Autore	Romero-González R
Pubbl/distr/stampa	New York, : Nova Science Publishers, c2010
Descrizione fisica	1 online resource (75 p.)
Disciplina	664.001/579
Altri autori (Persone)	Martínez VidalJ. L Garrido FrenichA
Collana	Food science and technology series
Soggetto topico	Food - Microbiology Mycotoxicoses Liquid chromatography Food contamination
ISBN	1-61728-442-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Presence of mycotoxins in food -- Sample preparation -- Chromatographic methods for mycotoxin analysis.
Record Nr.	UNINA-9910828334103321

Autore	Ardrey R. E
Pubbl/distr/stampa	New York, : J. Wiley, 2003
Descrizione fisica	1 online resource (298 p.)
Disciplina	543.84 543/.0894
Collana	Analytical techniques in the sciences
Soggetto topico	Liquid chromatography Mass spectrometry
Soggetto genere / forma	Electronic books.
ISBN	1-280-27145-0 0-470-86217-3 9786610271450 0-470-46889-0 0-470-86729-9
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY: AN INTRODUCTION; Contents; Series Preface; Preface; Acknowledgements; Abbreviations, Acronyms and Symbols; About the Author; 1 Introduction; 1.1 What are the Advantages of Linking High Performance Liquid Chromatography with Mass Spectrometry?; 1.2 What Capabilities are Required of the Combination?; 1.3 What Problems, if Any, Have to be Addressed to Allow the LC-MS Combination to Function, and Function Effectively?; References; 2 Liquid Chromatography; 2.1 Introduction; 2.2 High Performance Liquid Chromatography; 2.2.1 Pump 2.2.2 Sample Introduction (Injector)2.2.3 Mobile Phase; 2.2.4 Stationary Phase; 2.2.5 Detectors; 2.3 Chromatographic Properties; 2.4 Identification Using High Performance Liquid Chromatography; 2.5 Quantitation Using High Performance Liquid Chromatography; 2.6 The Need for High Performance Liquid Chromatography-Mass Spectrometry; References; 3 Mass Spectrometry; 3.1 Introduction; 3.2 Ionization Methods; 3.2.1 Electron Ionization; 3.2.2 Chemical Ionization; 3.2.3 Fast-Atom Bombardment; 3.2.4 Matrix-Assisted Laser Desorption Ionization; 3.2.5 Negative Ionization; 3.3 Ion Separation 3.3.1 The Quadrupole Mass Analyser3.3.2 The (Quadrupole) Ion-Trap Mass Analyser; 3.3.3 The Double-Focusing and Tri-Sector Mass Analysers; 3.3.4 The Time-of-Flight Mass Analyser; 3.4 Tandem Mass Spectrometry (MS-MS); 3.4.1 Instrumentation; 3.4.2 Techniques; 3.5 Data Acquisition; 3.5.1 Identification; 3.5.2 Quantitation; 3.6 Processing of Mass Spectral Data; 3.6.1 The Total-Ion-Current Trace; 3.6.2 Qualitative Analysis; 3.6.3 Quantitative Analysis; 3.6.4 The Use of Tandem Mass Spectrometry; References; 4 Interface Technology; 4.1 Introduction; 4.2 The Moving-Belt Interface 4.3 The Direct-Liquid-Introduction Interface4.4 The Continuous-Flow/Frit (Dynamic) Fast-Atom-Bombardment Interface; 4.5 The Particle-Beam Interface; 4.6 The Thermospray Interface; 4.7 The Electrospray Interface; 4.7.1 The Mechanism of Electrospray Ionization; 4.7.2 Sample Types; 4.7.3 The Appearance of the Electrospray Spectrum; 4.7.4 Structural Information from Electrospray Ionization; 4.8 The Atmospheric-Pressure Chemical Ionization Interface; 4.8.1 The Mechanism of Atmospheric-Pressure Chemical Ionization; References 5 Applications of High Performance Liquid Chromatography-Mass Spectrometry5.1 Method Development; 5.1.1 The Use of Experimental Design for Method Development; 5.1.2 The Choice of Electrospray or APCI; 5.2 The Molecular Weight Determination of Biopolymers; 5.2.1 Electrospray Spectra of Co-Eluting Components; 5.2.2 The Use of Selected-Ion Monitoring to Examine the Number of Terminal Galactose Moieties on a Glycoprotein; 5.2.3 The Effect of Mobile-Phase Additives and Cone-Voltage; 5.3 Structure Determination of Biopolymers; 5.3.1 Amino Acid Sequencing of Proteins 5.3.2 The Use of Enzymes for Amino Acid Sequencing
Record Nr.	UNINA-9910146250203321

Autore	Ferrer Imma <1970->
Pubbl/distr/stampa	Hoboken, NJ, : Wiley, 2008
Descrizione fisica	1 online resource (281 p.)
