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Manual of clinical oncology / / editors, Bartosz Chmielowski, MD, PhD, Associate Clinical Professor, Jonsson Comprehensive Cancer Center, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, California, Mary Territo, MD, Emeritus Professor of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
| Manual of clinical oncology / / editors, Bartosz Chmielowski, MD, PhD, Associate Clinical Professor, Jonsson Comprehensive Cancer Center, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, California, Mary Territo, MD, Emeritus Professor of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California |
| Edizione | [8th edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer, , [2017] |
| Descrizione fisica | 1 online resource (1,092 pages) |
| Disciplina | 616.99/4 |
| Collana | Lippincott Manual |
| Soggetto topico |
Neoplasms - diagnosis
Neoplasms - therapy Medical Oncology - methods Oncology |
| Soggetto genere / forma | Handbooks |
| ISBN | 1-4963-4959-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910826687803321 |
| Philadelphia : , : Wolters Kluwer, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Biomarkers for Cancer Diagnosis and Therapy
| Molecular Biomarkers for Cancer Diagnosis and Therapy |
| Autore | Sobti Ranbir Chander |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore Pte. Limited, , 2024 |
| Descrizione fisica | 1 online resource (770 pages) |
| Disciplina | 616.994075 |
| Altri autori (Persone) |
SugimuraHaruhiko
SobtiAastha |
| Soggetto topico |
Early Detection of Cancer
Biomarkers, Tumor Neoplasms - diagnosis Neoplasms - therapy |
| ISBN | 9789819937462 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Introduction -- References -- Contents -- Editors and Contributors -- 1: Molecular Biomarkers of Cancer and Their Diagnostic Applications -- 1.1 Introduction -- 1.2 Advancement and Challenges in Cancer Biomarker Science -- 1.2.1 Specificity of the Biomarkers -- 1.2.2 Screening Strategies -- 1.2.3 Inheritance of Particular Cancer -- 1.2.4 Identification and Monitoring of Biomarkers -- 1.3 Clinical Implications of Various Cancer Biomarkers -- 1.3.1 DNA Methylation as an Epigenetic Cancer Biomarker -- 1.3.2 Noncoding RNAs (MicroRNAs) as Cancer Biomarkers -- 1.3.3 Protein Biomarkers in various cancers -- 1.3.4 Fusion Genes in Cancer Diagnostics -- 1.4 Concluding Remarks -- References -- 2: Statistical Models in Cancer Management -- 2.1 Introduction -- 2.2 Markov Framework Model for Cancer Screening -- 2.3 Analytical Models -- 2.4 The Standardized Regression Model in Cancer -- 2.5 Ordinary Differential Equations (ODEs) -- 2.6 PARADIGM -- 2.6.1 Generalized Diagram of Working of PARADIGM -- 2.7 Logistic Model -- 2.8 Cox Survival Model -- 2.9 Continuous Growth Model -- 2.10 Conclusion -- References -- 3: Cancer: Epidemiology, Racial, and Geographical Disparities -- 3.1 Epidemiology -- 3.1.1 Cancer and Age Group -- 3.1.2 Cancer and Gender -- 3.1.3 Cancer Type and Risk Factor -- 3.1.4 Cancer and Sex Ratio -- 3.1.5 Cancer and Mortality Rate -- 3.2 Racial Disparities -- 3.3 Geographical Disparities -- 3.3.1 Lung and Bronchus -- 3.3.2 Colon and Rectum -- 3.3.3 Female Breast -- 3.3.4 Prostate -- 3.3.5 Stomach -- 3.3.6 Liver -- 3.3.7 Oesophagus -- 3.3.8 Cervix Uteri -- 3.4 Conclusion -- References -- 4: Protein Markers in the Detection of Cancer -- 4.1 Introduction -- 4.1.1 Tumor Markers Used in Cancer -- 4.1.1.1 Two Types of Tumor Markers Are Used Clinically -- 4.2 Circulating Tumor Markers -- 4.3 Tumor Tissue Markers.
