Recent trends on QSAR in the pharmaeutical perceptions [[electronic resource] /] / edited by Mahmud Tareq Hassan Khan |
Pubbl/distr/stampa | [Oak Park, Ill.], : Bentham eBooks, [2012] |
Descrizione fisica | 1 online resource (407 p.) |
Disciplina | 614.35 |
Altri autori (Persone) | KhanMahmud Tareq Hassan |
Soggetto topico | QSAR (Biochemistry) |
ISBN | 1-60805-379-2 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Cover; TItle; EUL; Contents; Foreword by Alexandru T; Foreword by Roberto Todeschini; Preface; List of Contributors; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chapter 07; Chapter 08; Chapter 09; Chapter 10; Chapter 11; Chapter 12 |
Record Nr. | UNINA-9910811441803321 |
[Oak Park, Ill.], : Bentham eBooks, [2012] | ||
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Lo trovi qui: Univ. Federico II | ||
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SAR and QSAR in environmental research |
Pubbl/distr/stampa | London : , : Gordon and Breach, , 1993- |
Descrizione fisica | 1 online resource |
Disciplina | 574.19/28 |
Soggetto topico |
Structure-activity relationships (Biochemistry)
QSAR (Biochemistry) Environment Environmental Pollutants - analysis Structure-Activity Relationship Relations structure-activité (Biochimie) Relations structure-activité quantitatives (Biochimie) |
Soggetto genere / forma |
Periodical
Periodicals. |
Soggetto non controllato |
structuuractiviteitsrelaties
structure activity relationships milieuchemie environmental chemistry ecotoxicologie ecotoxicology milieuwetenschappen environmental sciences Chemistry (General) Environmental Toxicology, Ecotoxicology Chemie (algemeen) Milieutoxicologie, ecotoxicologie |
ISSN | 1029-046X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Record Nr. | UNISA-996204660103316 |
London : , : Gordon and Breach, , 1993- | ||
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Lo trovi qui: Univ. di Salerno | ||
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SAR and QSAR in environmental research |
Pubbl/distr/stampa | London : , : Gordon and Breach, , 1993- |
Descrizione fisica | 1 online resource |
Disciplina | 574.19/28 |
Soggetto topico |
Structure-activity relationships (Biochemistry)
QSAR (Biochemistry) Environment Environmental Pollutants - analysis Structure-Activity Relationship Relations structure-activité (Biochimie) Relations structure-activité quantitatives (Biochimie) |
Soggetto genere / forma |
Periodical
Periodicals. |
Soggetto non controllato |
structuuractiviteitsrelaties
structure activity relationships milieuchemie environmental chemistry ecotoxicologie ecotoxicology milieuwetenschappen environmental sciences Chemistry (General) Environmental Toxicology, Ecotoxicology Chemie (algemeen) Milieutoxicologie, ecotoxicologie |
ISSN | 1029-046X |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910231854003321 |
London : , : Gordon and Breach, , 1993- | ||
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Lo trovi qui: Univ. Federico II | ||
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Structure-based ligand design [[electronic resource] /] / edited by Klaus Gubernator, Hans-Joachim Böhm |
Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c1998 |
Descrizione fisica | 1 online resource (170 p.) |
Disciplina | 615.19 |
Altri autori (Persone) |
GubernatorKlaus
BöhmHans-Joachim |
Collana | Methods and principles in medicinal chemistry |
Soggetto topico |
Ligand binding (Biochemistry)
Pharmaceutical chemistry QSAR (Biochemistry) Drugs - Design |