Disciplina	543.84 543/.84
Altri autori (Persone)	ThurmanE. M <1946-> (Earl Michael)
Collana	Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications
Soggetto topico	Liquid chromatography Time-of-flight mass spectrometry
ISBN	1-282-11306-2 9786612113062 0-470-42996-8 0-470-42995-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	LIQUID CHROMATOGRAPHY TIME-OF-FLIGHT MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; PART I PRINCIPLES AND THEORETICAL ASPECTS OF ACCURATE MASS; CHAPTER 1 ACCURATE MASS MEASUREMENTS WITH ORTHOGONAL AXIS TIME-OF-FLIGHT MASS SPECTROMETRY; CHAPTER 2 THE MASS DEFECT, ISOTOPE CLUSTERS, AND ACCURATE MASS FOR ELEMENTAL DETERMINATION; PART II TOOLS FOR UNKNOWN IDENTIFICATION USING ACCURATE MASS; CHAPTER 3 ION COMPOSITIONS DETERMINED WITH INCREASING SIMPLICITY; CHAPTER 4 EXISTENCE AND USE OF ACCURATE MASS DATABASES AND ELEMENTAL COMPOSITION TOOLS FOR TARGET AND NON-TARGET ANALYSES CHAPTER 5 USE OF UPLC-(Q)TOF MS FOR RAPID SCREENING OF ORGANIC MICROPOLLUTANTS IN WATER CHAPTER 6 THE USE OF ACCURATE MASS, ISOTOPE RATIOS, AND MS/MS FOR THE ANALYSIS OF PPCPs IN WATER; PART III APPLICATIONS OF LC/TOF-MS FOR THE IDENTIFICATION OF SMALL MOLECULES; CHAPTER 7 APPLICATIONS OF LC/TOF-MS IN THE ENVIRONMENTAL FIELD: WHEN DID IT START AND WHERE IS IT GOING?; CHAPTER 8 LIQUID CHROMATOGRAPHY AND AMBIENT IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY FOR THE ANALYSIS OF GENUINE AND COUNTERFEIT PHARMACEUTICALS CHAPTER 9 QUANTITATIVE ANALYSIS OF VETERINARY DRUG RESIDUES BY SUB 2-μm PARTICULATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMNS AND TIME-OF-FLIGHT MASS SPECTROMETRY (UPLC-TOF)CHAPTER 10 INDUSTRIAL APPLICATIONS OF LIQUID CHROMATOGRAPHY TIME-OF-FLIGHT MASS SPECTROMETRY; CHAPTER 11 COMPREHENSIVE TOXICOLOGICAL AND FORENSIC DRUG SCREENING BY LC/TOF-MS; CHAPTER 12 APPLICATION OF UPLC/TOF-MS FOR RESIDUE ANALYSIS OF VETERINARY DRUGS AND GROWTH-PROMOTING AGENTS IN PRODUCTS OF ANIMAL ORIGIN CHAPTER 13 ACCURATE MASS MEASUREMENTS WITH A REFLECTRON TIME-OF-FLIGHT MASS SPECTROMETER AND THE DIRECT ANALYSIS IN REAL TIME (DART) INTERFACE FOR THE IDENTIFICATION OF UNKNOWN COMPOUNDS BELOW MASSES OF 500 DACHAPTER 14 COMPARISON OF LC/TOF-MS AND LC/MS-MS FOR THE ANALYSIS OF 100 PESTICIDES IN FOOD: FINDING THE "CROSSOVER POINT""; INDEX
Record Nr.	UNINA-9910143082803321

Pubbl/distr/stampa	Hoboken, N.J., : Wiley-Interscience, c2008
Descrizione fisica	1 online resource (490 p.)