4.3.1 Some Important Tumor Markers Are Currently Being Used for Detection of Cancer -- 4.3.2 Proteomic Signatures of Cancer -- 4.3.3 Heat Shock Proteins -- 4.3.4 Carcino Embryonic Antigen -- 4.3.5 Tissue Inhibitor of Matrix Metalloproteinase 1 -- 4.3.6 Enzymes -- 4.3.7 MiRNAs -- 4.3.8 Cytokines -- 4.3.9 Chemokines -- 4.3.10 Stem Cell Associated Markers -- 4.3.10.1 Test Routinely Used for Cancer Detection -- 4.3.11 Prostate-Specific Antigen (PSA) -- 4.3.12 Liquid Biopsy Based Assays Test -- 4.3.12.1 Future Prospective of Protein Markers in Cancer Treatment -- References -- 5: Computer-Aided Diagnosis System for Early Detection of Malignant Tissues -- 5.1 Introduction -- 5.2 CAD for Different Types of Cancers -- 5.2.1 Prostate Cancer -- 5.2.2 Cervical Cancer -- 5.2.3 Pancreatic Cancer -- 5.2.4 Colon Polyps -- 5.2.5 Kidney -- 5.2.6 Skin Cancer -- 5.2.7 Breast Cancer -- 5.3 Conclusion -- References -- 6: Molecular Mechanisms of Oncogenesis -- 6.1 Oncogenesis: A Multistep Process -- 6.1.1 Cell-Cycle Dysregulation -- 6.1.2 Alteration in Apoptosis, Senescence, and Cell Growth Arrest -- 6.1.3 Autonomous to Growth Factors Signaling -- 6.1.4 Metastasis and Invasion -- 6.2 Factors Triggering Oncogenesis -- 6.2.1 Carcinogenic Chemicals -- 6.2.2 Ionizing and Ultraviolet Radiation -- 6.2.3 Oncogenic Viruses -- 6.2.4 The Tumor Microenvironment -- 6.2.5 Chemotherapeutic Agents -- 6.2.6 Tumor Promoters -- 6.3 Molecular Mechanisms Underlying the Process of Oncogenesis -- 6.3.1 Activation of Oncogenes -- 6.3.2 Inactivation of Tumor-Suppressor Genes -- 6.3.3 Epigenetic Alterations -- 6.3.4 OncomiR (microRNA Genes) -- 6.3.5 Mutations in DNA Repair Genes/Genomic Stability Genes -- 6.3.6 Defects in Cell-Cycle Regulation -- References -- 7: Application of CRISPR in Cancer Research and Treatment -- 7.1 Introduction -- 7.2 CRISPR/Cas9 in Cancer Research. 7.2.1 Generation of Cancer Models -- 7.2.2 Target Discovery and Validation in Oncology -- 7.3 CRISPR/Cas9 for Diagnostics -- 7.4 Applications of CRISPR/Cas9 in Cancer Treatment -- 7.4.1 CRISPR/Cas9 System in CAR-T Cell Immunotherapy -- 7.4.2 CRISPR/Cas9 for Inhibition of Immune Checkpoint Signaling -- 7.5 Conclusions and Perspectives -- References -- 8: Nanobiosensing Platforms for Early Detection of Cancer -- 8.1 Introduction -- 8.2 Conventional Methods of Cancer Detection and Challenges -- 8.3 Biomarkers for Cancer Detection -- 8.3.1 Nanoparticle-Based Biosensor Platforms for Cancer Detection -- 8.4 Gold Nanoparticle-Based Biosensing Probe for Cancer Detection -- 8.5 Carbon-Based Nanobiosensors -- 8.6 Quantum Dot-Based Cancer Biosensing and Bioimaging Platform -- 8.6.1 Nanoparticle-Based Multiplexed Biosensing Assay -- 8.7 Conclusion -- References -- 9: Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy -- 9.1 Cancer Burden and Impact -- 9.2 Oral Cancer and Burden -- 9.2.1 Oral Cancer: Screening Accuracy, Efficacy and Harms -- 9.2.2 Oral Cancer: Role of Nanotechnology -- 9.2.3 Clinical Diagnosis: Oral Cancer -- 9.2.4 Management: Oral Cancer -- 9.2.5 Economics of Nano Strategies: Oral Cancer -- 9.3 Colon Cancer and Burden -- 9.3.1 Colon Cancer: Screening Accuracy, Efficacy and Harms -- 9.3.2 Colon Cancer: Role of Nanotechnology -- 9.3.3 Clinical Diagnosis: Colon Cancer -- 9.3.4 Management: Colon Cancer -- 9.3.5 Economics of Nano Strategies: Colon Cancer -- 9.4 Challenges in Bionanotechnological Interventions -- 9.5 Way Forward -- 9.6 Conclusion -- References -- 10: Central Nervous System Tumors -- 10.1 Part I: Gliomas -- 10.1.1 Background -- 10.1.2 Anatomical Location -- 10.1.3 Epidemiology -- 10.1.4 Clinical Presentation -- 10.1.5 History and Physical Examination -- 10.1.6 Investigations. 