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Tissue barriers in disease, injury and regeneration / / edited by Nikolai V. Gorbunov
| Tissue barriers in disease, injury and regeneration / / edited by Nikolai V. Gorbunov |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Elsevier, , [2021] |
| Descrizione fisica | 1 online resource (197 pages) : illustrations |
| Disciplina | 571.5 |
| Soggetto topico |
Tissues - Mechanical properties
Histology, Pathological Membranes (Biology) Immunology Homeostasis Regeneration (Biology) |
| ISBN |
0-12-822756-7
0-12-818561-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910583023203321 |
| Amsterdam, Netherlands : , : Elsevier, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Voltage-gated ion channels as drug targets [[electronic resource] /] / edited by David J. Triggle ...[et al.]
| Voltage-gated ion channels as drug targets [[electronic resource] /] / edited by David J. Triggle ...[et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley VCH |
| Descrizione fisica | 1 online resource (493 p.) |
| Disciplina | 571.64 |
| Altri autori (Persone) | TriggleD. J |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Ion channels
Membranes (Biology) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-72345-9
9786610723454 3-527-60814-1 3-527-60774-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Voltage-Gated Ion Channels as Drug Targets; Contents; Preface; 1 Introduction - On Ion Channels; 2 The Voltage-gated Ion Channel Superfamily; 2.1 Introduction; 2.2 Voltage-gated Sodium Channels; 2.3 Voltage-gated Calcium Channels; 2.4 Voltage-gated Potassium Channels; 2.5 Inwardly Rectifying Potassium Channels; 2.6 Common Aspects of Ion Channel Structure and Function; 2.7 Conclusions; 3 State-dependent Drug Interactions with Ion Channels; 3.1 Introduction; 3.2 Ion Channels as Drug Receptors; 3.3 Ion Channels Adopt Multiple Conformations
3.4 Biophysics Meets Pharmacology: State Dependence, Voltage Dependence, and the Modulated Receptor Model3.5 Use Dependence; 3.6 Physical Meaning of State Dependence; 3.7 State Dependence in Drug Discovery; 3.8 Future Directions for Ion Channel Drug Discovery; 4 Assay Technologies: Techniques Available for Quantifying Drug-Channel Interactions; 4.1 Introduction; 4.2 Patch Clamp; 4.2.1 Basic Description of Technique; 4.2.2 Advantages and Disadvantages of Manual Patch Clamp; 4.2.3 Use of Patch Clamp for Quantification of Drug-Channel Effects; 4.2.4 Caveats of Interpretations in Patch Clamp 4.3 Planar Patch Clamp4.4 Two-electrode Voltage Clamp (TEVC) of Xenopus Oocytes; 4.5 Membrane Potential Sensing Dyes; 4.5.1 Basic Description of Membrane Potential-sensing Dyes; 4.5.2 Advantages and Disadvantages of Membrane Potential-sensing Dyes; 4.6 Binding; 4.7 Ion Flux; 4.7.1 Fluorescent Indicators of Ion Flux; 4.7.2 Direct Measurement of Ion Flux; 4.8 What Technologies Cannot be Used ... Yet?; 4.9 Summary; 5 Calcium Channels; 5.1 Overview of Voltage-gated Calcium Channels; 5.1.1 Introduction; 5.1.2 Native and Cloned Calcium Channels: Nomenclature and Classification 5.1.3 Distribution of VGCCs and their Physiological Roles5.1.4 Structure of VGCC α(1) Subunits; 5.1.5 VGCC Modulation; 5.1.6 VGCCs: Channelopathies and Pathologies; 5.1.7 Summary; 5.2 Drugs Active at T-type Ca(2+) Channels; 5.2.1 Introduction; 5.2.2 Methodology; 5.2.3 Indications; 5.2.4 Conclusions; 5.3 L-type Calcium Channels; 5.3.1 Introduction; 5.3.2 Drugs that Interact with L-type Channels; 5.3.3 Specific Drug Classes; 5.3.4 Other Drug Classes Active at Ca(V)1 Channels; 5.3.5 Drug Interactions at Non-α-subunit Sites; 5.3.6 Calcium Antagonism through Gene Delivery 5.4 N-type Calcium Channels5.4.1 Introduction; 5.4.2 N-type Calcium Channel Pharmacology; 5.4.3 Inorganic Cations; 5.4.4 Peptide Blockers; 5.4.5 Small Organic Molecule N-type Blockers; 5.4.6 Conclusions; 6 Sodium Channels; 6.1 Molecular, Biophysical and Functional Properties of Voltage-gated Sodium Channels; 6.1.1 Introduction; 6.1.2 Primary and Tertiary Structure; 6.1.3 Sodium Channel Expression; 6.1.4 Biophysical Properties of Voltage-dependent Sodium Channels; 6.1.5 Disease Association; 6.1.6 Conclusions; 6.2 Small Molecule Blockers of Voltage-gated Sodium Channels 6.2.1 Drugs that Act on Sodium Channels |
| Record Nr. | UNINA-9910144274503321 |
| Weinheim, : Wiley VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Voltage-gated ion channels as drug targets [[electronic resource] /] / edited by David J. Triggle ...[et al.]
