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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Intelligence in Healthcare
| Computational Intelligence in Healthcare |
| Autore | Castellano Giovanna |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico | Information technology industries |
| Soggetto non controllato |
sEMG
deep learning neural networks gait phase classification everyday walking convolutional neural network CRISPR leukemia nucleus image segmentation soft covering rough set clustering machine learning algorithm soft computing multistage support vector machine model multiple imputation by chained equations SVM-based recursive feature elimination unipolar depression diabetic retinopathy (DR) pre-trained deep ConvNet uni-modal deep features multi-modal deep features transfer learning 1D pooling cross pooling IMU gait analysis long-term monitoring multi-unit multi-sensor time synchronization Internet of Medical Things body area network MIMU early detection sepsis evaluation metrics machine learning medical informatics feature extraction physionet challenge electrocardiogram Premature ventricular contraction sparse autoencoder unsupervised learning Softmax regression medical diagnosis artificial neural network e-health Tri-Fog Health System fault data elimination health status prediction health status detection health off diffusion tensor imaging ensemble learning decision support systems healthcare computational intelligence Alzheimer's disease fuzzy inference systems genetic algorithms next-generation sequencing ovarian cancer interpretable models |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674044803321 |
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Castellano Giovanna
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Crime without criminals? : seniors, dementia, and the aftermath : hearing before the Special Committee on Aging, United States Senate, One Hundred Eighth Congress, second session, Washington, DC, March 22, 2004
| Crime without criminals? : seniors, dementia, and the aftermath : hearing before the Special Committee on Aging, United States Senate, One Hundred Eighth Congress, second session, Washington, DC, March 22, 2004 |
| Descrizione fisica | 1 online resource (iii, 141 p.) |
| Soggetto topico |
Crime and age - United States
Older offenders - Mental health - United States Older offenders - Legal status, laws, etc - United States Mentally ill older people - Legal status, laws, etc - United States Alzheimer's disease - Patients - Legal status, laws, etc - United States Senile dementia - United States |
| Soggetto non controllato |
Crime and age
Mental health laws Alzheimer's disease Senile dementia Law Social science Health & fitness Medical |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Crime without criminals? |
| Record Nr. | UNINA-9910689613103321 |
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology
| Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology |
| Autore | Fioravanti Antonella |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (320 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
miR-27a-5p
acute myocardial infarction autophagy apoptosis hypoxia MicroRNA (miRNA) miR526b miR655 oxidative stress reactive oxygen species (ROS) superoxide (SO) Thioredoxin Reductase 1 (TXNRD1) breast cancer nucleic acid medicine pancreatic cancer clinical trial siRNA antisense oligonucleotide MicroRNA signal transduction therapeutic target miRNAs ROS noncoding RNA microRNA long noncoding RNA mitochondrial dysfunction nitrosative stress. exosome cross-talk systemic lupus erythematosus visfatin resistin osteoarthritis synovial fibroblasts synovitis NF-κB thyroid hormone liver cancer metabolism physiology ASH NAFLD NASH HCC HCV HBV endometriosis high-grade serous ovarian cancer endometriosis-associated ovarian cancer epithelial-to-mesenchymal transition chemoresistance antioxidants miRNA cancer diabetes beta cells microRNAs translation regulation neurodegeneration Alzheimer's disease Parkinson's disease Huntington's disease ALS reactive oxygen species redox signaling therapeutic tolerance therapeutic resistance |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557526003321 |
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Fioravanti Antonella
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Curcumin in Health and Disease
| Curcumin in Health and Disease |
| Autore | Bachmeier Beatrice |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (274 p.) |
| Soggetto non controllato |
minerals
cancer treatment chitosan neurodegeneration antioxidant activity senescence tumor proliferation nanoparticles antimicrobial agents oxidative metabolites drug discovery Akt/mTOR signaling micronutrients ulcerative colitis transmission electron microscopy metabolic reprogramming curcumin death receptor chaperone-mediated autophagy wound healing brain ischemia autophagy Alzheimer's disease genes transthyretin inflammatory bowel disease cellular pathway centrifugal partition chromatography nutrition amyloid Curcuma longa protein aggregation supportive care IL-17 senolytics complementary medicine macronutrients structure activity relationship gastroprotection Zingiberaceae anti-inflamation TLC bioautography microbiota glioblastoma multiforme amyloidosis SHMT2 antioxidants silica apoptosis reflux esophagitis gastric ulcer TLC-MS anti-cancer anticancer ImageJ anti-tumor delivery system wound Helicobacter pylori direct protein binding protein misfolding tumor growth diet Crohn's disease hydrostatic counter-current chromatography ageing renal cell cancer gastric cancer amino-acids STAT3 mechanism of action inflamm-aging mitophagy necrotizing enterocolitis cell cycling vitamins turmeric tuber cancer tau protein |
| ISBN | 3-03921-450-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367753703321 |
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Bachmeier Beatrice
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Diet in brain health and neurological disorders : risk factors and treatments / / special issue editor, Jason Brandt