Soggetto genere / forma | Electronic books. |
ISBN |
1-282-01029-8
9786612010293 3-527-61217-3 3-527-61216-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Structure-Based Ligand Design; Preface; List of Contributors; Contents; 1 Rational Design of Bioactive Molecules; 1.1 Introduction; 1.1.1 From Ligand Design to Drug Discovery; 1.2 Source of Structural Information; 1.3 Classes of Therapeutic Agents; 1.4 Protein-Ligand Interaction; 1.4.1 Covalent versus Noncovalent Inhibitors; 1.4.2 Nonbonded Interactions in Protein-Ligand Complexes; 1.4.3 HydrogenBonds; 1.4.4 The Role of Solvent in Polar Protein-Ligand Interactions; 1.4.5 Lipophilic Interactions; 1.4.6 Criteria for Strong Protein-Ligand Interactions
1.5 Approaches to Structure-Based Ligand Design1.5.1 Ligands Derived from Substrate or Natural Ligand; 1.5.2 Structures Derived from 3D Database Searches; 1.5.3 De-Novo Design of Ligands; 1.6 Methods and Toois used in Structure-Based Ligand Design; 1.7 Outlook and Future Developments; References; 2 Examples of Active Areas of Structure-Based-Design; 2.1 Thrombin Inhibitors; 2.2 Design of Orally Active Inhibitors of Elastase; 2.3 Dorzolamide:A Success Story of Structure-Based Drug Design; 2.4 Inhibitors of Serine Esterases; 2.4.1 Human Pancreatic Lipase (hPL) 2.4.2 Model of the Trilaurin Triglyceride Substrate Binding2.4.3 Tetrahydrolipstatin (THL); 2.5 Acetylcholinesterase (AChE); 2.5.1 Model of the Acetylcholine Substrate Binding; 2.5.2 Physostigmine; 2.5.3 Eisai E2020; References; 3 From Renin to HIV-1 Protease; 3.1 Introduction; 3.2 Renin; 3.2.1 Catalytic Site Binding; 3.2.2 Backbone Variations; 3.2.3 Subsite Interdependencies; 3.2.4 Renin Crystal Structure; 3.2.5 Summary - Renin Modeling; 3.3 HIV-1 Protease; 3.3.1 3D Structures of HIV-1 Protease; 3.3.2 HIV-1 Protease Nonpeptide Inhibitors 3.3.3 Docking/Modeling HIV-1 Protease Nonpeptide Inhibitors3.4 Summary: Comparison of HIV-1 Protease versus Renin Structure-Based Design; 3.5 Current Limitations/Future Perspective; 3.6 Conclusion; References; 4 Zinc Endoproteases: A Structural Superfamily; 4.1 Introduction; 4.2 Structural Classification of Zinc Endopeptidase Families; 4.2.1 Short Spacer or Metzincins Family; 4.2.2 Long Spacer or Gluzincins Family; 4.3 Overview of Inhibitor Design; 4.4 Current Limitations; 4.5 Future Prospects; References; 5 Structure-Based Design of Potent Beta-Lactamase Inhibitors; 5.1 Introduction 5.2 Structure of Citrobacter freundii Class C Beta-Lactamase5.3 Model of the Mechanism of Action: Cleavage of Penicillin G; 5.4 Structure of the Complex with Aztreonam; 5.5 Design of Inhibitors; 5.6 Kinetics of the Inhibition Reaction; 5.7 Hydrolysis by Class A Beta-Lactamases; 5.8 X-Ray Structure of the Complex with a Bridged Monobactam; 5.9 Structure-Activity Relationship among Bridged Monobactams; 5.10 Conclusion; References; 6 Inhibition of Sialidase; 6.1 Introduction; 6.2 Influenza: Disease and Virus; 6.3 Structure of Sialidase; 6.4 Mechanism of Catalysis 6.5 Binding of Substrate and Transition State Mimics |
Record Nr. | UNINA-9910144097903321 |
Weinheim ; ; New York, : Wiley-VCH, c1998 | ||
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Lo trovi qui: Univ. Federico II | ||
|
Structure-based ligand design [[electronic resource] /] / edited by Klaus Gubernator, Hans-Joachim Böhm |
Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c1998 |
Descrizione fisica | 1 online resource (170 p.) |
Disciplina | 615.19 |
Altri autori (Persone) |
GubernatorKlaus
BöhmHans-Joachim |