Disciplina	543.84 543/.84
Altri autori (Persone)	CohenSteven A. <1953-> SchureMark R
Soggetto topico	Biochemistry Chemical engineering Chemistry, Technical Liquid chromatography
Soggetto genere / forma	Electronic books.
ISBN	1-281-28497-1 9786611284978 0-470-27626-6 0-470-27625-8
Classificazione	35.71 35.29 58.14 VG 7500
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY; CONTENTS; Foreword; Preface; Contributors; 1 Introduction; 1.1 Previous Literature Which Covers MDLC; 1.2 How this Book is Organized; References; PART I THEORY; 2 Elements of the Theory of Multidimensional Liquid Chromatography; 2.1 Introduction; 2.2 Peak Capacity; 2.3 Resolution; 2.4 Orthogonality; 2.5 Two-Dimensional Theory of Peak Overlap; 2.6 Dimensionality, Peak Ordering, and Clustering; 2.7 Theory of Zone Sampling; 2.8 Dilution and Limit of Detection; 2.9 Chemometric Analysis; 2.10 Future Directions; References 3 Peak Capacity in Two-Dimensional Liquid Chromatography3.1 Introduction; 3.2 Theory; 3.3 Procedures; 3.4 Results and Discussion; 3.5 Conclusions; Appendix 3A Generation of Random Correlated Coordinates; Appendix 3B Derivation of Limiting Correlation Coefficient r; References; 4 Decoding Complex 2D Separations; 4.1 Introduction; 4.2 Fundamentals: The Statistical Description of Complex Multicomponent Separations; 4.3 Decoding 1D and 2D Multicomponent Separations by Using the SMO Poisson Statistics; 4.4 Decoding Multicomponent Separations by the Autocovariance Function 4.5 Application to 2D Separations4.5.1 Results from SMO Method; 4.5.2 Results from 2D Autocovariance Function Method; 4.6 Concluding Remarks; Acknowledgments; References; PART II COLUMNS, INSTRUMENTATION AND METHODS DEVELOPMENT; 5 Instrumentation for Comprehensive Multidimensional Liquid Chromatography; 5.1 Introduction; 5.2 Heart-Cutting Versus Comprehensive Mode; 5.3 Chromatographic Hardware; 5.3.1 Valves; 5.4 CE Interfaces; 5.4.1 Gated Interface for HPLC-CE; 5.4.2 Microfluidic Valves for On-Chip Multidimensional Analysis; 5.5 Columns and Combinations 5.5.1 Column Systems, Dilution, and Splitting5.6 Detection; 5.7 Computer Hardware and Software; 5.7.1 Software Development; 5.7.2 Valve Sequencing; 5.7.3 Data Format and Storage; 5.8 Zone Visualization; 5.8.1 Contour Visualization; 5.8.2 2D Peak Presentation; 5.8.3 Zone Visualization in Specific Chemical (pI) Regions; 5.8.4 External Plotting Programs; 5.8.5 Difference Plots; 5.8.6 Multi-channel Data; 5.9 Data Analysis and Signal Processing; 5.10 Future Prospects; References; 6 Method Development in Comprehensive Multidimensional Liquid Chromatography; 6.1 Introduction; 6.2 Previous Work 6.3 Column Variables6.4 Method Development; 6.4.1 The Cardinal Rules of 2DLC Method Development; 6.5 Planning the Experiment; 6.6 General Comments on Optimizing the 2DLC Experiment: Speed-Resolution Trade-off; Acknowledgment; References; 7 Monolithic Columns and Their 2D-HPLC Applications; 7.1 Introduction; 7.2 Monolithic Polymer Columns; 7.2.1 Structural Properties of Polymer Monoliths; 7.2.2 Chromatographic Properties of Polymer Monolithic Columns; 7.2.3 Two-Dimensional HPLC Using Polymer Monoliths; 7.3 Monolithic Silica Columns; 7.3.1 Preparation 7.3.2 Structural Properties of Monolithic Silica Columns
Record Nr.	UNINA-9910145267303321

Pubbl/distr/stampa	New York, : J. Wiley & Sons, c2002
Descrizione fisica	1 online resource (308 p.)