| Diet in brain health and neurological disorders : risk factors and treatments / / special issue editor, Jason Brandt |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (68 p.) |
| Disciplina | 616.8/04654 |
| Soggetto topico | Brain - Diseases - Diet therapy |
| Soggetto non controllato |
epilepsy
glioblastoma multiforme ADHD prefrontal cortex regainers functional neuroimaging malignant glioma nutrients caffeine children inflammation working memory cytokines modified Atkins diet fish intake insulin resistance transpulmonary administration obesity maintainers electroencephalography Alzheimer's disease omega-3 fatty acids diet-deficient weight loss maintenance neural processing hippocampal neurogenesis |
| ISBN | 3-03921-651-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Diet in Brain Health and Neurological Disorders |
| Record Nr. | UNINA-9910367747803321 |
| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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DNA Replication Stress
| DNA Replication Stress |
| Autore | Brosh Jr Robert M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto non controllato |
Werner Syndrome
A549 cells epigenetic neurodegeneration Genome integrity adaptation cellular senescence genome instability Werner Syndrome Protein lipofuscin cell cycle checkpoints exonuclease 1 template-switching energy metabolism mutation frequency DNA replication fork regression motor neuron disease Microsatellites Alzheimer's disease chromatin remodeler repair of DNA damage AP site analogue mutagens replication timing Thermococcus eurythermalis nucleolar stress gene expression mutations spectra origin firing Fanconi Anemia superfamily 2 ATPase DNA translocation DNA repair SSB signaling homologous recombination common fragile sites 8-chloro-adenosine replication genome stability mutagenicity fork reversal multiple sclerosis non-B DNA protein stability heterogeneity ubiquitin SenTraGorTM (GL13) replication restart EdU ?-arrestin NER aging SSB end resection oxidative stress ATR dormant origins R loops DNA damage response Difficult-to-Replicate Sequences DNA double-strand repair endonuclease IV ALS double strand break repair premature aging replication stress EXO1 POL? translesion synthesis strand displacements G2-arrest DNA replication pattern SSB repair genome integrity G protein-coupled receptor kinase interacting protein 2 (GIT2) MMR replicative stress senolytics spacer interactome ATR-Chk1 DDR pathway C9orf72 replication fork restart translesion DNA synthesis DNA damage mismatch repair DNA replication stress DNA helicase Polymerase kappa DNA fiber assay H1299 cells TLS APE2 ageing cell death chromosome TopBP1 barley clock proteins post-translational modification 8-oxoG S phase ataxia telangiectasia mutated (ATM) G protein-coupled receptor (GPCR) Polymerase eta cancer G protein-coupled receptor kinase (GRK) helicase genomic instability Parkinson's disease nucleotide excision repair SupF |
| ISBN | 3-03921-390-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367564903321 |
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Brosh Jr Robert M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Down Syndrome : Neuropsychological Phenotype across the Lifespan
| Down Syndrome : Neuropsychological Phenotype across the Lifespan |
| Autore | Pulsifer Margaret B |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
trisomy 21
decoding vocabulary letters phonological awareness down syndrome fluency disfluency co-occurrence comorbidity language Down syndrome social cognition social behavior measurement children attention audiovisual processing communicative abilities in infants Trisomy 21 independence transition to adulthood proxy-report regression Alzheimer's disease biomarkers dementia cognition functional independence neuropsychological assessment primary care screening early regression idiopathic regression depression selective serotonin reuptake inhibitor mild cognitive impairment cognitive decline neuropsychological tests cognitive function early-onset Alzheimer disease late-onset Alzheimer disease hypothyroidism thyroid autoantibodies TSH Free T4 APOE Ɛ4 autism spectrum disorder co-occurring prevalence |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Down Syndrome |
| Record Nr. | UNINA-9910576881203321 |
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Pulsifer Margaret B
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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From Natural Polyphenols to Synthetic Bioactive Analogues
| From Natural Polyphenols to Synthetic Bioactive Analogues |
| Autore | Tringali Corrado |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (98 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Melaleuca styphelioides
polyphenols LC/MS-MS anti-oxidant activity anti-inflammatory activity keratinocytes Tamarix ramosissima polyphenolics antioxidant activity antimicrobial activity isorhamnetin hispidulin cirsimaritin multicomponent reactions β-amyloid proteins Alzheimer's disease Ugi reaction β-lactams trans-resveratrol aza-stilbene azo-stilbene bio-isosterism structure-activity relationship honokiol bisphenol neolignans Suzuki-Miyaura cross-coupling antitumor activity apoptosis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557467903321 |
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Tringali Corrado
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Glutamate-Related Biomarkers for Neuropsychiatric Disorders
| Glutamate-Related Biomarkers for Neuropsychiatric Disorders |
| Autore | Lane Hsien-Yuan |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (115 p.) |
| Soggetto topico |
Medicine
Psychiatry |
| Soggetto non controllato |
glutamate
NMDA schizophrenia depression Alzheimer's disease autoimmune encephalitis autism addiction |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557572303321 |
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Lane Hsien-Yuan
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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