10.1.6.1 MR Spectroscopy -- 10.1.6.2 PET-CT Scan -- 10.1.7 Risk Factors -- 10.1.7.1 Environmental Factors -- 10.1.7.2 Hereditary Factors -- 10.1.8 Histology -- 10.1.9 Management -- 10.1.9.1 Low-Grade Gliomas (LGG) -- 10.1.9.1.1 Surgery -- Circumscribed Low-Grade Gliomas -- Infiltrative or Diffuse Low-Grade Gliomas -- 10.1.9.1.2 Radiotherapy (RT) -- Adjuvant Radiotherapy Alone -- Adjuvant Radiotherapy and Chemotherapy -- Dose/Fractionation -- Advanced Radiotherapy Modalities -- 10.1.10 Anaplastic Gliomas -- 10.1.11 Anaplastic Astrocytomas -- 10.1.12 Anaplastic Oligodendroglial Tumors -- 10.1.13 Grade IV Glial Tumors -- 10.1.14 Immunotherapy -- 10.1.15 Tumor Treating Fields -- 10.1.16 Elderly Patients with GBM -- 10.1.17 Pseudoprogression in Glioma -- 10.1.18 Recurrent Malignant Gliomas -- 10.1.18.1 Surgery -- 10.1.18.2 Reirradiation -- 10.1.18.2.1 Brachytherapy -- 10.1.18.2.2 Radiosurgery -- 10.1.18.2.3 Fractionated EBRT -- 10.1.18.2.4 Systemic Therapy -- 10.1.19 Irradiation Techniques and Toxicities -- 10.1.20 Toxicities of Radiotherapy -- 10.1.21 Radiotherapy for Grade III Gliomas -- 10.2 Part II: Other CNS Tumors -- 10.2.1 Meningioma -- 10.2.2 Clinical Features -- 10.2.3 Radiological Features -- 10.2.4 Histopathology -- 10.2.5 Management -- 10.2.6 Primitive Neuroectodermal (PNET) Tumors -- 10.2.7 Treatment -- 10.2.8 Vestibular Schwannoma -- 10.2.9 Pituitary Adenoma -- 10.2.10 Craniopharyngioma -- 10.2.11 Glomus Jugulare -- 10.2.12 Pineal Region Tumors -- 10.2.13 Ependymoma -- 10.2.14 Metastases -- References -- 11: Biomedical Approaches in the Research and Management of Head and Neck Squamous Cell Carcinoma -- 11.1 Introduction -- 11.2 Risk Factors for the Development of HNSCC -- 11.3 Overview of HNSCC Tumorigenesis and Biology -- 11.4 miRNA Deregulation in HNSCC and Circulating miRNAs in Liquid Biopsies -- 11.5 Machine-Learning (ML) Techniques. 11.6 Raman Spectroscopy (RS) -- 11.7 Organoid Models (Three-Dimensional [3D] Cancer Cell Cultures) -- 11.8 Conclusions -- References -- 12: Applications of Molecular Biology and Biomedical Advances in Ocular Oncology -- 12.1 Introduction -- 12.2 Retinoblastoma -- 12.2.1 Introduction -- 12.2.2 Genetics -- 12.2.3 Genomic Landscape in Retinoblastoma -- 12.2.4 Etiopathogenesis -- 12.2.5 Cell of Origin -- 12.2.6 Development of Three-Dimensional Organoid Models -- 12.2.7 Techniques to Test RB1 Mutations -- 12.2.8 New Heritable Marker in Retinoblastoma: p16INK4a -- 12.2.9 Surging Potential of Liquid Biopsy -- 12.2.10 Oncolytic Virus VCN-01: A New Ray of Hope in RB Treatment -- 12.2.11 Role of Negative Transcriptional Regulators: MicroRNAs (miRNAs) -- 12.2.11.1 Introduction -- 12.2.11.2 miRNAs in Retinoblastoma -- 12.2.12 p53 in Peripheral Blood of RB Patients as a Biomarker -- 12.2.13 Novel Targets for RB Treatment -- 12.2.14 Noncoding RNAs in RB -- 12.2.15 Prenatal Diagnostic Testing -- 12.2.16 Autofluorescence in RB -- 12.2.17 PDT for RB In Vitro Studies -- 12.2.18 Spectral Domain Optical Coherence Tomography in Retinoblastoma -- 12.2.19 Optical Coherence Tomography Angiography in RB -- 12.3 Uveal Melanoma -- 12.3.1 Introduction -- 12.3.2 Genetics of Uveal Melanoma -- 12.3.2.1 Genetic Prognostic Tests -- 12.3.3 Current Innovative Therapeutic Options for Metastatic Tumors -- 12.3.3.1 Targeted Therapy -- 12.3.3.2 Immunotherapy -- 12.3.3.2.1 Checkpoint Inhibitors -- 12.3.3.2.2 Innovative Immune-Based Approaches -- 12.3.3.2.3 Epigenetic Approach -- 12.3.4 Conclusion -- 12.4 Primary Vitreoretinal Lymphoma -- 12.4.1 Introduction -- 12.4.2 Genetics of Vitreoretinal Lymphoma -- 12.4.3 Diagnosis of Vitreoretinal Lymphoma -- 12.4.4 Advances in the Treatment of Vitreoretinal Lymphoma -- 12.5 Conclusion -- References -- 13: Molecular Biomarkers of Oral Cancer. 13.1 Introduction. |