Collana | Methods and principles in medicinal chemistry |
Soggetto topico |
Ligand binding (Biochemistry)
Pharmaceutical chemistry QSAR (Biochemistry) Drugs - Design |
ISBN |
1-282-01029-8
9786612010293 3-527-61217-3 3-527-61216-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Structure-Based Ligand Design; Preface; List of Contributors; Contents; 1 Rational Design of Bioactive Molecules; 1.1 Introduction; 1.1.1 From Ligand Design to Drug Discovery; 1.2 Source of Structural Information; 1.3 Classes of Therapeutic Agents; 1.4 Protein-Ligand Interaction; 1.4.1 Covalent versus Noncovalent Inhibitors; 1.4.2 Nonbonded Interactions in Protein-Ligand Complexes; 1.4.3 HydrogenBonds; 1.4.4 The Role of Solvent in Polar Protein-Ligand Interactions; 1.4.5 Lipophilic Interactions; 1.4.6 Criteria for Strong Protein-Ligand Interactions
1.5 Approaches to Structure-Based Ligand Design1.5.1 Ligands Derived from Substrate or Natural Ligand; 1.5.2 Structures Derived from 3D Database Searches; 1.5.3 De-Novo Design of Ligands; 1.6 Methods and Toois used in Structure-Based Ligand Design; 1.7 Outlook and Future Developments; References; 2 Examples of Active Areas of Structure-Based-Design; 2.1 Thrombin Inhibitors; 2.2 Design of Orally Active Inhibitors of Elastase; 2.3 Dorzolamide:A Success Story of Structure-Based Drug Design; 2.4 Inhibitors of Serine Esterases; 2.4.1 Human Pancreatic Lipase (hPL) 2.4.2 Model of the Trilaurin Triglyceride Substrate Binding2.4.3 Tetrahydrolipstatin (THL); 2.5 Acetylcholinesterase (AChE); 2.5.1 Model of the Acetylcholine Substrate Binding; 2.5.2 Physostigmine; 2.5.3 Eisai E2020; References; 3 From Renin to HIV-1 Protease; 3.1 Introduction; 3.2 Renin; 3.2.1 Catalytic Site Binding; 3.2.2 Backbone Variations; 3.2.3 Subsite Interdependencies; 3.2.4 Renin Crystal Structure; 3.2.5 Summary - Renin Modeling; 3.3 HIV-1 Protease; 3.3.1 3D Structures of HIV-1 Protease; 3.3.2 HIV-1 Protease Nonpeptide Inhibitors 3.3.3 Docking/Modeling HIV-1 Protease Nonpeptide Inhibitors3.4 Summary: Comparison of HIV-1 Protease versus Renin Structure-Based Design; 3.5 Current Limitations/Future Perspective; 3.6 Conclusion; References; 4 Zinc Endoproteases: A Structural Superfamily; 4.1 Introduction; 4.2 Structural Classification of Zinc Endopeptidase Families; 4.2.1 Short Spacer or Metzincins Family; 4.2.2 Long Spacer or Gluzincins Family; 4.3 Overview of Inhibitor Design; 4.4 Current Limitations; 4.5 Future Prospects; References; 5 Structure-Based Design of Potent Beta-Lactamase Inhibitors; 5.1 Introduction 5.2 Structure of Citrobacter freundii Class C Beta-Lactamase5.3 Model of the Mechanism of Action: Cleavage of Penicillin G; 5.4 Structure of the Complex with Aztreonam; 5.5 Design of Inhibitors; 5.6 Kinetics of the Inhibition Reaction; 5.7 Hydrolysis by Class A Beta-Lactamases; 5.8 X-Ray Structure of the Complex with a Bridged Monobactam; 5.9 Structure-Activity Relationship among Bridged Monobactams; 5.10 Conclusion; References; 6 Inhibition of Sialidase; 6.1 Introduction; 6.2 Influenza: Disease and Virus; 6.3 Structure of Sialidase; 6.4 Mechanism of Catalysis 6.5 Binding of Substrate and Transition State Mimics |
Record Nr. | UNINA-9910830551903321 |
Weinheim ; ; New York, : Wiley-VCH, c1998 | ||
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Lo trovi qui: Univ. Federico II | ||
|
Structure-based ligand design [[electronic resource] /] / edited by Klaus Gubernator, Hans-Joachim Böhm |
Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c1998 |
