimoto thyroiditis infection inflammation long-COVID rheumatoid arthritis selenoprotein P sepsis selenoprotein W thioredoxin 14-3-3 Akt cell death Selenof selenium selenoprotein colon cancer barrier integrity cardiovascular heart selenoproteins Keshan's Disease bacteria selenite selenium delivery system Trsp hypothalamus Agrp neuron sex differences diet-induced obesity leptin resistance macrophage differentiation redox signaling NRF2 NF-κB lipid mediators seleocysteine autoimmunity lymphocyte cadmium cytotoxicity cancer therapy cisplatin ICP-MS nonsynonymous mutation selenium homeostasis ZIP8 Trit1 isopentenylation tRNA[Ser]Sec selenocysteine genetic variance human disease selenophosphate synthetase endothelial cell reactive oxygen species cell growth angiogenesis SEPHS1 early embryogenesis embryonic lethality prostate cancer tumor suppressor selenoprotein deficiency SECISBP2 Sec-tRNA[Ser]Sec SEPSECS antioxidative defense autoantibody Hashimoto's thyroiditis trace element recoding SECIS-binding protein translation termination nonsense-mediated decay ribosome rescue health mouse models selenocysteine (Sec) virus viral antioxidant HIV HCV HBV coxsackie virus influenza HIV-1 viral infection SELENOS SELENOO primary T cells Jurkat SupT1 translational control |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566482103321 |
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Tsuji Petra A
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanism of Alzheimer's Disease
| Molecular Mechanism of Alzheimer's Disease |
| Autore | Macreadie Ian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto non controllato |
HOTAIR
neurosciences sleep disturbance positron emission tomography (PET) vitamin B complex neurodegeneration Tau miR-15/107 default-mode network complement receptor 1 neuronal differentiation epigenetics brain glucose metabolism oligomerization genetic risk A?O receptors prion ryanodine receptor type 3 diabetes complement cognitive behavioral therapy for insomnia cognitive function epigenome-wide association study Alzheimer’s disease calcium signaling ?-secretase tau Prolyl isomerases NEAT1 complement C3b/C4b receptor proteostasis amyloid beta yeast slow-wave sleep amyloid ? nutrition 4 protein aggregation apolipoprotein E dementia MALAT1 inositol 1 lncRNAs molecular biology methylenetetrahydrofolate reductase MTHFR gene 5-trisphosphate receptor CR1 density miR-34c aggregation heat shock protein dendritic spine S-adenosylmethionine beta amyloid ion channel inflammation sleep fragmentation cystathionine-?-lyase CTH gene DNA methylation heat shock response microglia drug target discovery amyloid-? oligomer therapy CR1 length polymorphism methylome APOE gene ubiquitin magnetic resonance imaging (MRI) neuronal degeneration type 2 diabetes Pin1 mild cognitive impairment dairy products endoplasmic reticulum oxidative stress Hispanics CDK5R1 |
| ISBN | 3-03921-408-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750403321 |
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Macreadie Ian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Psychiatry
| Molecular Psychiatry |
| Autore | Rein Theo |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico |
Medicine
Mental health services |
| Soggetto non controllato |
cardiovascular disease
cell adhesion molecules immunology inflammation nervous system schizophrenia bipolar disorder major depressive disorder DNA methylation response variability antipsychotics drug design multi-target drugs polypharmacology multi-task learning machine learning biomarker discovery psychiatry serotonin 5-HT 4 receptor 5-HT4R depression mood disorder expression Alzheimer's disease cognition Parkinson's disease forced swimming Roman rat lines stress hippocampus BDNF trkB PSA-NCAM western blot immunohistochemistry general cognitive function intelligence GWAS genetic correlation childhood-onset schizophrenia (COS) induced pluripotent stem cell (iPSC) copy number variation (CNV) early neurodevelopment neuronal differentiation synapse dendritic arborization miRNAs stress physiology cytoskeleton actin dynamics DRR1 TU3A FAM107A acid sphingomyelinase alcohol dependence liver enzymes sphingolipid metabolism withdrawal Hsp90 GR stress response steroid hormones molecular chaperones psychiatric disease circadian rhythms FKBP51 FKBP52 CyP40 PP5 DISC1 neurodevelopment CRMP-2 proteomics antidepressant treatment HPA axis gene expression FKBP5 sleep sleep EEG biomarkers antidepressants cordance gender sex difference antidepressant rapid-acting Ketamine endocrinology (2R,6R)-Hydroxynorketamine electroconvulsive therapy basic-helix-loop-helix brain coactivator glucocorticoids mineralocorticoid receptor knockout transcription biology dopaminergic gene polymorphisms affective temperament obesity alpha-synuclein SNCA major depression Hamilton Scale of Depression chemokines neuroinflammation social defeat Immune response T cells susceptibility resilience Treg cells Th17 cells behavior PPARγ |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557793503321 |