| Record Nr. | UNINA-9910869175103321 |
Sobti Ranbir Chander
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| Singapore : , : Springer Singapore Pte. Limited, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular cancer therapeutics
| Molecular cancer therapeutics |
| Pubbl/distr/stampa | [Philadelphia, Pa.], : American Association for Cancer Research, ©2001- |
| Disciplina | 615 |
| Soggetto topico |
Cancer - Molecular aspects
Cancer - Treatment Molecular Biology Neoplasms - therapy |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1538-8514 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910134074203321 |
| [Philadelphia, Pa.], : American Association for Cancer Research, ©2001- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular cancer therapeutics
| Molecular cancer therapeutics |
| Pubbl/distr/stampa | [Philadelphia, Pa.], : American Association for Cancer Research, ©2001- |
| Disciplina | 615 |
| Soggetto topico |
Cancer - Molecular aspects
Cancer - Treatment Molecular Biology Neoplasms - therapy |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1538-8514 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996198235103316 |
| [Philadelphia, Pa.], : American Association for Cancer Research, ©2001- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Nature reviews Clinical oncology
| Nature reviews Clinical oncology |
| Pubbl/distr/stampa | London, : Nature Pub. Group, 2009- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Oncology
Clinical medicine Oncology - Diseases - Diagnosis Oncology - Diseases - Treatment - Research Neoplasms - therapy Neoplasms - diagnosis Palliative Care Cancérologie Médecine clinique Cancérologie - Maladies - Diagnostic Cancérologie - Maladies - Traitement - Recherche |
| Soggetto genere / forma |
Periodical
Periodicals. periodicals. Périodiques. |
| Soggetto non controllato | Oncology |
| ISSN | 1759-4782 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Oncology |
| Record Nr. | UNISA-996335456703316 |
| London, : Nature Pub. Group, 2009- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Nature reviews Clinical oncology
| Nature reviews Clinical oncology |
| Pubbl/distr/stampa | London, : Nature Pub. Group, 2009- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Oncology
Clinical medicine Oncology - Diseases - Diagnosis Oncology - Diseases - Treatment - Research Neoplasms - therapy Neoplasms - diagnosis Palliative Care Cancérologie Médecine clinique Cancérologie - Maladies - Diagnostic Cancérologie - Maladies - Traitement - Recherche |
| Soggetto genere / forma |
Periodical
Periodicals. periodicals. Périodiques. |
| Soggetto non controllato | Oncology |
| ISSN | 1759-4782 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Oncology |
| Record Nr. | UNINA-9910144400603321 |
| London, : Nature Pub. Group, 2009- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Oncoimmunology
| Oncoimmunology |
| Pubbl/distr/stampa | [Abingdon] : , : Taylor & Francis, , 2012- |
| Descrizione fisica | 1 online resource |
| Disciplina | 616.9 |
| Soggetto topico |
Tumors - Immunological aspects
Neoplasms - therapy Immunotherapy |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2162-402X |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910139153003321 |
