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Farmaceutická chemie léčiv působících na centrální nervový systém / / Martin Dolezal
| Farmaceutická chemie léčiv působících na centrální nervový systém / / Martin Dolezal |
| Autore | Dolezal Martin |
| Pubbl/distr/stampa | [Prague, Czech Republic] : , : Karolinum, , 2013 |
| Descrizione fisica | 1 online resource (188 p.) |
| Disciplina | 615.19 |
| Collana | Učební texty Univerzity Karlovy v Praze |
| Soggetto topico |
Pharmaceutical chemistry
Neuropharmacology |
| ISBN | 80-246-2407-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | cze |
| Record Nr. | UNINA-9910787240103321 |
Dolezal Martin
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| [Prague, Czech Republic] : , : Karolinum, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Farmaceutická chemie léčiv působících na centrální nervový systém / / Martin Dolezal
| Farmaceutická chemie léčiv působících na centrální nervový systém / / Martin Dolezal |
| Autore | Dolezal Martin |
| Pubbl/distr/stampa | [Prague, Czech Republic] : , : Karolinum, , 2013 |
| Descrizione fisica | 1 online resource (188 p.) |
| Disciplina | 615.19 |
| Collana | Učební texty Univerzity Karlovy v Praze |
| Soggetto topico |
Pharmaceutical chemistry
Neuropharmacology |
| ISBN | 80-246-2407-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | cze |
| Record Nr. | UNINA-9910819999203321 |
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Dolezal Martin
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| [Prague, Czech Republic] : , : Karolinum, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Handbook of Neuroemergency Clinical Trials
| Handbook of Neuroemergency Clinical Trials |
| Autore | Skolnick Brett E |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Saint Louis : , : Elsevier Science & Technology, , 2017 |
| Descrizione fisica | 1 online resource (408 pages) |
| Disciplina | 616.8/0461 |
| Altri autori (Persone) | AlvesWayne M |
| Soggetto topico |
Nervous system - Diseases
Neuropharmacology Clinical trials |
| ISBN | 0-12-804064-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover -- HANDBOOK OF NEUROEMERGENCY CLINICAL TRIALS -- HANDBOOK OF NEUROEMERGENCY CLINICAL TRIALS -- Copyright -- Dedications -- Contents -- List of Contributors -- Introduction -- CURRENT STATUS OF TREATMENT OF NEUROEMERGENCIES -- ACUTE NEUROCLINICAL TRIALS -- PURPOSE OF THIS VOLUME -- References -- 1 - ACUTE ISCHEMIC STROKEPARTI -- 1 - Acute Ischemic Stroke -- INTRODUCTION -- TRIALS OF REPERFUSION THERAPIES FOR ISCHEMIC STROKE -- Stroke Alteplase Thrombolysis Trials -- The NINDS tPA Trial -- ECASS 1 and 2 Trials -- ATLANTIS Trial -- ECASS 3 Trial -- EPITHET Trial -- IST-3 Trial -- Metaanalyses of Thrombolysis Trials -- Phase 4 Data: Postmarketing Studies in Alteplase Stroke Thrombolysis -- Future Priorities -- Implementation -- Ongoing Trials and Future Directions -- Endovascular Revascularization Trials -- Early Mechanical Thrombectomy Trials -- Endovascular Thrombectomy Using Stent Retrievers -- Metaanalyses of Thrombectomy Trials -- Major Unresolved Questions Around Endovascular Thrombectomy -- ANTITHROMBOTIC DRUGS -- NEUROPROTECTIVE DRUGS IN ACUTE ISCHEMIC STROKE -- STUMBLING FROM THE BENCH TO BEDSIDE -- PHYSIOLOGICAL MODIFICATION OF THE ISCHEMIC ENVIRONMENT -- CONCLUSIONS -- References -- 2 - Subarachnoid Hemorrhage -- CHARACTERISTICS OF THE DISEASE -- Etiology-Why Do Studies Restrict Inclusion to Aneurysmal Subarachnoid Hemorrhage? -- Pathophysiology Considerations Relevant to Clinical Trials -- Clinical Features and Diagnosis -- GUIDELINES FOR MANAGEMENT OF SUBARACHNOID HEMORRHAGE -- SUCCESSES AND DISAPPOINTMENTS -- Ineffective Interventions -- Treatment Side Effects -- Sample Size and Outcome Measures -- The Quagmire of Rescue Therapy -- Center Variation and Practice Misalignment -- Multifactorial Nature of Delayed Cerebral Ischemia and Prognostic Factors for Outcome -- SUBPOPULATIONS AND OUTCOMES AND THEIR ASSESSMENT.