| Voltage-gated ion channels as drug targets [[electronic resource] /] / edited by David J. Triggle ...[et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley VCH |
| Descrizione fisica | 1 online resource (493 p.) |
| Disciplina | 571.64 |
| Altri autori (Persone) | TriggleD. J |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Ion channels
Membranes (Biology) |
| ISBN |
1-280-72345-9
9786610723454 3-527-60814-1 3-527-60774-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Voltage-Gated Ion Channels as Drug Targets; Contents; Preface; 1 Introduction - On Ion Channels; 2 The Voltage-gated Ion Channel Superfamily; 2.1 Introduction; 2.2 Voltage-gated Sodium Channels; 2.3 Voltage-gated Calcium Channels; 2.4 Voltage-gated Potassium Channels; 2.5 Inwardly Rectifying Potassium Channels; 2.6 Common Aspects of Ion Channel Structure and Function; 2.7 Conclusions; 3 State-dependent Drug Interactions with Ion Channels; 3.1 Introduction; 3.2 Ion Channels as Drug Receptors; 3.3 Ion Channels Adopt Multiple Conformations
3.4 Biophysics Meets Pharmacology: State Dependence, Voltage Dependence, and the Modulated Receptor Model3.5 Use Dependence; 3.6 Physical Meaning of State Dependence; 3.7 State Dependence in Drug Discovery; 3.8 Future Directions for Ion Channel Drug Discovery; 4 Assay Technologies: Techniques Available for Quantifying Drug-Channel Interactions; 4.1 Introduction; 4.2 Patch Clamp; 4.2.1 Basic Description of Technique; 4.2.2 Advantages and Disadvantages of Manual Patch Clamp; 4.2.3 Use of Patch Clamp for Quantification of Drug-Channel Effects; 4.2.4 Caveats of Interpretations in Patch Clamp 4.3 Planar Patch Clamp4.4 Two-electrode Voltage Clamp (TEVC) of Xenopus Oocytes; 4.5 Membrane Potential Sensing Dyes; 4.5.1 Basic Description of Membrane Potential-sensing Dyes; 4.5.2 Advantages and Disadvantages of Membrane Potential-sensing Dyes; 4.6 Binding; 4.7 Ion Flux; 4.7.1 Fluorescent Indicators of Ion Flux; 4.7.2 Direct Measurement of Ion Flux; 4.8 What Technologies Cannot be Used ... Yet?; 4.9 Summary; 5 Calcium Channels; 5.1 Overview of Voltage-gated Calcium Channels; 5.1.1 Introduction; 5.1.2 Native and Cloned Calcium Channels: Nomenclature and Classification 5.1.3 Distribution of VGCCs and their Physiological Roles5.1.4 Structure of VGCC α(1) Subunits; 5.1.5 VGCC Modulation; 5.1.6 VGCCs: Channelopathies and Pathologies; 5.1.7 Summary; 5.2 Drugs Active at T-type Ca(2+) Channels; 5.2.1 Introduction; 5.2.2 Methodology; 5.2.3 Indications; 5.2.4 Conclusions; 5.3 L-type Calcium Channels; 5.3.1 Introduction; 5.3.2 Drugs that Interact with L-type Channels; 5.3.3 Specific Drug Classes; 5.3.4 Other Drug Classes Active at Ca(V)1 Channels; 5.3.5 Drug Interactions at Non-α-subunit Sites; 5.3.6 Calcium Antagonism through Gene Delivery 5.4 N-type Calcium Channels5.4.1 Introduction; 5.4.2 N-type Calcium Channel Pharmacology; 5.4.3 Inorganic Cations; 5.4.4 Peptide Blockers; 5.4.5 Small Organic Molecule N-type Blockers; 5.4.6 Conclusions; 6 Sodium Channels; 6.1 Molecular, Biophysical and Functional Properties of Voltage-gated Sodium Channels; 6.1.1 Introduction; 6.1.2 Primary and Tertiary Structure; 6.1.3 Sodium Channel Expression; 6.1.4 Biophysical Properties of Voltage-dependent Sodium Channels; 6.1.5 Disease Association; 6.1.6 Conclusions; 6.2 Small Molecule Blockers of Voltage-gated Sodium Channels 6.2.1 Drugs that Act on Sodium Channels |
| Record Nr. | UNINA-9910830490903321 |
| Weinheim, : Wiley VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Membranes (Biology)
(53)
- Membranes (9)
- Biochemistry (7)
- Membranes (Biologie) (7)
- Cell membranes (5)