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Rein Theo
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Research of Endometrial Pathophysiology
| Molecular Research of Endometrial Pathophysiology |
| Autore | Viganò Paola |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (378 p.) |
| Soggetto non controllato |
endometrial stromal cells
endometrial cell uterine cancer regeneration stem cell markers RANK chronic endometritis small RNA sequencing HOXA10 Vitamin D PPP2R1A molecular marker translational research angiogenesis endometriosis oestradiol mtDNA mutations antioxidant response protein phosphatase SMAP circulating tumour cells (CTCs) circulating tumour DNA (ctDNA) estrogen dependent endometrial regeneration mesenchymal stem cells endometrial cancer niche gene expression phosphoinositide 3-kinase lncRNAs mitochondrial biogenesis inflammation preclinical studies miRNA orthoxenograft tight junction proliferation aromatase testosterone CRISPR/Cas9 endometrium developmental pathway PP2A avatar infertility prognosis gene editing kinase inhibitor implantation haploinsufficiency contrast-enhanced CT scan pathway dehydroepiandrosterone (DHEA) CTCF PIK3CB zinc finger ectopic stroma liquid biopsy type II endometrial carcinoma eutopic and ectopic endometrium preclinical models EDN1 uterine aspirate cell contacts tumour suppressor gene pathogenomics mitochondrial dynamics adult stem cells PIK3CA murine models menstrual cycle immunomodulation decidualisation breakdown bioluminescence imaging protein kinase macrophages adherens junction exosomes immunohistochemistry orthotopic xenograft model decidualization p110? deficit of complex I targeted therapy mesenchymal stem cell sulfatase TRP channels personalized medicine mitophagy miR-375 migration microRNA gap junction cancer LGR5 miR-139-5p |
| ISBN | 3-03921-496-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367752903321 |
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Viganò Paola
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Muscle Homeostasis and Regeneration : From Molecular Mechanisms to Therapeutic Opportunities
| Muscle Homeostasis and Regeneration : From Molecular Mechanisms to Therapeutic Opportunities |
| Autore | Musarò Antonio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (500 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
lysine
mTORC1 satellite cells proliferation skeletal muscle growth muscle satellite cell transthyretin thyroid hormone myogenesis exosomes skeletal muscle genotype genetic variation muscle phenotypes sarcopenia aging calcium homeostasis hibernation mitochondria sarcoplasmic reticulum Acvr1b Tgfbr1 myostatin Col1a1 fibrosis atrophy IGF2R muscle homeostasis inflammation muscular dystrophy pericytes macrophages Nfix phagocytosis RhoA-ROCK1 splicing isoforms CRISPR-Cas9 exon deletion NF-Y muscle differentiation C2C12 cells denervation neuromuscular junction heavy resistance exercise acetylcholine receptor cell culture neonatal myosin neural cell adhesion molecule biomarkers mitophagy mitochondrial dynamics mitochondrial quality control mitochondrial-derived vesicles (MDVs) mitochondrial-lysosomal axis Hibernation electron microscopy immunocytochemistry α-smooth muscle actin confocal microscopy connexin 43 connexin 26 gap junctions myofibroblasts Platelet-Rich Plasma transforming growth factor (TGF)-β1 muscle regeneration inflammatory response cell precursors experimental methods stem cell markers muscles heterotopic ossification skeletal muscle stem and progenitor cells HO precursors muscle atrophy septicemia mitochondrial fusion mitochondrial fission iPSC extracellular vesicles Drosophila muscle genetic control muscle diversification fascicle myofiber myofibril sarcomere hypertrophy hyperplasia splitting radial growth longitudinal growth exercise muscle stem cells stem cells niche neuromuscular disorders Duchenne muscular dystrophy pharmacological approach single-cell mass cytometry skeletal muscle regeneration skeletal muscle homeostasis fibro/adipogenic progenitors myogenic progenitors muscle populations evolution metazoans differentiation transdifferentiation muscle precursors regenerative medicine stem cells FAPs tissue niche growth factors muscle pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Muscle Homeostasis and Regeneration |
| Record Nr. | UNINA-9910557587003321 |
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Musarò Antonio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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