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mTOR in Human Diseases
| mTOR in Human Diseases |
| Autore | Dormond Olivier |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (480 p.) |
| Soggetto non controllato |
primary cilia
neurodegeneration nutrient sensor PI3K transcriptomics phosphorylation metabolic reprogramming autophagy Alzheimer's disease rapalogs liver angiogenesis mTOR complex MBSCs advanced biliary tract cancers Medulloblastoma epithelial to mesenchymal transition AMPK p70S6K lipid metabolism thyroid cancer sodium iodide symporter (NIS)/SLC5A5 male fertility anesthesia illumina mTOR inhibitor miRNA Hutchinson-Gilford progeria syndrome (HGPS) eIFs Emery-Dreifuss muscular dystrophy (EDMD) glucose AKT oral cavity squamous cell carcinoma (OSCC) glucose and lipid metabolism cellular signaling aging tumor microenvironment rapamycin leukemia chloral hydrate rapalogues schizophrenia T-cell acute lymphoblastic leukemia senescence lamin A/C neurotoxicity neurodevelopment inhibitor methamphetamine pulmonary fibrosis mTOR mTOR inhibitors combination therapy proteolysis fluid shear stress tumour cachexia biomarkers synapse gluconeogenesis mTOR signal pathway Sertoli cells immunosenescence miRNome protein aggregation senolytics metabolism NGS mTORC2 mTORC1 metabolic diseases IonTorrent apoptosis dopamine receptor nocodazole microenvironment everolimus acute myeloid leukemia immunotherapy spermatogenesis bone remodeling signalling targeted therapy ageing therapy NVP-BEZ235 fructose physical activity laminopathies MC3T3-E1 cells cell signaling microRNA cancer lipolysis melatonin Parkinson's disease |
| ISBN | 3-03921-061-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346684303321 |
Dormond Olivier
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Disease Prevention, Relief and Treatment
| Natural Products and Disease Prevention, Relief and Treatment |
| Autore | Islam Md Soriful |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (234 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
Rubi Fructus
Rubus coreanus lipopolysaccharide macrophage ER stress calcium chop STAT cytokine nitric oxide β-glucan anticancer activity antioxidant anti-inflammatory cyclooxygenase lipoxygenase cauliflower mushroom breast cancer Spirulina tocotrienol immunomodulatory synergistic metastasis YG-1 extract bronchodilation fine particulate matter (PM2.5) acute lung injury airway inflammation pancreatic cancer natural product traditional medicine apoptosis angiogenesis drug resistance inflammation interleukin-6 sepsis Dracocephalum moldavica NASH lactoferrin fibrosis hepatocarcinogenesis connexin brown algae Sargassum plagiophyllum constipation gastrointestinal transit gut microbiota transepithelial transport glaucoma herbs retinal ganglion cells intraocular pressure SLC22A12 quercetin fisetin uricosuric activity anti-hyperuricemia functional food transporter uric acid health promotion rooibos tea doxorubicin mokko lactone heart Mokko lactone Dracocephalum moldavica ethanol extract Sparassis crispa fisetin and quercetin Sargassum plagiophyllum extract |
| ISBN | 3-0365-6138-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639988903321 |
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Islam Md Soriful
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Drug Discovery
| Natural Products and Drug Discovery |
| Autore | Avato Pinarosa |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (392 p.) |
| Soggetto non controllato |
dihydrochalcones
cytotoxicity-guided harpagoside biotechnology synergy Imperata cylindrica 5?-dimethylchalcone (DMC) antioxidant activity marine resources phenolic derivatives secondary metabolites antimicrobial agents antimicrobial resistance metabolomics Humulus lupulus chromatography stereochemistry FSE cytokines cytotoxic activity glutamate angiogenesis traditional medicine Ca2+ L6 cell human colon cancer cell lines siphonous green algae anti-inflammatory activity Phyllanthus chamacristoides spectroscopic analysis Physcomitrella patens Leishmania mexicana mexicana dementia prenylated phenolic compounds T2DM HPLC-ESI-microTOF-Q-MS/MS Eruca sativa Dryopteris fragrans chemosystematics 2? cerebellum Cleistocalyx operculatus inflammation multivariate data analysis Phyllanthus orbicularis HPLC cardiovascular disease Kv7 potassium channels marine peptides proliferation sulfated coumarins Orobanche s.l. phenylpropanoid glycosides Harpagophytum procumbens sesquiterpenoids TRPV1 Fideloside phenylethanoid glycosides Cuba molecular network NMR ketamine aging GLUT4 diabetes oxidative stress Lamiales circular dichroism psychosis antinociceptive immuno-regulation activity terpenoids NADPH oxidases diabetic neuropathy spagyric tincture H2S celastrol isolation and quantification 4?-dihydroxy-6?-methoxy-3? Leea indica C-glycoside neuropathic pain PANC-1 glucosinolates flavonoids bioactivities of natural products cardamonin isoflavones terpenes methicillin-resistant Staphylococcus aureus malaria artemisinin natural products devil's claw ACE inhibitory peptide pPancreatic cancer growth inhibitory activity mass spectrometry flavonoid phenolics Astragalus boeticus L. proanthocyanidins opioid Trifolium Trypanosoma brucei brucei acetylated astragalosides Fabaceae bioactive peptides LC-MS Dasycladus vermicularis Orobanchaceae migration glucoerucin ESI-MS/MS cancer zebrafish antihypertensive Bacopa monnieri chemical derivatization hypertension |