Disciplina	543.089 543/.0877
Altri autori (Persone)	AlbertKlaus
Soggetto topico	Nuclear magnetic resonance spectroscopy Liquid chromatography
Soggetto genere / forma	Electronic books.
ISBN	1-280-27011-X 9786610270118 0-470-31452-4 0-470-85481-2 0-470-85482-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	On-Line LC-NMR and Related Techniques; Contents; Contributors; Preface; 1 LC-NMR: Theory and Experiment; 1.1 Introduction; 1.2 NMR in a Flowing Liquid; 1.3 Design of Continuous-Flow NMR Probes; 1.4 Experimental Arrangement for HPLC-(1)H NMR Coupling; 1.5 Practical Considerations, Solvent Suppression Techniques, Gradient Elution and Purity of HPLC Solvents; 1.5.1 Solvent Signal Suppression; 1.5.2 Purity of HPLC-Grade Solvents; References; 2 LC-NMR: Automation; 2.1 Practical Use of LC-NMR and LC-NMR/MS; 2.2 Different Working Modes in LC-NMR; 2.2.1 On-Flow; 2.2.2 Direct Stop-Flow 2.2.3 Loop Storage/Loop Transfer2.2.4 Conclusions; 2.3 Use of Mass Spectrometry in the Set-Up; 2.4 Measurement Procedures; 2.4.1 Sample Preparation and Introduction ('Injection') into the Chromatography System; 2.4.2 Chromatographic Separation; 2.4.3 Peak Detection and Selection; 2.4.4 Mass Spectrometric Measurements; 2.4.5 Nuclear Magnetic Resonance Measurements; 2.4.6 Sample Recovery; 2.5 Conclusions; References; 3 Biomedical and Pharmaceutical Applications of HPLC-NMR and HPLC-NMR-MS; 3.1 Introduction; 3.2 Technical and Operational Overview; 3.3 Applications in Combinatorial Chemistry 3.4 Application to Chemical Impurities3.5 Application to Chiral Separations of Pharmaceutical Mixtures; 3.6 Application to Natural Products; 3.7 Application to Chemical Reactivity of Drug Glucuronides; 3.8 Application to Futile Deacetylation Reactions; 3.9 Application to Trapping of Reactive Intermediates; 3.10 Application to Uptake and Transformation of Xenobiotics by Plants; 3.11 Separation of Lipoproteins and their Characterisation using HPLC-NMR; 3.12 Superheated-Water HPLC-NMR and HPLC-NMR-MS Studies on Pharmaceuticals 3.13 Application of Hypernation to a Mixture of Non-Steroidal Anti-Inflammatory Drugs3.14 Concluding Remarks; References; 4 Application of On-Line LC-NMR and Related Techniques to Drug Metabolism Studies; 4.1 Introduction; 4.2 LC-NMR Techniques; 4.2.1 Continuous-Flow LC-NMR; 4.2.2 Time-Slice LC-NMR; 4.2.3 Stop-Flow LC-NMR; 4.2.4 Loop-Storage; 4.2.5 LC-NMR-MS; 4.3 Application of LC-NMR-MS to Drug Metabolism: The Structure Elucidation of Rat Urinary Metabolites of Efavirenz by LC-NMR-MS; 4.3.1 Experimental; 4.3.2 Results; 4.4 Conclusions; References; 5 LC-NMR for Natural Products Analysis 5.1 Application of LC-NMR and LC-NMR-MS Hyphenation to Natural Products Analysis5.1.1 Introduction; 5.1.1.1 General Aspects; 5.1.1.2 Applications; 5.1.2 Application of LC-NMR-MS to Glycosidic Natural Products of Marine Origin; 5.1.2.1 Introduction - Need for LC-NMR; 5.1.2.2 Methodology: On-Flow LC-NMR-MS Screening; 5.1.2.3 NMR - Structural Information; 5.1.2.4 Mass Spectrometry and D-H Back-Exchange Experiments; 5.1.2.5 Stop-Flow Experiments; 5.1.2.6 Complimentary Structural Information of NMR and MS; 5.1.2.7 Conclusions; 5.1.3 Acknowledgements; References 5.2 Hyphenation of Modern Extraction Techniques to LC-NMR for the Analysis of Geometrical Carotenoid Isomers in Functional Food and Biological Tissues
Record Nr.	UNINA-9910142493503321