| [Abingdon] : , : Taylor & Francis, , 2012- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Oncoimmunology
| Oncoimmunology |
| Pubbl/distr/stampa | [Abingdon] : , : Taylor & Francis, , 2012- |
| Descrizione fisica | 1 online resource |
| Disciplina | 616.9 |
| Soggetto topico |
Tumors - Immunological aspects
Neoplasms - therapy Immunotherapy |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2162-402X |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996203073703316 |
| [Abingdon] : , : Taylor & Francis, , 2012- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Oncologic Emergency Medicine : Principles and Practice / / edited by Knox H. Todd, Charles R. Thomas, Jr
| Oncologic Emergency Medicine : Principles and Practice / / edited by Knox H. Todd, Charles R. Thomas, Jr |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (530 p.) |
| Disciplina | 610 |
| Soggetto topico |
Emergency medicine
Oncology Primary care (Medicine) Neoplasms - therapy Emergency Medicine Oncology Primary Care Medicine |
| ISBN | 3-319-26387-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Models of Care for Cancer Emergencies -- Quality Measures for Oncologic Emergency Medicine -- Ethics of Emergency Department Cancer Care -- Patient Navigation -- The Interface of Emergency Department, Oncology, and Palliative Social Work: Psychosocial Interventions in Oncologic Emergencies -- Rapid Learning Systems -- Tobacco-Related Illnesses and Management -- Ionizing Radiation -- Cervical Cancer Prevention -- Radiological and Nuclear Terrorism: The Oncological Emergency Response -- Emergent Management of Acute Airway Obstruction from Malignant Disease -- Oncologic Emergencies of the Central Nervous System (CNS) -- Malignant Spinal Cord Compression -- Head and Neck Oncologic Emergencies -- Cardiovascular Emergencies -- Pulmonary Complications in Cancer Patients -- Venous Thromboembolism -- Superior Vena Cava Syndrome (SVCS) -- Neutropenic Fever -- Bleeding and Thrombosis in Cancer Patients -- Endocrine and Metabolic Emergencies -- Pituitary Apoplexy -- Nephro-Urologic Emergencies in Patients with Cancer -- Oncologic Emergencies: Gastroenterology -- The Acute Abdomen -- Colorectal Cancer Prevention and Emergency Management -- Diarrhea in Cancer Patients -- Constipation in Cancer Patients -- Dermatologic Emergencies in Oncologic Patients -- Gynecologic Oncology Emergencies -- Ophthalmic Emergencies in Cancer Patients -- Psychiatry and Oncologic Emergencies -- Chemotherapy-Induced Toxicities -- Treatment Toxicity: Radiation -- Emergency Radiology -- Pain Management -- Substance Abuse Issues in Oncology: What the ED Professional Needs to Know -- Dyspnea in the Dying Patient -- Palliative Surgery -- Cardiopulmonary Resuscitation in the Cancer Patient -- Emergency Department Use at End of Life Among Cancer Patients -- Capacity Building: Integration of Palliative Care in Emergency Medicine. |
| Record Nr. | UNINA-9910254272603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Oncology and therapy
| Oncology and therapy |
| Pubbl/distr/stampa | Cham, Switzerland, : Springer International Publishing AG, , [2016]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Oncology
Neoplasms Neoplasms - therapy |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2366-1089 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910136266403321 |
| Cham, Switzerland, : Springer International Publishing AG, , [2016]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
-
Neoplasms - therapy
(140)
- Cancer - Treatment (47)
- Oncology (32)
- Cancer (28)
- Medical Oncology (23)