| ISBN | 3-03928-747-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404086803321 |
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Avato Pinarosa
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neovascularization, Angiogenesis and Vasculogenic Mimicry in Cancer
| Neovascularization, Angiogenesis and Vasculogenic Mimicry in Cancer |
| Autore | López-Camarillo César |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (296 p.) |
| Soggetto topico |
Medicine
Oncology |
| Soggetto non controllato |
vasculogenic mimicry
angiogenesis lncRNAs microRNAs therapy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557248003321 |
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López-Camarillo César
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Trends in Sport and Exercise Medicine
| New Trends in Sport and Exercise Medicine |
| Autore | Galli Daniela |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (248 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
rehabilitation
compliance anterior cruciate ligament reconstruction (ACLR) range of motion (ROM) self-efficacy behavioral design gamification microparticles microvesicles extracellular vesicles molecular markers cell-cell communication physical exercise physical activity angiogenesis secretome paracrine signaling cellular crosstalk ginseng performance recovery eccentric exercise inflammation allometry standing broad jump children growth maturity offset bench pull vertical jump power talent detection training insertional Achilles tendinopathy Achilles tendon moment arm suture bridge method cool-down strategy heart rate fatigue perception muscle strain quadriceps football invasive physiotherapy post-injury performance reinjury return to play autonomic nervous system cardiac autonomic regulation cardiorespiratory fitness daily training endurance secreted protein acidic and rich in cysteine (Sparc) exercise muscle performance metabolic phenotype lactate ageing high-impact weight-bearing exercise bone mineral density bone metabolic markers serum 25-(OH) D middle-aged premenopausal women ROS signal transduction aging air pollution lungs skeletal muscle mass muscular strength anaerobic power arterial stiffness cholinesterases heart rate variability autonomic recovery mechanisms sympathetic-parasympathetic modulation postexercise recovery ceramides cytokines diacylglycerol biomarkers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557624503321 |
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Galli Daniela
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nongenomic Actions of Thyroid Hormones in Cancer
| Nongenomic Actions of Thyroid Hormones in Cancer |
| Autore | Ashur-Fabian Osnat |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (102 p.) |
| Soggetto topico |
Medicine
Endocrinology |
| Soggetto non controllato |
integrin αvβ3
angiogenesis anti-apoptosis thyroxine signal transduction driver genes tumor microenvironment tetrac |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557540403321 |
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Ashur-Fabian Osnat
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action
| Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action |
| Autore | Allison Simon J |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (206 p.) |
| Soggetto topico |
Technology: general issues
History of engineering & technology |
| Soggetto non controllato |
microtubule acetylation
triple-negative breast cancer anti-cancer agent apoptosis K562 8-hydroxydaidzein autophagy BCR-ABL MAPK NF-κB c-myc RNA interference siRNA oncogene gene silencing expression nanosystems Cytochrome P450 CYP1A1 CYP1B1 CYP2W1 breast cancer prodrug bioprecursor duocarmycin phortress AQ4N 5-FU resistance colorectal cancer drug repurposing Genomics of Drug Sensitivity in Cancer Connectivity Map anticancer drug B-lactam steroid alkylators synthetic lethality poly (ADP-ribose) polymerase inhibitors ovarian cancer hybrid steroidal alkylating agents migration invasion glioblastoma CCN1 mesenchymal-amoeboid transition biomarker HepG2 Huh7 isatin sulfonamides angiogenesis cancer hallmarks molecular docking EGFR tyrosine kinase inhibitor photon upconversion triplet-triplet annihilation in vivo imaging PLGA nanoparticles affibody molecule human epidermal growth factor receptor 3 (HER3) BxPC-3 emtansine DM1 albumin binding domain affibody drug conjugate (AffiDC) |
| ISBN | 3-0365-5222-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Novel Anti-cancer Agents and Cellular Targets and Their Mechanism |
| Record Nr. | UNINA-9910619465503321 |