BIOMARKERS AND SURROGATE ENDPOINTS -- PHARMACOKINETICS AND PHARMACODYNAMICS -- CONSENSUS REGARDING FAILURES AND POSSIBLE SOLUTIONS -- CURRENT "STATE OF PRACTICE" IN DESIGN AND ANALYSIS OF RANDOMIZED CONTROLLED TRIALS FOR SUBARACHNOID HEMORRHAGE -- Disclosures -- References -- 3 - Clinical Trials in Spontaneous Intracerebral Hemorrhage -- INTRODUCTION -- HEMATOMA GROWTH -- Blood Pressure -- Hemostasis -- NEUROPROTECTION -- Cerebral Edema -- Neuroinflammation -- Iron Toxicity/Chelation -- Apoptosis -- Cryoprotection -- SURGERY -- CONCLUSIONS -- References -- 4 - Imaging Biomarkers in Stroke Trials -- INTRODUCTION AND DESCRIPTION OF IMAGING BIOMARKERS -- IMAGING OF INTRALUMINAL THROMBUS -- VASCULAR IMAGING -- COLLATERAL ARTERIAL SUPPLY -- ISCHEMIC CORE AND PENUMBRA -- PREDICTIVE VERSUS PROGNOSTIC BIOMARKERS -- UTILITY OF IMAGING BIOMARKERS -- CONCLUSIONS AND FUTURE DIRECTIONS -- References -- II - TRAUMATIC BRAIN INJURY -- 5 - Traumatic Brain Injury -- INTRODUCTION -- HISTORICAL CONTEXT OF TRAUMATIC BRAIN INJURY TRIALS -- DRUG DEVELOPMENT PROGRAMS FOR TRAUMATIC BRAIN INJURY -- Underlying Logic of Traumatic Brain Injury Trials -- Classes of Novel Drugs Tested in Traumatic Brain Injury -- DRUGS AND TREATMENTS TESTED TO DATE FOR TRAUMATIC BRAIN INJURY -- Barbiturates -- High-Dose Corticosteroids -- Tromethamine (THAM) -- ION CHANNEL BLOCKERS -- Free Radical Scavengers -- Glutamate Antagonists -- Glutamate Agonists -- CDP-Choline -- Immune System Modulators -- Statins -- Progesterone -- Hypothermia -- WHY HAVE TRAUMATIC BRAIN INJURY TRIALS PROVEN TO BE SO DIFFICULT? -- KEY ISSUES IN TRAUMATIC BRAIN INJURY CLINICAL TRIAL DESIGN -- Multiplicity of Injuries -- Anatomic Classification of Traumatic Brain Injury -- Treatment-Related Problems -- Limitations of Traumatic Brain Injury Classification -- Limitations of the Outcome Measures -- Glasgow Coma Scale. CT Classification of Traumatic Brain Injury Population -- Prognostic Factors -- Glasgow Outcome Scale -- Outcomes in Traumatic Brain Injury Clinical Trials -- Time Course of Recovery -- Respecifying the Glasgow Outcome Scale -- Shape of Outcome Distribution -- Pharmacokinetic-Pharmacodynamic Correlations -- Censoring Treatment Populations -- CONCLUSIONS -- References -- 6 - Improving Approaches to Evaluate Efficacy and Safety of Drugs for Traumatic Brain Injury -- TRANSLATIONAL APPROACHES -- Extended Experimental Studies -- Better Characterization of Disease Biology and Drug Distribution in Human Traumatic Brain Injury -- IMPROVING TRIAL DESIGN AND ANALYSIS -- Heterogeneity and Statistical Power -- Heterogeneity and Risk of Imbalances -- Dealing With Heterogeneity in Efficacy Analysis -- ALTERNATIVE STRATEGIES TO EXPLORING CLINICAL EFFICACY -- References -- 7 - Brain Imaging in Traumatic Brain Injury -- INTRODUCTION -- TYPES OF BRAIN INJURIES -- Primary Injuries -- Secondary Injuries -- CLASSIFICATION OF TRAUMATIC BRAIN INJURY -- Imaging Modalities -- Conventional Radiography -- Ultrasound -- Computed Tomography -- Computed Tomography Angiography -- Conventional Magnetic Resonance Imaging -- Advanced Techniques -- Diffusion Weighted Imaging-Diffusion Tensor Imaging -- Functional Magnetic Resonance Imaging -- Perfusion Imaging -- Magnetic Resonance Spectroscopy -- Magnetization Transfer Imaging -- Magnetoencephalography -- Single-Photon Emission Computed Tomography -- Positron Emission Tomography -- IMPLICATIONS AND CHALLENGES FOR CLINICAL TRIALS -- CONCLUSION -- References -- 8 - The Use of Blood-Based Biomarkers to Improve the Design of Clinical Trials of Traumatic Brain Injury -- INTRODUCTION -- Traumatic Brain Injury Diagnostics -- Traumatic Brain Injury Management. Recent Successes and Disappointments of Clinical Trials for Novel Drugs to Treat Traumatic Brain Injury Management -- Promises of Biomarker Applications in Traumatic Brain Injury Clinical Trials -- SUMMARY OF SEARCH OF CLINICAL TRIALS IN TRAUMATIC BRAIN INJURY USING BIOMARKERS -- SURROGATE ENDPOINTS AND SELECTION OF CENTRAL NERVOUS SYSTEM-SPECIFIC PROTEIN BIOMARKERS FOR SEVERE TRAUMATIC BRAIN INJURY DIAGNO... -- Biomarkers Potentially Useful in Traumatic Brain Injury Trials -- Biomarkers of Glial Injury -- Glial Fibrillary Acidic Protein -- S100 Calcium Binding Protein B (S100B) -- Biomarkers of Neuronal Injury -- Ubiquitin Carboxy-Terminal Hydrolase L1 -- αII-Spectrin Breakdown Products 120, 145, and 150 (SBDP120, SBDP145, SBDP150) -- Microtubule-Associated Protein 2 -- Myelin Basic Protein and Its Autoantibody -- Neuron-Specific Enolase -- Neurofilaments -- Total Tau and Its Cleaved Forms -- Biomarkers of Inflammation and Vascular Injury -- Cytokines -- Cell Adhesion Molecules -- Other Biomarkers -- MicroRNAs -- DISCUSSION -- Improving of the Study Design Using Blood-Based Biomarkers and Their Combination With Other Outcomes Measures -- Statistical Considerations in Clinical Trials Using Biomarker Studies -- PROSPECTS AND PATHWAYS FOR INCORPORATION OF BLOOD-BASED BIOMARKERS INTO THE DESIGN OF CLINICAL TRIALS FOR TRAUMATIC BRAIN INJURY... -- References -- 9 - Biostatistical Issues in TBI Clinical Trials -- INTRODUCTION -- CLINICAL TRIAL DESIGN -- Dose-Finding Designs -- Selection Designs -- Futility Designs -- Confirmatory Designs -- Adaptive Designs -- APPROACHES TO RANDOMIZATION -- Achieving Balance With Respect to Known Prognostic Variables -- Covariate-Adaptive Randomization -- Response-Adaptive Randomization -- Comparing Baseline Characteristics in a Randomized Trial -- OUTCOME MEASURES -- Glasgow Outcome Scale/Glasgow Outcome Scale Extended. Performance-Based Measures -- Patient-Reported Outcomes -- Clinician-Reported Outcomes -- Biomarkers -- ANALYTICAL APPROACHES -- The Fixed Dichotomy -- The Sliding Dichotomy -- Ordinal Analysis -- MISSING DATA -- MULTIPLICITY -- SUBGROUP ANALYSIS -- ASSESSMENTS CONDUCTED OVER TIME -- HETEROGENEITY OF THE PATIENT POPULATION -- SUMMARY -- References -- III - SEIZURE EMERGENCIES -- 10 - Acute Seizures and Status Epilepticus -- OVERVIEW -- DIAGNOSIS AND DEFINITION OF STATUS EPILEPTICUS -- CLASSIFICATION OF STATUS EPILEPTICUS -- Semiology -- Etiology -- Electroencephalographic Correlates -- Age -- ANIMAL MODELS: RELEVANT ISSUES FOR CLINICAL DEVELOPMENT PROGRAMS -- EPIDEMIOLOGY AND NATURAL HISTORY -- Acute Repetitive Seizures -- Generalized Convulsive Status Epilepticus -- Refractory Status Epilepticus -- Super-refractory Status Epilepticus -- Nonconvulsive Status Epilepticus -- MECHANISMS OF DISEASE AND PATHOLOGY -- DIAGNOSIS AND SUBPOPULATIONS -- Severity of Injury Measures -- Seizure Type -- Level of Consciousness -- Duration -- Response to Treatment (Status Epilepticus Stage) -- Etiology -- Concomitant Medical Illnesses -- Defining Relevant Treatment Populations -- Defining Good and Poor Prognoses -- Relevant Prognostic Factors for Defining Inclusion and Exclusion Criteria -- Subsetting Patients for Planned and Ad Hoc Comparisons -- CURRENT DISEASE MANAGEMENT AND CONTROVERSIES -- Initial Management Steps -- Prevention of Status Epilepticus: Acute Repetitive Seizures -- Generalized Convulsive Status Epilepticus -- Early Status Epilepticus Treatment -- Established Status Epilepticus -- Refractory Status Epilepticus and Super-refractory Status Epilepticus -- Nonconvulsive Status Epilepticus -- Specific Drugs -- ISSUES IN CLINICAL PROTOCOL DEVELOPMENT -- Time to Treatment -- Operational Definitions of Status Epilepticus -- Site Selection -- Sample Size. Treatment Selection. |
| Record Nr. | UNINA-9910583058203321 |
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Skolnick Brett E
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| Saint Louis : , : Elsevier Science & Technology, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The international journal of neuropsychopharmacology
| The international journal of neuropsychopharmacology |
| Pubbl/distr/stampa | [Cambridge, England], : Cambridge University Press |
| Disciplina | 615.78 |
| Soggetto topico |
Neuropsychopharmacology
Neuropharmacology Psychopharmacology Mental Disorders - drug therapy Psychotropic Drugs - pharmacology Neuropsychopharmacologie Neuropharmacologie Psychopharmacologie Neuropharmakologie Zeitschrift Online-Ressource Psychopharmakologie Psychopharmakon |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1469-5111 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996321135603316 |
| [Cambridge, England], : Cambridge University Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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The international journal of neuropsychopharmacology