Descrizione fisica | 1 online resource (170 p.) |
Disciplina | 615.19 |
Altri autori (Persone) |
GubernatorKlaus
BöhmHans-Joachim |
Collana | Methods and principles in medicinal chemistry |
Soggetto topico |
Ligand binding (Biochemistry)
Pharmaceutical chemistry QSAR (Biochemistry) Drugs - Design |
ISBN |
1-282-01029-8
9786612010293 3-527-61217-3 3-527-61216-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Structure-Based Ligand Design; Preface; List of Contributors; Contents; 1 Rational Design of Bioactive Molecules; 1.1 Introduction; 1.1.1 From Ligand Design to Drug Discovery; 1.2 Source of Structural Information; 1.3 Classes of Therapeutic Agents; 1.4 Protein-Ligand Interaction; 1.4.1 Covalent versus Noncovalent Inhibitors; 1.4.2 Nonbonded Interactions in Protein-Ligand Complexes; 1.4.3 HydrogenBonds; 1.4.4 The Role of Solvent in Polar Protein-Ligand Interactions; 1.4.5 Lipophilic Interactions; 1.4.6 Criteria for Strong Protein-Ligand Interactions
1.5 Approaches to Structure-Based Ligand Design1.5.1 Ligands Derived from Substrate or Natural Ligand; 1.5.2 Structures Derived from 3D Database Searches; 1.5.3 De-Novo Design of Ligands; 1.6 Methods and Toois used in Structure-Based Ligand Design; 1.7 Outlook and Future Developments; References; 2 Examples of Active Areas of Structure-Based-Design; 2.1 Thrombin Inhibitors; 2.2 Design of Orally Active Inhibitors of Elastase; 2.3 Dorzolamide:A Success Story of Structure-Based Drug Design; 2.4 Inhibitors of Serine Esterases; 2.4.1 Human Pancreatic Lipase (hPL) 2.4.2 Model of the Trilaurin Triglyceride Substrate Binding2.4.3 Tetrahydrolipstatin (THL); 2.5 Acetylcholinesterase (AChE); 2.5.1 Model of the Acetylcholine Substrate Binding; 2.5.2 Physostigmine; 2.5.3 Eisai E2020; References; 3 From Renin to HIV-1 Protease; 3.1 Introduction; 3.2 Renin; 3.2.1 Catalytic Site Binding; 3.2.2 Backbone Variations; 3.2.3 Subsite Interdependencies; 3.2.4 Renin Crystal Structure; 3.2.5 Summary - Renin Modeling; 3.3 HIV-1 Protease; 3.3.1 3D Structures of HIV-1 Protease; 3.3.2 HIV-1 Protease Nonpeptide Inhibitors 3.3.3 Docking/Modeling HIV-1 Protease Nonpeptide Inhibitors3.4 Summary: Comparison of HIV-1 Protease versus Renin Structure-Based Design; 3.5 Current Limitations/Future Perspective; 3.6 Conclusion; References; 4 Zinc Endoproteases: A Structural Superfamily; 4.1 Introduction; 4.2 Structural Classification of Zinc Endopeptidase Families; 4.2.1 Short Spacer or Metzincins Family; 4.2.2 Long Spacer or Gluzincins Family; 4.3 Overview of Inhibitor Design; 4.4 Current Limitations; 4.5 Future Prospects; References; 5 Structure-Based Design of Potent Beta-Lactamase Inhibitors; 5.1 Introduction 5.2 Structure of Citrobacter freundii Class C Beta-Lactamase5.3 Model of the Mechanism of Action: Cleavage of Penicillin G; 5.4 Structure of the Complex with Aztreonam; 5.5 Design of Inhibitors; 5.6 Kinetics of the Inhibition Reaction; 5.7 Hydrolysis by Class A Beta-Lactamases; 5.8 X-Ray Structure of the Complex with a Bridged Monobactam; 5.9 Structure-Activity Relationship among Bridged Monobactams; 5.10 Conclusion; References; 6 Inhibition of Sialidase; 6.1 Introduction; 6.2 Influenza: Disease and Virus; 6.3 Structure of Sialidase; 6.4 Mechanism of Catalysis 6.5 Binding of Substrate and Transition State Mimics |
Record Nr. | UNINA-9910841066003321 |
Weinheim ; ; New York, : Wiley-VCH, c1998 | ||
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Lo trovi qui: Univ. Federico II | ||
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