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Allison Simon J
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrition and Eye Health
| Nutrition and Eye Health |
| Autore | Downie Laura |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (242 p.) |
| Soggetto non controllato |
polyphenols
crocin chyrsin glaucoma dietary assessment photoreceptor degeneration dry eye RR-zeaxanthin nutritional supplements drug discovery corneal neovascularization (CNV) AMD dietary antioxidants micronutrients age-related macular degeneration preclinical models lenses microvascular lesions cyclooxigenase-2 (COX-2) angiogenesis fish oil macrophage anti-oxidant vascular endothelial growth factor (VEGF) rosmarinic acid visual cycle diabetic retinopathy lutein gut-retina axis light damage crocetin supplements clinical practice guidelines nutrition light eye disease dietary habits flavonoids phytoconstituents saffron carotenoids fatty acid electroretinography lens advanced glycation end products interleukin-1? (IL-1?) mesozeaxanthin (RS zeaxanthin) endoplasmic reticulum stress omega-3 polyunsaturated fatty acids clinical survey corneal chemical burn reduced glutathione omega-3 AGREE II retina inflammation anti-inflammatory retinal pigment epithelium diet Lactobacillus paracasei KW3110 Crocus Sativus L. saponins cataract CODS neoangiogenesis estrogen-deficient rats food frequency questionnaire gut microbiota antioxidant supplements sinapic acid personalised medicine systematic reviews nuclear factor-kappaB (NF-?B) diabetes Cucurbita argyrosperma oxidative stress endoplasmic reticulum |
| ISBN | 3-03921-991-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910372786403321 |
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Downie Laura
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Organs-on-chips
| Organs-on-chips |
| Autore | Tung Yi-Chung |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto non controllato |
tissue engineering
microfluidic device ischemia/reperfusion injury syringe pump liver-on-a-chip vacuum chuck epithelial-endothelial interface vessel branching organs-on-chips nanogrooves passive delivery functional neuron imaging organ-on-a-chip lung epithelial cell MEMS drug absorption strain 3D cell culture system mechanical cue multi-culture angiogenesis high-throughput screening fluoroelastomer membranes cell culture paracellular/transcellular transport beating force microfabrication drug hepatotoxicity biomimetic oxidation compression microfluidics surfactant protein PDMS neuronal cell networks neuronal guidance trans-epithelial electrical resistance spheroid array organ-on-a-chip (OOC) biomechanics cell organ-on-chips organ-on-chip stretch shear stress shear flow image-based screening drug metabolism vascularization human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) stress barrier permeability bio-mechanical property cardiac 3D tissue endothelial cell activation organoid silicon lattice light-sheet microscopy integrated pump SH-SY5Y cells thrombolysis 3D cell culture neuronal cells drug efficacy vascularized tumor model |
| ISBN | 3-03928-918-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404077903321 |
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Tung Yi-Chung
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Osteoarthritis: From Molecular Pathways to Therapeutic Advances
| Osteoarthritis: From Molecular Pathways to Therapeutic Advances |
| Autore | Veronese Nicola |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (306 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
osteoarthritis
cartilage type II collagen matrix metalloproteinases MMP-13 regulation inhibitor NO synthase Interleukin-1β chondrocytes mitochondrial dysfunction mesenchimal stem cells chondrocytic commitment autophagy miRNAs hydrostatic pressure adipokines visfatin Wnt/β-catenin mechanical loading obesity microRNA oxidative stress vibrational spectroscopy near-infrared spectroscopy infrared spectroscopy Raman spectroscopy early diagnosis exercise physical activity nutraceuticals dietary supplements inflammation aging inflammaging osteochondral explant culture joint modelling pharmacological assay native tissue analysis hexosamine biosynthetic pathway cartilage trauma post-traumatic osteoarthritis O-GlcNAcylation glucosamine cell death therapy sex as a biological variable whole transcriptome sequencing molecules TGF-β SMAD2/3 signaling linker modifications meniscus proteomics MRM ECM celecoxib glucosamine sulfate chondroprotection NF-κB cytokines chemokines pathogenesis biomarker chondrocyte IL-1β IFNγ, IL-17 IL-4 RNA-Seq hypertrophy remodeling angiogenesis chondroitin collagen methylsulfonylmethane vitamin C vitamin D hyaluronic acid |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Osteoarthritis |
| Record Nr. | UNINA-9910566461503321 |
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Veronese Nicola
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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