| The international journal of neuropsychopharmacology |
| Pubbl/distr/stampa | [Cambridge, England], : Cambridge University Press |
| Disciplina | 615.78 |
| Soggetto topico |
Neuropsychopharmacology
Neuropharmacology Psychopharmacology Mental Disorders - drug therapy Psychotropic Drugs - pharmacology Neuropsychopharmacologie Neuropharmacologie Psychopharmacologie Neuropharmakologie Zeitschrift Online-Ressource Psychopharmakologie Psychopharmakon |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1469-5111 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910140517403321 |
| [Cambridge, England], : Cambridge University Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Journal of autonomic pharmacology
| Journal of autonomic pharmacology |
| Pubbl/distr/stampa | [Oxford, England], : Blackwell Science, -©2001 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Autonomic nervous system - Effect of drugs on
Autonomic drugs Neuropharmacology Système nerveux autonome, Effets des médicaments sur le Médicaments du système nerveux autonome Neuropharmacologie Système nerveux autonome - Effets des médicaments sur Neurology Pharmacology |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1365-2680 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910154519303321 |
| [Oxford, England], : Blackwell Science, -©2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Journal of autonomic pharmacology
| Journal of autonomic pharmacology |
| Pubbl/distr/stampa | [Oxford, England], : Blackwell Science, -©2001 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7 |
| Soggetto topico |
Autonomic nervous system - Effect of drugs on
Autonomic drugs Neuropharmacology Système nerveux autonome, Effets des médicaments sur le Médicaments du système nerveux autonome Neuropharmacologie Système nerveux autonome - Effets des médicaments sur Neurology Pharmacology |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1365-2680 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996202278503316 |
| [Oxford, England], : Blackwell Science, -©2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Journal of cognitive enhancement
| Journal of cognitive enhancement |
| Pubbl/distr/stampa | Basel, Switzerland : , : Springer International Publishing, , [2017]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Cognitive neuroscience
Nootropic agents Cognitive science Cognitive therapy Neuropharmacology Cognition Biomedical Enhancement Nootropic Agents |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2509-3304 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910481984903321 |
| Basel, Switzerland : , : Springer International Publishing, , [2017]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Journal of neuroimmune pharmacology
| Journal of neuroimmune pharmacology |
| Pubbl/distr/stampa | New York, NY, : Springer Science + Business Media, ©2006- |
| Disciplina | 615.37 |
| Soggetto topico |
Neuropharmacology
Immunopharmacology Neuroimmunology Allergy and Immunology Neuro-immunologie Immunopharmacologie |
| Soggetto genere / forma |
Periodicals.
Périodique électronique (Descripteur de forme) Répertoire (Descripteur de forme) |
| ISSN | 1557-1904 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | JNIP |
| Record Nr. | UNINA-9910144187803321 |
| New York, NY, : Springer Science + Business Media, ©2006- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Journal of neuroimmune pharmacology
| Journal of neuroimmune pharmacology |
| Pubbl/distr/stampa | New York, NY, : Springer Science + Business Media, ©2006- |
| Disciplina | 615.37 |
| Soggetto topico |
Neuropharmacology
Immunopharmacology Neuroimmunology Allergy and Immunology Neuro-immunologie Immunopharmacologie |
| Soggetto genere / forma |
Periodicals.
Périodique électronique (Descripteur de forme) Répertoire (Descripteur de forme) |
| ISSN | 1557-1904 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | JNIP |
| Record Nr. | UNISA-996211653503316 |
| New York, NY, : Springer Science + Business Media, ©2006- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Soggetto topico
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Neuropharmacology
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